LOCAL HYPERTHERMIA IN TREATMENT FOR MALIGNANT BRAIN TUMORS

2018 ◽  
Vol 64 (1) ◽  
pp. 54-61
Author(s):  
A. Ryabova ◽  
O. Gribova ◽  
V. Novikov ◽  
E. Choinzonov ◽  
Zh. Starceva ◽  
...  
Keyword(s):  
Experimental Data ◽  
Radiation Therapy ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Combined Treatment ◽  
Complex Treatment ◽  
Local Hyperthermia ◽  
Malignant Brain Tumors ◽  
Sensitizing Effect ◽  
Methods Of Treatment

Unsatisfactory results of complex treatment for malignant brain tumors stimulate search of new effective methods of treatment. Radiation therapy is an integral part of the combined treatment but often does not influence lethally on resistant tumor cells. Thereby in recent decades there has been an active search for different modifiers, which can increase the sensitivity of tumors to chemotherapy and radiotherapy. One of the universal sensitizers is the local hyperthermia. Experimental data showed that the effect of high temperatures had both a direct damaging effect on tumor cells and a sensitizing effect. The literature review given in the article provides an overview of the existing methods of the local hyperthermia for brain tumors treatment.

scholarly journals CURRENT APPROACHES TO CHEMORADIOTHERAPY FOR MALIGNANT GLIOMAS

2014 ◽  
Vol 13 (3) ◽  
pp. 119-125 ◽  
Author(s):  
Ye. L. Choinzonov ◽  
O. V. Gribova ◽  
Zh. A. Startseva ◽  
A. I. Ryabova ◽  
V. A. Novikov ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Tumor Cells ◽  
Combined Treatment ◽  
Malignant Gliomas ◽  
Survival Rates ◽  
Chemotherapeutic Drugs ◽  
Who Grade ◽  
Local Hyperthermia ◽  
Novel Approaches ◽  
Sensitizing Effect

High-grade malignant gliomas (WHO grade G III–IV) account for more than 50% of all primary brain tumors. Despite aggressive treatment, survival rates are still very low with a median reported survival of no more than 1.5 years.Radiation therapy is an integral part of the combined treatment, but often does not influence lethally on resistant tumor cells. Thereby, in recent decades there has been an active search for novel approaches to the treatment of malignant gliomas (chemotherapeutic drugs, biological modifiers, local hyperthermia). Experimental data showed that the effect of high temperatures has both a direct damaging effect on tumor cells and a sensitizing effect. Significant advantages are achieved when the complex treatment of different malignant tumorsincludes local hyperthermia. However data on the treatment of patients with primary and recurrent gliomas G III–IV using local hyperthermia are scarce.The literature review is given in the article provides an overview of the existing treatment methods for brain tumors.

Multiagent Chemotherapy and Deferred Radiotherapy in Infants With Malignant Brain Tumors: A Report From the Children’s Cancer Group

2005 ◽  
Vol 23 (30) ◽  
pp. 7621-7631 ◽  
Author(s):  
J. Russell Geyer ◽  
Richard Sposto ◽  
Mark Jennings ◽  
James M. Boyett ◽  
Richard A. Axtell ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Induction Chemotherapy ◽  
Metastatic Disease ◽  
Response Rate ◽  
Residual Tumor ◽  
Study Entry ◽  
Receive Radiation Therapy ◽  
Malignant Brain Tumors ◽  
Significant Difference

Purpose To evaluate response rate, event-free survival (EFS), and toxicity of two chemotherapeutic regimens for treatment of children younger than 36 months with malignant brain tumors and to estimate control intervals without irradiation in children with no residual tumor after initial surgery and induction chemotherapy and with delayed irradiation in patients with residual tumor or metastatic disease at diagnosis. Patients and Methods Patients were randomly assigned to one of two regimens of induction chemotherapy (vincristine, cisplatin, cyclophosphamide, and etoposide v vincristine, carboplatin, ifosfamide, and etoposide). Maintenance chemotherapy began after induction in children without progressive disease. Children with no residual tumors after induction therapy and no metastatic disease at diagnosis were not to receive radiation therapy unless their tumors progressed. Results Two hundred ninety-nine infants were enrolled. Forty-two percent of patients responded to induction chemotherapy. At 5 years from study entry, the EFS rate was 27% ± 3%, and the survival rate was 43% ± 3%. There was no significant difference between the two arms in terms of response rate or EFS. For medulloblastoma, supratentorial primitive neuroectodermal tumor, ependymoma, and rhabdoid tumors, 5-year EFS rates were 32% ± 5%, 17% ± 6%, and 32% ± 6%, and 14% ± 7%, respectively. Fifty-eight percent of patients who were alive 5 years after study entry had not received radiation therapy. Conclusion Intensified induction chemotherapy resulted in a high response rate of malignant brain tumors in infants. Survival was comparable to that of previous studies, and most patients who survived did not receive radiation therapy.

scholarly journals Effect of Lymphokine—activated Killer Cells with or without Radiation Therapy against Malignant Brain Tumors

1995 ◽  
Vol 35 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Kunio NAKAGAWA ◽  
Takao KAMEZAKI ◽  
Yasushi SHIBATA ◽  
Takashi TSUNODA ◽  
Kotoo MEGURO ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells ◽  
Malignant Brain Tumors

In vitro efficacy of recombinant diphtheria toxin–murine interleukin-4 immunoconjugate on mouse glioblastoma and neuroblastoma cell lines and the additive effect of radiation

2000 ◽  
Vol 9 (6) ◽  
pp. 1-6 ◽  
Author(s):  
Ki-Uk Kim ◽  
Daniel A. Vallera ◽  
Hsaio-Tzu Ni ◽  
Kwan H. Cho ◽  
Walter C. Low ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Cell Lines ◽  
Diphtheria Toxin ◽  
Cytotoxic Effect ◽  
Neuroblastoma Cell ◽  
Interleukin 4 ◽  
Treatment Modalities ◽  
Malignant Brain Tumors

