scholarly journals Hypothalamic-pituitary-adrenal axis hypofunction after adrenocorticotropic hormone therapy

2018 ◽  
Vol 10 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Yuichi Abe ◽  
Kaori Sassa ◽  
Toru Kikuchi ◽  
Hideo Yamanouchi
Keyword(s):  
Hormone Therapy ◽  
Adrenocorticotropic Hormone ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Plasma Interleukin-1, Tumour Necrosis Factor and Hypothalamic-Pituitary-Adrenal Axis Responses During Migraine Attacks

Cephalalgia ◽  
1991 ◽  
Vol 11 (2) ◽  
pp. 65-67 ◽  
Author(s):  
JJ van Hilten ◽  
MD Ferrari ◽  
JWM Van der Meer ◽  
HJ Gijsman ◽  
BJ Looij
Keyword(s):  
Body Temperature ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Adrenocorticotropic Hormone ◽  
Interleukin 1 ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Necrosis Factor

To evaluate systemic cytokine and hypothalamic-pituitary-adrenal axis responses in migraine, we measured plasma levels of tumour necrosis factor, interleukin-1, adrenocorticotropic hormone, and cortisol, as well as body temperature during and between attacks in 20 migraine patients. We found no evidence of systemic rise of cytokines during migraine attacks. Plasma cortisol and adrenocorticotropic hormone responses were similar to those found to experimentally-induced pain in normal subjects, i.e. elevated cortisol and unchanged adrenocorticotropic hormone levels. Unexpectedly, body temperature tended to be lower during attacks.

scholarly journals The influence of chronic psycho-emotional stress on cognitive function

2015 ◽  
Vol 96 (4) ◽  
pp. 523-531
Author(s):  
I S Lutskiy ◽  
E I Lutskiy
Keyword(s):  
Cognitive Function ◽  
Emotional Stress ◽  
Cognitive Functions ◽  
Neuropsychological Tests ◽  
Adrenocorticotropic Hormone ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Egb 761 ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Aim. The influence of the chronic psycho-emotional stress on the cognitive function was studied. Methods. 160 railroad engineers of main-line locomotives, whose occupation is acknowledged to be one of the most stressful, were examined. 100 healthy volunteers were examined as a control group. A scale of psychological tension PSM-25 was used to evaluate the effect of the stress. Neurohumoral response to stress was studied by the activity of the hypothalamic-pituitary-adrenal axis, defining adrenocorticotropic hormone, cortisol and corticosterone concentrations. Cognitive functions were examined by the neuropsychological tests: Schulte tables, F. Grobov tables, Burdon correction tests. Attention assessment was emphasized due to railroad engineer’s profession specifics. Result. The reaction of the hypothalamic-pituitary-adrenal axis depended on the duration of chronic psycho-emotional stress: resistance period with reduced levels of the stress hormones in the next 5-7 years replaced the period of activation in the first years (with increased production of adrenocorticotropic hormone, cortisol and corticosterone). The reactivation of the hypothalamic-pituitary-adrenal axis occurred after 12-15 years. Neuropsychological tests revealed that the effect of chronic psycho-emotional stress was accompanied by decreased cognitive functions compared to controls. Time for passing the tests and the number of errors increased, productivity, stability and attention concentration dropped. The term of cognitive function disorders onset and their severity depend on chronic psycho-emotional stress duration. The extract of Ginkgo biloba (EGb 761, 240 mg per day for three months) intake has significantly improved the results of neuropsychological retests. Conclusion. Chronic psycho-emotional stress leads to deterioration of cognitive functions, and, in particular, attention. The use of Ginkgo biloba (EGb 761) extract is rational for treatment of cognitive malfunction.

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