Faculty Opinions recommendation of In utero exposure to antibiotics and risk of congenital malformations: a population-based study.

2020 ◽  
Author(s):  
Ronnie Lamont
Keyword(s):  
Congenital Malformations ◽  
Population Based ◽  
In Utero ◽  
In Utero Exposure ◽  
Population Based Study

scholarly journals In utero exposure to antibiotics and risk of congenital malformations: a population-based study

2019 ◽  
Vol 221 (6) ◽  
pp. 648.e1-648.e15 ◽  
Author(s):  
Per Damkier ◽  
Louise M.S. Brønniche ◽  
Johan F.B. Korch-Frandsen ◽  
Anne Broe
Keyword(s):  
Congenital Malformations ◽  
Population Based ◽  
In Utero ◽  
In Utero Exposure ◽  
Population Based Study

scholarly journals In Utero Exposure to Glucocorticoids and Pubertal Timing in Sons and Daughters

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sofie Aagaard Sand ◽  
Andreas Ernst ◽  
Lea Lykke Harrits Lunddorf ◽  
Nis Brix ◽  
Anne Gaml-Sørensen ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Pubertal Timing ◽  
Population Based ◽  
In Utero ◽  
In Utero Exposure ◽  
Confounding By Indication ◽  
Glucocorticoid Treatment ◽  
Population Based Study ◽  
Axillary Hair ◽  
Potential Impact

AbstractEarly pubertal timing has been associated with adult diseases, and identifying preventable causes is of importance. In utero exposure to exogenous glucocorticoids, has been associated with changes in the reproductive hormonal axes in the children, which may influence pubertal timing. Exogenous glucocorticoids can be indicated for diseases such as asthma, allergy, skin diseases, as well as muscle and joint diseases. The aim was to explore the association between in utero exposure to glucocorticoids and pubertal timing in the children. This population-based study was conducted in the Puberty Cohort including 15,819 children, which is a sub-cohort of the Danish National Birth Cohort. Information on maternal glucocorticoid treatment was collected through interviews during pregnancy. Information on pubertal timing was obtained by questionnaires every 6 months throughout puberty, including Tanner Stages, axillary hair, acne, voice break, first ejaculation and menarche. The potential impact of confounding by indication was explored by stratifying on indication and treatment status. Overall, 6.8% of the children were exposed to glucocorticoids in utero. Exposure to glucocorticoids in utero was not associated with earlier puberty for neither boys nor girls with combined estimates of 0.4 months (95% CI: –1.5; 2.2) and –0.7 months (95% CI: –2.5; 1.2).

Psychomotor development and minor anomolies in children exposed to antiepileptic drugs in utero: a population-based study

2000 ◽  
Vol 42 (5) ◽  
pp. 356-356
Author(s):  
Katarina Wide ◽  
Birger Winbladh ◽  
Torbjörn Tomson ◽  
Kerstin Sars-Zimmer ◽  
Eva Berggren
Keyword(s):  
Antiepileptic Drugs ◽  
Population Based ◽  
In Utero ◽  
Psychomotor Development ◽  
Population Based Study

scholarly journals In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jungsoo Chae ◽  
Geum Joon Cho ◽  
Min-Jeong Oh ◽  
KeonVin Park ◽  
Sung Won Han ◽  
...  
Keyword(s):  
National Health ◽  
Screening Program ◽  
Hazard Analysis ◽  
Population Based ◽  
In Utero ◽  
National Database ◽  
Rank Test ◽  
In Utero Exposure ◽  
Exposure Group ◽  
Increased Risk

AbstractBeta-2 adrenergic receptor (B2AR) agonists, used as asthma treatments and tocolytics during pregnancy, have recently been reported to be associated with autism in their offspring. However, the particular link between autism and ritodrine, a common type of B2AR agonist used solely as tocolytics, has never been substantiated with any nationwide database. Thus, we aimed to examine the association between in utero exposure of ritodrine and the risk of autism in their offspring using a national database. This population-based cohort study was conducted by merging the Korea National Health Insurance claims database and National Health Screening Program for Infants and Children database. These databases included all women who had delivered singleton between January 2007 and December 2008 in Korea. Out of the total 770,016 mothers, 30,959 (4.02%) were exposed to ritodrine during pregnancy, and 5583 (0.73%) of their children were identified as having autism, defined until 8 years of age. According to our analysis, the overall cumulative incidence of autism up to 8 years was 1.37% in ritodrine exposure group and 0.70% in ritodrine non-exposure group (p < 0.05, log-rank test). By Cox proportional hazard analysis, use of ritodrine in preterm birth was associated with significantly higher hazard of autism [adjusted hazard ratio: 1.23, 95% CI 1.04–1.47], after adjusting for confounding variables including maternal age, parity, cesarean section, preterm labor, steroid use, birth weight, gender, and preeclampsia. Thus, in utero exposure to ritodrine was associated with an increased risk of autism in their offspring.

