scholarly journals Psychometric properties of the Fear of COVID-19 Scale amongst black South African university students

2021 ◽  
Vol 3 ◽  
Author(s):  
Malose Makhubela ◽  
Solomon Mashegoane
Keyword(s):  
University Students ◽  
South African ◽  
Discriminant Validity ◽  
Global Public Health ◽  
Infection Rates ◽  
Health Crisis ◽  
Black South African ◽  
Public Health Crisis ◽  
Life Threatening ◽  
Acceptable Internal Consistency

Coronavirus disease 2019 (COVID-19) has spread widely leading to a global public health crisis of a pandemic proportion. Whilst infection rates tend to fluctuate in South Africa, COVID-19 remains a life-threatening disease with the capacity to wreak fear and concern. The present study evaluated the psychometric qualities of the Fear of COVID-19 Scale (FCV-19S) amongst black South African university students (N = 433; Female: 58%; Mage = 23.51 [SD = 4.18]). The FCV-19S demonstrated a unidimensional factor structure and acceptable internal consistency (α = 0.87), Omega (ω = 0.88) and the greatest lower bound (GLB = 0.90) reliabilities. In addition, discriminant validity was demonstrated when FCV-19S items loaded separately from ordinary fear. The FCV-19S can be used as a measure of COVID-19-related fear amongst black South African university students.

Preparation and Antitubercular Activities of Palindromic Hydrazinecarbothioamides and Carbonothioic Dihydrazides

2019 ◽  
Vol 16 (11) ◽  
pp. 1202-1210 ◽  
Author(s):  
Michael Joseps Hearn ◽  
Gwendolyn Towers ◽  
Michael Henry Cynamon
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Virulent Strain ◽  
Chemotherapeutic Agents ◽  
Disc Diffusion ◽  
Global Public Health ◽  
Health Crisis ◽  
Chemical Structures ◽  
Public Health Crisis ◽  
Zones Of Inhibition ◽  
Diffusion Assay

Background:With approximately one-third of the world’s population infected, tuberculosis continues to be a global public health crisis. The rise of strains that are unusually virulent or highly resistant to current drugs is a cause of special concern, prompting research into new classes of compounds, as well as the re-evaluation of known chemotherapeutic agents.Objectives:The antimycobacterial activities associated with some recently-reported thiocarbonyl compounds kindled our interest in the synthesis of substituted hydrazinecarbothioamides (3) and carbonothioic dihydrazides (4), with the aim of investigating their potential in antitubercular drug design and discovery.Methods:In the present study, the title compounds 3 and 4 were prepared by the condensation of hydrazines with isothiocyanates in reactions readily controlled by stoichiometry, temperature and solvent. The compounds were assessed against Mycobacterium bovis BCG in Kirby-Bauer disc diffusion, and minimum inhibitory concentrations were determined against the virulent strain M. tuberculosis Erdman.Results:The chemical structures of these thermally stable compounds were determined by IR, 1HNMR, 13C-NMR, high-resolution mass spectrometry and elemental analysis. In the Kirby-Bauer disc diffusion assay, some of the compounds showed substantial diameters of inhibition against BCG. In some cases, the zones of inhibition were so large that no growth at all was observed on the assay plates. Against M. tuberculosis Erdman, several of the compounds showed significant activities. Compound 3h was the most active, demonstrating a minimum inhibitory concentration of 0.5 µg/mL.Conclusion:We found that the title compounds may be prepared conveniently in excellent purity and good yields. They are readily identified on the basis of their characteristic spectra. Some members of this class showed significant activities against mycobacteria. We conclude that further work will be warranted in exploring the antitubercular properties of these compounds.

scholarly journals A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Guo ◽  
Lisu Huang ◽  
Guangshun Zhang ◽  
Yanfeng Yao ◽  
He Zhou ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Complex Structure ◽  
Neutralizing Antibody ◽  
Economic Consequences ◽  
Binding Motif ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Monkey Model ◽  
Therapeutic Outcomes

AbstractCOVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can provide an important treatment option to fight COVID-19, especially for the most vulnerable populations. In this work, potent antibodies binding to SARS-CoV-2 Spike protein were identified from COVID-19 convalescent patients. Among them, P4A1 interacts directly with and covers majority of the Receptor Binding Motif of the Spike Receptor-Binding Domain, shown by high-resolution complex structure analysis. We further demonstrate the binding and neutralizing activities of P4A1 against wild type and mutant Spike proteins or pseudoviruses. P4A1 was subsequently engineered to reduce the potential risk for Antibody-Dependent Enhancement of infection and to extend its half-life. The engineered antibody exhibits an optimized pharmacokinetic and safety profile, and it results in complete viral clearance in a rhesus monkey model of COVID-19 following a single injection. These data suggest its potential against SARS-CoV-2 related diseases.

