Immunohistochemistry Particularities of Retroperitoneal Tumors

Retroperitoneal space is called sometimes no man�s land�and for a good reason: this is disputed anatomical territory for many surgical and medical specialties. Their wide histological diversity and unspecific clinical presentation make them a challenge for the surgeon. In order to improve their detection immunohistochemistry seems to show promising results. Methods of detection have evolved over time to identify as much as possible the histological type of tumor. Because of this extreme variability immunohistochemistry through its various markers is the one that often sets the definitive diagnosis, the simple histopathological examination being insufficient. This paper aims to highlight the main markers used in retroperitoneal tumors. As it can be seen there is a huge histologic areal for these tumors. Some have proven some of them still not. Given the fact that there is a tendency toward personalized therapy it is imperative to identify the histological type of tumor as soon as possible.

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Pedunculated obstructive lipoma of the ileocecal valve: A case report

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1412721v ◽

2014 ◽

Vol 142 (11-12) ◽

pp. 721-723

Author(s):

Berislav Vekic ◽

Rastko Zivic

Keyword(s):

Clinical Presentation ◽

Histopathological Examination ◽

Ileocecal Valve ◽

Right Hemicolectomy ◽

Acute Intestinal Obstruction ◽

Definitive Diagnosis ◽

Benign Tumors ◽

Acute Obstruction ◽

Postoperative Course

Introduction. Colonic lipomas are relatively common but they rarely progress to complete acute obstruction. Case Outline. We report a case of a 67-year-old woman with acute intestinal obstruction caused by a large pedunculated lipoma of the ileocecal valve. Preoperatively, the patient presented acutely with clinical and radiographic signs of small intestine ileus. A right hemicolectomy with subsequent terminolateral ileocolostomy was performed. The histopathological examination revealed a benign lipoma of the ileocecal valve which telescoped into the cecum and caused ileocolonic intussusception. The postoperative course was uneventful and the patient was free of symptoms during a 12-month follow-up period. Conclusion. Since these benign tumors are frequently revealed by laparotomy and the definitive diagnosis is made on the basis of histopathological examination, we can conclude that extensive resections of the large intestine are justified in cases with acute clinical presentation.

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Stereotactic Body Radiotherapy of a Solitary Metachronous Sphenoid Metastasis from Renal Cell Cancer: A Case Report

Case Reports in Oncology ◽

10.1159/000513743 ◽

2021 ◽

pp. 269-273

Author(s):

Charles Marchand Crety ◽

Estelle Vigneau ◽

Camille Invernizzi

Keyword(s):

Renal Cell Cancer ◽

Renal Cell ◽

Stereotactic Body Radiation Therapy ◽

Clinical Presentation ◽

Histopathological Examination ◽

Cell Cancer ◽

Papillary Renal Cell Carcinoma ◽

Complete Response ◽

Resonance Imaging ◽

The Right

Nasosinus metastases from kidney cancer are an unusual clinical presentation although some cases are reported in the literature. Among these cases, sphenoidal metastases are even rarer. Here we report a case of lone sphenoid metastasis in patients with papillary renal cell cancer. Eight months after radical nephrectomy, the patient presented with progressively worsening diplopia. Magnetic resonance imaging showed a mass in the right sphenoid sinus. Histopathological examination of the biopsy sample confirmed diagnosis of sinonasal metastasis from papillary renal cell carcinoma. The patient was declined for surgical management and received stereotactic body radiation therapy. Reassessment MRI at 4 months showed a complete response of the treated sphenoid lesion.

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Ambulatory Pediatricians of North America, Unite! Run, Do Not Walk to Your Nearest Grammar School

PEDIATRICS ◽

10.1542/peds.44.2.300a ◽

1969 ◽

Vol 44 (2) ◽

pp. 300-301

Author(s):

Richard B. Goldbloom

Keyword(s):

North America ◽

Scientific Information ◽

Grammar School ◽

Medical Specialties ◽

To Come ◽

The One

The continuing "explosion" of scientific information and the arborization of medical specialties have caused physicians to invent names and catch phrases to define their new activities. Regrettably, much of this latter-day vocabulary is unmusical and clumsy. Some examples represent a downright assault on the English Ianguage. It is alarming that a profession whose members demand such precision in their work would tolerate such slapdash semantic shenanigans. One has winced at such utterances as "examination of the chest showed no pathology;" one has cringed when otherwise esteemed colleagues have indulged in such semantic horrors as "coagulogram" and "febrile agglutinins;" but, in years to come the one atrocity whose promulgation may be remembered with particular mal de mer by the older pediatricians will be the term "ambulatory pediatrics."

