scholarly journals Control of parallel hippocampal output pathways by amygdalar long-range inhibition

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Rawan AlSubaie ◽  
Ryan WS Wee ◽  
Anne Ritoux ◽  
Karyna Mishchanchuk ◽  
Jessica Passlack ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Long Range ◽  
Pyramidal Neurons ◽  
Ventral Hippocampus ◽  
Excitatory Input ◽  
Place Value ◽  
Inhibitory Input ◽  
Downstream Targets ◽  
Basal Amygdala

Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons, and avoids prefrontal cortex-projecting vH neurons; while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

scholarly journals Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition

2021 ◽  
Author(s):  
Rawan AlSubaie ◽  
Ryan W S Wee ◽  
Anne Ritoux ◽  
Karyna Mischanchuk ◽  
Daniel Regester ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Long Range ◽  
Pyramidal Neurons ◽  
Ventral Hippocampus ◽  
Excitatory Input ◽  
Place Value ◽  
Inhibitory Input ◽  
Downstream Targets ◽  
Basal Amygdala

ABSTRACTProjections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons, and avoids prefrontal cortex-projecting vH neurons; while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

Dendritic morphology changes in neurons from the ventral hippocampus, amygdala and nucleus accumbens in rats with neonatal lesions into the prefrontal cortex

Synapse ◽  
2015 ◽  
Vol 69 (6) ◽  
pp. 314-325 ◽  
Author(s):  
Zayda Lazcano ◽  
Oscar Solis ◽  
Alfonso Díaz ◽  
Eduardo Brambila ◽  
Patricia Aguilar-Alonso ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Ventral Hippocampus ◽  
Dendritic Morphology ◽  
Neonatal Lesions ◽  
Morphology Changes

scholarly journals Cell-type and endocannabinoid specific synapse connectivity in the adult nucleus accumbens core

2019 ◽  
Author(s):  
Marion A. Deroche ◽  
Olivier Lassalle ◽  
Olivier J. Manzoni
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Basolateral Amygdala ◽  
Ventral Hippocampus ◽  
Cb1 Receptors ◽  
Medium Spiny Neurons ◽  
Cell Type ◽  
Spiny Neurons ◽  
Trpv1 Receptors ◽  
Specific Manner

ABSTRACTThe nucleus accumbens (NAc) is a mesocorticolimbic structure that integrates cognitive, emotional and motor functions. Although its role in psychiatric disorders is widely acknowledged, the understanding of its circuitry is not complete. Here we combined optogenetic and whole-cell recordings to draw a functional portrait of excitatory disambiguated synapses onto D1 and D2 medium spiny neurons (MSNs) in the adult mouse NAc core. Comparing synaptic properties of ventral hippocampus (vHipp), basolateral amygdala (BLA) and prefrontal cortex (PFC) inputs revealed a hierarchy of synaptic inputs and feedforward inhibition that depends on the identity of the postsynaptic target MSN. Thus, the BLA is the dominant excitatory pathway onto D1 MSNs (BLA > PFC = vHipp) while PFC inputs dominate D2 MSNs (PFC > vHipp > BLA). Feedforward inhibition of MSN firing too, was input and cell-type specific: while minimal at vHipp-D1 and vHipp-D2 inputs; it inhibited with similar efficacy BLA-D1 or BLA-D2 inputs, was minimal at PFC-D1 but maximal at PFC-D2 inputs. We also tested the hypothesis that endocannabinoids endow excitatory circuits with pathway- and cell-specific plasticity. Thus, while CB1 receptors (CB1R) uniformly depress excitatory pathways irrespective of MSNs identity, TRPV1 receptors (TRPV1R) bidirectionally control inputs onto the NAc core in a pathway-specific manner. Finally, we show how the interplay of TRPV1R/CB1R shapes plasticity at identified BLA-NAc synapses. Together these data shed new light on synapse and circuit specificity in the adult NAc core and illustrate how endocannabinoids contribute to pathway-specific synaptic plasticity.SIGNIFICANCE STATEMENTWe examined the impact of connections from the ventral hippocampus (vHipp,) basolateral amygdala (BLA) and prefrontal cortex (PFC) onto identified medium spiny neurons (MSN) in the adult accumbens core. We found BLA inputs were strongest at D1 MSNs while PFC inputs dominate D2 MSNs. We evaluated the role of the endocannabinoid system in pathway- and cell-specific plasticity and found that CB1 receptors (CB1R) and TRPV1 receptors (TRPV1R) bidirectionally control synaptic transmission and plasticity onto accumbens’ MSNs in a pathway- and cell-specific manner. Finally, we clarify how the interplay of TRPV1R/CB1R shapes plasticity at identified BLA-NAc synapses.

scholarly journals Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Joachim Ahlbeck ◽  
Lingzhen Song ◽  
Mattia Chini ◽  
Sebastian H Bitzenhofer ◽  
Ileana L Hanganu-Opatz
Keyword(s):  
Long Range ◽  
Pyramidal Neurons ◽  
High Efficiency ◽  
Dorsal Hippocampus ◽  
Phase Locking ◽  
Ventral Hippocampus ◽  
Neuronal Firing ◽  
Projection Neurons ◽  
Cellular Origin ◽  
Hippocampal Networks

The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain.

scholarly journals A genuine layer 4 in motor cortex with prototypical synaptic circuit connectivity

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Naoki Yamawaki ◽  
Katharine Borges ◽  
Benjamin A Suter ◽  
Kenneth D Harris ◽  
Gordon M G Shepherd
Keyword(s):  
Motor Cortex ◽  
Long Range ◽  
Pyramidal Neurons ◽  
Excitatory Input ◽  
Synaptic Connections ◽  
Input Output ◽  
Layer 4 ◽  
Traditional Assumption ◽  
Dendritic Arbors ◽  
Inputs And Outputs

The motor cortex (M1) is classically considered an agranular area, lacking a distinct layer 4 (L4). Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with input–output circuits like those of the L4 neurons in sensory areas. Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs. M1-L4 neurons were electrophysiologically diverse but morphologically uniform, with pyramidal-type dendritic arbors and locally ramifying axons, including branches extending into L2/3. Our findings therefore identify pyramidal neurons in M1 with the expected prototypical circuit properties of excitatory L4 neurons, and question the traditional assumption that motor cortex lacks this layer.

Sign in / Sign up

Export Citation Format

Share Document