Tissue Reaction to Subcutaneous Implantation of SuperEBA (Reinforced Zinc Oxide Cement) Used as Root-End Filling Material: A Histological Study in Rats

2016 ◽  
Vol 695 ◽  
pp. 247-251
Author(s):  
Alexandru Andrei Iliescu ◽  
Cristian Marian Petcu ◽  
Ileana Cristiana Petcu ◽  
Irina Maria Gheorghiu ◽  
Andrei Iliescu ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Histological Study ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Successful Outcome ◽  
Filling Material ◽  
Clinical Value ◽  
Filling Materials ◽  
Retrograde Filling ◽  
Specific Tissue

The retrograde filling is a critical step to a successful outcome of the endodontic surgery. Despite the progress in the technology of novel root-end filling materials, zinc oxide-eugenol cement superEBA is still preserving its clinical value on long-term basis. The study aimed to reconsider the tissue response to the initial irritating effect of this material. Silicon tubes filled with superEBA were subcutaneously implanted for 120 days in white Wistar rats which were afterwards sacrificed. The connective tissue surrounding the superEBA implants revealed fibroblast proliferation and a definite reparatory process without inflammatory reaction. A non-specific tissue healing in progress around the implants, without calcifications, necrosis, and apoptosis was also described after 4 months. SuperEBA proved on animal model that its cytotoxicity is reducing gradually in time until no adverse reaction is observed. The reduced content in eugenol compared to other surgical zinc oxide cements and the benefic effect of o-ethoxybenzoic acid are the support to reconsider SuperEBA as a biocompatible retrograde filling material.

Mechanical Property Evaluation of Fiber-Reinforced and Fabric-Reinforced Zinc Oxide-Eugenol Temporary Filling Materials

2014 ◽  
Vol 9 (2) ◽  
pp. 155892501400900
Author(s):  
Chao-Tsang Lu ◽  
Jia-Horng Lin
Keyword(s):  
Zinc Oxide ◽  
Composite Materials ◽  
Dental Treatment ◽  
Statistical Significance ◽  
Setting Time ◽  
Compressive Load ◽  
Filling Material ◽  
Fiber Reinforced ◽  
Filling Materials ◽  
Zinc Oxide Eugenol

Zinc oxide-eugenol (ZOE) is usually applied clinically as dental filling material for thermal insulation and temporary restoration. The objective of this study was to use ZOE as a composite matrix and low melting-point polyester fibers or fabrics as reinforcement. The added fibers or fabrics increased the composite materials’ compressive load by 250 N and 290 N, respectively. Fiber length and thermal-drying temperatures had no significant influence on setting time ( p>0.05), but the degree of solubility of the filling material had statistical significance ( p<0.05). Only the compressive load results were raised at the end of the curve. The optimum compressive load results, 290 N and 331 N, were observed in the 10 mm PET fiber processed at 130 °C. With its excellent compressive load, this composite material has the ability to sustain a bigger bite force; thus, the fiber-reinforced or fabric-reinforced composite materials are feasible for temporary clinical dental treatment.

scholarly journals In vitro evaluation of apical microleakage using different root-end filling materials

2006 ◽  
Vol 14 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Márcia Carneiro Valera ◽  
Carlos Henrique Ribeiro Camargo ◽  
Alessandra Sverberi Carvalho ◽  
Eduardo Ramalho Pereira Gama
Keyword(s):  
Zinc Oxide ◽  
Root Apex ◽  
Tissue Fluid ◽  
Filling Material ◽  
Human Teeth ◽  
Root Canals ◽  
Filling Materials ◽  
Gutta Percha ◽  
Significant Difference

