scholarly journals A case of atopic dermatitis with a severe resistant course in adult patient with atopic march

2020 ◽  
Vol 17 (2) ◽  
pp. 69-73
Author(s):  
Galiya M. Tusupbekova ◽  
Aigul A. Syzdykova ◽  
Botagoz M. Davletova
Keyword(s):  
Atopic Dermatitis ◽  
Adult Patient ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Atopic Disease ◽  
Significant Others ◽  
Natural Course ◽  
Atopic March ◽  
Typical Sequence

Introduction. The atopic march is the natural course of development of atopy symptoms. It is characterized by a typical sequence of development of clinical symptoms of atopic disease, when some symptoms become more significant, others are recede. Timely allergological diagnostics with the identification of causal allergens allows to preventor suspend the atopic march. Purpose of the study was to demonstrate the stages of the atopic march formation and clinical manifestations of atopy, the importance of on timely detection of causal allergens, the capability of modern diagnostics and treatment of severe resistant forms of allergic diseases.

scholarly journals Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March

2020 ◽  
Vol 21 (23) ◽  
pp. 9011
Author(s):  
Émile Bélanger ◽  
Anne-Marie Madore ◽  
Anne-Marie Boucher-Lafleur ◽  
Marie-Michelle Simon ◽  
Tony Kwan ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Immunoglobulin E ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Allergic Diseases ◽  
Forced Expiratory Volume ◽  
Inflammatory Reactions ◽  
Atopic March ◽  
History Of

(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and clinical manifestations post-transcriptionally. Actually, their implication in allergic diseases is not fully understood, but they are believed to play a role in inflammation-related patterns and epithelial cell proliferation. (2) Methods: Next-generation sequencing was performed on RNA samples from eosinophils of individuals with atopic dermatitis, atopy, allergic rhinitis and asthma to obtain differential counts of primary miRNA (pri-miRNA); these were also analyzed for asthma-related phenotypes such as forced expiratory volume in one second (FEV1), immunoglobulin E (IgE) and provocative concentration of methacholine inducing a 20% fall in forced expiratory volume in 1 s (PC20) levels, as well as FEV1 to forced vital capacity (FEV1/FVC) ratio. (3) Results: Eighteen miRNAs from eosinophils were identified to be significantly different between affected individuals and unaffected ones. Based on counts from these miRNAs, individuals were then clustered into groups using Ward’s method on Euclidian distances. Groups were found to be explained by asthma diagnosis, familial history of respiratory diseases and allergic rhinitis as well as neutrophil counts. (4) Conclusions: The 18 differential miRNA counts for the studying phenotypes allow a better understanding of the epigenetic mechanisms underlying the development of the allergic diseases included in the atopic march.

scholarly journals FOOD ANAPHYLAXIS IN CHILDREN: RETROSPECTIVE ANALYSIS OF 53 CASES

2013 ◽  
Vol 10 (5) ◽  
pp. 22-26
Author(s):  
N V Esakova ◽  
A N Pampura
Keyword(s):  
Retrospective Analysis ◽  
Russian Federation ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Natural Course ◽  
Cow’S Milk ◽  
Topical Issue ◽  
Common Cause ◽  
Cow's Milk ◽  
Food Anaphylaxis

Introduction. There are no studies on anaphylaxis in children in Russian Federation therefore this problem is a topical issue. Background. To determine the etiology, natural course of food anaphylaxis in Russian Federation children, to analyse the therapeutic care of anaphylaxis. Methods. 53 patients with food anaphylaxis were included in the study. All patients completed a questionnaire included questions about the triggers, clinical manifestations and treatment of anaphylaxis. Results. In 94% episodes of anaphylactic reactions occurred at home, 2/3 (66%) of patients had two or more episodes of food anaphylaxis before, 5 (8%) infants didn’t have allergic diseases, 23 patients (43%) had anaphylactic reactions to more than one product. Cow’s milk (43%) was the most common cause of anaphylaxis. Cow’s milk caused anaphylaxis in 67% of children under 2 years (p

scholarly journals Principles of complementary food introduction in atopic dermatitis

2021 ◽  
Vol 5 (6) ◽  
pp. 421-426
Author(s):  
A.S. Botkina ◽  
◽  
M.I. Dubrovskaya ◽  
Keyword(s):  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Elimination Diet ◽  
Complementary Food ◽  
Childhood Nutrition ◽  
Atopic March ◽  
Special Diet ◽  
Starting Point ◽  
Keywords Atopic Dermatitis ◽  
Early Childhood Nutrition

