Faculty Opinions recommendation of Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study.

Abstract Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Methods In a Norwegian prospective cohort study, we enrolled 607 HCW before and after the first COVID-19 wave. Exposure history, COVID-19–like symptoms, and serum samples were collected. SARS-CoV-2–specific antibodies were characterized by spike-protein IgG/IgM/IgA enzyme-linked immunosorbent and live-virus neutralization assays. Results Spike-specific IgG/IgM/IgA antibodies increased after the first wave in HCW with, but not in HCW without, COVID-19 patient exposure. Thirty-two HCW (5.3%) had spike-specific antibodies (11 seroconverted with ≥4-fold increase, 21 were seropositive at baseline). Neutralizing antibodies were found in 11 HCW that seroconverted, of whom 4 (36.4%) were asymptomatic. Ninety-seven HCW were tested by reverse transcriptase polymerase chain reaction (RT-PCR) during follow-up; 8 were positive (7 seroconverted, 1 had undetectable antibodies). Conclusions We found increases in SARS-CoV-2 neutralizing antibodies in infected HCW, especially after COVID-19 patient exposure. Our data show a low number of SARS-CoV-2–seropositive HCW in a low-prevalence setting; however, the proportion of seropositivity was higher than RT-PCR positivity, highlighting the importance of antibody testing.

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Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

BMJ Open ◽

10.1136/bmjopen-2019-036275 ◽

2020 ◽

Vol 10 (6) ◽

pp. e036275

Author(s):

Maryse Volery ◽

Valentin Scherz ◽

William Jakob ◽

Diane Bandeira ◽

Vanessa Deggim-Messmer ◽

...

Keyword(s):

Antibiotic Resistance ◽

Cohort Study ◽

Breast Milk ◽

Health Outcomes ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Intestinal Microbiome ◽

Metagenomic Sequencing ◽

Adverse Health Outcomes ◽

Registration Number

IntroductionThere is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether effects are only short term or persist long term remain uncertain.Methods and analysesIn this prospective cohort study, we will use metagenomic sequencing to determine: (1) the effect of intrapartum antibiotics on the composition of the breast milk, and the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (2) the effect of antibiotic exposure in the first year of life on the composition of the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (3) the effect of disruption of the infant oral and intestinal microbiome on health outcomes and (4) the compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome.Ethics and disseminationThe ABERRANT study has been approved by the commission cantonale d’éthique de la recherche sur l’être humain (CER-VD) du Canton de Vaud (#2019–01567). Outcomes will be disseminated through publication and will be presented at scientific conferences.Trial registration numberNCT04091282.

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The MILC Study—Exploring the prevalence and outcomes associated with breast milk expression: A prospective cohort study

Women and Birth ◽

10.1016/j.wombi.2013.08.239 ◽

2013 ◽

Vol 26 ◽

pp. S7

Author(s):

D.A. Forster ◽

H. Johns ◽

L.H. Amir ◽

H.L. McLachlan ◽

A. Moorhead ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Breast Milk Expression

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Cross-sectional assessment of infants’ exposure to toxic metals through breast milk in a prospective cohort study of mining communities in Ghana

BMC Public Health ◽

10.1186/s12889-017-4403-8 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 10

Author(s):

David Kwaku Bansa ◽

Adolf Kofi Awua ◽

Rose Boatin ◽

Theodosia Adom ◽

Edward Christian Brown-Appiah ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Toxic Metals ◽

Prospective Cohort ◽

Cross Sectional ◽

Mining Communities

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Evaluation of the impact of breast milk expression in early postpartum period on breastfeeding duration: a prospective cohort study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-015-0698-6 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 18

Author(s):

Beiqi Jiang ◽

Jing Hua ◽

Yijing Wang ◽

Yun Fu ◽

Zhigang Zhuang ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Postpartum Period ◽

Prospective Cohort ◽

Breastfeeding Duration ◽

Breast Milk Expression ◽

Early Postpartum Period ◽

Early Postpartum ◽

The Impact

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Breast milk Vitamin B12 Concentration and Incidence of Diarrhea and Respiratory Infections among Infants in Urban Tanzania: a prospective cohort study

