scholarly journals Faculty Opinions recommendation of Signal transduction pathways in breast cancer: the important role of pi3k/akt/mtor.

Author(s):  
Daniel Olive
2017 ◽  
Vol 33 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Alexandra C. Kölbl ◽  
Kristina Schlenk ◽  
Nils Behrendt ◽  
Ulrich Andergassen

Human chorionic gonadotropin (hCG) is a peptide hormone which plays an important role during pregnancy. But its impact is not limited to pregnancy; it also influences tumor formation and metastatic outgrowth, especially in endometrial adenocarcinoma and breast cancer. This review summarizes what has been written in the literature about the role of hCG as a tumor marker in these 2 gynecological malignancies and also about the signal transduction pathways in which hCG is involved. HCG can, on the one hand, be a marker for the progression of a malignant disease, and on the other hand, it may be a point for therapeutical intervention, so further research into this molecule would be very much worthwhile.


FEBS Letters ◽  
2010 ◽  
Vol 584 (11) ◽  
pp. 2455-2460 ◽  
Author(s):  
Geoffrey Guittard ◽  
Eva Mortier ◽  
Hélène Tronchère ◽  
Guylène Firaguay ◽  
Audrey Gérard ◽  
...  

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