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Surgical treatment of rapidly advancing active ulcerative colitis: a case report

Nowa Medycyna ◽

10.25121/nm.2018.25.3.112 ◽

2018 ◽

Vol 25 (3) ◽

Author(s):

Sławomir Glinkowski ◽

Daria Marcinkowska

Keyword(s):

Ulcerative Colitis ◽

Clinical Presentation ◽

Histopathological Examination ◽

Vacuum Therapy ◽

Active Ulcerative Colitis ◽

Packed Red Blood Cells ◽

Surgical Department ◽

Bacterial Aetiology ◽

Good General Condition ◽

Impaired Immune Response

Ulcerative colitis is an inflammatory bowel disease with various clinical presentation. Due to an impaired immune response, diffuse inflammation develops in the intestinal tissue, which leads to bleeding and diarrhoea. The basis for diagnosis is the clinical presentation and the result of colonoscopy which confirms the presence of inflammatory lesions in the colon. The authors present the case of a patient admitted to their department following two previous hospitalisations at other centres who was suffering from active ulcerative colitis. After bacterial aetiology of the disease was excluded and conservative treatment was attempted at a gastroenterology ward, the patient was referred to a surgical department. During the previous hospitalisation colonoscopy was performed in which a lesion was observed in the splenic flexure, which precluded the visualisation of the further part of the colon. A colonoscopy performed at the surgical department did not confirm the presence of that lesion; however, it did reveal multiple pseudopolyps. Due to rapidly progressing cachexia and anaemia and a lack of improvement following attempted pharmacological treatment, a decision was made to perform an urgent colectomy with end ileostomy. After a week-long preparation of the patient (parenteral nutrition, packed red blood cells transfusion), pancolectomy was performed. Histopathological examination confirmed acute phase ulcerative colitis. In the postoperative period massive wound infection developed, which was treated for 14 days with vacuum therapy (VAC). The patient was treated for 30 days at the surgical department. He was discharged in a good general condition and instructed to report to his outpatient care centre.

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Treatment of Rhinocerebral Mucormycosis by Combination of Endoscopic Sinus Debridement and Amphotericin B

American Journal of Rhinology ◽

10.1177/194589240101500508 ◽

2001 ◽

Vol 15 (5) ◽

pp. 327-331 ◽

Cited By ~ 26

Author(s):

Isam Alobid ◽

Manuel Bernal ◽

Carlos Calvo ◽

Isabel Vilaseca ◽

Juan Berenguer ◽

...

Keyword(s):

Diabetes Mellitus ◽

Computed Tomography ◽

Histopathological Examination ◽

Ct Scanning ◽

Definitive Diagnosis ◽

Immunocompromised Patients ◽

Imaging Procedures ◽

Rhinocerebral Mucormycosis ◽

Uncontrolled Diabetes ◽

Mucosal Necrosis

Rhinocerebral mucormycosis (RCM) is an aggressive fungal infection with a high mortality rate. It frequently develops in patients with uncontrolled diabetes mellitus or immunocompromised patients. RCM typically presents in a rapidly fulminant manner with headache, fever, mucosal necrosis, and ophthalmic symptoms. Although the definitive diagnosis is achieved by histopathological examination, computed tomography (CT) scanning and magnetic resonance (MR) are the best imaging procedures in early diagnosis to assess the extent of the disease.

