Formulation design and evaluation of aceclofenac nanogel for topical application

2020 ◽  
Vol 11 (12) ◽  
pp. 767-778
Author(s):  
Md. Shoaib Alam ◽  
Mohammed S Algahtani ◽  
Javed Ahmad ◽  
Kanchan Kohli ◽  
Sheikh Shafiq-un-Nabi ◽  
...  
Keyword(s):  
High Pressure ◽  
Zeta Potential ◽  
Droplet Size ◽  
Tween 80 ◽  
Gelling Agent ◽  
High Pressure Homogenization ◽  
Cremophor El ◽  
Peg 400 ◽  
Carbopol 940 ◽  
Negative Zeta Potential

Aim: The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials & methods: Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressure homogenization technique. Carbopol 940 was added as a gelling agent. Results & conclusion: The composition of optimized NE consist of labrafil along with triacetin as oil, tween 80 and cremophor EL in combination as a surfactant and transcutol HP along with PEG 400 and ethanol as cosurfactant. The droplet size of the NE was 141.1 ± 3.65 nm, with low polydispersity index and negative zeta potential. The aceclofenac–nanoemulgel was developed using carbopol 940 and exhibited excellent permeation in comparison to the marketed sample.

Comparative Study Between Two Different High-Energy Emulsification Strategies for the Preparation of Bio-Oil Based Nanoemulsion

2018 ◽  
Vol 24 (8) ◽  
pp. 5953-5959
Author(s):  
J. S Swathy ◽  
Prabhakar Mishra ◽  
Amitava Mukherjee ◽  
Natarajan Chandrasekaran
Keyword(s):  
High Pressure ◽  
Comparative Study ◽  
Droplet Size ◽  
Tween 80 ◽  
High Energy ◽  
High Pressure Homogenization ◽  
Clove Oil ◽  
Antimicrobial Potential ◽  
The Comparative Study

The current experimentation deals about the comparative study of two different high-energy emulsification techniques used for nanoemulsion formulation. The preparation of clove oil nanoemulsion accomplished through high-energy methods such as ultrasonication and high pressure homogenization. The coarse emulsion formed after mixing the oil phase consisting of clove oil and the aqueous phase comprising of Tween 80 and Milli-Q water was subjected to the both high energy method in order to compare the efficiency. The comparative study was carried out based on droplet size, nanoemulsion stability and its antimicrobial potential. Significant differences has been observed in the droplet size and antibacterial activity of nanoemulsion prepared by ultrasonication and high pressure homogenization. The nanoemulsion prepared from high pressure homogenizer exhibit good stability compared to nanoemulsion prepared using ultrasonication technique, with a low droplet size. Further the antimicrobial activity of nanoemulsion prepared via ultrasonication and high pressure homogenization was evaluated against bacterial pathogen P. alcaligenes (in-vitro studies), among which nanoemulsion prepared through high pressure homogenization exhibited significant antimicrobial potential. Therefore the nanoemulsion prepared using high pressure homogenization showed effective antimicrobial potential against P. alcaligenes with low droplet size and higher stability.

scholarly journals Self-Nanoemulsifying Powder of Isotretinoin: Preparation and Characterization

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Hitesh Chavda ◽  
Jaimeen Patel ◽  
Gordhan Chavada ◽  
Shruti Dave ◽  
Ankini Patel ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Droplet Size ◽  
Tween 80 ◽  
Size Analysis ◽  
Scanning Calorimetry ◽  
Peg 400 ◽  
Ir Studies ◽  
Emulsification Capacity ◽  
Poorly Soluble

In the present investigation an attempt was made to enhance the solubility and dissolution of poorly soluble drug, isotretinoin, by formulating self-nanoemulsifying drug delivery system (SNEDDS). Liquid SNEDDSs were prepared using Transcutol P as oil, Tween 80 as surfactant, and PEG 400 as cosurfactant. Pseudoternary phase diagrams were constructed to identify the efficient self-nanoemulsification region. The formulation with 40% oil (Transcutol P) and 60% surfactant: cosurfactant (Tween 80: PEG 400) ratio of 1 : 1 was optimized based on evaluation parameters for droplet size analysis, self-emulsification capacity, zeta potential, and in vitro drug release performance. The optimized system contains mean droplet size of 36.60 nm and zeta potential (ζ) −26.73 mV. The optimized formulation A1 was adsorbed onto Fujicalin to produce solid SNEDDS, which exhibited good flow properties and preserved the self-emulsification properties of liquid SNEDDS. The differential scanning calorimetry, FT-IR studies of solid SNEDDS revealed transformation of isotretinoin into molecularly dissolved state in the liquid SNEDDS. In vitro dissolution profiles showed that dissolution rate of ISN from solid SNEDDS was significantly greater as compared to pure drug.