10.21203/rs.2.22305/v2 ◽

2020 ◽

Author(s):

Omar Ndano Lweno ◽

Christopher R Sudfeld ◽

Ellen Hertzmark ◽

Karim P Manji ◽

Anne Marie Darling ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Vitamin B12 ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Respiratory Infections ◽

Recent Trial ◽

Indian Children ◽

Childhood Infections ◽

Vitamin B12 Supplementation

Abstract Objective: A recent trial of vitamin B12 supplementation among Indian children 6-30 months found no effect on the incidence of diarrhea and respiratory infections. These results differ with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania. Results: A prospective cohort study was undertaken to determine the association of breast milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had breast milk vitamin B12 inadequacy (<310 pmol/L). Using generalized estimating equations, we found no overall association of milk vitamin B12 concentration with incident diarrhea and acute respiratory infections in infants. Studies measuring longitudinal changes of breast milk B12 concentration over time are needed to clarify the role of breast milk vitamin B12 in childhood infections.

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Seroprevalence of SARS-CoV-2–specific antibodies in cancer outpatients in Madrid (Spain): A single center, prospective, cohort study and a review of available data

Cancer Treatment Reviews ◽

10.1016/j.ctrv.2020.102102 ◽

2020 ◽

Vol 90 ◽

pp. 102102

Author(s):

Luis Cabezón-Gutiérrez ◽

Sara Custodio-Cabello ◽

Magda Palka-Kotlowska ◽

Eduardo Oliveros-Acebes ◽

María José García-Navarro ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Single Center ◽

Specific Antibodies

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Breast milk vitamin B12 concentration and incidence of diarrhea and respiratory infections among infants in urban Tanzania: a prospective cohort study

BMC Research Notes ◽

10.1186/s13104-020-05003-7 ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Omar N. Lweno ◽

Christopher R. Sudfeld ◽

Ellen Hertzmark ◽

Karim P. Manji ◽

Anne Marie Darling ◽

...

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Vitamin B12 ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Respiratory Infections

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Common Breastfeeding Problems and Their Effect on The Continuation of Exclusive or Predominant Breastfeeding in Kinshasa

10.21203/rs.3.rs-36783/v1 ◽

2020 ◽

Author(s):

Pelagie Babakazo ◽

Marc Bosonkie ◽

Eric Mafuta ◽

Nono Mvuama ◽

Mala-Ali Mapatano

Keyword(s):

Cohort Study ◽

Breast Milk ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Sociodemographic Characteristics ◽

Milk Supply ◽

Lactating Mothers ◽

Exclusive Or ◽

Breastfeeding Problems

Abstract Background: Breastfeeding has numerous advantages for infant, mother and society. However, many mothers discontinue breastfeeding due to problems they encounter. This study aimed to identify problems commonly experienced by breastfeeding mothers during the first six months in Kinshasa and to determine their effect on the continuation of exclusive or predominant breastfeeding.Methods: A prospective cohort study was carried out in Kinshasa from October 2012 to July 2013. A total of 422 mother-infant couples were recruited shortly after being discharged from twelve maternity facilities in Kinshasa and followed-up for six months. Interviews were conducted at the mother’s house during the first week after birth, and thereafter at monthly intervals for six months. Data included mother’s sociodemographic characteristics, the breastfeeding problems she experienced and information on child’s feeding. The Cox Proportional Model was used to determine the effect of breastfeeding problems on the continuation of exclusive or predominant breastfeeding.Results: Cracked or sore nipples, insufficient production of milk and breast engorgement were the most commonly experienced problems by lactating mothers. The problems occurred mainly during the first week (17.1%; CI95% 13.7–21.1) and the rest of the first month (16.2%; CI95% 12.8–20.3). Experiencing breastfeeding problems during any period negatively affected the continuation of exclusive or predominant breastfeeding.Conclusions: The first month after birth presents the most risk for the occurrence of breastfeeding problems. Those problems negatively affect the course of breastfeeding. Mothers should be supported as soon as possible after delivery, to improve their breastfeeding performance and to be informed on how to maintain breast milk supply.

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