Faculty Opinions recommendation of A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior.

2014 ◽  
Author(s):  
Brian Baldo
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Long Range ◽  
Avoidance Behavior ◽  
Gabaergic Neurons

scholarly journals Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition

2021 ◽  
Author(s):  
Rawan AlSubaie ◽  
Ryan W S Wee ◽  
Anne Ritoux ◽  
Karyna Mischanchuk ◽  
Daniel Regester ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Long Range ◽  
Pyramidal Neurons ◽  
Ventral Hippocampus ◽  
Excitatory Input ◽  
Place Value ◽  
Inhibitory Input ◽  
Downstream Targets ◽  
Basal Amygdala

ABSTRACTProjections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons, and avoids prefrontal cortex-projecting vH neurons; while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

scholarly journals Control of parallel hippocampal output pathways by amygdalar long-range inhibition

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Rawan AlSubaie ◽  
Ryan WS Wee ◽  
Anne Ritoux ◽  
Karyna Mishchanchuk ◽  
Jessica Passlack ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Long Range ◽  
Pyramidal Neurons ◽  
Ventral Hippocampus ◽  
Excitatory Input ◽  
Place Value ◽  
Inhibitory Input ◽  
Downstream Targets ◽  
Basal Amygdala

Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons, and avoids prefrontal cortex-projecting vH neurons; while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

scholarly journals Long-range GABAergic neurons in the prefrontal cortex modulate behavior

2015 ◽  
Vol 114 (3) ◽  
pp. 1357-1359 ◽  
Author(s):  
Christian Bravo-Rivera ◽  
Maria M. Diehl ◽  
Ciorana Roman-Ortiz ◽  
Jose Rodriguez-Romaguera ◽  
Luis E. Rosas-Vidal ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Learning And Memory ◽  
Long Range ◽  
Medial Prefrontal Cortex ◽  
Behavioral Neuroscience ◽  
Memory Models ◽  
Gabaergic Neurons

Cortical glutamatergic projections are extensively studied in behavioral neuroscience, whereas cortical GABAergic projections to downstream structures have been overlooked. A recent study by Lee and colleagues (Lee AT, Vogt D, Rubenstein JL, Sohal VS. J Neurosci 34: 11519–11525, 2014) used optogenetic and electrophysiological techniques to characterize a behavioral role for long-projecting GABAergic neurons in the medial prefrontal cortex. In this Neuro Forum, we discuss the potential implications of this study in several learning and memory models.

Sign in / Sign up

Export Citation Format

Share Document