Faculty Opinions recommendation of Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

2016 ◽  
Author(s):  
Martin Fernandez-Zapico
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Drug Screening ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Cancer Modeling ◽  
Ductal Pancreatic Cancer ◽  
Tumor Organoids

scholarly journals Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

2015 ◽  
Vol 21 (11) ◽  
pp. 1364-1371 ◽  
Author(s):  
Ling Huang ◽  
Audrey Holtzinger ◽  
Ishaan Jagan ◽  
Michael BeGora ◽  
Ines Lohse ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Drug Screening ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Cancer Modeling ◽  
Ductal Pancreatic Cancer ◽  
Tumor Organoids

Designer pancreatic cancer generated from human pluripotent stem cell derived ducts

2019 ◽  
Author(s):  
M Breunig ◽  
J Merkle ◽  
T Seufferlein ◽  
M Hohwieler ◽  
A Kleger
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell

scholarly journals Engineering a Human Pluripotent Stem Cell-Based in vitro Microphysiological System for Studying the Metformin Response in Aortic Smooth Muscle Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Nan Chen ◽  
Mieradilijiang Abudupataer ◽  
Sisi Feng ◽  
Shichao Zhu ◽  
Wenrui Ma ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Stem Cell ◽  
Aortic Aneurysm ◽  
Drug Screening ◽  
Pluripotent Stem Cell ◽  
Aortic Aneurysms ◽  
Potential Drug ◽  
Human Pluripotent Stem Cell ◽  
Aortic Smooth Muscle

Aortic aneurysm is a common cardiovascular disease characterised by continuous dilation of the aorta, and this disease places a heavy burden on healthcare worldwide. Few drugs have been suggested to be effective in controlling the progression of aortic aneurysms. Preclinical drug responses from traditional cell culture and animals are usually controversial. An effective in vitro model is of great demand for successful drug screening. In this study, we induced an in vitro microphysiological system to test metformin, which is a potential drug for the treatment of aortic aneurysms. Human pluripotent stem cell-derived aortic smooth muscle cells (hPSC-HASMCs) were cultured on an in vitro microphysiological system, which could replicate the cyclic stretch of the human native aortic wall. By using this system, we found that HASMCs were more likely to present a physiologically contractile phenotype compared to static cell cultures. Moreover, we used hPSC-HASMCs in our microphysiological system to perform metformin drug screening. The results showed that hPSC-HASMCs presented a more contractile phenotype via NOTCH 1 signalling while being treated with metformin. This result indicated that metformin could be utilised to rescue hPSC-HASMCs from phenotype switching during aortic aneurysm progression. This study helps to elucidate potential drug targets for the treatment of aortic aneurysms.

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