scholarly journals Dose enhancement in gold nanoparticle-aided radiotherapy for the therapeutic photon beams using Monte Carlo technique

2015 ◽  
Vol 11 (1) ◽  
pp. 94 ◽  
Author(s):  
SunilDutt Sharma ◽  
NitinRamesh Kakade
Keyword(s):  
Monte Carlo ◽  
Gold Nanoparticle ◽  
Monte Carlo Technique ◽  
Photon Beams ◽  
Dose Enhancement ◽  
Therapeutic Photon Beams

A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale

2021 ◽  
Vol 171 ◽  
pp. 109638
Author(s):  
Tara Gray ◽  
Nema Bassiri ◽  
Shaquan David ◽  
Devanshi Yogeshkumar Patel ◽  
Sotirios Stathakis ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Gold Nanoparticle ◽  
Monte Carlo Analysis ◽  
External Beam ◽  
Macroscopic Scale ◽  
Dose Enhancement

Monte Carlo study on mucosal dose in oral and naval cavity using photon beams with small field

2011 ◽  
Vol 10 (4) ◽  
pp. 261-271 ◽  
Author(s):  
James C.L. Chow ◽  
Amir M. Owrangi
Keyword(s):  
Monte Carlo ◽  
Beam Energy ◽  
Field Size ◽  
Small Field ◽  
Beam Angle ◽  
Photon Beams ◽  
Dose Ratio ◽  
Dose Enhancement ◽  
Bone Interface ◽  
Energy Beam

AbstractWe study how mucosal dose in the oral or nasal cavity depends on the irradiated small segmental photon fields varying with beam energy, beam angle and mucosa thickness. Dose ratio (mucosal dose with bone underneath to dose at the same point without bone) reflecting the dose enhancement due to the bone backscatter was determined by Monte Carlo simulation (EGSnrc-based code), validated by measurements. Phase space files based on the 6 and 18 MV photon beams with small field size of 1 × 1 cm2, produced by a Varian 21 EX linear accelerator, were generated using the BEAMnrc Monte Carlo code. Mucosa phantoms (mucosa thickness = 1, 2 and 3 mm) with and without a bone under the mucosa were irradiated by photon beams with gantry angles varying from 0 to 30°. Doses along the central beam axis in the mucosa and the dose ratio were calculated with different mucosa thicknesses. For the 6 MV photon beams, the dose at the mucosa-bone interface increased by 44.9–41.7%, when the mucosa thickness increased from 1 to 3 mm for the beam angle ranging from 0 to 30°. These values were lower than those (58.8–53.6%) for the 18 MV photon beams with the same beam angle range. For both the 6 and 18 MV photon beams, depth doses in the mucosa were found to increase with an increase of the beam angle. Moreover, the dose gradient in the mucosa was greater for the 18 MV photon beams compared to the 6 MV. For the dose ratio, it was found that the dose enhancement due to the bone backscatter increased with a decrease of mucosa thickness, and was more significant at both the air-mucosa and mucosa-bone interface. Mucosal dose with bone was investigated by Monte Carlo simulations with different experimental configurations, and was found vary with the beam energy, beam angle and mucosa thickness for a small segmental photon field. The dosimetric information in this study should be considered when searching for an optimized treatment strategy to minimize the mucosal complications in the head-and-neck intensity-modulated radiation therapy.

scholarly journals A Monte Carlo Study on Dose Enhancement in the Presence of Nanoparticles by Photon Source: A Comparison between Various Concentration and Material of Nanoparticles

2021 ◽  
Author(s):  
Arezoo Kazemzadeh ◽  
Habiballah Moradi
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
High Energy ◽  
Energy Sources ◽  
Photon Beams ◽  
Treatment Efficiency ◽  
Dose Enhancement ◽  
Gold Silver ◽  
Photon Source ◽  
Energetic Photon

