scholarly journals Faculty Opinions recommendation of Early-life exposures to persistent organic pollutants in relation to overweight in preschool children.

2020 ◽  
Author(s):  
Stephen Safe
Keyword(s):  
Preschool Children ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Early Life ◽  
Early Life Exposures

scholarly journals Early-life exposures to persistent organic pollutants in relation to overweight in preschool children

2017 ◽  
Vol 68 ◽  
pp. 145-153 ◽  
Author(s):  
Martina Karlsen ◽  
Philippe Grandjean ◽  
Pal Weihe ◽  
Ulrike Steuerwald ◽  
Youssef Oulhote ◽  
...  
Keyword(s):  
Preschool Children ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Early Life ◽  
Early Life Exposures

scholarly journals Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants

2019 ◽  
Vol 2019 ◽  
pp. 1-19 ◽  
Author(s):  
Nathalie Grova ◽  
Henri Schroeder ◽  
Jean-Luc Olivier ◽  
Jonathan D. Turner
Keyword(s):  
Neurodegenerative Diseases ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Early Life ◽  
Organic Pollutant ◽  
Later Life ◽  
Epidemiological Studies ◽  
Autism Spectrum ◽  
Increased Risk ◽  
The Individual

The incidence of neurodevelopmental and neurodegenerative diseases worldwide has dramatically increased over the last decades. Although the aetiology remains uncertain, evidence is now growing that exposure to persistent organic pollutants during sensitive neurodevelopmental periods such as early life may be a strong risk factor, predisposing the individual to disease development later in life. Epidemiological studies have associated environmentally persistent organic pollutant exposure to brain disorders including neuropathies, cognitive, motor, and sensory impairments; neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD); and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). In many ways, this expands the classical “Developmental Origins of Health and Disease” paradigm to include exposure to pollutants. This model has been refined over the years to give the current “three-hit” model that considers the individual’s genetic factors as a first “hit.” It has an immediate interaction with the early-life exposome (including persistent organic pollutants) that can be considered to be a second “hit.” Together, these first two “hits” produce a quiescent or latent phenotype, most probably encoded in the epigenome, which has become susceptible to a third environmental “hit” in later life. It is only after the third “hit” that the increased risk of disease symptoms is crystallised. However, if the individual is exposed to a different environment in later life, they would be expected to remain healthy. In this review, we examine the effect of exposure to persistent organic pollutants and particulate matters in early life and the relationship to subsequent neurodevelopmental and neurodegenerative disorders. The roles of those environmental factors which may affect epigenetic DNA methylation and therefore influence normal neurodevelopment are then evaluated.

scholarly journals Early-life exposure to multiple persistent organic pollutants and metals and birth weight: Pooled analysis in four Flemish birth cohorts

2020 ◽  
Vol 145 ◽  
pp. 106149
Author(s):  
Eva Govarts ◽  
Lützen Portengen ◽  
Nathalie Lambrechts ◽  
Liesbeth Bruckers ◽  
Elly Den Hond ◽  
...  
Keyword(s):  
Birth Weight ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Early Life ◽  
Pooled Analysis ◽  
Birth Cohorts ◽  
Early Life Exposure

Early life developmental effects of marine persistent organic pollutants on the sea urchin Psammechinus miliaris

2011 ◽  
Vol 74 (8) ◽  
pp. 2182-2192 ◽  
Author(s):  
Henrique M.R. Anselmo ◽  
Lina Koerting ◽  
Sarah Devito ◽  
Johannes H.J. van den Berg ◽  
Marco Dubbeldam ◽  
...  
Keyword(s):  
Organic Pollutants ◽  
Sea Urchin ◽  
Persistent Organic Pollutants ◽  
Early Life ◽  
Developmental Effects ◽  
Psammechinus Miliaris

scholarly journals Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home

2003 ◽  
Vol 13 (3) ◽  
pp. 187-202 ◽  
Author(s):  
Nancy K Wilson ◽  
Jane C Chuang ◽  
Christopher Lyu ◽  
Ronald Menton ◽  
Marsha K Morgan
Keyword(s):  
Preschool Children ◽  
Organic Pollutants ◽  
Persistent Organic Pollutants ◽  
Day Care ◽  
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