Use of Nimesulide During Early Pregnancy and the Risk of Congenital Malformations: A Population-Based Study from Italy

2018 ◽  
Vol 35 (7) ◽  
pp. 981-992 ◽  
Author(s):  
Anna Cantarutti ◽  
Matteo Franchi ◽  
Federico Rea ◽  
Luca Merlino ◽  
Giovanni Corrao
Keyword(s):  
Early Pregnancy ◽  
Congenital Malformations ◽  
Population Based ◽  
Population Based Study

scholarly journals In utero exposure to breast cancer treatment: a population-based perinatal outcome study

2019 ◽  
Vol 121 (8) ◽  
pp. 719-721 ◽  
Author(s):  
Nadom Safi ◽  
Antoinette Anazodo ◽  
Jan E. Dickinson ◽  
Kei Lui ◽  
Alex Y. Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Perinatal Outcome ◽  
Population Based ◽  
In Utero ◽  
Breast Cancer Treatment ◽  
In Utero Exposure ◽  
Outcome Study

Exposure to genocide and the risk of schizophrenia: a population-based study

2015 ◽  
Vol 46 (4) ◽  
pp. 855-863 ◽  
Author(s):  
S. Z. Levine ◽  
I. Levav ◽  
Y. Goldberg ◽  
I. Pugachova ◽  
Y. Becher ◽  
...  
Keyword(s):  
Cox Regression ◽  
Population Based ◽  
In Utero ◽  
Sensitivity Analyses ◽  
Critical Periods ◽  
Population Based Study ◽  
Regression Modelling ◽  
Direct Exposure ◽  
The Holocaust ◽  
Indirect Exposure

BackgroundNo evidence exists on the association between genocide and the incidence of schizophrenia. This study aims to identify critical periods of exposure to genocide on the risk of schizophrenia.MethodThis population-based study comprised of all subjects born in European nations where the Holocaust occurred from 1928 to 1945, who immigrated to Israel by 1965 and were indexed in the Population Register (N = 113 932). Subjects were followed for schizophrenia disorder in the National Psychiatric Case Registry from 1950 to 2014. The population was disaggregated to compare groups that immigrated before (indirect exposure: n = 8886, 7.8%) or after (direct exposure: n = 105 046, 92.2%) the Nazi or fascist era of persecutions began. The latter group was further disaggregated to examine likely initial prenatal or postnatal genocide exposures. Cox regression modelling was computed to compare the risk of schizophrenia between the groups, adjusting for confounders.ResultsThe likely direct group was at a statistically (p < 0.05) greater risk of schizophrenia (hazard ratio = 1.27, 95% confidence interval 1.06–1.51) than the indirect group. Also, the likely combined in utero and postnatal, and late postnatal (over age 2 years) exposure subgroups were statistically at greater risk of schizophrenia than the indirect group (p < 0.05). The likely in utero only and early postnatal (up to age 2 years) exposure subgroups compared with the indirect exposure group did not significantly differ. These results were replicated across three sensitivity analyses.ConclusionsThis study showed that genocide exposure elevated the risk of schizophrenia, and identified in utero and postnatal (combined) and late postnatal (age over 2 years) exposures as critical periods of risk.

Preterm birth in pregnancies complicated by major congenital malformations: a population-based study

2008 ◽  
Vol 199 (3) ◽  
pp. 287.e1-287.e8 ◽  
Author(s):  
Stephanie E. Purisch ◽  
Emily A. DeFranco ◽  
Louis J. Muglia ◽  
Anthony O. Odibo ◽  
David M. Stamilio
Keyword(s):  
Preterm Birth ◽  
Congenital Malformations ◽  
Population Based ◽  
Population Based Study ◽  
Major Congenital Malformations

scholarly journals In response to “In utero exposure to methotrexate and risk of congenital malformations”

2015 ◽  
Vol 167 (10) ◽  
pp. 2490-2490
Author(s):  
April L. Dawson ◽  
Tiffany Riehle-Colarusso ◽  
Jennita Reefhuis ◽  
J. Fernando Arena ◽  
Keyword(s):  
Congenital Malformations ◽  
In Utero ◽  
In Utero Exposure
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