Predictive Factors for Successful Percutaneous Sclerotherapy of Venous and Lymphatic Malformations

Objectives: To determine the predictive factors for good response outcome of venous (VMs) and lymphatic malformations (LMs) by percutaneous sclerosing therapy and to compare the complications associated with bleomycin versus alcohol treatment. Methods: A retrospective analysis of 225 patients with lymphatic and venous malformation who had treated by percutaneous sclerotherapy using alcohol and/or bleomycin was performed The treatment outcome was graded from 0-3, in orderly of clinical responsiveness by using visual assessment of changing in size and subjective improvement of symptoms. Predictive factors of good treatment outcome were determined by uni- and multivariate analysis which were conducted on sex, age, onset of disease, location, type, characteristic of lesion and sclerosant usage. Results: Of 225 patients, 87.6% were VMs and 12.4% were LMs. VMs were predominating in female (6.2:3.8). Between ethanol and bleomycin, there was no statistical significant of treatment sessions, dose and treatment outcome. (p= .42) Sclerosing therapy provided better response on VMs than LMs. (49.2% and 21.4% respectively, p=.002), and had more effective on focal lesions than diffuse patterns (64.9% and 26.1% respectively p<.001) The gender, onset of disease, locations, characteristic on venography and preceding treatment showed no correlation with treatment result. Major complications of ethanol occurred in 38.6%,including hematuria, gangrene, facial paralysis, pulmonary embolism and death. Minor adverse reactions of bleomycin encountered in 19.8% with hyperpigmentation, flu-like symptom and localized fibrosis. Conclusion: Both absolute alcohol and bleomycin were effective sclerosing agents for percutaneous treatment of venous malformations, but no serious complications encountered with bleomycin. The characteristic of focal single lesion, at any region of body part, can be a predictor for good response.

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Factors influencing orthodontic treatment outcome in South East Wales and implications for service commissioning

Journal of Orthodontics ◽

10.1177/1465312519881454 ◽

2019 ◽

Vol 46 (4) ◽

pp. 311-322

Author(s):

Stacey Quach ◽

Hashmat Popat ◽

Anup Karki ◽

Rebecca Playle ◽

Stephen Richmond

Keyword(s):

Treatment Outcome ◽

Predictive Factors ◽

Orthodontic Treatment ◽

Dental Health ◽

Peer Assessment ◽

Dental Services ◽

Need For Treatment ◽

Good Treatment Outcome ◽

Fixed Appliances ◽

Treatment Use

Aim: To determine factors that may influence the outcome of orthodontic treatment undertaken in General Dental Services/Personal Dental Services in South East Wales. Design and setting: A retrospective study of a requested 20 consecutively treated cases (for the year 2014–2015) provided by 26 performers in South East Wales. Method: Performer and patient information was obtained by use of a questionnaire and FP17OW forms, respectively. A calibrated investigator recorded the Index of Orthodontic Treatment Need (IOTN), Peer Assessment Rating (PAR) and the Index of Complexity, Outcome and Need (ICON) on start- and end-study models for each case. Descriptive and regression analyses were undertaken to identify any predictive factors of a good treatment outcome. Results: Two respondents completed < 20 cases, so all of their cases were assessed. A total of 495 cases were assessed. The overall achieved mean end-PAR score of 5 is collectively a good occlusal outcome. Predictive factors of a good quality of occlusal outcome (end-PAR score being ⩽ 5) were: dual arch treatment; use of functional with fixed appliances; treatment undertaken in non-corporate practices; and treatment undertaken by registered specialists ( P < 0.001). Predictive factors for occlusal improvement (change in PAR score) were: IOTN aesthetic component (AC); IOTN dental health component (DHC) (1–3 or 4–5); and number of arches treated and malocclusion type ( P < 0.001). Conclusions: Dual arch fixed appliances undertaken by orthodontic specialists in non-corporate environments produced the highest quality orthodontic outcomes. Those who have the highest need for treatment according to IOTN DHC and AC benefit most in terms of improvement achieved in PAR score.

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Percutaneous sclerotherapy of para-orbital and orbital venous malformation: A single center, case series

Phlebology The Journal of Venous Disease ◽

10.1177/0268355518805364 ◽

2018 ◽

Vol 34 (5) ◽

pp. 355-361 ◽

Cited By ~ 3

Author(s):

Saima Ahmad ◽

Fahd Kamal Akhtar

Keyword(s):

Venous Malformation ◽

Symptomatic Relief ◽

Case Series ◽

Uneventful Recovery ◽

Venous Malformations ◽

Sclerosing Agents ◽

Percutaneous Sclerotherapy ◽

Angiography Suite ◽

Orbital Region

Purpose To present a case series of percutaneous sclerotherapy of para-orbital and orbital venous malformations. Method Seven patients with venous malformations in the orbital and para-orbital region were reviewed. Puncture venogram was performed on all patients and image guided bleomycin injections using biplane digital subtraction in angiography suite. Results Average age of patients at the time of the procedure was 22 years old with the youngest being five years of age and the oldest being 50 years. Follow-ups ranged from 3 months to 18 months and the average follow-up duration was 13 months. The patients had no intraprocedural complications and reported symptomatic relief of pain as per the last follow-up. Patients have shown no symptoms or signs of recurrence of lesions with uneventful recovery so far. Conclusions Percutaneous sclerotherapy of orbital Venous Malformations with bleomycin is a safe and well-controlled procedure done in real time; it has no major systemic adverse side effects and higher efficacy than other sclerosing agents.

