MAGE-1, GAGE-1/-2 gene expression in FNAB of classic variant of papillary thyroid carcinoma and papillary hyperplasia in nodular goiter.

Abstract Introduction: This is the first report of multiple endocrine neoplasia type 1 (MEN1) combined with papillary thyroid carcinoma (PTC) and nodular goiter in China. MEN1 is a rare hereditary tumor syndrome inherited in an autosomal dominant manner and presenting mostly as tumors of the parathyroid, endocrine pancreas (such as gastrinoma) and anterior pituitary. However, PTC and nodular goiter were not previously regarded as components.Patient concerns: We present a 35-year-old woman with MEN1 accompanied with coinstantaneous PTC and nodular goiter.Diagnosis: The pathological diagnosis was PTC with cervical lymph node metastasis, nodular goiter, parathyroid cyst and adenomatoid hyperplasia. Genetic analysis was performed and a germ-line MEN1 gene mutation was detected.Interventions: The patient underwent unilateral lobectomy of the thyroid gland and surgical removal of the parathyroid tumors.Outcomes: After 6 months of follow-up, ultrasonic examination of the patient’s neck showed no abnormality. Serum calcium and parathyroid hormone levels were normal.Conclusion: This is the first experience of a case of MEN1 combined with PTC and nodular goiter in China. MEN1 syndrome may have predisposed the present patient to PTC and nodular goiter. PTC and/or nodular goiter may be new components of MEN1. More cases are required to confirm this association.

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Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma

Cancer Research ◽

10.1158/0008-5472.can-21-0761 ◽

2021 ◽

pp. canres.0761.2021

Author(s):

Ana Stosic ◽

Fabio Fuligni ◽

Nathaniel D. Anderson ◽

Scott Davidson ◽

Richard de Borja ◽

...

Keyword(s):

Gene Expression ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Expression Patterns ◽

Gene Expression Patterns ◽

Papillary Thyroid ◽

Distinct Gene ◽

Genomic Landscape

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Gene Expression Profiling Identifies Platelet-Derived Growth Factor as a Diagnostic Molecular Marker for Papillary Thyroid Carcinoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-0807-03 ◽

2004 ◽

Vol 10 (6) ◽

pp. 2035-2043 ◽

Cited By ~ 43

Author(s):

Yukiko Yano ◽

Naoya Uematsu ◽

Tohru Yashiro ◽

Hisato Hara ◽

Ei Ueno ◽

...

Keyword(s):

Gene Expression ◽

Growth Factor ◽

Papillary Thyroid Carcinoma ◽

Molecular Marker ◽

Thyroid Carcinoma ◽

Gene Expression Profiling ◽

Expression Profiling ◽

Platelet Derived Growth Factor ◽

Papillary Thyroid

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Altered TEG Parameters Identify Hypercoagulablilty and are of Diagnosis Value for Papillary Thyroid Carcinoma Patients

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/a-0723-3295 ◽

2018 ◽

Vol 128 (05) ◽

pp. 297-302

Author(s):

Songsong Lu ◽

Rui Kang ◽

Yongchao Wang ◽

Mengjie Zhu ◽

Lei Zhao ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Correlation Analysis ◽

Thyroid Carcinoma ◽

Roc Curve ◽

Nodular Goiter ◽

Roc Curves ◽

Control Group ◽

Healthy Controls ◽

Papillary Thyroid ◽

Routine Coagulation

Abstract Objective The goal of this study was to clarify the changes and clinical significance of thromboelastography (TEG) parameters in papillary thyroid carcinomas and nodular goiters. Methods 62 nodular goiter (NG) patients and 53 papillary thyroid carcinoma (PTC) patients were included. Coagulation indicators, together with a series of TEG parameters were collected and analyzed, compared with results of 61 healthy controls (HC). Correlation analysis was conducted between routine coagulation indicators and TEG parameters. ROC curves were used to evaluate the potential diagnosis value of the TEG parameters that were altered in papillary thyroid carcinoma patients. Results APTT and PT in papillary thyroid carcinoma group were statistically significant higher than that in control group (p<0.05). MPV was found to be higher in PTC than NG and healthy controls.R, K and SP levels were significantly lower in PTC group than that in HC group; Angle, CI and TPI levels were significantly higher in PTC group than that in HC group. Areas under the ROC curve of CI, TPI, and angle were 0.725, 0.714, and 0.687 for distinguishing PTC from HC, 0.662, 0.668 and 0.591 for distinguishing PTC from NG. Conclusion TEG parameters are altered and indicate hypercoagulablilty status of papillary thyroid carcinoma patients; CI, TPI, and angle could be potential diagnosis indicators for detecting papillary thyroid carcinoma.

