scholarly journals HISTOPATHOLOGICAL STUDY OF BONE LESIONS AT DARBHANGA MEDICAL COLLEGE, LAHERIASARAI, BIHAR.

2021 ◽  
pp. 1-3
Author(s):  
Ragini Kumari ◽  
Kunal Shankar ◽  
Ajit Kumar Chaudhary ◽  
Debarshi Jana
Keyword(s):  
Bone Tumors ◽  
Bone Biopsy ◽  
Correct Diagnosis ◽  
Benign Tumors ◽  
Bone Lesions ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Male Predominance ◽  
Medical College ◽  
Neoplastic Lesions

Background: A spectrum of pathological bone lesions can be presented in any form from inflammatory to neoplastic conditions. Diagnosis of all bone lesions is made by radiological modalities like plain X-ray, CT scan, MRI and bone scintigraphy. Aim and Objectives: To study histopathological features of bone lesions and correlate them with age, site and type of lesions. Material and Methods: The study was carried out at Department of Pathology associated with Orthopaedics, Darbhanga Medical College, Lahertiasarai, Bihar from April 2020 to November 2020. A total of 102 bone lesions were analyzed. Bone biopsy was performed after detailed clinical and radiological examination. After fixation, decalcification, processing and H&E staining, histopathological diagnosis was made. Results: Out of all 102 cases, 44.11% bone lesions were found between 25-50 years with male predominance. The incidence of non neoplastic lesions was 74.5% and neoplastic lesions were 25.4%. Amongst neoplastic lesions, incidence of benign tumors was 17.64% and malignant tumors were 7.8%. The Tuberculous Osteomyelitis was most common non neoplstic lesion while giant cell tumor and osteochondroma were common among benign tumors and osteosarcoma and Secondary metastasis were common among malignant bone tumors. Conclusion: Though Bone tumors are less common, if viewed in perspective of clinico radiology and histopathology, correct diagnosis can be made.

scholarly journals Evaluation of neoplastic bone lesions: A morphological study at a tertiary care centre.

2019 ◽  
Vol 26 (11) ◽  
pp. 1983-1988
Author(s):  
Karam Ali Shah ◽  
Qaiser Husain Naqvi ◽  
Saeed Ali Shah ◽  
Zahoor Illahi Soomro ◽  
Muhammed Azeem Akhund ◽  
...  
Keyword(s):  
Bone Tumors ◽  
Malignant Tumors ◽  
Bone Biopsy ◽  
Tertiary Care ◽  
Benign Tumors ◽  
Bone Lesions ◽  
Age Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Histopathological Report

Objectives: To determine the pattern and frequency of various bone tumors at a tertiary care centre in rural area. Study Design: Retrospective study. Setting: Orthopaedic Peoples University of Medical and Health Sciences (PUMHS), Nawabshah. Period: June to December 2018. Material and Methods:  The 5 years record from July 2015 to June 2018, of all the patients who were admitted and operated for any bone tumor was retrieved. A total of 68 cases were included in the study having complete file record, regardless of their age and sex, the histopathological report of their bone biopsy was mandatory for inclusion in the study. The patients of incomplete file record, without histopathological report and the cases of other bone non-neoplastic conditions were not included in the study. All the collected data was recorded on a proforma, analysed statistically and results were tabulated. Results: In present study 68 cases of bone tumors were evaluated. The patients were aged between 7.5 to 73 years with a mean of 26.4 + 12.7 years. Among these 68 cases 41 (60.3%) were male. The malignant tumors were diagnosed in 25 (36.8%) cases among these 14 (20.6%) cases in male patients and 11 (16.2%) cases in female. The overall benign tumors were observed in 43 (63.2%) cases, and among these 27 (39.7%) cases were male and 16 (23.5%) cases were female. Osteosarcoma was the most common malignant tumor diagnosed in 14/25 (56%) cases followed by chondrosarcoa in 4/25 (16%) cases. In benign tumors the osteochondroma was the commonest tumor detected in 11/43 (25.6%) cases followed by benign giant cell tumor which was diagnosed in 9/43 (21%) cases. Most of the malignant tumors (24%) were diagnosed in 11 - 20 years age group, and most of benign tumors were detected in 21-30 and 31- 40 age groups each comprising of 23.3% cases. Three cases of metastatic tumors were also diagnosed and all were present in older 61 – 70 years age group. Conclusion: The bone tumors are more common in males, occurred predominantly in the second decade of life. osteochondroma and osteosarcoma was the most common benign and malignant bone tumors. Metastatic lesions were observed in older age group.

