Faculty Opinions recommendation of Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.

2012 ◽  
Author(s):  
Jonathan Dostrovsky
Keyword(s):  
Neuropathic Pain ◽  
Rostral Ventromedial Medulla ◽  
Descending Inhibition ◽  
Chronic Neuropathic Pain ◽  
Ventromedial Medulla

scholarly journals Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

Pain ◽  
2011 ◽  
Vol 152 (12) ◽  
pp. 2701-2709 ◽  
Author(s):  
Milena De Felice ◽  
Raul Sanoja ◽  
Ruizhong Wang ◽  
Louis Vera-Portocarrero ◽  
Janice Oyarzo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Rostral Ventromedial Medulla ◽  
Descending Inhibition ◽  
Chronic Neuropathic Pain ◽  
Ventromedial Medulla

scholarly journals Descending inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla

2021 ◽  
Author(s):  
Taylor Follansbee ◽  
Dan Domocos ◽  
Eileen Nguyen ◽  
Amanda Nguyen ◽  
Aristea Bountouvas ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Rostral Ventromedial Medulla ◽  
Projection Neurons ◽  
Descending Pathways ◽  
Descending Inhibition ◽  
Neurokinin 1 Receptor ◽  
Nociceptive Transmission ◽  
Descending Modulation ◽  
Ventromedial Medulla ◽  
Neurokinin 1

The rostral ventromedial medulla (RVM) is important in descending modulation of spinal nociceptive transmission, but it is unclear if these descending pathways also modulate spinal pruriceptive transmission. RVM ON cells are activated by noxious algesic and pruritic stimuli and are pronociceptive. Many RVM-spinal projection neurons express the neurokinin-1 receptor (Tacr1), and ON-cells are excited by local administration of substance P (SP). We hypothesized that Tacr1-expressing RVM ON cells exert an inhibitory effect on itch opposite to their pronociceptive action. Intramedullary microinjection of SP significantly potentiated RVM ON cells and reduced pruritogen-evoked scratching while facilitating mechanical nociception. Chemogenetic activation of RVM Tacr1-expressing RVM neurons also reduced acute pruritogen-evoked scratching behavior while enhancing mechanonociception. Optotagging experiments confirmed RVM Tacr1-expressing neurons to be ON cells. We conclude that Tacr1-expressing ON cells in RVM play a significant role in the descending inhibition of spinal pruriceptive transmission.

Sign in / Sign up

Export Citation Format

Share Document