scholarly journals COMPARATIVE EVALUATION OF SAFETY AND IMMUNOGENICITY INACTIVATED VACCINE FOR POLYOMIELITIS PREVENTION (NETHERLANDS) AND VACCINE «IMOVAX POLIO» (FRANCE) IN CHILDREN USING TRIPLE IMMUNIZATION

2019 ◽  
Vol 1 (3) ◽  
pp. 53-60
Author(s):  
I. V. Feldblyum ◽  
V. V. Romanenko ◽  
M. G. Menshikova ◽  
I. A. Okuneva ◽  
A. E. Makarov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Multicenter Study ◽  
Safety Profile ◽  
Comparative Evaluation ◽  
Vaccination Schedule ◽  
Inactivated Vaccine ◽  
Poliomyelitis Vaccine ◽  
The Russian Federation ◽  
Group 2 ◽  
Group 1

Aim is comparative evaluation of the safety and immunogenicity of inactivated poliomyelitis vaccine (IPV) «Bilthoven Biologicals B.V.» (Netherlands) and «Imovax Polio» (France) with subcutaneous and intramuscular modes of administration. Materials and methods. In a doubleblind, comparative clinical randomized multicenter study, 120 children at the age of 3 months participated as volunteers. They were divided into 4 groups: 1 and 2 groups were given IPV intramuscular (group 1) and subcutaneous (group 2) mode of administration, children of groups 3 and 4 were given the vaccine «Imovax Polio». Results. IPV is characterized by a high safety profile and immunogenicity both in subcutaneous and intramuscular modes of administration and it is comparable in its characteristics with the vaccine «Imovax Polio». Conclusion. Vaccine IPV (Netherlands) is recommended for registration in the territory of the Russian Federation and its further using in the National Vaccination Schedule.

scholarly journals DIFFERENCES IN PHYSICAL PREPAREDNESS OF DIFFERENT GENERATIONS OF FEMALES BORN BY THE MIGRANTS TO YUGRA

2020 ◽  
Vol 19 (S2) ◽  
pp. 74-80
Author(s):  
R Kuchin ◽  
M Stogov ◽  
N Nenenko ◽  
N Chernitsyna ◽  
T Maksimova
Keyword(s):  
Russian Federation ◽  
Physiological Parameters ◽  
Middle Zone ◽  
Autonomous District ◽  
Group 3 ◽  
The Russian Federation ◽  
Group 2 ◽  
Children First ◽  
Khanty Mansi Autonomous ◽  
Group 1

Aim. The purpose of the article is to study the characteristics of changes in physiological parameters and physical preparedness of different generations of females born by migrants to the Khanty-Mansi Autonomous District–Yugra and living there. Materials and methods. The study involved 60 females of which three groups were formed. Group 1 (n = 20) – females born in the regions of the middle zone of the Russian Federation who moved to the Khanty-Mansi Autonomous District-Yugra no more than 8 months ago. Group 2 (n = 20) – females born and permanently living in the Khanty–Mansi Autonomous District–Yugra, who are children (first generation) of migrants from the regions of the middle zone of the Russian Federation. Group 3 (n = 20) females born and permanently living in the Khanty-Mansi Autonomous Okrug-Yugra, who are grandchildren (second generation) of migrants from the regions of the middle zone of the Russian Federation. All subjects were comparable in age. A comprehensive examination was carried out, including an assessment of physical preparedness, anthropometry, physiological parameters, phy­sical activity. Results. No significant differences between the average values of anthropometric indicators were found in the examined subjects. In girls of groups 2 and 3 compared to group 1, a statistically significant increase in variation in body weight, body mass index and chest circumference was found. In group 3, significant differences were noted in the indicators of strength and speed-strength endurance, as well as speed and coordination of movement. The girls of group 1 had a significantly increased value of the Ruffier index compared to other groups. Conclusion. Group 1 had a lower training status of the cardiovascular system and adaptation to living conditions compared to groups 2 and 3. The level of physical preparedness was lower in the subjects of group 3.