Histopathological Study of Lesions of the Nasal Cavity, Paranasal Sinuses and Nasopharynx in a Tertiary Care Centre, Visakhapatnam over a Period of 2 Years

2021 ◽  
Vol 8 (33) ◽  
pp. 3054-3059
Author(s):  
Rajendra Prasad Jagannadham ◽  
Lakshmi Latchupatula ◽  
Sravani Ponnada ◽  
Neelima Lalam ◽  
Raghunadhababu Gudipudi ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Malignant Tumours ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Male Predominance

BACKGROUND A variety of non - neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinuses and nasopharynx and these are very common lesions encountered in clinical practice. Histopathological examination of these lesions is the gold standard for diagnosis because management and prognosis vary among different lesions. The aim of the present study was to evaluate the histopathological study of the lesions of the nasal cavity, paranasal sinuses and nasopharynx in relation to their incidence, age, gender and site wise distribution and to compare the results with the available data. METHODS A study of 88 cases was conducted for a period of 2 years from August 2017 to July 2019. After fixation, Processing and Haematoxylin and Eosin staining and special stains histopathological diagnosis was made. RESULTS Among 88 total cases, 58 were males and 30 were females. A male predominance was observed with a male to female ratio of 1.93 : 1. They were more common in third, fourth and fifth decade of life. Malignant nasal lesions were seen after fourth decade of life. Nasal lesions were more common in nasal cavity (67.05 %), followed by paranasal sinuses (18.18 %) and nasopharynx (14.75). Out of 88 total cases, 39 (44.32 %) were non - neoplastic, 30 (34.09 %) were benign and 19 (21.59 %) were malignant nasal lesions. CONCLUSIONS Sinonasal lesions and nasopharyngeal lesions can have various differential diagnoses. A complete clinical, radiological and histopathological correlation helps to categorize these sinonasal lesions into various non - neoplastic and neoplastic types. But histopathological examination remains the mainstay of definitive diagnosis. KEYWORDS Nasal Cavity, Paranasal Sinuses, Nasopharynx, Benign Tumours, Malignant Tumours, Histopathological Examination

HISTOPATHOLOGICAL SPECTRUM OF SKIN LESIONS: A TWO YEAR RETROSPECTIVE STUDY.

2021 ◽  
pp. 26-29
Author(s):  
Shruti Shemawat ◽  
Sakshi Apurva ◽  
D.P Soni ◽  
Saurabh Soni
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Relative Frequency ◽  
Malignant Tumors ◽  
Skin Lesions ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Neoplastic Lesions ◽  
Skin Biopsies ◽  
Age And Sex

INTRODUCTION: The skin being largest organ of the body has vast spectrum of disorders which can be difcult to diagnose correctly solely on the basis of clinical features. Hence histopathological examination is necessary to categorise skin lesions. The aim was to study relative frequency of various skin lesions and distribution of these lesions according to age and sex. METHODS: This is a retrospective descriptive hospital based study. The skin biopsies samples which came in the duration of two years from January 2019 to December 2020 at the Department of Pathology, Sardar Patel Medical college and associated group of hospitals, Bikaner, Rajasthan were taken in this study. All skin biopsies that showed denite histopathological diagnosis were included. After proper xing and staining procedures these lesions were examined under light microscopy and categorized as non-neoplastic and neoplastic. Relative frequency of various lesions, distribution of lesions according to age and sex was analyzed. The data collected was tabulated, interpreted and compared with other similar studies. RESULTS: Out of 346 patients, incidence of neoplastic lesions 259 (74.9%) were higher than non-neoplastic lesions 87(25.1%). Males were affected more compared to females with male to female ratio 1.45:1. Non-neoplastic lesions were mostly caused because of infectious etiologies among which leprosy was the most common infection. Keratinocytic tumors 99(52.2%) constituted most common type of neoplastic lesion. Benign tumors 191(73.7%) outnumbered malignant tumors 68(26.3%). The cases of benign tumors were seen more in younger population while that of malignant tumors were seen in older age groups. Among the keratinocytic type of malignant skin tumors squamous cell carcinoma (63.5%) was the most common variant which was followed by basal cell carcinoma 19(36.5%). Male predominance was observed in both squamous cell carcinoma and basal cell carcinoma. CONCLUSION: A wide heterogenesity of skin lesions was observed in the present study . These skin lesions were mostly affecting age group of 10-30 years. Inspite of extensive programmes and research, leprosy and tuberculosis remains a rampant cause of infectious non-neoplastic skin lesions. Sometimes ignorance by patient for a very small appearing skin lesions becomes life threatening. Hence early clinician consultation with proper examination and accurate histopathological diagnosis becomes the mainstay in early treatment and recovery.