scholarly journals COVID-19 in obstetrics 2020: the experience at a New York City medical center

2020 ◽  
Vol 48 (9) ◽  
pp. 892-899
Author(s):  
Ashlesha K. Dayal ◽  
Armin S. Razavi ◽  
Amir K. Jaffer ◽  
Nishant Prasad ◽  
Daniel W. Skupski
Keyword(s):  
New York ◽  
Medical Center ◽  
Severe Disease ◽  
Infection Rates ◽  
Health Crisis ◽  
The Public ◽  
Public Health Crisis ◽  
Asymptomatic Carriage ◽  
Global Spread ◽  
Workforce Flexibility

AbstractThe global spread of the SARS-CoV-2 virus during the early months of 2020 was rapid and exposed vulnerabilities in health systems throughout the world. Obstetric SARS-CoV-2 disease was discovered to be largely asymptomatic carriage but included a small rate of severe disease with rapid decompensation in otherwise healthy women. Higher rates of hospitalization, Intensive Care Unit (ICU) admission and intubation, along with higher infection rates in minority and disadvantaged populations have been documented across regions. The operational gymnastics that occurred daily during the Covid-19 emergency needed to be translated to the obstetrics realm, both inpatient and ambulatory. Resources for adaptation to the public health crisis included workforce flexibility, frequent communication of operational and protocol changes for evaluation and management, and application of innovative ideas to meet the demand.

scholarly journals The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

Diseases ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 46
Author(s):  
Feng Xu ◽  
Yawei Wen ◽  
Xinge Hu ◽  
Tiannan Wang ◽  
Guoxun Chen
Keyword(s):  
Vitamin C ◽  
Distress Syndrome ◽  
Kidney Injury ◽  
Mortality Rates ◽  
Protective Effects ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Renal Functions ◽  
Potential Use

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

Synergising International Public Health Law and International Disaster Law

2020 ◽  
pp. 1-11
Author(s):  
Pratik DIXIT
Keyword(s):  
Public Health ◽  
International Health ◽  
Health Law ◽  
Global Public Health ◽  
Public Health Law ◽  
Health Crisis ◽  
Response Strategies ◽  
Public Health Crisis ◽  
International Public Health ◽  
Health Regulations

There is no time more opportune to review the workings of the International Health Regulations (IHR) than the present COVID-19 crisis. This article analyses the theoretical and practical aspects of international public health law (IPHL), particularly the IHR, to argue that it is woefully unprepared to protect human rights in times of a global public health crisis. To rectify this, the article argues that the IHR should design effective risk reduction and response strategies by incorporating concepts from international disaster law (IDL). Along similar lines, this article suggests that IDL also has a lot to learn from IPHL in terms of greater internationalisation and institutionalisation. Institutionalisation of IDL on par with IPHL will provide it with greater legitimacy, transparency and accountability. This article argues that greater cross-pollination of ideas between IDL and IPHL is necessary in order to make these disciplines more relevant for the future.

An Essay on the Political Economy Effects of the COVID-19 Pandemic as Twin Crises

2022 ◽  
pp. 1-18
Author(s):  
Irfan Kalaycı
Keyword(s):  
Economic Crisis ◽  
Global Public Health ◽  
Health Crisis ◽  
Global Epidemic ◽  
Public Health Crisis ◽  
Political Approach ◽  
New Type ◽  
The Subject ◽  
Twin Crises ◽  
Trade Education

The subject and purpose of this study is to examine the new type of coronavirus disease (COVID-19), which has turned into a global epidemic, with an economic-political approach. There are twin crises in the form of a health crisis (high human deaths) and an economic crisis (recession). Trillion-dollar aid packages from governments and international financial organizations also show that this global public health crisis has created an economic crisis. In the context of these crises, G-20 countries that did not intervene in their transmission channels in a timely manner showed the worst situations. This epidemic, calculated with the SIR model, is global, but the measures are local. What makes a clean, masked, and socially distant life obligatory against the risk of contamination is that this epidemic locks or restricts the whole economy, especially trade, education, and tourism. Measures called “new normalization” have started to relax in order to prevent further increase in unemployment and poverty.

scholarly journals Coronavirus Pandemic: a major public health crisis for the developed and developing world

2021 ◽  
Vol 15 (03) ◽  
pp. 366-369
Author(s):  
Rooh Ullah ◽  
Muhammad Suleman Rana ◽  
Mehmood Qadir ◽  
Muhammad Usman ◽  
Niaz Ahmed
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Day By Day

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. The risk from this epidemic depends on the nature of the virus, including how well it transmits from person to person, and the complications resulting from this current illness. The novel coronavirus has killed thousands of people in China and other countries as well; its rate of mortality is increasing day by day. There is an urgent need to control the virus by developing vaccine or any other antiviral drugs to save the world from this deadly viral infection.

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