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Thromboembolic Conditions, Aetiology Diagnosis and Treatment in Dogs and Cats

Acta Veterinaria Brno ◽

10.2754/avb201079030497 ◽

2010 ◽

Vol 79 (3) ◽

pp. 497-508 ◽

Cited By ~ 2

Author(s):

Filip Konečný

Keyword(s):

Veterinary Medicine ◽

Clinical Presentation ◽

Medical Condition ◽

Definitive Diagnosis ◽

Diagnosis And Treatment ◽

Window Of Opportunity ◽

Timely Manner ◽

Human Counterpart ◽

Life Threatening ◽

Diagnostic Capabilities

In veterinary medicine, thrombo-embolism (TE) is an under-appreciated medical condition that requires immediate recognition. Since TE is multifactorial and its mode of presentation may vary, veterinarians face great difficulties in making a definitive diagnosis in a timely manner. In addition, most of the underlying conditions that give rise to TE are life-threatening and an aggressive diagnostic and therapeutic approach is required. Not only does the diagnosis and treatment of this condition require the collaboration of many specialties, the costs of therapy can be excessive with a high risk of recurrence. As such, owners have to be thoroughly informed before the therapy commences. While TE has been well-characterized in humans and is associated with significant morbidity and mortality, little information of similar quality is available in veterinary medicine. In addition, TE in animals is distinct from its human counterpart and we cannot simply adapt what is known from human clinical trials. With the promise of improvements in imaging modalities that improve our diagnostic capabilities, the window of opportunity to treat TE increases. This article focuses on aetiology, clinical presentation, diagnosis, and treatment of dogs and cats affected by TE.

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Ovarian tumors: Incidence, histological type of lesions and treatment in pediatric age group

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0014.8603 ◽

2021 ◽

Vol 75 ◽

pp. 292-296

Author(s):

Patrycja Sosnowska-Sienkiewicz ◽

Piotr Nogal ◽

Dawid Gawron ◽

Korneliusz Wójcik ◽

Danuta Januszkiewicz-Lewandowska ◽

...

Keyword(s):

Clinical Symptoms ◽

Malignant Tumors ◽

Histopathological Examination ◽

Tumor Staging ◽

Benign Lesion ◽

Mature Teratoma ◽

Malignant Lesion ◽

Ovarian Tumors ◽

Histological Type ◽

Tumor Type

Background: The aim of this study was to evaluate the incidence and histological type of lesions affecting the ovaries and to analyze employed methods of invasive treatment. Materials&Methods: Medical records of patients who were treated surgically for ovarian tumors in the years 2015 -2019 were reviewed. The study group was comprised of 31 female patients. Results: During 5 years time, there were 31 girls in the age from 3 months to 17 years hospitalized in the department. The mean age was 11 years. Histopathological examination was performed in all of these cases. 12 patients were diagnosed with malignant lesion, 19 with benign lesion. The most commonly diagnosed malignant tumors were a dysgerminoma and a mixed germ cell tumor. In the group of benign lesions, the most frequent tumor type was mature teratoma. The first occurring symptom was abdominal pain. Some of the lesions were diagnosed accidentally during ultrasonography. The diagnostics was expanded depending on the size of the tumor, staging and clinical condition of the patient. All the patients were treated surgically, 16 of them underwent laparoscopic surgery. Torsion of the ovary or oviduct was observed in 3 cases. Chemotherapy was introduced in 8 cases as complementary treatment. Conclusions: The most commonly diagnosed tumor was mature teratoma. Ultrasonography is the most frequent method of the ovaries’ examination. Ovarian lesions are characterized by non-specific clinical symptoms, which is associated with prevalent incidental detection during ultrasonography.

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Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India

10.21203/rs.2.23477/v1 ◽

2020 ◽

Author(s):

Basavaprabhu Achappa ◽

Nipuni Chamathka Herath ◽

Jyoti Ramanath Kini ◽

Ramesh Holla ◽

Bodhi Sebastian ◽

...

Keyword(s):

