scholarly journals Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia

2019 ◽  
Vol 119 (12) ◽  
pp. 785-789
Author(s):  
M. Dugatova ◽  
A. Kristufkova ◽  
B. Nemethova ◽  
J. Danis ◽  
M. Borovsky
Keyword(s):  
Risk Factors ◽  
Active Surveillance ◽  
Liver Enzymes ◽  
Elevated Liver Enzymes

The Biochemical Parameters and Vitamin D Levels in ICU Patients with Covid-19: A Cross-Sectional Study

2021 ◽  
Vol 21 ◽  
Author(s):  
Hamed Abdollahi ◽  
Farahnaz Salehinia ◽  
Mostafa Badeli ◽  
Elmira Karimi ◽  
Hossein Gandomkar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Immune System ◽  
Liver Enzymes ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elevated Liver Enzymes ◽  
Vitamin D Levels

Background: In Covid-19 infection, leukopenia, inflammation, and elevated liver enzymes are found in most patients. Also, vitamin D deficiency attenuate the immune system and predispose a person more susceptible to infection. In this context, we aimed to evaluate vitamin D, Electrolytes, Complete blood count, Liver enzymes, Urea, Creatinine, Albumin, CRP and ESR levels in patients with Covid-19. Methods: We conducted a cross-sectional study on 118 patients with Covid-19 who were hospitalized from 2020/2/19 to 2020/4/3 in ICU. Serum levels of electrolytes, liver enzymes, blood factors, urea, creatinine, CRP and ESR as well as anthropometric parameters and serum vitamin D concentration were measured. Results: A total of 118 patients (80 male and 38 female) was enrolled in the study (65.05±15.75 years). Only 5.08% of patients had no risk factors and 55.9% had ≥ 2 risk factors. Diabetes (44.1%) and obesity (23.7%) were more common among patients. Laboratory finding showed that 80.50% of patients had hyponatremia, but other electrolytes included K, Mg, Ca and P were normal in majority of participants as well as CBC, Cr, Urea, Alb, ALT and ALKP. The AST concentration increased in most patients (66.94%). All patients had high levels of inflammatory factors such as CRP and ESR. The mean of 25-hydroxy-vitamin D levels in participants (25.95 ± 14.56 ng/mL) was lower than its levels in general papulation. However, it was not statistically significant (P= 0.88). A significant negative correlation found between vitamin D and ALT (P= 0.02, -0.21) as well as vitamin D and CRP (P= 0.05, -0.17). Conclusion: Regarding to the regulatory role of vitamin D in immune system and low levels of vitamin D in Covid-19 infected patients, the evaluation of vitamin D levels and prescribe supplements if necessary is suggested.

scholarly journals Assessment of Hepatic Steatosis and Fibrosis in Egyptian Patients with Type 2 Diabetes Mellitus

2021 ◽  
pp. 144-151
Author(s):  
Eman Basiouny ◽  
Faiza Lashin ◽  
Manal Hamisa ◽  
Amal Selim
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Hepatic Steatosis ◽  
Liver Enzymes ◽  
Early Management ◽  
Elevated Liver Enzymes

Aims: To assess hepatic steatosis and fibrosis in patients of type 2 diabetes mellitus (T2DM), their possible risk factors and their association with metabolic syndrome and micro or macro-albuminuria. Study Design: Cross sectional study. Place and Duration of Study: Outpatient Clinic of Diabetes, Metabolism and Endocrinology Unit in internal medicine department, Tanta University, Egypt in a period between September 2019 to March 2020. Methodology: We included 200 patients had a diagnosis of T2DM according to American Diabetes Association criteria. Then patients were assessed for presence of hepatic steatosis and fibrosis using fibroscan and we used liver stiffness measurements (LSMs, as a measure of fibrosis) and controlled attenuation parameter (CAP, as a measure of steatosis) and routine laboratory data were done to rule out possible risk factors. Results: 98.5% of participants had hepatic steatosis and 53.5% of participants had hepatic fibrosis. Those patients had longer duration of DM, higher BMI, bad control of T2DM, higher lipid profile values, association with metabolic syndrome, micro and macro-albuminuria and non-significantly elevated liver enzymes. Conclusion: Hepatic steatosis and fibrosis are highly prevalent in patients with T2DM, incidence of hepatic steatosis and fibrosis is positively correlated with longer duration of DM, higher BMI, bad control of DM, dyslipidemia, presence of metabolic syndrome, diabetic nephropathy, weakly correlated with liver enzymes. TE is an accurate and non-invasive tool to be used in screening for hepatic steatosis and fibrosis ,so we recommend screening for hepatic steatosis and fibrosis using fibroscan to help in early management and prevent its progression into liver cirrhosis.

