scholarly journals Rasmussen encephalitis after traumatic brain injury in a young adult / Encefalite de Rasmussen após lesão cerebral traumática em um jovem adulto

2021 ◽  
Vol 4 (6) ◽  
pp. 28175-28178
Author(s):  
Yuri Ferreira Felloni Borges ◽  
Marco Antônio Delazeri ◽  
Flávia Rauber Felkl ◽  
Carolina Pellenz ◽  
Eduarda Rosa Fernandes ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Adult ◽  
Rasmussen Encephalitis

Abstract W P260: Role of the Prostaglandin E2 EP1 Receptor in Traumatic Brain Injury

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Alexander V Glushakov ◽  
Jawad A Fazal ◽  
Shuh Narumiya ◽  
Sylvain Dore
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Adult ◽  
Brain Injuries ◽  
Neurological Deficits ◽  
Cortical Lesions ◽  
Brain Pathology ◽  
Adult Mice ◽  
Ep1 Receptor

Introduction: Brain injuries promote upregulation of so-called proinflammatory prostaglandin E2 leading to overactivation of a class of its cognate G-protein coupled receptors, notably EP1, which is considered as a promising target for treatment of ischemic stroke and, possibly, other neurological disorders involving excitotoxicity. However, our recent data suggest that of EP1 receptor in intracerebral hemorrhage may play a protective role. The goal of this study was to investigate a translational potential of EP1 receptor for treatment of traumatic brain injury (TBI). Methods: The acute brain injury was induced using controlled cortical impact (CCI) in wildtype (WT) and genetic EP1 receptor knockout mice (EP1-/-). Neurological deficit scores (NDS) and anatomical brain pathology were accessed at 48h after injury. Results: CCI resulted in significant cortical lesions, localized hippocampal edema and neurological deficits compared to animals from sham group underwent craniotomy only. The NDS after CCI were significantly higher in older mice (7-11mo) compared to young adult animals (2-4mo) in both WT and EP1-/- groups. Treatment with a selective antagonist SC-51089 with repeated doses of 20-100μg/kg after CCI had no significant effects on cortical lesions, hippocampal edema and NDS in young adult mice of both WT and EP1-/- genotypes. Post-treatment with 17-pt-PGE2 (300μg/kg) had no significant effects on anatomical brain pathology in young adult mice, but improved NDS at 24h in WT but not in EP1-/- mice. Immunohistochemistry revealed significant increases in GFAP and Iba1 immunoreactivity in selected brain regions surrounding injury suggesting astrogliosis and microglia activation. EP1 receptor knockout had no effects on GFAP and Iba1 expression in young adult mice, whereas lead to a significant attenuation of GFAP immunoreactivity in older mice. Conclusions: This study provides, for the first time, a clarification on the role of EP1 receptor in a preclinical model of contusive TBI. The results suggest that EP1 receptor might be involved in complex pathways differentially associated with neurological deficits. In addition, this study provides further clarification on clinical use of EP1 receptor ligands for treatment of acute brain injuries.

scholarly journals Prevalence and Predictors of Externalizing Behavior in Young Adult Survivors of Pediatric Traumatic Brain Injury

2015 ◽  
Vol 30 (2) ◽  
pp. 75-85 ◽  
Author(s):  
Nicholas P. Ryan ◽  
Nathan Hughes ◽  
Celia Godfrey ◽  
Stefanie Rosema ◽  
Cathy Catroppa ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Adult ◽  
Externalizing Behavior ◽  
Adult Survivors ◽  
Pediatric Traumatic Brain Injury ◽  
Young Adult Survivors

Surgical management of head injury

2019 ◽  
pp. 509-520
Author(s):  
Hadie Adams ◽  
Angelos G. Kolias ◽  
Adel Helmy ◽  
Peter J.A. Hutchinson ◽  
Randall M. Chesnut
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Adult ◽  
Head Injury ◽  
Glasgow Coma Scale ◽  
Motor Vehicle ◽  
Adult Males ◽  
Coma Scale ◽  
The United Kingdom ◽  
The World

Traumatic brain injury (TBI) is a significant cause of preventable morbidity and mortality in the United Kingdom and across the world, leading to disability and loss of productivity. The estimated incidence of TBI in Europe is on average 235 per 100 000, ranging of 150–300/100 000 per year. The Glasgow Coma Scale (GCS) is often used to classify the severity of TBI, with patients scoring 8 or less being classified as severe, 9–12 as moderate, and scores of 13–15 as mild. Mild TBI is the most common form of head injury, and the incidence of TBI is the highest in young adult males. In Western countries the major causes of TBI-related hospitalizations are falls, assaults, and motor vehicle traffic collisions.

scholarly journals Forensic anthropological report of Elba

2017 ◽  
Vol 39 ◽  
pp. 35-72
Author(s):  
Fernando Serrulla Rech ◽  
Margarita Sanín Matias
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Adult ◽  
Nutritional Stress ◽  
Human Bone ◽  
Adult Woman ◽  
Young Adult Woman ◽  
Anthropological Study ◽  
The One ◽  
Bone Remains

This paper presents the results of the forensic anthropological study of human bone remains found in a cave in the area of Pedrafita do Cebreiro (Lugo, Galicia, Spain). The remains correspond to a young adult woman (20-40 years) and an estimated size between 150 and 152 centimeters that was killed by fall in a dolina about 10,000 years ago. The pathology of the bones is also analyzed, indicating, on the one hand, nutritional stress, some signs of osteoarthritis and other traumatic brain injury that did not cause the individual’s death.

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