Clinical Presentation ◽

Histopathological Examination ◽

Cervical Lymphadenopathy ◽

Symptomatic Treatment ◽

Lymph Node Biopsy ◽

Unknown Etiology ◽

Extensive Literature ◽

Cervical Lymphadenitis ◽

Benign Condition ◽

The Mean

Abstract Background Kikuchi-Fujimoto disease is a rare, benign condition, of unknown etiology, presenting as cervical lymphadenitis, usually tender and maybe associated with systemic symptoms. Despite the extensive literature on this disease, it continues to be misdiagnosed owing to its misleading clinical presentation. Results The mean age in our study was 26.9 (±11.3) years with a female majority of 65.7%. The clinical presentation of most cases was, tender swelling over the side of the neck ( n =50, 74.6%). On local examination, the mean length and width were 2.3 (±1.0) cm and 2.2 (±0.7) cm respectively. Histopathological examination revealed that most patients presented in the proliferative stage ( n =40, 59.7%). In 83.6% of the patients lymphadenopathy resolved in less than 2 months. Follow up of these patients over 9 months revealed that a vast majority of the patients underwent full recovery with symptomatic treatment ( n =42, 62.7%). Conclusions The disease is prevalent in young, female patients of Asian descent and often presents as cervical lymphadenopathy. Early diagnosis with excisional lymph node biopsy is crucial to avoid unnecessary investigations and treatment. Treatment is only symptomatic unless complicated, where steroid therapy is considered. Kikuchi’s disease has an excellent prognosis with almost no risk of fatality.

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EP.TU.533A rare clinical presentation of Goblet Cell Adenocarcinoma of the appendix: Recommendations for safe & effective management

British Journal of Surgery ◽

10.1093/bjs/znab311.072 ◽

2021 ◽

Vol 108 (Supplement_7) ◽

Author(s):

Ganeshan Ramsamy ◽

Zoe Slack ◽

Giovanni Tebala

Keyword(s):

Small Bowel ◽

Goblet Cell ◽

Clinical Presentation ◽

Histopathological Examination ◽

Clinical Signs ◽

Operative Management ◽

Small Bowel Resection ◽

Right Hemicolectomy ◽

Bowel Ischaemia ◽

Operative Recovery

Abstract Background Goblet cell carcinoma (GCC) is a rare mixed neoplasm arising from the appendix, consisting of glandular and neuroendocrine tissue. It typically presents in adults with a mean age of 55-65 years old. Diagnosis is usually incidental via histopathological examination after 0.3% to 0.9% of all appendicectomies. Literature remains sparse on classification and prognosis of GCC, and cases documented in younger patients. Aims To highlight an interesting clinical presentation and intra- and post-operative management of GCC. To increase awareness for future practice when managing patients with GCC. Methods A 37 year-old male presented with left sided abdominal pain, constipation and fresh rectal bleeding. Computed Tomography demonstrated extensive SMV thrombus causing small bowel ischaemia. On the Intensive Care Unit, he underwent thrombolysis through a Transjugular Intrahepatic Porto-Systemic Shunt. A few days later, he developed bowel obstruction, necessitating a small bowel resection secondary to an ischaemic stricture. 9 months later, he presented with clinical signs of appendicitis. After an uneventful appendicectomy, he was diagnosed with GCC upon histopathological examination of the specimen. Results The patient made an uneventful post-operative recovery. A multidisciplinary team (MDT) decision was made to perform a completion right hemicolectomy, with histology confirming pT3N1M0 GCC. Adjuvant chemotherapy with 5-Fluorouracil was started. Conclusion This case highlights GCC with a preceding clinical course not yet published in the literature. It stresses the importance of the MDT in managing GCC. Although primarily diagnosed histologically, a clinical suspicion of GCC of the appendix is worth considering in pro-thrombotic patients.

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AGGRESSIVE MESENTRIC FIBROMATOSIS: A RARE CASE REPORT AND REVIEW OF LITERATURE

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703641 ◽

2013 ◽

Vol 03 (01) ◽

pp. 79-82

Author(s):

Rohan Shetty ◽

Shubha Bhat ◽

Rajesh Ballal ◽

Pramod Makannavar ◽

Anil Kumar K. N.

Keyword(s):

Case Report ◽

Male Patient ◽

Rare Case ◽

Clinical Presentation ◽

Aggressive Fibromatosis ◽

Definitive Diagnosis ◽

Review Of Literature ◽

Therapeutic Challenge ◽

Rare Case Report ◽

Small Intestinal

AbstractMesentric fibromatosis is a proliferative fibroblastic neoplasm of the small intestinal mesentery with varied clinical presentation. Giant mesentric fibromatosis is uncommon and its rarity poses a diagnostic and therapeutic challenge. This paper presents a recurrent aggressive fibromatosis in a 38 year old male patient, who had initially undergone a laparotomy outside for mass abdomen but only pus was evacuated and definitive diagnosis was not made.

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