scholarly journals Prevalence and Risk Factors of Elevated Liver Enzymes in Japanese Women With Polycystic Ovary Syndrome

2018 ◽  
Vol 10 (12) ◽  
pp. 904-910 ◽  
Author(s):  
Satomi Minato ◽  
Naoki Sakane ◽  
Kazuhiko Kotani ◽  
Shinsuke Nirengi ◽  
Ikuyo Hayashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Polycystic Ovary Syndrome ◽  
Liver Enzymes ◽  
Polycystic Ovary ◽  
Japanese Women ◽  
Ovary Syndrome ◽  
Elevated Liver Enzymes

Prevalence of elevated liver enzymes and their association with type 2 diabetes risk factors in children

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Victor Lin ◽  
Tyler Hamby ◽  
Siddharth Das ◽  
Amritpaul Chatrath ◽  
Riyaz Basha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Liver Enzyme ◽  
Liver Enzymes ◽  
Pediatric Population ◽  
Serum Samples ◽  
Early Screening ◽  
Potential Marker ◽  
Elevated Liver Enzymes

Abstract Objectives Given their established role in hepatic function and insulin resistance for adults, early screening of type 2 diabetes mellitus (T2DM) in the pediatric population may potentially be improved by the assessment of elevated liver enzymes. Methods Our study enrolled 151 nondiabetic children aged 10–14 years. Patients were assessed for demographics and five risk factors for T2DM. The levels of γ-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels were determined in serum samples. The effects of demographics and risk factors on abnormal liver enzyme levels were assessed with univariate chi-square analyses and also with multivariate logistic regression analyses, which were controlled for gender. Results Frequencies for abnormal liver enzyme values were as follows: 13 (9%) for GGT, 5 (3%) for ALT, and 20 (13%) for ALP. Across analyses, two results were consistently statistically significant. Females were more likely to have abnormal ALP levels, and patients with BMI percentile ≥95% and with acanthosis nigricans were more likely to have abnormal GGT levels. Conclusions Our study suggests GGT as potential marker for T2DM discovery in children. Subsequent long-term longitudinal studies would help to more clearly delineate GGT’s association with T2DM. Additionally, future studies that elucidate the molecular contribution of GGT elevation to T2DM pathogenesis are needed.

scholarly journals Correlation between bright echogenic liver, elevated liver enzymes and liver histology

2012 ◽  
Vol 17 (1) ◽  
pp. 8-13
Author(s):  
Iqbal Murshed Kabir ◽  
Mahbub Alam ◽  
Mohammad Mahmuduzzaman ◽  
Abdullah Al Mamoon ◽  
Mostak Uddin Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Hepatitis C ◽  
Alcohol Consumption ◽  
Hepatitis B ◽  
Liver Enzymes ◽  
Histological Findings ◽  
Hepatitis C Infection ◽  
Elevated Liver Enzymes ◽  
History Of