scholarly journals Clinicopathological study of leiomyomas in hysterectomy specimens

2018 ◽  
Vol 7 (4) ◽  
pp. 1509 ◽  
Author(s):  
Manpreet Kaur ◽  
Rajiv Kamal Gupta ◽  
Simrat Jit Kaur ◽  
Panchampreet Kaur
Keyword(s):  
Histopathological Examination ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Age Group ◽  
Diagnosis And Prognosis ◽  
Common Complaint ◽  
A Prospective Study ◽  
Reproductive Age Group

Background: Leiomyomas are benign tumors of smooth muscle cells commonly encountered in women of reproductive age group. Aim of this study was to conduct a histopathological study of leiomyomas in hysterectomy specimens and to correlate them with clinical findings.Methods: A prospective study was done on 130 hysterectomy specimens clinically diagnosed as leiomyoma. The specimens were subjected to histopathological examination.Results: In this study, the most common age group was 31-50 years (87.69%). Most common complaint was menorrhagia (51.54%). In endometrium, the most common histopathological diagnosis was proliferative phase (46.15%) followed by endometrial hyperplasia (19.23%). The most common secondary change was hyalinization and the most common site was intramural (62.9%).Conclusions: Hysterectomy is a commonly performed procedure in the management of uterine leiomyomas. The ultimate diagnosis and prognosis depends on the histopathological examination; therefore, every operated specimen must be subjected to histopathology. 

scholarly journals Study of Bone Tumors in a Tertiary Care Hospital of Dhaka City

2018 ◽  
Vol 5 (1) ◽  
pp. 23-28
Author(s):  
Kazi Nishat Ara Begum ◽  
Syed Salahuddin Ahmed ◽  
Md Ayub Ali ◽  
Md Abdul Gani Mollah ◽  
Md Nurul Amin ◽  
...  
Keyword(s):  
Giant Cell ◽  
Bone Tumors ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Benign Tumors ◽  
Bone Lesions ◽  
Anatomical Location ◽  
Anatomical Site ◽  
Care Hospital ◽  
Orthopedic Rehabilitation

Background: The wide spectrum of bone tumors, their rarity, diverse origin and tendency to produce overlapping anatomic patterns pose a definite diagnostic challenge to the orthopedic surgeons and the pathologists.Objective: The present study was intended to find the pattern of bone tumors and their anatomical locations, and histopathological characteristics in a tertiary care hospital of Dhaka.Methodology: A retrospective review of the histopathological records of patients with established diagnosis of bone tumors at National Institute of Traumatology and Orthopedic Rehabilitation (NITOR), Dhaka, Bangladesh was done from January 2015 to December 2016 for a period of two (02) years. The demographic data such as the age and sex, anatomical location and histopathological findings were studied from the existing records of the patients and their slides were reexamined. Bone lesions of inflammatory origin were excluded from this study leaving the lesions of both neoplastic and tumor-like origin for further study.Result: A total 283 cases of bone lesions were primarily included in the study. Bone lesions of inflammatory origin (n = 65) were excluded from this study leaving 218 lesions of both neoplastic and tumor-like origin for further study. The median age of the patients was 22 (range: 3 – 75) years. In terms of anatomical site of the tumors, over one-third (36.6%) was located in femur 21.1% in tibia, 12.2% in humerus, 6.1% in radius and 5.6% in ulna. In terms of types of bone tumor, 105(48.2%) were benign, 66(30.3%) malignant, 47(21.5%) tumor-like lesions. About 65% of the benign tumors were of Giant cell tumor, 28.5% were osteochondroma, 1% osteoma and 5.7% were of other types. Of the malignant tumors, one-third (33.3%) was of metastatic type, 27.3% Ewing’s sarcoma, 22.7% osteosarcoma, 9.1% chondrosarcoma and 4.6% were of other varieties.Conclusion: Primary bone tumors are mainly benign; however, giant cell and metastatic tumors are the most common benign and malignant bone tumors respectively.Journal of Current and Advance Medical Research 2018;5(1):23-28

scholarly journals Histopathological Study of Endometrial Biopsy Specimens for Abnormal Uterine Bleeding

2016 ◽  
Vol 4 (2) ◽  
pp. 72
Author(s):  
Archana Tiwari ◽  
Narinder Kaur ◽  
Sushila Jain ◽  
Ramji Rai ◽  
Surendra Kumar Jain
Keyword(s):  
Light Microscopy ◽  
College Teaching ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Histopathological Study ◽  
Medical College ◽  
Biopsy Specimens ◽  
Neoplastic Lesions ◽  
Post Menopausal