FREQUENCY RATE OF BCG VACCINATION AND SELECTED INDICATORS OF CLINICAL CHARACTERISTICS OF TUBERCULOSIS IN SCHOOL-AGE CHILDREN

2021 ◽  
Vol 100 (5) ◽  
pp. 124-130
Author(s):  
V.A. Aksenova ◽  
◽  
A.V. Gordina ◽  
S.A. Sterlikov ◽  
D.A. Kucheryawaya ◽  
...  
Keyword(s):  
Repeated Administration ◽  
Bcg Vaccine ◽  
School Age Children ◽  
Confounding Factors ◽  
Bcg Vaccination ◽  
Data Registration ◽  
Comparison Groups ◽  
The Russian Federation ◽  
Group 2 ◽  
Group 1

Objective of the study: to assess the effect of the frequency of administration of the BCG vaccine on the nature and structure of clinical forms of tuberculosis (TB) in children. Materials and methods of research: a cohort observational retrospective continuous comparative multicenter crosssectional study was carried out. The data (registration form № 089/u-tube) of 3253 children of 7–14 years old with newly revealed changes in the lungs of a specific genesis, registered in 2019–2020 in the institutions of the anti-tuberculosis service of the Russian Federation were analyzed. Two comparison groups were identified: group 1 (observation group) – children who received a double injection of BCG vaccine (vaccination and revaccination) (n=184), group 2 (comparison group) – children who received a single BCG vaccination (n=3358). To achieve this goal, 5 null hypotheses were identified for testing which groups are formed from the received data array with the necessary parameters. The data were analyzed using univariate and multivariate analyzes (including confounding factors). Results: it was found that BCG revaccination does not reduce the risk of TB compared with residual changes after, it does not reduce the proportion of generalized forms of TB compared with localized forms (OR=2,4, p=0,08). The frequency of vaccination has not a statistically significant effect on the frequency of bacterial excretion (aOR=1,6, p=0,15) and destruction of lung tissue (OR=1,1, p=1). Revaccination has a statistically significant effect on the ratio of primary and secondary forms of TB, reducing the likelihood of its primary forms (aOR=0,4, p<0,001). In the course of multivariate analysis, it was found that the formation of primary or secondary TB, as well as the frequency of bacterial excretion in the comparison groups, was significantly influenced by confounding factors. Conclusion: this work has demonstrated the absence of a pronounced protective effect of repeated administration of the BCG vaccine on the clinical course of a specific process.

scholarly journals 2699. Pneumococcal Vaccination During Chemotherapy in Children Treated for Acute Lymphoblastic Leukemia

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S949-S949
Author(s):  
Sarah Dorval ◽  
Léna Coïc ◽  
Denis Blais ◽  
Jean-Marie Leclerc ◽  
Caroline Laverdière ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Pneumococcal Infection ◽  
Pneumococcal Vaccination ◽  
Booster Vaccination ◽  
Maintenance Phase ◽  
Vaccination Schedule ◽  
Serum Samples ◽  
Group 2 ◽  
Group 1

Abstract Background Children undergoing therapy for acute lymphoblastic leukemia (ALL) are at high risk of invasive pneumococcal disease (IPD). Immunization with conjugated vaccines following chemotherapy is recommended for pediatric patients. In an attempt to provide an earlier protection against invasive pneumococcal infection, we aimed to assess immunity to S. pneumoniae among children vaccinated during chemotherapy for ALL. Methods We retrospectively analyzed the rate of seroprotection among ALL children treated in our institution in accordance with the DFCI ALL Consortium protocol between 2007 and 2014. A pneumococcal conjugate vaccine (PCV) booster was given to all subjects after the end of chemotherapy (groups 1 and 2). In group 2, a PCV dose was also administered during the maintenance phase. Clinical characteristics as well as individual immunization records were collected from our local immunization database. All children were up to date with their vaccination schedule at diagnosis. Serum samples were obtained on a routine follow-up visit, after the end of chemotherapy and after the PCV vaccine booster to measure serotype-specific IgG pneumococcal antibodies. Antibody level ≥0.35µg/mL was considered protective. Patients with seroprotective antibodies level for ≥ 50% of serotypes contained in vaccines were defined as seroprotected. Results 62 children [34 girls (54.8%)] were included in the analysis. Median age at diagnosis was 45 months (range:12–160). At the end of chemotherapy, 34.2% of children in group 1 (13/38) and 79.2% in group 2 (19/24) were seroprotected (P < 0.01). Median interval of time between the end of chemotherapy and the PCV booster vaccination was 6 months (range: 2–64 months). After PCV-13 booster, the rate of seroprotection raised to 100% (38/38) in group 1 and 91.7% in group 2 (22/24). Conclusion Rates of pneumococcal seroprotected children treated for ALL are low at the end of chemotherapy. However, PCV booster during chemotherapy could be useful to increase the level of seroprotection and shorten the period of susceptibility to IPD. After chemotherapy for ALL, children benefit from a PCV booster to enhance seroprotection. Disclosures All authors: No reported disclosures.