Object The prognosis for patients with primary malignant brain tumors is poor despite aggressive treatment, and tumor recurrence is common regardless of the chosen therapy. Although multimodal treatment does not provide a cure, it is necessary to determine which treatment modalities have the greatest cytotoxic effect and can potentially prolong survival. Immunotoxin therapy is a novel approach for the treatment of tumors, and it has been successfully used in the central nervous system. Because the interleukin (IL)–4 receptor is commonly expressed on brain tumor cells, the purpose of this study was to evaluate the cytotoxic effect of using a modified diphtheria toxin–murine IL-4 (DT390-mIL4) immunoconjugate for the treatment of murine brain tumor cell lines and to determine whether the addition of radiation therapy could potentiate the effect of this agent. Methods Spontaneous murine glioblastoma (SMA-560) and two neuroblastoma (Neuro-2a and NB41A3) cell lines were treated using DT390-mIL4 at different concentrations, and the anti–mouse IL-4 monoclonal antibody (11B11) was used for blocking its cytotoxicity. Other SMA-560 and Neuro-2a cell lines were treated using 500 cGy of radiation 3 hours before DT390-mIL4 treatment. Cytotoxity was evaluated using a trypan blue viability assay. The immunoconjugate exhibited a dose-dependent cytotoxic effect with 50% inhibitory concentration values of 0.56 × 10−9 M in SMA-560, 1.28 × 10−9 M in Neuro-2a, and 0.95 × 10−10 M in NB41A3 cell lines. The cytotoxicity of DT390-mIL4 was specifically blocked by an excess of 11B11. Cytotoxicity was additive when the DT390-mIL4 at 10−9 M immunoconjugate administration was followed by radiation therapy. Conclusions These results indicate that the IL-4 receptor can be a target for diphtheria toxin fusion proteins and that radiation can potentiate the effects of DT390-mIL4. The development of multimodal approaches to treat malignant brain tumors with agents that have different mechanisms of action may be beneficial.

Development of a Protocol for Photoradiation Therapy of Malignant Brain Tumors: Part 1

Neurosurgery ◽  
1982 ◽  
Vol 11 (4) ◽  
pp. 500-505 ◽  
Author(s):  
Donald E. Rounds ◽  
Skip Jacques ◽  
Hunter C. Shelden ◽  
Charles A. Shaller ◽  
Robert S. Olson
Keyword(s):  
Brain Tumors ◽  
Tumor Cells ◽  
Brain Tissue ◽  
Light Exposure ◽  
Assay Method ◽  
Normal Brain ◽  
Hematoporphyrin Derivative ◽  
Cerebral Damage ◽  
Malignant Brain Tumors

Abstract The successful application of phototherapy to subcutaneous tumors has suggested that a similar procedure should be developed for treating gliomas. As a result, attempts are being made to determine a set of conditions that would optimize the destruction of tumor cells while minimizing injury to surrounding brain tissue. To initiate this task, we developed a novel assay method to assess the amount of phototoxicity induced in normal brain by light exposure of mice treated with hematoporphyrin derivative (HPD). The application of this procedure demonstrated that a sufficient amount of HPD was retained in brain tissue, even 72 hours after injection, to cause severe cerebral damage in light-treated mice.

scholarly journals LOCAL HYPERTHERMIA IN THE TREATMNET OF LOCALLY ADVANCED CERVICAL CANCER: CURRENT VIEW ON THE PROBLEM

2021 ◽  
Vol 20 (4) ◽  
pp. 122-129
Author(s):  
O. V. Shpileva ◽  
L. A. Kolomiets ◽  
Zh. A. Startseva ◽  
O. N. Churuksaeva
Keyword(s):  
Cervical Cancer ◽  
Radiation Therapy ◽  
Treatment Outcomes ◽  
Tumor Cells ◽  
Locally Advanced ◽  
Cytotoxic Agents ◽  
Cochrane Library ◽  
Advanced Cervical Cancer ◽  
Local Hyperthermia ◽  
Locally Advanced Cervical Cancer

The purpose of the study was to review available data on the combined use of local hyperthermia and chemotherapy/radiotherapy in the treatment of locally advanced cervical cancer, as well as to analyze longterm treatment outcomes.Material and methods. A systemic literature review was conducted using medline, cochrane library, and elibrary databases in the interval time between 2003 and 2020.Results. The review describes the mechanisms of biological efficiency of local hyperthermia and evaluates the effect of hyperthermia combined with chemotherapy and radiation therapy on cancer cells. Analysis of the thermobiological effects of local hyperthermia indicates that it is a potent sensitizer of cell killing by ionizing radiation and chemotherapy. The increase in tumor radiosensitivity is caused by the inhibition of the repair processes of damaged dna strands. Hyperthermia enhances perfusion and oxygenation of hypoxic tumor cells with a consecutive increase in tumor radiosensitivity. During chemotherapy, local hyperthermia ensures the maximum targeted delivery of cytotoxic agents to the tumor, thus increasing the effectiveness of treatment. Moreover, local hyperthermia has a direct cytotoxic effect on tumor cells. Randomized trials on the use of hyperthermia in the treatment of locally advanced cervical cancer have shown positive immediate and long-term treatment outcomes.Conclusion. Local hyperthermia combined with chemotherapy and radiation therapy is a promising treatment modality for locally advanced cervical cancer, because it can significantly improve treatment outcomes and reduce the frequency of early and late adverse effects. However, despite the available world experience, there are no unified methodological approaches to local hyperthermia, and therefore further research is required.

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