scholarly journals NADPH Oxidase–Independent Formation of Extracellular DNA Traps by Basophils

2014 ◽  
Vol 192 (11) ◽  
pp. 5314-5323 ◽  
Author(s):  
Mahbubul Morshed ◽  
Ruslan Hlushchuk ◽  
Dagmar Simon ◽  
Andrew F. Walls ◽  
Kazushige Obata-Ninomiya ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Extracellular Dna ◽  
Extracellular Dna Traps

Detection of Eosinophil Extracellular DNA Traps

2021 ◽  
pp. 193-198
Author(s):  
Marina Valente Barroso ◽  
Josiane Sabbadini Neves
Keyword(s):  
Extracellular Dna ◽  
Extracellular Dna Traps

scholarly journals Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

Blood ◽  
2009 ◽  
Vol 113 (25) ◽  
pp. 6419-6427 ◽  
Author(s):  
Christian C. Yost ◽  
Mark J. Cody ◽  
Estelle S. Harris ◽  
Nathan L. Thornton ◽  
Alison M. McInturff ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Newborn Infants ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Infectious Complications ◽  
Extracellular Dna ◽  
Neutrophil Extracellular Trap ◽  
Bacterial Killing ◽  
Effector Cells ◽  
Innate Effector ◽  
Human Neonates

Abstract Neutrophils are highly specialized innate effector cells that have evolved for killing of pathogens. Human neonates have a common multifactorial syndrome of neutrophil dysfunction that is incompletely characterized and contributes to sepsis and other severe infectious complications. We identified a novel defect in the antibacterial defenses of neonates: inability to form neutrophil extracellular traps (NETs). NETs are lattices of extracellular DNA, chromatin, and antibacterial proteins that mediate extracellular killing of microorganisms and are thought to form via a unique death pathway signaled by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase–generated reactive oxygen species (ROS). We found that neutrophils from term and preterm infants fail to form NETs when activated by inflammatory agonists—in contrast to leukocytes from healthy adults. The deficiency in NET formation is paralleled by a previously unrecognized deficit in extracellular bacterial killing. Generation of ROSs did not complement the defect in NET formation by neonatal neutrophils, as it did in adult cells with inactivated NADPH oxidase, demonstrating that ROSs are necessary but not sufficient signaling intermediaries and identifying a deficiency in linked or downstream pathways in neonatal leukocytes. Impaired NET formation may be a critical facet of a common developmental immunodeficiency that predisposes newborn infants to infection.

Extracellular DNA traps in bronchoalveolar fluid from a murine eosinophilic pulmonary response

Allergy ◽  
2014 ◽  
Vol 69 (12) ◽  
pp. 1696-1700 ◽  
Author(s):  
A. A. Cunha ◽  
B. N. Porto ◽  
N. K. Nuñez ◽  
R. G. Souza ◽  
M. H. M. Vargas ◽  
...  
Keyword(s):  
Extracellular Dna ◽  
Pulmonary Response ◽  
Bronchoalveolar Fluid ◽  
Extracellular Dna Traps

Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus

2018 ◽  
Vol 141 (2) ◽  
pp. 571-585.e7 ◽  
Author(s):  
Valdirene S. Muniz ◽  
Juliana C. Silva ◽  
Yasmim A.V. Braga ◽  
Rossana C.N. Melo ◽  
Shigeharu Ueki ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Extracellular Dna ◽  
Extracellular Dna Traps

scholarly journals Multiple Origins of Extracellular DNA Traps

2021 ◽  
Vol 12 ◽  
Author(s):  
Edgar Ramos-Martínez ◽  
Leticia Hernández-González ◽  
Iván Ramos-Martínez ◽  
Laura Pérez-Campos Mayoral ◽  
Georgina I. López-Cortés ◽  
...  
Keyword(s):  
Extracellular Dna ◽  
Multiple Origins ◽  
Evolutionarily Conserved ◽  
Evolutionary Convergence ◽  
Multicellular Organisms ◽  
Extracellular Dna Traps

Extracellular DNA traps (ETs) are evolutionarily conserved antimicrobial mechanisms present in protozoa, plants, and animals. In this review, we compare their similarities in species of different taxa, and put forward the hypothesis that ETs have multiple origins. Our results are consistent with a process of evolutionary convergence in multicellular organisms through the application of a congruency test. Furthermore, we discuss why multicellularity is related to the presence of a mechanism initiating the formation of ETs.

Eosinophil Extracellular DNA Traps In Skin Diseases

2011 ◽  
Vol 127 (2) ◽  
pp. AB205-AB205
Author(s):  
D. Simon ◽  
S. Hoesli ◽  
N. Roth ◽  
S. Staedler ◽  
S. Yousefi ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Extracellular Dna ◽  
Extracellular Dna Traps
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