scholarly journals Cytomegalovirus Infection in Adolescents of Russian Federation: Results of Cross-Sectional Population Analysis of Seroprevalence

2021 ◽  
pp. 354-362
Author(s):  
E. Yu. Dubonosova ◽  
L. S. Namazova-Baranova ◽  
E. A. Vishneva ◽  
N. A. Mayanskiy ◽  
T. V. Kulichenko ◽  
...  
Keyword(s):  
Immune Response ◽  
Russian Federation ◽  
Cytomegalovirus Infection ◽  
Well Being ◽  
Clear Understanding ◽  
Childbearing Age ◽  
Response Intensity ◽  
The Social ◽  
Group 2 ◽  
Group 1

Background. Cytomegalovirus infection (CMVI) is the reason of high mortality in perinatal period, disability in children from risk groups with further development of congenital malformations and chronic diseases. Clear understanding of epidemiology and determination of focus population groups is crucial for development of measures and algorithms of congenital CMVI prevention.Objective. The aim of the study is to study CMVI seroprevalence among immunocompetent adolescents in Russian Federation with reference to the gender, regional, social and economic, and age factors.Methods. We have used for our study data from the survey of senior schoolchildren from 7 municipalities representing various regions of Russian Federation: group 1 (10–12 years old) and group 2 (14–16 years old). The study of CMVI seroprevalence and immune response was performed via the analysis of the level of IgG antibodies to cytomegalovirus (CMV) in blood serum. The social and economic well-being of the region was determined by "RIA Rating" experts.Results. Serological prevalence of CMVI in the study group of adolescents (n = 1403) was 70.6% (n = 990). There were no statistically significant gender differences in the distribution of seropositive children in regions (p = 0.525). Infection in boys (72.6%; n = 455; median age — 12.9 (11.0; 14.9)) did not prevail over the infection in girls (68.8%; n = 535; median age — 13.1 (11.0; 14,9)); p = 0,117. The overall prevalence of CMVI increased statistically significant with age — from 68% (n = 486) in group 1 to 73% (n = 504) in group 2 (p = 0.036). The prevalence of CMVI varied statistically significant by region (p = 0.003). There was no correlation between the regional seropositive level and the social and economic situation in the region (r = 0.034, p = 0.192). Immune response intensity did not differ by age, gender, and region with the antibody median of 88.9 CU/ml.Conclusion. More than half of adolescents (by the age of 10) in Russian Federation are infected, and infection increases with approaching to childbearing age, however, age is not the only aspect associated with serological status. Factors affecting immune response intensity require further study. Understanding of the CMV prevalence among children is crucial for determining future prevention approaches in target groups.

scholarly journals A Comparative Evaluation of Three Commercially Available Dentin Desensitizers on the Shear Bond Strength of Composite Resins: An in vitro Study

2015 ◽  
Vol 5 (2) ◽  
pp. 65-68
Author(s):  
Shruti Patil ◽  
Prajna Shetty
Keyword(s):  
Bond Strength ◽  
Comparative Evaluation ◽  
Shear Bond Strength ◽  
In Vitro Study ◽  
Composite Resins ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