The objective of this study was to evaluate the apical leakage of retrograde cavities filled with Portland Cement (Concrebrás S/A-MG-Brazil), ProRoot MTA TM (Dentsply International, Johnson City, TN, USA) and Sealapex (Kerr Corporation, Orange, California, USA) with addition of zinc oxide (Odahcam Herpo Produtos Dentários Ltda, Rio de Janeiro, RJ, Brazil). Forty-two extracted single-rooted human teeth were decoronated and used for this study. The root canals were instrumented at 1.0mm short of the apical foramen using the step-back technique to an apical ISO size 60. The roots were obturated with gutta-percha points and sealer Sealapex (Kerr Corporation-USA) and then 3mm of each root apex was sectioned at a 90° angle. Ultrasonic retrograde preparation was performed with a diamond tip to 3mm depth and the roots were randomly divided into 3 groups according to the filling material: G1-Portland, G2-ProRoot MTA, G3- Sealapex zinc oxide-added cement. The root surfaces were covered with nail varnish up to 2mm from the apical foramen, immersed in simulated tissue fluid for 30 days, and then immersed in 0.2% Rhodamine B solution for 24 hours for evaluation of marginal leakage. The results showed mean leakage of 0.75, 0.35 and 0.35 for groups 1, 2 and 3, respectively; however, Kruskal-Wallis test revealed that there was no statistically significant difference among the results (p>0.05).

scholarly journals Subcutaneous connective tissue response to primary root canal filling materials

2011 ◽  
Vol 22 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Alexandra Mussolino de Queiroz ◽  
Sada Assed ◽  
Alberto Consolaro ◽  
Paulo Nelson-Filho ◽  
Mario Roberto Leonardo ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Quantitative Analysis ◽  
Connective Tissue ◽  
Inflammatory Infiltrate ◽  
Collagen Fiber ◽  
Fiber Formation ◽  
Tissue Response ◽  
Filling Materials ◽  
Significant Difference ◽  
Subcutaneous Connective Tissue

This study evaluated the response of the subcutaneous connective tissue of BALB/c mice to root filling materials indicated for primary teeth: zinc oxide/eugenol cement (ZOE), Calen paste thickened with zinc oxide (Calen/ZO) and Sealapex sealer. The mice (n=102) received polyethylene tube implants with the materials, thereby forming 11 groups, as follows: I, II, III: Calen/ZO for 7, 21 and 63 days, respectively; IV, V, VI: Sealapex for 7, 21 and 63 days, respectively; VII, VIII, IX: ZOE for 7, 21 and 63 days, respectively; X and XI: empty tube for 7 and 21 days, respectively. The biopsied tissues were submitted to histological analysis (descriptive analysis and semi-quantitative analysis using a scoring system for collagen fiber formation, tissue thickness and inflammatory infiltrate). A quantitative analysis was performed by measuring the area and thickness of the granulomatous reactionary tissue (GRT). Data were analyzed by Kruskal-Wallis, ANOVA and Tukey's post-hoc tests (?=0.05). There was no significant difference (p>0.05) among the materials with respect to collagen fiber formation or GRT thickness. However, Calen/ZO produced the least severe inflammatory infiltrate (p<0.05). The area of the GRT was significantly smaller (p<0.05) for Calen/ZO and Sealapex. In conclusion, Calen/ZO presented the best tissue reaction, followed by Sealapex and ZOE.

scholarly journals The effect of retrograde material type and surgical techniques on the success rate of surgical endodontic retreatment: systematic review of prospective randomized clinical trials

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ashraf Abou ElReash ◽  
Hamdi Hamama ◽  
John C. Comisi ◽  
Ahmed Zaeneldin ◽  
Xie Xiaoli
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Success Rate ◽  
Randomized Clinical Trials ◽  
Surgical Techniques ◽  
Filling Material ◽  
Material Type ◽  
Filling Materials ◽  
Retrograde Filling ◽  
Endodontic Retreatment