Purpose: Recently, the application of high atomic number nanoparticles is suggested in the field of radiotherapy to improve physical dose enhancement and hence treatment efficiency. Several factors such as concentration and material of nanoparticles and energy of beam define the amount of dose enhancement in the target in the presence of nanoparticles. Materials and Methods: In this approach, a spherical cell was simulated through the Geant4 Monte Carlo toolkit which contained a nucleus and nanoparticles distributed through the cell. To investigate the effect of the concentration of nanoparticles on the deposited dose, it ranged from 3 mg/g to 30 mg/g for different materials like gold, silver, gadolinium, and platinum. Also, various mono-energetic photon beams included low and high energy sources were applied. Results: The results proved that as the concentration increased, the Dose Enhancement Factor (DEF) enlarged. Overall, almost for all energy and material that were used in this study, the maximum of DEF values occurred in the concentration of 30 mg/g. Moreover, lower energy sources presented higher DEF compared to other sources. The results indicated that the highest amount of DEF transpired for 35 keV photon beams equal to 14.67. Also, the K-edge energy of each material affects DEF values. Conclusion: To obtain a better outcome in the use of nanoparticles in combination with radiotherapy, a higher concentration of nanoparticles and low-energy photons should be considered to optimize the DEF and thus the treatment ratio.

Estimation of Cerenkov Radiation Generated in Various Dielectrics Using MCNPX Simulation

2014 ◽  
Vol 1033-1034 ◽  
pp. 1127-1130
Author(s):  
Jae Seok Kim ◽  
Kyoung Won Jang ◽  
Sang Hun Shin ◽  
Seon Guen Kim ◽  
Seung Han Hong ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Water Depth ◽  
Dielectric Materials ◽  
Cerenkov Radiation ◽  
Photon Beams ◽  
Transport Code ◽  
The Relationship ◽  
Therapeutic Photon Beams

To estimate Cerenkov radiation generated in various dielectric materials, in this study, we calculated therapeutic photon beams induced electron fluxes in a CaF2, PMMA, SiO2 and Al2O3 by using the Monte Carlo N-particle Extended transport code (MCNPX). Also, we clarified the relationship between electron fluxes produced in various dielectrics and energy depositions in water by irradiation of therapeutic photon beams. The electron fluxes and the energy depositions were calculated as a function of water depth.

scholarly journals Depth Dose Enhancement on Flattening-Filter-Free Photon Beam: A Monte Carlo Study in Nanoparticle-Enhanced Radiotherapy

2020 ◽  
Vol 10 (20) ◽  
pp. 7052
Author(s):  
James C. L. Chow
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
Photon Beam ◽  
Depth Range ◽  
Photon Beams ◽  
Dose Enhancement ◽  
Au Nps ◽  
Depth Dose ◽  
Flattening Filter Free ◽  
Flattening Filter

The aim of this study is to investigate the variations of depth dose enhancement (DDE) on different nanoparticle (NP) variables, when using the flattening-filter-free (FFF) photon beam in nanoparticle-enhanced radiotherapy. Monte Carlo simulation under a macroscopic approach was used to determine the DDE ratio (DDER) with variables of NP material (gold (Au) and iron (III) oxide (Fe2O3)), NP concentration (3–40 mg/mL) and photon beam (10 MV flattening-filter (FF) and 10 MV FFF). It is found that Au NPs had a higher DDER than Fe2O3 NPs, when the depths were shallower than 6 and 8 cm for the 10 MV FF and 10 MV FFF photon beams, respectively. However, in a deeper depth range of 10–20 cm, DDER for the Au NPs was lower than Fe2O3 NPs mainly due to the beam attenuation and photon energy distribution. It is concluded that DDER for the Au NPs and Fe2O3 NPs decreased with an increase of depth in the range of 10–20 cm, with rate of decrease depending on the NP material, NP concentration and the use of FF in the photon beam.

scholarly journals Radiation dose delivered by 125I, 103Pd and 131Cs and dose enhancement by gold nanoparticle (GNP) solution in prostate brachytherapy: a comparative analysis by Monte Carlo simulation

2019 ◽  
Vol 20 (2) ◽  
pp. 176-187 ◽  
Author(s):  
Hamda Khan ◽  
Umair Aziz ◽  
Zafar Ullah Koreshi
Keyword(s):  
Monte Carlo ◽  
Comparative Analysis ◽  
Radiation Dose ◽  
Gold Nanoparticle ◽  
Energy Deposition ◽  
Radiation Transport ◽  
Absorbed Dose ◽  
Prostate Brachytherapy ◽  
Dose Enhancement ◽  
Effective Doses