scholarly journals DEVELOPMENT OF MICROEMULSION FORMULATION FOR ORAL DELIVERY OF ROSUVASTATIN CALCIUM

2020 ◽  
pp. 35-39
Author(s):  
Himanshu Paliwal ◽  
Ram Singh Solanki ◽  
Chetan Singh Chauhan
Keyword(s):  
Zeta Potential ◽  
Droplet Size ◽  
Oral Delivery ◽  
Water Solubility ◽  
Tween 80 ◽  
In Vitro Dissolution ◽  
Microemulsion Formulation ◽  
Polyethylene Glycol 400 ◽  
Rosuvastatin Calcium

The purpose of conducting this study was to prepare an oral microemulsion formulation of Rosuvastatin calcium (RC) to improve its water solubility. Oil in water microemulsion was formulated using Oleic acid, Tween 80 and Polyethylene Glycol-400(PEG-400) as oil, surfactant and co-surfactant, respectively. The ideal proportion of surfactant: co-surfactant (Smix) was chosen by constructing pseudoternary diagrams. The microemulsion formulations which proved to be stable after thermodynamic stability testing were further evaluated for physical characteristics. Selected formulations were evaluated for droplet size, zeta potential, polydispersity index, viscosity and % drug content. The results were suggestive that optimized microemulsion formulation (F2) was thermodynamically stable and clear having a droplet size of 74.29 nm and zeta potential of -18.44.  In vitro dissolution study for optimized microemulsion was performed using a dialysis bag method and cumulative % drug release was determined. The result from the release study was indicative of improved solubility of Rosuvastatin calcium which may serve to boost up the oral bioavailability of drug.

scholarly journals The Effect of pH and High-Pressure Homogenization on Droplet Size

2017 ◽  
Vol 2 (4) ◽  
pp. 110-122
Author(s):  
Ah Pis Yong ◽  
Md. Aminul Islam ◽  
Nurul Hasan
Keyword(s):  
High Pressure ◽  
Light Scattering ◽  
Droplet Size ◽  
Skim Milk ◽  
Egg Yolk ◽  
Continuous Phase ◽  
High Pressure Homogenization ◽  
Emulsion Droplets ◽  
Droplet Sizes ◽  
Basil Oil

The aims of this study are to revisit the effect of high pressure on homogenization and the influence of pH on the emulsion droplet sizes. The high-pressure homogenization (HPH) involves two stages of processing, where the first stage involves in blending the coarse emulsion by a blender, and the second stage requires disruption of the coarse emulsion into smaller droplets by a high-pressure homogenizer. The pressure range in this review is in between 10-500 MPa. The homogenised droplet sizes can be reduced by increasing the homogenization recirculation, and there is a threshold point beyond that by applying pressure only, the size cannot be further reduced. Normally, homogenised emulsions are classified by their degree of kinetic stability. Dispersed phase present in the form of droplets while continuous phase also known as suspended droplets. With a proper homogenization recirculation and pressure, a more kinetically stable emulsion can be produced. The side effects of increasing homogenization pressure are that it can cause overprocessing of the emulsion droplets where the droplet sizes become larger rather than the expected smaller size. This can cause kinetic instability in the emulsion. The droplet size is usually measured by dynamic light scattering or by laser light scattering technique. The type of samples used in this reviews are such as chocolate and vanilla based powders; mean droplet sizes samples; basil oil; tomato; lupin protein; oil; skim milk, soymilk; coconut milk; tomato homogenate; corn; egg-yolk, rapeseed and sunflower; Poly(4-vinylpyridine)/silica; and Complex 1 until complex 4 approaches from author case study. A relationship is developed between emulsion size and pH. Results clearly show that lower pH offers smaller droplet of emulsion and the opposite occurs when the pH is increased.