Atopic dermatitis (AD) is one of the most common inflammatory skin disorders. In most patients, AD is a starting point for developing other atopic diseases, e.g., food allergy, allergic diseases of the gastrointestinal tract, allergic rhinitis, and asthma known under the umbrella of "atopic march". In addition to genetic predisposition, various environmental factors are essential for the development of this dermatosis. In young children, food is the most relevant factor. This paper discusses principles of the selection of complementary food, techniques, and terms of its introduction. Prolonging of breastfeeding, the adequate introduction of complementary food, and personified nutrition program prevent the atopic march. The authors highlight that there is no special diet for atopic dermatitis. Meanwhile, food should be safe, low allergy, and balanced to provide a child with essential macro-and micronutrients. In addition, the paper addresses the utility and validity of an elimination diet which should be prescribed only in established food sensitization and used under the control o f a specialist. KEYWORDS: atopic dermatitis, atopic march, infancy, early childhood, nutrition, complementary foods, prevention. FOR CITATION: Botkina A.S., Dubrovskaya M.I. Principles of complementary food introduction in atopic dermatitis. Russian Medical Inquiry. 2021;5(6):421–426 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-421-426.

scholarly journals Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with Infectious Mononucleosis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Hong Sun ◽  
Weiqun Wang ◽  
Chenglei Lin ◽  
Min Chen
Keyword(s):  
Infectious Mononucleosis ◽  
Clinical Symptoms ◽  
Venous Blood ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Early Morning ◽  
Control Group ◽  
Serum Ige ◽  
Immune Factor ◽  
Reference Index

Objective. To investigate the correlation between serum immune factor levels and allergic constitution in children with infectious mononucleosis. Methods. A total of 120 children who visited our hospital from March, 2019, to December, 2020, were selected as the research objects, and 40 children who came to our hospital for physical examination were included in the control group (CG). 40 children with IM were classified into the IM group (IG), and 40 IM children with allergic rhinitis, allergic dermatitis, asthma, and other allergic diseases were classified into the IM allergy group (AG). On the second day of admission, 5 ml of fasting venous blood was collected from all children in the early morning to observe the serum IgE level, the level of lymphocyte subsets, and the level of immunoglobulin of the patient. Results. The serum CD3, CD4, and CD8 levels of children in AG were significantly higher than those in IG and CG ( P < 0.05 ). The serum IgE, IgA, IgM, and IgG levels of children in AG were significantly higher than those of IG and CG ( P < 0.05 ). The serum IgE levels of children in AG were positively correlated with the serum CD3, CD4, and CD8 levels ( P < 0.05 ). There was a positive correlation between the serum IgE level and serum IgA, IgM, and IgG levels in children with AG ( P < 0.05 ). Conclusion. The results of this study showed that there may be a certain relationship between allergic constitution and the incidence, clinical manifestations, and prognosis of infectious mononucleosis. IgE level can be used as a reference index for the early severity of IM clinical symptoms.

scholarly journals Clinical manifestations of childhood asthma persisting until the age of seven

2016 ◽  
Vol 44 (1) ◽  
pp. 1
Author(s):  
Rini Asterina ◽  
Sjawitri P Siregar ◽  
Bambang Madiyono ◽  
Bambang Supriyatno
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Childhood Asthma ◽  
Clinical Symptoms ◽  
Age Of Onset ◽  
Clinical Manifestations ◽  
Persistent Asthma ◽  
Cigarette Smoke Exposure ◽  
Atopic Diseases ◽  
Inclusion Criteria

Background Asthma is a chronic illness commonly found in chil-dren. We aimed to find out the clinical manifestations of childhoodasthma persisting until the age of seven and the influencing factors.Methods A review was performed at the outpatient clinic of theDepartment of Child Health Cipto Mangunkusumo Hospital Jakarta,from January 1992 to December 2001, on children with asthmawho still had symptoms until the age of seven.Results During the period of 10 years, there were 322 childrenwith clinical symptoms of asthma persisting until the age of 7. Onehundred and forty-six (45.3%) met the inclusion criteria, consistingof 75 (51.4%) boys and 71 (48.6%) girls. The average age was11.7 years. There were 101 (69.2%) patients with rare episodicasthma, 26.0% with frequent episodic asthma, and 4.8% with per-sistent asthma. Age of onset was mostly beyond 3 year-old (51%).Besides asthma, atopic diseases noted in these patients were al-lergic rhinitis in 85 (58.2%) and atopic dermatitis in 42 (28.8%).Logistic regression found that cigarette smoke exposure (adjustedOR 4.72, 95%CI 2.05;10.87, p=0.000), allergic rhinitis (adjustedOR 3.44, 95%CI 1.40;8.45, p=0.007), and atopic dermatitis (ad-justed OR 2.37, 95%CI 1.01;5.72, p=0.048) had significant asso-ciation with the degree of asthma.Conclusion Of 146 children who still had asthma until the age ofseven, there were 69% with rare episodic asthma, 26% with fre-quent episodic asthma, and 4.8% with persistent asthma. Factorspresumably influencing this manifestations were cigarette smokeexposure, allergic rhinitis, and atopic dermatitis

scholarly journals Hypersensitivity in a dog accompanied by generalised onychodystrophy

2018 ◽  
Vol 72 (1) ◽  
pp. 56-63
Author(s):  
Tina Kotnik
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Symptoms ◽  
Fungal Infections ◽  
Allergic Diseases ◽  
Elimination Diet ◽  
Food Hypersensitivity ◽  
Strong Impact ◽  
External Ear ◽  
Allergen Specific Immunotherapy ◽  
Canine Atopic Dermatitis