: The energy deposition and radiation dose from commonly used radioisotopes, 125I,103Pd, and 131Cs, used for brachytherapy of cancers is estimated using Monte Carlo (MC) simulations. To enhance the dose, gold nanoparticle (GNP) solutions are injected into the tumor; this results in more effective and shorter therapy duration. It is thus important to estimate the dose enhancement factor (DEF) achievable by a radioisotope. The research presented in this paper thus focuses on a comparative analysis of radioisotopes. To estimate the radiation dose, the Monte Carlo N-particle code MCNP5 was used for a coupled photon-electron simulation of radiation transport from radiation emanating from seeds of radioisotopes implanted in the prostate at positions prescribed to deliver effective doses to the tumor while protecting neighbouring vital organs such as the rectum and urethra. The quantities tallied were the energy deposition (F6 tally) and the pulse heights (*F8 tally) in specified energy bins. The energy deposited in the tumor was used to estimate the absorbed dose to the prostate incorporating the transformations of the radioisotopes during decay. The absorbed dose was subsequently estimated for a GNP-tissue solution with a concentration of 25 mg Au/g of prostate tissue, modelled as a homogenous mixture. From the simulations, it was found that the lifetime absorbed dose is ~96 Gy from 98 seeds, each of 0.31 mCi, of 125I; ~102 Gy, from 115 seeds, each of 1.4 mCi, of 103Pd, and ~90 Gy from 131Cs seeds replacing 103Pd seeds of the same initial activity. The main advantage of 131Cs, over 125I and 103Pd, is observed in the larger dose rate (~26 cGy/hr) delivered initially i.e. in the first few days which is 1.5 and 5.7 times higher than that for 103Pd and 125I. The absorbed dose for 125I, 103Pd and 131Cs increases to ~245, ~130, ~187 Gy respectively with GNP-tissue solution of 25 mg Au/g tissue. From the analysis, it is found that while the lifetime absorbed dose of all three radioisotopes is of the same order, there are advantages in using 131Cs; these advantages are further quantified. ABSTRAK: Pemendapan tenaga dan dos sinaran radiasi daripada radioisotop yang biasa digunakan, 125I,103Pd, dan 131Cs, digunakan bagi terapibraki kanser dianggar menggunakan simulasi Monte Carlo (MC). Bagi meningkatkan dos, larutan partikel nano emas (GNP) telah disuntik ke dalam tumor; ini lebih memberi kesan dan mengurangkan masa terapi. Oleh itu, adalah penting menganggar faktor dos penggalak (DEF) dapat dicapai dengan radioisotop. Kajian ini mengfokuskan pada analisis perbandingan radioisotop. Bagi menganggarkan dos radiasi, kod Monte Carlo N-partikel MCNP5 telah digunakan pada simulasi pasangan foton-elektron pengangkutan radiasi daripada pancaran radioaktif benih radioisotop yang ditanam dalam prostat pada posisi yang disebut bagi mencetuskan dos penghantaran yang berkesan pada sel tumor. Dalam masa sama melindungi organ penting seperti rektum dan uretra. Kuantiti diselaras dengan pemendapan tenaga (selaras F6) dan ketinggian denyut (selaras *F8) dalam aras tenaga sebenar. Tenaga yang dienap dalam sel tumor ini telah digunakan bagi menganggarkan dos serapan pada prostat dengan menggabungkan transformasi radioisotop ketika susutan. Dos yang diserap telah kemudiannya dianggarkan bagi larutan tisu-GNP dengan ketumpatan 25 mg Au/g tisu prostat, dimodelkan sebagai campuran homogen. Daripada simulasi, dapatan kajian menunjukkan dos diserap sebanyak ~96 Gy daripada 98 benih, setiap satu daripada 0.31 mCi, 125I; ~102 Gy, dari 115 benih, setiap 1.4 mCi, dari 103Pd, dan ~90 Gy daripada benih 131Cs menggantikan benih 103Pd pada pemulaan aktiviti yang sama. Keistimewaan utama adalah 131Cs, ke atas 125I dan 103Pd, telah dilihat dalam kadar dos lebih besar (~26 cGy/hr) dikeluarkan pada pemulaannya iaitu dalam beberapa hari pertama iaitu 1.5 dan 5.7 kali lebih tinggi daripada 103Pd dan 125I. Dos yang diserap pada 125I, 103Pd dan 131Cs bertambah kepada ~245, ~130, ~187 Gy masing-masing dengan larutan tisu-GNP sebanyak 25 mg Au/g tisu. Hasil analisis menunjukkan penyerapan seumur hidup dos diserap pada ketiga-ketiga radioisotop dalam aturan yang sama, ini adalah keistimewaan menggunakan 131Cs; keistimewaan ini akan terus diuji pada masa depan dan diukur kuantitinya.

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