scholarly journals Oleic Acid Based Emulgel for Topical Delivery of Ofloxacin

2019 ◽  
Vol 9 (4-A) ◽  
pp. 183-190
Author(s):  
A. Manaswitha ◽  
P. V. L. D. Sai Swetha ◽  
N.K.D. Devi ◽  
K. Naveen Babu ◽  
K. Ravi Shankar
Keyword(s):  
Oleic Acid ◽  
Drug Release ◽  
Ph Value ◽  
Liquid Paraffin ◽  
Tween 80 ◽  
Gelling Agent ◽  
Compatibility Study ◽  
Zero Order Kinetics ◽  
Carbopol 940

The objective of the present study is to formulate and evaluate ofloxacin emulgel. Emulgel formulations of ofloxacin were prepared using different concentrations of gelling agent’s Carbopol-940 and Xanthum gum. Tween-80 and span-80 were used as emulsifiers and propylene glycol as a humectant in the preparation of emulgel. The effect of the concentration of gelling agent on the drug release from the prepared emulgel was investigated. The compatibility study was conducted using Fourier-transform infrared (FTIR). The formulated emulgel was characterized by their physical appearance, pH determination, viscosity, spreadability, drug content, microbial test and in vitro diffusion study. FTIR indicated that the drug and excipients used in the study are compatible with each other. All the prepared formulations showed acceptable physical properties, homogeneity, consistency, spreadability, viscosity, and pH value. Drug release from all the formulations depended upon the concentration of the polymer used. As the concentration of Carbopol 940 increased the spreadability and drug release was found to be decreased. Emulgels formulated with oleic acid gave a much higher release rate of ofloxacin than emulgels formulated with liquid paraffin. The release of drug from all the emulgels prepared followed Zero-order kinetics. The linear Higuchi plots indicated that the drug release from all the emulgels prepared followed diffusion kinetics. Emulgel formulated with oleic acid exhibited greater flux when compared with those formulated with liquid paraffin. The formulations were found to be stable during stability testing. It can be concluded that Carbopol 940 and oleic acid are recommended for the formulation and preparation of Ofloxacin emulgels for topical drug delivery. Key words: Ofloxacin, Emulgel, Spreadibility, Zone of inhibition.

Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine

2021 ◽  
pp. 2548-2556
Author(s):  
Sonia Dhiman ◽  
Gurjeet Singh Thakur ◽  
Shivangi Anand ◽  
Priyanka Yadav
Keyword(s):  
Drug Delivery ◽  
High Pressure ◽  
Zeta Potential ◽  
Solid Lipid Nanoparticles ◽  
Controlled Drug Delivery ◽  
Lipid Nanoparticles ◽  
Polydispersity Index ◽  
High Pressure Homogenization ◽  
X Ray ◽  
Solid Lipid

Zidovudine is one of the chief nucleoside analogue and reverse inhibitor licensed for HIV infection which is placed along with a group of retroviruses. The present research study on Zidovudine solid dosage form surveyed the feasibility utilizing solid lipid nanoparticles (SLNs) for controlled drug delivery of zidovudine embracing glyceryl behenate as lipidic material, tween 80 as a stabilizer and blend of sodium chelate with poloxamer as surfactant. The SLNs were prepared utilizing high pressure homogenization followed by ultrasonication method. The prepared SLNs were characterized by particle size analysis, polydispersity index, zeta potential, DSC, TEM, IR spectroscopy, and X-ray diffractometry. Narrow size distribution of the particles was marked having polydispersity index values under 0.8. The high zeta potential of the different SLN formulations additionally showed their physical stability. Differential scanning calorimetry and powder X-ray diffraction showed decline in crystallinity of drug in the nanoparticle formulation. In vitro release study showed sustained release for up to 12 hours in the SLN formulations prepared. The current study results revealed that zidovudine SLN formulation prepared by high pressure homogenization followed by ultrasonication is a suitable method for controlled drug delivery system.