Introduction: Endometrial specimen for abnormal uterine bleeding (AUB) is the one of the commonest specimens received in histopathology laboratory. Histopathological characteristics of endometrial tissues, as assessed by light microscopy, remains the diagnostic standard for the management of AUB. The objective of study is to find out the histopathological pattern of endometrium in AUB in the light of clinical details.   Methods: This was a prospective observational study carried out in the department of Pathology, Lumbini Medical College Teaching Hospital for a period of two years from June 2014 to May 2016. Formalin fixed endometrial specimens were processed, paraffin embedded, sectioned at 3-4 µm, stained with hematoxylin and eosin, and studied under light microscopy along with their demographics. Data were collected, entered and analyzed using SPSS version 20.   Results: The study included 100 cases of endometrial biopsy specimens with clinical diagnosis of AUB. Menstrual disturbances was found in wide age range between 17-75 years with the mean age of 45 (SD=13.36) years. Menorrhagia was the commonest (n=60, 60%) clinical presentation. Most (n=85; 85 %) endometrium had non-neoplastic lesions. Among them, normal endometrial patterns were commonest (n=50, 50 %). Neoplastic lesions (n=15, 15%) were distributed in all menstruation status with majority in postmenopause (n=7, 7%) and included malignant cases (n=5, 5%) among others.   Conclusion: Post-menopausal bleeding was common presentation among women with malignant and premalignant disease which was present in 15% of the cases together. Timely evaluation of AUB  by histopathology can be life saving with early tissue diagnosis and management.

CLINICOPATHOLOGICAL STUDY OF GASTRIC BIOPSIES

2021 ◽  
pp. 38-40
Author(s):  
Manu Jethalya ◽  
Saurabh Totla
Keyword(s):  
Clinical Presentation ◽  
Early Stage ◽  
Gastric Biopsy ◽  
Histopathological Study ◽  
Age Group ◽  
Malignant Tumours ◽  
Early Management ◽  
Medical College ◽  
Neoplastic Lesions ◽  
Gastric Biopsies

Background: Stomach is an important site for variety of lesions especially malignant tumours. Gastric biopsies along with clinical prole of cases play an important role in the diagnosis of gastric neoplasm and therefore aids in early management. Aim and Objectives: To study the histopathology of Gastric biopsies and correlate them with clinical presentation, age, sex and to differentiate them between neoplastic and non neoplastic lesions. Materials and Methods: The prospective study was done in the Department of Pathology Geetanjali Medical College and Hospital, Udaipur between 1stJanuary 2019 to 30thJune 2020. A total of 83 gastric biopsies were included in the study and were analyzed along with their clinical proles. Results: A total of 83 gastric biopsies were included in the study. Most commonly affected age group was 50-69 years with 41 patients (49.40%) followed by 40-49 years with 14(16.87%). Out of 83 cases, 58 (69.88%) were males & 25 (30.12%) were females, 26 (31.33%) cases were non neoplastic & 57 (68.67%) cases were neoplastic.Conclusion: The gastric biopsy not only permits exact diagnosis of specic entity but also helps to plan for early medical or surgical therapy. The histopathological study detects mucosal lesions at an early stage especially atrophy, metaplasia and dysplasia as to prevent progress of these lesions to invasive cancer.

scholarly journals A histopathological study of unusual findings in appendectomy specimens in a tertiary care hospital of Andhra Pradesh

2021 ◽  
Vol 6 (4) ◽  
pp. 291-294
Author(s):  
Suneetha Kona ◽  
Srinivasulu Kande ◽  
Boddu Penchala Prasanna ◽  
Sushma Chandulee Kancharla
Keyword(s):  
Acute Appendicitis ◽  
Andhra Pradesh ◽  
Carcinoid Tumour ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Medical College ◽  
Retrospective Assessment ◽  
Inflammatory Bowel