Canine food hypersensitivity and canine atopic dermatitis are two of the most common allergic diseases in dogs. Food hypersensitivity is typically non-seasonal reaction of types I, III and IV, directed most commonly against glycoproteins in the foods. Canine atopic dermatitis is a genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features associated with IgE most commonly directed against environmental allergens. Irrespective of allergens that dogs are sensitised to, clinical symptoms in acute cases involve pruritus with erythema of the skin around lips, axillae, inguinal and perianal region or feet as well as external ear canal inflammation. In chronic cases, consequences of self-trauma and secondary bacterial or fungal infections may be present as excoriations, lichenification and hyperpigmentation. Hypersensitivity can have a strong impact on quality of life of diseased dogs as well as of their owners. A mixed breed female dog with heavily expressed generalised onychodystrophy accompanied by mild erythema of the groin and external ear canals, which responded to elimination diet and allergen-specific immunotherapy, is presented.

scholarly journals Clinical manifestations of atopy in children up to two years of age

2011 ◽  
Vol 68 (8) ◽  
pp. 690-695 ◽  
Author(s):  
Nevenka Ilic ◽  
Vesna Velickovic ◽  
Dragoljub Djokic ◽  
Nebojsa Rankovic ◽  
Gordana Kostic ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Specific Ige ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Ige Antibodies ◽  
Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

scholarly journals Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

2018 ◽  
Vol 17 (2) ◽  
pp. 114-120
Author(s):  
E. E. Varlamov ◽  
A. N. Pampura ◽  
A. N. Asmanov
Keyword(s):  
Allergic Rhinitis ◽  
Early Childhood ◽  
Atopic Dermatitis ◽  
Primary Prevention ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
The State ◽  
Older Age ◽  
Epidermal Barrier ◽  
Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

scholarly journals ETIOPATHOGENETIC FEATURES OF ATOPIC DERMATITIS IN PRESCHOOL CHILDREN

2017 ◽  
Vol 20 (6) ◽  
pp. 347-351
Author(s):  
Khusan Kh. Akhrorov ◽  
D. D Nabieva
Keyword(s):  
Atopic Dermatitis ◽  
Preschool Children ◽  
Severe Disease ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Specific Ige ◽  
Preschool Age ◽  
Food Factor ◽  
Co Morbidity

Objective. To determine the most important etiopathogenetic factors of formation, with their subsequent influence on the severity of atopic dermatitis (AD) in preschool children. Material and methods. 58 children aged 2 to 5 years with AD were examined. Clinical examination of patients, a general analysis of blood and urine, koproovocystoscopy, the determination of specific IgE (to food, household, epidermal, pollen allergens) by ELISA, examination of feces for dysbiosis were performed. Assessment of clinical manifestations of AD was carried out on the bases of the SCORAD system (1997). Results. The obtained data indicated that in the severe course of the disease the first clinical signs of AD were observed already in early childhood (up to a year). Hereditary burden for allergic diseases was determined on average 74.1%, but with moderate and severe pollen sensitization was recorded - in 46.6%, epidermal - in 13.8% of patients. Factors contributing to AD aggravation in pre-school children are the food factor (72.4%), contact with plant dust (43.1%) and stressful situations (17.2%). In patients with severe disease the rates of these factors were higher from 9 to 35%. The highest incidence of co-morbidity noted among children with severe AD was 2 times higher in patients with moderate severity. Conclusion. The AD severity in children of preschool age depends directly on the simultaneous presence of several major etiopathogenetic factors. In particular, the presence of food (72.47%) and pollen (54.5%) sensitization of the organism against the background of hereditary burden on allergic diseases (90.9%) leads to disease complication, which is 9% to 35% higher than in patients with moderate to mild severity.

scholarly journals Modern Outlooks on «Atopic March» Secondary Prevention Capabilities in Children with Atopic Dermatitis

2020 ◽  
Vol 19 (6) ◽  
pp. 514-519
Author(s):  
Nikolay N. Murashkin ◽  
Leyla S. Namazova-Baranova ◽  
Roman A. Ivanov ◽  
Dmitri V. Fedorov ◽  
Eduard T. Ambarchian ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Allergic Diseases ◽  
Disease Course ◽  
Therapeutic Approaches ◽  
Atopic March ◽  
Gradual Development ◽  
Severity Of The Disease

Atopic dermatitis (AD) is one of the most common inflammatory diseases of childhood, and it is the first one in gradual development of allergic diseases, also known as «atopic march». Sensitization establishment during the AD uncontrolled course is associated with the high risk of developing of serious allergic pathologies, increase in the severity of the disease course, and patients’ quality of life reduction. Thereby, it is crucial to achieve quick jugulation of the inflammatory process in case of severe AD with early onset of disease. This article shows modern therapeutic approaches to disease control in children.

Sign in / Sign up

Export Citation Format

Share Document