Doppler ultrasound evaluation of blood flow patterns of the uterine arteries in pre- and postmenopausal women with cervical cancer and controls in Zaria

Cervical cancer remains an important health issue especially in the developing countries that account for about 85% of the world burden of cervical cancer. Finding a role for Doppler ultrasound in the evaluation of these patients, may reduce the cost and improve access to management. This study was aimed at evaluating the Doppler flow parameters in patients with cervical cancer when compared to normal subjects. This was a prospective case control, descriptive and observational study conducted in radiology department, ABU Teaching Hospital, Zaria, Nigeria. Eighty-one patients with cervical cancer and 81 age-matched controls had transabdominal Doppler ultrasound examination of the main uterine arteries. The data was analyzed using SPSS version 20.0 Chicago Illinois USA. Difference between two groups was tested using student ttest and P<0.05 considered as statistically significant. The mean Resistivity Index (RI) and Pulsatility Index (PI) were significantly lower in patients with cervical cancer than the control (P<0.0001). The mean end diastolic velocity was significantly higher in patients than the control (P<0.0001). There was however no significant difference in the mean peak systolic velocity in patients and control (P=0.97). The findings have demonstrated that significant differences exist in the uterine artery Doppler flow parameters in patients with cervical cancer compared to the healthy controls. This emphasizes the role of Doppler scan in the evaluation and management of patients with cervical cancer.

Download Full-text

The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot Study

Diagnostics ◽

10.3390/diagnostics10090654 ◽

2020 ◽

Vol 10 (9) ◽

pp. 654

Author(s):

Natalija Vedmedovska ◽

Diana Bokucava ◽

Anda Kivite-Urtane ◽

Vita Rovite ◽

Liene Zake-Nikitina ◽

...

Keyword(s):

Blood Flow ◽

Uterine Artery ◽

Matched Control ◽

First Trimester ◽

Flow Patterns ◽

Uterine Arteries ◽

Sequence Variations ◽

Artery Flow ◽

Blood Flow Patterns ◽

Singleton Pregnancies

Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All patients were genotyped for sequence variations in F5, F2, F11, MTHFR, SERPINE-1, CYP4V2, SELE, GP6, angiotensinogen (AGT) and fibrinogen gamma (FGG) genes and followed up until delivery. Results. There were no differences between groups regarding selected sequence variations in any of these genes. The co-occurrence of several polymorphisms in the same patient was also not related to the blood flow patterns in the uterine arteries. Conclusions. Although we found certain trends of genetic polymorphisms being related to preeclampsia and fetal growth, we failed to find an association between clotting gene polymorphisms, single or in combination, with the abnormal uterine flow in the first trimester.

Download Full-text