ABSTRACT Background The dentin desensitizers available for in-office application for prevention and/or treatment of post restorative dentinal hypersensitivity, act by blocking the open dentinal tubules. In doing so, they may influence the bond strength of the restorative resins. Thus, the aim of the study was to evaluate the effect of desensitizers on the shear bond strength of dentin adhesives and to check the extent of dentinal tubule occlusion caused by these desensitizers. Materials and Methods Sixty-four premolars were randomly divided into four groups of sixteen each. The middle depth dentin was exposed by on the buccal surface and was etched using 37% phosphoric acid and rinsed. They were assigned to, Group 1: Gluma desensitizer, Group 2: Vivasens desensitizer, Group 3: Gluma Comfort Bond and desensitizer, and Group 4: Adper Single Bond 2. Composite resin post of 2 mm in height and width were built on these specimens. The samples were then mounted in acrylic resin blocks. Universal testing machine was used to test the shear bond strength. The data were analyzed using one-way analysis of variance (ANOVA) and post hoc Tukey's test. Results The mean values of the shear bond strength were for: Group 1—18.61 ± 1.03 MPa, Group 2—17.53 ± 1.36 MPa, Group 3—22.63 ± 1.61 MPa and Group 4—23.12 ± 1.02 MPa. There was a statistically significant difference (p < 0.05) among the groups. Conclusion The use of dentin desensitizers’ influences bond strength between the tooth and the adhesive. Among the various agents, the single bottle system containing Gluma comfort bond and desensitizer had the best adhesion among the desensitizer groups. How to cite this article Patil S, Naik B, Shetty P. A Comparative Evaluation of Three Commercially Available Dentin Desensitizers on the Shear Bond Strength of Composite Resins: An in vitro Study. J Contemp Dent 2015;5(2):65-68.

scholarly journals Shorter interlesion distance is associated with a longer procedure time but not with poorer acute results of pulmonary vein isolation: results from a prospective ablation index registry

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
N Gasimova ◽  
EB Kropotkin ◽  
EA Ivanitsky ◽  
GV Kolunin ◽  
AA Nechepurenko ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Pulmonary Veins ◽  
Anterior Wall ◽  
Procedure Time ◽  
Af Ablation ◽  
Ablation Index ◽  
First Pass ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source(s): This work was supported by the Ministry of Science and Higher Education grant (Russian Federation President Grant) #MD-2314.2020.7. Background/Introduction. Radiofrequency ablation (RFA) is the mainstay of invasive management of atrial fibrillation (AF). Amongst a variety of performance indicators, interlesion distance (ILD) has a potential to become a guiding one. Uptodate clinical AF RFA protocols suggest that ILD has to be less than 6 mm, however the research is still lacking in regard to its actual targeted value. Purpose. The aim of the research is to study a relationship between ILD and first-pass isolation (FPI) in ablation-index guided AF ablation procedures. Methods. This was a prospective observational multicenter study. Data were derived from the web-based system. Pulmonary veins (PV) isolation procedures were performed according to the local practice, and RFA settings depended on operators’ preferences. A total of 446 patients were enrolled, 407 of them underwent first-time AF ablation, data on ILD available in 322 subjects (177 (55%) males, mean age 62 ± 9 years old, 259 (80%) with paroxysmal AF). A mean ILD was calculated manually in each case as a sum of all ILDs divided by number of ablation tag points. FPI was considered in cases when no additional applications were required for bidirectional PV block following creation of a one circle around ipsilateral PVs and after a 20-min waiting period. Patients were divided into two groups according to ILD (Group 1 ILD≤ 4 mm, 163 patients and Group 2 ILD &gt; 4m, 159 patients) post-procedurally. Results.  The mean procedure time was 102 ± 52 min, the median fluoro time was 9 min [IQR 6; 15]. The following VisiTag parameters were used: the median target ablation index 400 [IQR 400; 500] on the left atrial anterior wall and 380 [IQR 380; 400] on the posterior segments, the median minimal contact force 3g [IQR 3; 4], median minimal time per a point - 4 sec [IQR 3; 15], mean catheter stability 3 mm (ranged between 2.5 and 3 mm). In 261 (81%) cases operators used 3 mm ablation tag size, and in 19% - 2 mm. The mean ILD was 4,1 ± 1,0 mm (3,2 ± 0,5 mm in Group 1 vs 4,6 ± 0,5 mm Group 2). FPI was achieved in 189 (59%) cases. In the "ILD ≤ 4 mm" group FPI was achieved in 93 (49,2%) cases and there were 96 (50,8%) cases of durable FPI in the "ILD &gt;4 mm" group (χ2 = 2,4, p = 0,124). The mean procedure time was 111 ± 46 min and 100 ± 35 min in Group 1 and 2 (p = 0,01), respectively. The mean fluoro time was 13 ± 4 min and 11 ± 4 min in Group 1 and 2 (p = 0,08), respectively Conclusion(s). The results of our multicenter study suggest that shortening of the distance ≤4 mm has no effect on the achievement of first-pass PV isolation, but required more procedure and relatively more X-ray exposure time.

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