Influence of Emulsifiers on Physical Properties of Oil/Water Emulsions Containing Ostrich Oil

2018 ◽  
Vol 777 ◽  
pp. 592-596
Author(s):  
Juthaporn Ponphaiboon ◽  
Sontaya Limmatvapirat ◽  
Chutima Limmatvapirat
Keyword(s):  
Zeta Potential ◽  
Physical Properties ◽  
Droplet Size ◽  
Emulsion Stability ◽  
Tween 80 ◽  
High Viscosity ◽  
Soy Lecithin ◽  
Oil Emulsion ◽  
Oil Water ◽  
Oil Emulsions

The fabrication of oil/water (O/W) emulsions in order to prepare the spray-dried encapsulated bioactive ostrich oil emulsions can be useful for increasing stability of commercial products. In this study, O/W emulsions were stabilized with mixed emulsifiers (Span and Tween) or soy lecithin. The effects of emulsifiers on the physical properties of emulsions containing ostrich oil were investigated. Results showed that the addition of a mixture of Span and Tween emulsifiers at concentrations between 5 and 15% w/w reduced the droplet size of the emulsions but did not decrease the zeta potential in the emulsion system. The smallest droplet size of 5.01±0.43 μm was obtained from the emulsion containing 15% w/w mixture of Span 20 and Tween 80. The zeta potential values of all emulsions containing a mixture of Span and Tween emulsifiers in the concentration range of 5 to 20% w/w were between-23 and-55 mV. In addition, the viscosity of these emulsions increased with increases in the concentrations of both emulsifiers. The stable 20% w/w ostrich oil emulsion stabilized with 15% w/w Span 20/Tween 80 presented viscosity equal to 69.56±1.82 cP. For 10% w/w ostrich oil emulsions stabilized with lecithin, the droplet size and zeta potential of the emulsions tended to decrease with increasing lecithin concentrations. An emulsion containing 10% w/w lecithin exhibited the smallest droplet size (3.93±0.11 μm). The zeta potential values of all emulsions composed of 1-15% w/w lecithin were between-33 and –66 mV and the viscosity of these emulsions increased with increases in the concentrations of lecithin. The stable 10% w/w ostrich oil emulsion stabilized with 10% w/w lecithin exhibited a high viscosity of 172.50±1.01cP. In summary, 10% w/w lecithin provides better emulsion stability than 15% w/w Span 20/Tween 80. These results therefore reveal important parameters for the fabrication of stable O/W emulsions containing ostrich oil.

Effects of High-Pressure Homogenization at Different Pressures on Structure and Functional Properties of Oyster Protein Isolates

2018 ◽  
Vol 14 (4) ◽  
Author(s):  
Cuiping Yu ◽  
Fan Wu ◽  
Yue Cha ◽  
Yuting Qin ◽  
Ming Du
Keyword(s):  
Particle Size ◽  
High Pressure ◽  
Secondary Structure ◽  
Zeta Potential ◽  
Functional Properties ◽  
Surface Hydrophobicity ◽  
Random Coil ◽  
Foaming Properties ◽  
High Pressure Homogenization ◽  
Protein Profiles

Abstract Oyster protein isolate (OPI) suspensions (6.19 % ± 0.82 %, w/v) were treated by high-pressure homogenization (HPH) at 0 (control), 20, 40, 60, 80 or 100 MPa for three cycles. Protein profiles, secondary structure, free sulfhydryl, surface hydrophobicity, particle size distribution, zeta-potential, solubility, water and oil holding capacity (OHC), emulsifying and foaming properties of the obtained suspensions were analyzed. The results showed that HPH treatment did not cause changes in protein profiles of OPI, but caused changes in secondary structure, content of α-helix decreased but content of β-turn and random coil increased significantly (P < 0.05). Free sulfhydryl and surface hydrophobicity all increased significantly (P < 0.05) after HPH treatment, indicating that tertiary and quaternary structures changed. Functional properties of OPI significantly (P < 0.05) improved after HPH treatment, such as zeta-potential (from −12.67 to −33.57 mV), solubility (from 20.24 % to 57.99 %), OHC (from 981.77 % to 1229.40 %), foaming ability (from 17.50 % to 35.00 %), foaming stability (from 44.49 % to 66.60 %), emulsifying activity index (from 8.87 to 17.06 m2/g) and emulsion stability index (from 14.65 to 41.68 min). At 60 MPa and 80 MPa, the improvements were more remarkable. However, HPH treatment significantly (P < 0.05) decreased particle size (from 200–500 nm to 0–200 nm) and water holding capacity (from 341.15 % to 216.96 %). These improvements were closely related to structural changes and reduction of particle size. Application of different pressures affected functional properties of OPI. These results could provide information for determining HPH applying condition in OPI modification.

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