Faculty Opinions recommendation of The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.

2021 ◽  
Author(s):  
Kristiina Vuori ◽  
Ming Zhao
Keyword(s):  
Lung Cancer ◽  
Biosynthesis Pathway ◽  
Hexosamine Biosynthesis ◽  
Hexosamine Biosynthesis Pathway

scholarly journals The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

2020 ◽  
Vol 2 (12) ◽  
pp. 1401-1412
Author(s):  
Jiyeon Kim ◽  
Hyun Min Lee ◽  
Feng Cai ◽  
Bookyung Ko ◽  
Chendong Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Biosynthesis Pathway ◽  
Hexosamine Biosynthesis ◽  
Hexosamine Biosynthesis Pathway

266-LB: Evidence for a Hexosamine Biosynthesis Pathway-Mediated Sp1 Cholesterolgenic Response Being an Early Etiological Factor of Insulin Resistance

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 266-LB
Author(s):  
BRIAN A. GRICE ◽  
JACOB D. COVERT ◽  
ALEC M. KREILACH ◽  
MATTHEW THORNBURG ◽  
LIXUAN TACKETT ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Etiological Factor ◽  
Biosynthesis Pathway ◽  
Hexosamine Biosynthesis ◽  
Hexosamine Biosynthesis Pathway

scholarly journals Acute Regulation of Cardiac Metabolism by the Hexosamine Biosynthesis Pathway and Protein O-GlcNAcylation

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18417 ◽  
Author(s):  
Boglárka Laczy ◽  
Norbert Fülöp ◽  
Arzu Onay-Besikci ◽  
Christine Des Rosiers ◽  
John C. Chatham
Keyword(s):  
Cardiac Metabolism ◽  
Biosynthesis Pathway ◽  
Hexosamine Biosynthesis ◽  
Hexosamine Biosynthesis Pathway

scholarly journals Agm1/Pgm3-Mediated Sugar Nucleotide Synthesis Is Essential for Hematopoiesis and Development

2007 ◽  
Vol 27 (16) ◽  
pp. 5849-5859 ◽  
Author(s):  
Kylie T. Greig ◽  
Jennifer Antonchuk ◽  
Donald Metcalf ◽  
Phillip O. Morgan ◽  
Danielle L. Krebs ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Cell Types ◽  
Protein Glycosylation ◽  
Biosynthesis Pathway ◽  
Nucleotide Synthesis ◽  
Glycosylphosphatidylinositol Anchor ◽  
Sugar Nucleotide ◽  
Hexosamine Biosynthesis ◽  
Hypomorphic Alleles ◽  
Hexosamine Biosynthesis Pathway

ABSTRACT Carbohydrate modification of proteins includes N-linked and O-linked glycosylation, proteoglycan formation, glycosylphosphatidylinositol anchor synthesis, and O-GlcNAc modification. Each of these modifications requires the sugar nucleotide UDP-GlcNAc, which is produced via the hexosamine biosynthesis pathway. A key step in this pathway is the interconversion of GlcNAc-6-phosphate (GlcNAc-6-P) and GlcNAc-1-P, catalyzed by phosphoglucomutase 3 (Pgm3). In this paper, we describe two hypomorphic alleles of mouse Pgm3 and show there are specific physiological consequences of a graded reduction in Pgm3 activity and global UDP-GlcNAc levels. Whereas mice lacking Pgm3 die prior to implantation, animals with less severe reductions in enzyme activity are sterile, exhibit changes in pancreatic architecture, and are anemic, leukopenic, and thrombocytopenic. These phenotypes are accompanied by specific rather than wholesale changes in protein glycosylation, suggesting that while universally required, the functions of certain proteins and, as a consequence, certain cell types are especially sensitive to reductions in Pgm3 activity.

scholarly journals Glucose regulates expression of pro-inflammatory genes IL-1β and IL-12 through a mechanism involving hexosamine biosynthesis pathway dependent regulation of αEcatenin

2021 ◽  
Author(s):  
Waruni C Dissanayake ◽  
Jin Kyo Oh ◽  
Brie Sorrenson ◽  
Peter R Shepherd
Keyword(s):  
High Glucose ◽  
Inflammatory Responses ◽  
Macrophage Polarization ◽  
Mrna Levels ◽  
Biosynthesis Pathway ◽  
Glucose Levels ◽  
Raw264.7 Macrophages ◽  
Hexosamine Biosynthesis ◽  
Induced Changes ◽  
Hexosamine Biosynthesis Pathway

High glucose levels are associated with changes in macrophage polarization and evidence indicates that the sustained or even short-term high glucose levels modulate inflammatory responses in macrophages. However, the mechanism by which macrophages can sense the changes in glucose levels are not clearly understood. We find that high glucose levels rapidly increase the α-E catenin protein level in RAW264.7 macrophages. We also find an attenuation of glucose induced increase of α-E catenin when hexosamine biosynthesis pathway is inhibited either with glutamine depletion or with the drugs azaserine and tunicamycin. This indicates the involvement of hexosamine biosynthesis pathway in this process. Then, we investigated the potential role of α-E catenin in glucose induced macrophage polarization. We find that the reduction of α-E catenin level using siRNA attenuates the glucose induced changes of both IL-1β and IL-12 mRNA levels under LPS stimulated condition but does not affect TNF-α expression. Together this indicates that α-E catenin can sense the changes in glucose levels in macrophages via hexosamine biosynthesis pathway and also can modulate the glucose induced gene expression of inflammatory markers such as IL-1β and IL-12.  This identifies a new part of the mechanism by which macrophages are able to respond to changes in glucose levels.

scholarly journals THE EFFECT OF AGING ON THE HEXOSAMINE BIOSYNTHESIS PATHWAY AND ON O‐LINKED N‐ACETYLGLUCOSAMINE LEVELS IN RATS

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Norbert Fülöp ◽  
Wenguang Feng ◽  
Dongqi Xing ◽  
Kai He ◽  
László G Nõt ◽  
...  
Keyword(s):  
Biosynthesis Pathway ◽  
Hexosamine Biosynthesis ◽  
Hexosamine Biosynthesis Pathway
Sign in / Sign up

Export Citation Format

Share Document