A total of 30 cases having bright echogenic liver on ultrasonography and raised ALT levels without Hepatitis B and Hepatitis C infection and without having history of alcohol consumption were referred to Gastroenterology department of BIRDEM Hospital and selected for liver biopsy in the study. The patient’s BMI and demographic profiles were recorded and necessary biochemical tests were carried out. After obtaining the histopathological reports, the correlation between different possible risk factors including biochemical findings and histological findings was sorted out. Based on BMI of Asian population, 73.4% of patients were over weight, 23.3% were obese and only 3.3% were with normal BMI. 90% patients presented with diabetes and 80% had some form of dyslipidaemia. 41% patients exhibited hypertriglycerdaemia, 21% had hypercholesterolaemia and both cholesterol and triglyceride were high in 34% patients. Histopathological study revealed that all 30 patients exhibited fatty change with macrovesicular type being the predominant. 43.3% patients had mild (<33%) steatosis and the rest 56.7% had moderate (33-66%) steatosis. In terms of staging of fibrosis in the liver, 83.3% exhibited stage-1 fibrosis and only 6.7% had stage-2 fibrosis. The rest 10% of the patients did not have any fibrosis. No correlation was established between hepatic enzyme levels (AST & ALT levels) and grading of steatosis & stage of fibrosis. Study of association between possible risk factors (Age, Sex, Diabetes Mellitus, Dyslipidaemia & BMI) and grading of steatosis and stage of fibrosis demonstrated that none of these risk factors was associated with those histological findings. Therefore it can be concluded that the patients presenting with bright echogenic liver on ultrasonography and elevated liver enzymes without having hepatitis B and hepatitis C infection and history of alcohol consumption are almost certainly to have Nonalcoholic fatty liver disease (NAFLD) specially if they are diabetic, dyslipidaemic and overweight or obese.The level of liver enzymes and the possible risk factors like age, sex, diabetes mellitus, dyslipidaemia and BMI do not seem to be good estimates of the severity of NAFLD. DOI: http://dx.doi.org/10.3329/jdnmch.v17i1.12184 J. Dhaka National Med. Coll. Hos. 2011; 17 (01): 8-13

scholarly journals The Incidence and Risk Factors of Extrapulmonary Manifestations in Mycoplasma Pneumoniae Pneumonia

2021 ◽  
Author(s):  
Yoo Kyung Park ◽  
You Na Park ◽  
Ji Eun Moon ◽  
Hyo-Bin Kim ◽  
Mee Yong Shin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mycoplasma Pneumoniae ◽  
Respiratory Virus ◽  
Liver Enzymes ◽  
Multivariable Analysis ◽  
Clinical Aspects ◽  
Laboratory Findings ◽  
Neurologic Manifestation ◽  
Factors Associated ◽  
Elevated Liver Enzymes

Abstract Background: Mycoplasma pneumoniae pneumonia (MP) is a major cause of community acquired pneumonia (CAP) in children and it is known to be associated with extrapulmonary manifestations (EPM). The incidence and risk factors of EPM in children are not known.Methods: This is a retrospective study involving 65,243 pediatric CAP patients between 2010 and 2015 at 23 nationwide hospitals was conducted in South Korea. The medical records were reviewed to collect the information regarding the clinical characteristics, radiological results, and laboratory findings. In total, 9,190 children with MP were identified and included in the analysis. Logistic regression with multivariable analysis was performed to evaluate the risk factors associated with EPM in MP.Results: The mean age of the enrolled patients with MP was 64.3±39.8 months, and the proportion of male patients was 49.5%. The incidence of EPM was 23.9% and included elevation of liver enzymes (18.1%), mucocutaneous manifestations (4.4%), proteinuria (4.1%), cardiovascular and neurologic manifestation (0.4%), hematologic manifestation (0.2%) and arthritis (0.2%). Statistical analysis showed that mucocutaneous manifestations were significantly increased with elevated alanine aminotransferase (adjusted odds ratio [aOR] 3.623, 95% confidence intervals [CI] 1.933-6.790) and atopic sensitization (aOR 2.973, 95% CI 1.615-5.475) and decreased with respiratory virus co-infection (aOR 0.273, 95% CI 0.084-0.887). Elevated liver enzymes was significantly associated with the elevation of lactate dehydrogenase (aOR 3.055, 95% CI 2.257-4.137) and presence of pleural effusion (aOR 2.635, 95% CI 1.767-3.930) and proteinuria with respiratory virus co-infection (aOR 2.245, 95% CI 1.113-4.527). Conclusions: About 24% of pediatric MP patients were identified with various EPM. Since risk factors associated with each EPM was different, it is necessary to evaluate the various clinical aspects and findings of MP to predict and prepare for the occurrence of EPM.

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