Acute appendicitis is sudden inflammation of the appendix, usually initiated by obstruction of the lumen. This results in invasion of the appendix wall by gut flora, and it becomes inflamed and infected.: To investigate retrospectivelythe prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis.This is retrospective assessment of hospital records of 150 patients who were diagnosed as acute appendicitis and underwent appendicectomy during March 2018 to February 2020 at Government Medical College, Bhagya Nagar, Ongole, Andhra Pradesh .Data of the patients were assessed based on age, sex, histopathological diagnosis, coexisting pathologies and uncommon findings on histology. According to histopathology report, negative for acute appendicitis were noted in 82 cases (55%), whereas positive for acute appendicitis in 68 cases (45.3%) . Rare findings were foundin 38 (55.8%) cases out of 68 cases. Parasites were found in 7 (18.4%) (Enterobius Vermicularis, Balantidum Coli, Schistosoma Haematobium), Mucocele in 12 (32%), carcinoid tumour in 8(21%), B cell malignant lymphoma in 2 (5%), leiomyoma in 2 (5%), Primary appendiceal adenocarcinoma in 3 (8%), Acute appendicitis with dysplastic changes in 2 (5%) and inflammatory bowel polyp was reported in remaining two cases(5%).: Even though unusualpathologies can be seen rarely during appendectomy, this should be kept in mind for further evaluation of each cases.

scholarly journals Clinical and histopathological correlation of breast lesions

2018 ◽  
Vol 6 (4) ◽  
pp. 1348
Author(s):  
Kavita Sharma ◽  
S. P. Vyas ◽  
Subhash Dhayal
Keyword(s):  
Invasive Carcinoma ◽  
Histopathological Examination ◽  
Breast Tumors ◽  
Mucinous Carcinoma ◽  
Malignant Tumour ◽  
Benign Tumors ◽  
Histopathological Study ◽  
Breast Lesions ◽  
Malignant Tumours ◽  
Neoplastic Lesions

Background: To study the histopathological features of neoplastic and non neoplastic lesions of breast.  To correlate the pathological findings with clinical parameters.Methods: We have studied total 170 cases of breast lesions over a period of two years in our institute. The specimens were received in histopathology section of our department. Detailed gross examination of specimens was done followed by fixation, thorough sampling, and tissue processing. The different lesions were studied by histopathological examination and analysed. Neoplastic lesions were classified according to the WHO classification.Results: Out of the 170 cases, 128 cases had neoplastic lesions and 41 cases had non-neoplastic lesions, and one case had coexistent neoplastic and nonneoplastic lesions. Out of the total 129 cases with neoplastic lesions, 76 cases had benign breast tumors, 51 cases had malignant breast tumors, and 2 cases had precursor lesions. Fibroadenoma was the most common benign tumour with 62 cases. Invasive carcinoma no special type was the most common malignant tumour with 43 cases. Special subtypes of invasive carcinoma found in our study were mucinous carcinoma (2 case). The most common nonneoplastic lesion was mastitis with 12 cases, followed by duct ectasia and fibrocystic change. There were 6 cases of gynaecomastia. All the tumors involved upper outer quadrant most frequently. The benign tumors were most frequent in second, third and fourth decades, malignant tumours were seen beyond 4th decade. The nonneoplastic lesions were common in 4th decade.Conclusions: Histopathological study is important in the management of breast lesions.

scholarly journals Histopathological Study of Pathological Specimens of Various Organs in a Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 34 (1) ◽  
pp. 16-25
Author(s):  
Monira Parveen ◽  
SM Asafudullah ◽  
Md Nowshad Ali ◽  
M Rokeya Khatun ◽  
Khadiza Khanom ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Tertiary Care ◽  
Transitional Cell ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Screening Programs ◽  
Medical College ◽  
Wide Range ◽  
Bladder Pathology

This retrospective study of histopathological specimens was done at the Department of Pathology of Rajshahi Medical College, Bangladesh, from July 2019 to June 2020, emphasizing challenges and diagnosis outcomes. Data obtained from their case notes included age at admission, the site from where the specimens were collected, and histopathological diagnosis.  Out of the 2026 histopathology samples, chronic cervicitis constitutes about 50% of the cases. Serous cystadenoma (about 1/4th cases) was common among ovarian pathology. 54.16% of the breast pathology exhibited Invasive ductal carcinoma. Reactive follicular hyperplasia and lymphoma constitute 49.44% of the lymph node pathology. About 80% of the gall bladder pathology was chronic cholecystitis, and metastatic adenocarcinoma was the commonest pathology involving the liver. Squamous cell carcinoma constitutes about 40% of the skin pathology. Osteosarcoma, osteochondroma, and giant cell tumor were the common pathologies involved in bones. Transitional cell carcinoma constitutes about 45% of urinary bladder pathology, and renal cell carcinomas were the commonest pathology of the kidney. Adenocarcinoma constitutes about 45 % of stomach pathology, 28% of small intestine pathology, and 14% of large intestine pathology.  Histopathological specimens at the pathology Rajshahi Medical College department with a wide range of pathologies are a major problem. From this study necessity of screening programs for early cancer detection appeared as a time-demanding issue. TAJ 2021; 34: No-1: 16-25

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