Abstract Background Endodontic surgical procedures, when performed, require retrograde filling materials that are biocompatible, non-toxic, non-irritant, dimensionally stable, and ideally promote bone formation. Precise evaluation of retrograde filling materials in clinical trials is necessary to give holistic view for properties of material and potential outcome from its use. The purpose of this review is to evaluate the effect of retrograde material type and surgical techniques on the success rate of surgical endodontic retreatment. Methods An electronic search was performed in the time frame between 1st of January 2000 to 1st of September 2020 using database. Sources Web of Science, PubMed and redundant hand searches through their references. Seven inclusion–exclusion criteria were set for the selection and identification of relevant articles. Risk of bias was conducted for the included studies. Results Nine randomized clinical trials (RCTs) fulfilled the inclusion criteria for this systematic review. The outcome of this review revealed that none of the reviewed trials totally-fulfilled CONSORT 2010 criteria. Conclusions In light of the outcome of this review, there is no enough evidence to support the superiority of certain retrograde filling material or surgical technique over another in the success rate of surgical endodontics retreatment. The variety of methodologies and strategies, such as patient selection, the method of treatment and study analysis, led to doubtful credibility of the obtained clinical evidence. Further prospective randomized controlled clinical trials evaluating the specific effect of the various used materials are needed.

scholarly journals COMPARATIVE EVALUATION OF EDGE PENETRATION SEALING MATERIALS USED FOR RETROGRADE ROT CANAL TETH (LABORATORY STUDY )

2014 ◽  
Vol 10 (5) ◽  
pp. 30-32
Author(s):  
С. Токмакова ◽  
S. Tokmakova ◽  
Ю. Луницына ◽  
Y. Lunitsyna
Keyword(s):  
Comparative Evaluation ◽  
Filling Material ◽  
Glass Ionomer ◽  
Root Canals ◽  
Endodontic Surgery ◽  
Filling Materials ◽  
Retrograde Filling ◽  
Actual Direction ◽  
Materials Used ◽  
Sealing Materials

<p>Therapeutic endodontic treatment is not always possible for various reasons. There is need for methods of endodontic surgery, particularly retrograde filling. Actual direction is to study the efficiency of the use of a filling material for root canals of teeth roots. We have experimentally studied the apical mikropermeability filling materials «MTA ProRoot», «Trioksident», «Rutdent», «Biodentine», «Ketac Cem»; proven advantage calcium materials to glass ionomer cements. </p>

scholarly journals Comparison of Root End Sealing Ability of Three Retrograde Filling Materials in Teeth with Root Apices Resected at 90° using Dye Penetration Method under Fluorescent Microscope: An In-vitro Study

2021 ◽  
pp. 319-325
Author(s):  
Payal Chaudhari ◽  
Manoj Chandak ◽  
Arvind Ramdas ◽  
Patil Bhagat
Keyword(s):  
Bone Cement ◽  
In Vitro Study ◽  
Filling Material ◽  
Dye Penetration ◽  
Fluorescent Microscope ◽  
Filling Materials ◽  
Anterior Teeth ◽  
Sealing Ability ◽  
Retrograde Filling

Background: Inadequate seal at the apex is the substantial cause for surgical endodontic dissatisfaction. The retrograde filling material which is used should prevent the egress of potential contaminants into periradicular tissue. Objectives: To evaluate the ability of MTA Angelus, Zirconomer and Bioactive bone cement to seal the root end as retrograde filling material; and to compare root end sealing ability of these three different retrograde filling materials with apices resected at 900 angles using dye penetration method under fluorescent microscope. Methodology: Thirty six extracted upper anterior teeth are to be cut horizontally at the CEJ. After following the standard protocols of, “cleaning, shaping and obturation” with gutta percha and “AH Plus sealer”, the samples will be resected 3mm at the apical end at 90 degree angle along the long axis of the tooth with the help of diamond disc. A root end cavity of depth 3mm will be made with Diamond coated ultrasonic surgical tip S12 90 ND. The teeth will be randomly categorized in 3 groups: Group 1: MTA angelus; Group 2: Zirconomer; Group 3: Bioactive Bone Cement. Following which the roots to be coated with nail varnish except the tip. Each material will be compressed in the root end cavity with the help of small pluggers. All the samples which are retrofilled will be kept in acrydine orange for a duration of 24 hours, following which cleaning & bucco-lingual sectioning(vertical) will be done. Fluorescent microscope will be used for observation of sectioned root samples. Expected Results: Bioactive bone cement is expected to have better sealing ability of the retrograde cavity preparation with minimal or no microleakage followed by MTA Angelus and then Zirconomer. Conclusion: If this study proves correct, this would be helpful for the clinicians to choose better and the most efficient retrograde filling material with best sealing ability and minimal microleakage in a retrograde preparation which will aid in success of the root canal treatment further resolving the infection.

