scholarly journals Influence of Chelidonium majus Water Extract onto Cancer Cells and Platelets

2018 ◽  
Vol 07 (04) ◽  
Author(s):  
Deulenko VN ◽  
Marunych RY ◽  
Chernyshenko VO ◽  
Rebriev AV ◽  
Lugovskoy EV ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Water Extract ◽  
Chelidonium Majus

scholarly journals Effect of Juice and Extracts from Saposhnikovia divaricata Root on the Colon Cancer Cells Caco-2

2019 ◽  
Vol 20 (18) ◽  
pp. 4526 ◽  
Author(s):  
Magdalena Matusiewicz ◽  
Katarzyna Barbara Bączek ◽  
Iwona Kosieradzka ◽  
Tomasz Niemiec ◽  
Marta Grodzik ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
High Performance ◽  
Membrane Integrity ◽  
Water Extract ◽  
Colon Cancer Cells ◽  
Molecular Weights ◽  
Induced Apoptosis ◽  
Saposhnikovia Divaricata ◽  
Hydroethanolic Extract

Colorectal cancer ranks 3rd in terms of cancer incidence. Growth and development of colon cancer cells may be affected by juice and extracts from Saposhnikovia divaricata root. The objective of the research was to analyze the effect of S. divaricata juice and extracts on the viability, membrane integrity and types of cell death of Caco-2 cells. Juice and extracts were analyzed using Ultra-High Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS) and in respect of the presence of antioxidants, total carbohydrates, protein, fat and polyphenols. The contents of cimifugin β-D-glucopyranoside, cimifugin, 4′-O-glucopyranosyl-5-O-methylvisamminol, imperatorin and protein were the highest in juice. 50% Hydroethanolic extract had the greatest antioxidant potential, concentration of polyphenols and fat. Water extract was characterized by the highest content of glutathione. Juice and 75% hydroethanolic extract contained the most carbohydrates. After the application of juice, 50% extract and the juice fraction containing the molecules with molecular weights >50 kDa, a decrease of the cell viability was noted. Juice and this extract exhibited the protective properties in relation to the cell membranes and they induced apoptosis. The knowledge of further mechanisms of anticancer activity of the examined products will allow to consider their use as part of combination therapy.

scholarly journals Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Nien-Cheng Chen ◽  
Charng-Cherng Chyau ◽  
Yi-Ju Lee ◽  
Hsien-Chun Tseng ◽  
Fen-Pi Chou
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Water Extract ◽  
Mitotic Catastrophe ◽  
Bladder Cancer Cells

scholarly journals The Apoptotic Effect of Polysaccharides with Specific Molecular Weight Extracted from Inonotus Obliquus on HT-29 Colon Cancer Cells

2020 ◽  
Author(s):  
Xue Han ◽  
Sainan Zhao ◽  
Yu Wang ◽  
Jialei Sun ◽  
Shiwei Chen
Keyword(s):  
Molecular Weight ◽  
Cancer Cells ◽  
Membrane Filtration ◽  
Water Extract ◽  
Potential Candidate ◽  
Dependent Manner ◽  
Inonotus Obliquus ◽  
Filtration Method ◽  
Apoptotic Effect ◽  
Ht 29

Abstract Background: Recently, much attention has been paid to natural products owing to their effective anticancer effects with relatively low toxicity, especially Inonotus obliquus (I. obliquus).Results: Polysaccharides with different molecular weights were filtered from water extract of I. obliquus using grading membrane filtration method. IOP60b (10 kDa ≤ molecular weight ≤ 30 kDa) was found to have the highest yield and the highest inhibition ratio of HT-29 cancer cells, therefore it was chosen to evaluate the apoptotic effect of HT-29 cancer cells. After treated with different concentrations of IOP60b, morphological changes including cell shrinkage and nuclear condensation and DNA fragmentation in HT-29 cancer cells were observed, and cells in early apoptosis and late apoptosis significantly (p<0.05) increased in a dose-dependent manner by arresting cell cycle at G0/G1 phase. To further explore the underlying mechanism, RT-PCR and Western blotting were applied. Results indicated that both Bcl-2 family and Caspase family were involved in the process of apoptosis regulation and IOP60b induced cellular apoptosis via upregulation of Bax/Bcl-2 ratio and activation of Caspase-3.Conclusion: These data suggested that IOP60b might be the potential candidate for the clinical prevention and treatment of colorectal cancer.

G2/M arrest and apoptosis of human colorectal cancer cells induced by water extract from residues of jelly fig achene

2015 ◽  
Vol 24 (s1) ◽  
pp. S147-S153 ◽  
Author(s):  
Wing-Ming Chou ◽  
Chun-Nan Chen ◽  
Hsiao-Ting Hsieh ◽  
Tsui-Yun Lo ◽  
Pei-Yi Juan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Water Extract ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Isolation of a Substance Inducing Apoptosis of Cultured Human Gastric Cancer Cells from a Hot-water Extract of Adzuki (Vigna angularis)

2005 ◽  
Vol 58 (5) ◽  
pp. 281-287 ◽  
Author(s):  
Tomohiro Itoh ◽  
Yuko Itoh ◽  
Hiroshige Hibasami ◽  
Hirotaka Katsuzaki ◽  
Kunio Imai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Water Extract ◽  
Hot Water ◽  
Human Gastric Cancer ◽  
Vigna Angularis ◽  
Gastric Cancer Cells ◽  
Hot Water Extract
Sign in / Sign up

Export Citation Format

Share Document