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TERT Promoter Mutations and Their Impact on Gene Expression Profile in Papillary Thyroid Carcinoma

Cancers ◽

10.3390/cancers12061597 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1597 ◽

Cited By ~ 2

Author(s):

Dagmara Rusinek ◽

Aleksandra Pfeifer ◽

Marta Cieslicka ◽

Malgorzata Kowalska ◽

Agnieszka Pawlaczek ◽

...

Keyword(s):

Gene Expression ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Gene Expression Profile ◽

Expression Profile ◽

Distant Metastases ◽

Gene Set Enrichment Analysis ◽

Braf V600e ◽

Papillary Thyroid ◽

Mutational Status

Background: Telomerase reverse transcriptase promoter (TERTp) mutations are related to a worse prognosis in various malignancies, including papillary thyroid carcinoma (PTC). Since mechanisms responsible for the poorer outcome of TERTp(+) patients are still unknown, searching for molecular consequences of TERTp mutations in PTC was the aim of our study. Methods: The studied cohort consisted of 54 PTCs, among them 24 cases with distant metastases. BRAF V600E, RAS, and TERTp mutational status was evaluated in all cases. Differences in gene expression profile between TERTp(+) and TERTp(−) PTCs were examined using microarrays. The evaluation of signaling pathways and gene ontology was based on the Gene Set Enrichment Analysis. Results: Fifty-nine percent (32/54) of analyzed PTCs were positive for at least one mutation: 27 were BRAF(+), among them eight were TERTp(+), and 1 NRAS(+), whereas five other samples harbored RAS mutations. Expression of four genes significantly differed in BRAF(+)TERTp(+) and BRAF(+)TERTp(−) PTCs. Deregulation of pathways involved in key cell processes was observed. Conclusions: TERTp mutations are related to higher PTC aggressiveness. CRABP2 gene was validated as associated with TERTp mutations. However, its potential use in diagnostics or risk stratification in PTC patients needs further studies.

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Many Thyroid Cancers Detected by Afirma Gene-Expression Classifier Are Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma

Clinical Thyroidology ◽

10.1089/ct.2016;28.261-263 ◽

2016 ◽

Vol 28 (9) ◽

pp. 261-263

Author(s):

Masha J. Livhits ◽

Michael W. Yeh

Keyword(s):

Gene Expression ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Papillary Thyroid ◽

Follicular Variant ◽

Thyroid Cancers ◽

Gene Expression Classifier

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Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma

Bioscience Reports ◽

10.1042/bsr20170678 ◽

2017 ◽

Vol 37 (4) ◽

Cited By ~ 9

Author(s):

Zhenzhen Zhou ◽

Jing Zhang ◽

Fang Jiang ◽

Yan Xie ◽

Xiaochen Zhang ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Nodular Goiter ◽

Iodine Intake ◽

Control Group ◽

Papillary Thyroid ◽

Excessive Iodine ◽

Gender Specific Differences ◽

Gender Specific ◽

Excessive Iodine Intake

In the present study, we investigated whether bisphenol A (BPA) levels and excessive iodine intake were associated with papillary thyroid carcinoma (PTC) and nodular goiter (NG). We determined total BPA concentrations (TBC) in paired serum and urine samples, and urinary iodine concentrations (UIC) in urine samples collected from PTC patients, NG patients, and healthy individuals, then compared BPA concentrations and UIC within and between each patient group. The results showed that there were no gender-specific differences in serum TBC and UIC in each group, and no differences across all patient groups. Urinary BPA concentrations (UBC) were higher in the NG and PTC groups compared with the control group. UBC showed gender-specific differences in the NG and PTC group. Furthermore, UIC were higher in the NG and PTC groups compared with the control group. Higher UBC and excessive iodine intake were risk factors for NG and PTC according to multivariate logistic regression analysis. There was a significant correlation between UBC and UIC in each group. These data suggested that higher UBC and excessive iodine intake are associated with NG and PTC. The metabolic and functional pathways between BPA and iodine are potentially linked to the pathogenesis and progression of NG and PTC.

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