Endoflas, Zinc Oxide Eugenol and Metapex as Root Canal Filling Materials in Primary Molars—A Comparative Clinical Study

2011 ◽  
Vol 35 (4) ◽  
pp. 365-370 ◽  
Author(s):  
Priya Subramaniam ◽  
Kanupriya Gilhotra
Keyword(s):  
Zinc Oxide ◽  
Calcium Hydroxide ◽  
Root Canal ◽  
Primary Molars ◽  
Filling Material ◽  
Root Canal Filling ◽  
Filling Materials ◽  
Zinc Oxide Eugenol ◽  
Root Canal Filling Materials ◽  
Significant Difference

Several materials have been used to fill root canals of primary teeth. Traditionally, zinc oxide eugenol was used for the purpose, until the introduction of calcium hydroxide and iodoform based materials. Another root canal filling material that contains zinc oxide eugenol, calcium hydroxide and iodoform is commercially available as Endoflas. The aim of the study was to evaluate and compare the efficacy of Endoflas, zinc oxide eugenol and Metapex as root canal filling materials. Method: A total of forty-five primary molars from children aged 5-9 years were selected for a one stage pulpectomy procedure. Teeth were randomly divided into three groups of fifteen teeth each based on the type of root canal filling material used. All the molars were evaluated clinically and radiographically at regular intervals of 3, 6, 12 and 18 months. The observations were tabulated and statistically analyzed. Results: Endoflas and zinc oxide eugenol showed 93.3% success, whereas a higher percentage of success was observed with Metapex (100%). Overfilling and voids were more commonly seen in teeth filled with Metapex. Conclusion: There was no significant difference between the three root canal filling materials.

scholarly journals Indwelling Device-Associated Biofilms in Critically Ill Cancer Patients—Study Protocol

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 306
Author(s):  
Olguta Lungu ◽  
Ioana Grigoras ◽  
Olivia Simona Dorneanu ◽  
Catalina Lunca ◽  
Teodora Vremera ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Critically Ill ◽  
Pathogen Detection ◽  
Venous Catheter ◽  
Successful Outcome ◽  
Patient Specific ◽  
Clinical Value ◽  
Current Standard ◽  
Sepsis Management ◽  
Microorganism Identification

Health care-associated infections are a leading cause of inpatient complications. Rapid pathogen detection/identification is a major challenge in sepsis management that highly influences the successful outcome. The current standard of microorganism identification relies on bacterial growth in culture, which has several limitations. Gene sequencing research has developed culture-independent techniques for microorganism identification, with the aim to improve etiological diagnosis and, therefore, to change sepsis outcome. A prospective, observational, non-interventional, single-center study was designed that assesses biofilm-associated pathogens in a specific subpopulation of septic critically ill cancer patients. Indwelling device samples will be collected in septic patients at the moment of the removal of the arterial catheter, central venous catheter, endotracheal tube and urinary catheter. Concomitantly, clinical data regarding 4 sites (nasal, pharyngeal, rectal and skin) of pathogen colonization at the time of hospital/intensive care admission will be collected. The present study aims to offer new insights into biofilm-associated infections and to evaluate the infection caused by catheter-specific and patient-specific biofilm-associated pathogens in association with the extent of colonization. The analysis relies on the two following detection/identification techniques: standard microbiological method and next generation sequencing (NGS). Retrospectively, the study will estimate the clinical value of the NGS-based detection and its virtual potential in changing patient management and outcome, notably in the subjects with missing sepsis source or lack of response to anti-infective treatment.

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