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Percutaneous sclerotherapy for spongiform venous malformations – analysis of patient-evaluated outcome and satisfaction

VASA ◽

10.1024/0301-1526/a000650 ◽

2017 ◽

Vol 46 (6) ◽

pp. 477-483

Author(s):

Robert Karl Clemens ◽

Frederic Baumann ◽

Marc Husmann ◽

Thomas Oleg Meier ◽

Christoph Thalhammer ◽

...

Keyword(s):

Retrospective Study ◽

Medical Records ◽

Venous Malformation ◽

Primary Treatment ◽

Venous Malformations ◽

Treated Area ◽

Item Questionnaire ◽

Percutaneous Sclerotherapy ◽

Multiple Treatments ◽

Pain Improvement

Abstract. Background: Congenital venous malformations are frequently treated with sclerotherapy. Primary treatment goal is to control the often size-related symptoms. Functional impairment and aesthetical aspects as well as satisfaction have rarely been evaluated. Patients and methods: Medical records of patients who underwent sclerotherapy of spongiform venous malformations were reviewed and included in this retrospective study. The outcome of sclerotherapy as self-reported by patients was assessed in a 21 item questionnaire. Results: Questionnaires were sent to 166 patients with a total of 327 procedures. Seventy-seven patients (48 %) with a total of 159 procedures (50 %) responded to the survey. Fifty-seven percent of patients were male. The age ranged from 1 to 38.1 years with a median age of 16.4 years. The lower extremities were the most common treated area. Limitations caused by the venous malformation improved in the majority of patients (e.g. pain improvement 87 %, improvement of swelling 83 %) but also worsening of symptoms occurred in a minority of cases. Seventy-seven per cent would undergo sclerotherapy again. Conclusions: Sclerotherapy for treatment of venous malformations results in significant reduction of symptoms. Multiple treatments are often needed, but patients are willing to undergo them.

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Treatment Outcome, Toxicity, and Predictive Factors for Radioligand Therapy with 177Lu-PSMA-I&T in Metastatic Castration-resistant Prostate Cancer

European Urology ◽

10.1016/j.eururo.2018.11.016 ◽

2019 ◽

Vol 75 (6) ◽

pp. 920-926 ◽

Cited By ~ 43

Author(s):

Matthias M. Heck ◽

Robert Tauber ◽

Sebastian Schwaiger ◽

Margitta Retz ◽

Calogero D’Alessandria ◽

...

Keyword(s):

Prostate Cancer ◽

Treatment Outcome ◽

Predictive Factors ◽

Castration Resistant Prostate Cancer ◽

Radioligand Therapy ◽

Castration Resistant

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Treatment outcome and its predictors among diabetic patients attending at selected hospitals of southern ethiopia.

10.21203/rs.3.rs-917406/v2 ◽

2021 ◽

Author(s):

Bereket Beyene ◽

Dawit Hoyiso ◽

Kinfe Woldu

Keyword(s):

Treatment Outcome ◽

Blood Glucose ◽

Health Care Expenditure ◽

Fasting Blood Glucose ◽

World Health ◽

Outcome Variable ◽

Southern Ethiopia ◽

Diabetic Patients ◽

Source Population ◽

Good Treatment Outcome

Abstract Background: Diabetes is one of the largest health emergencies of the 21st century. The World Health Organization (WHO) estimates that globally, hyperglycaemia is the third highest risk factor for premature mortality, after high blood pressure and tobacco use. It is an important cause of blindness, kidney failure, lower limb amputation and other long-term consequences that impact significantly on quality of life. It result peoples in a disease, death and increase a health care expenditure.Objectives: To determine treatment outcome of Diabetes mellitus and its predictors among patients attending diabetes treatments at selected hospitals of southern Ethiopia, 2021.Methods: All diabetic patients who attended selected hospitals of southern Ethiopia were a source population. Institution based cross-sectional study design was conducted at selected hospitals of southern Ethiopia. Patient’s data was collected using pretested questionnaire. After cleaning and checking for errors, the data was entered in to Epi-data to minimize error then exported to SPSS for analysis. Descriptive findings were presented by tables and charts. The outcome variable was analyzed by using logistic regression model to identify predictors after assumptions of regression analysis had checked. All the independent variables with p<0.25 was used as a candidate for multivariate analysis. Then the level of significance will be set at p<0.05 and AOR with 95% CL was done as the final model.Result: From the total sample; 277 (65.6%) were found to be good treatment outcome. The number of medication taken AOR 95%CI; 0.924 (0.869, 0.983), presence of complication AOR 95%CI; 0.425 (0.217, .832), increased fasting blood glucose AOR 95%CI; 0.080 (0.034, 0.188) were found to be independent predictors. Since the magnitude of treatment outcome found to be low, provision of health information about the adhering to prescribed medication and monitoring fasting blood glucose level will bring good clinical outcome.

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A case of spinal epidural venous malformation with mediastinal extension: management with combined surgery and percutaneous sclerotherapy

Journal of Neurosurgery Pediatrics ◽

10.3171/2015.9.peds15341 ◽

2016 ◽

Vol 17 (5) ◽

pp. 612-617 ◽

Cited By ~ 1

Author(s):

Gurpreet S. Gandhoke ◽

Sabri Yilmaz ◽

Lorelei Grunwaldt ◽

Ronald L. Hamilton ◽

David J. Salvetti ◽

...

Keyword(s):

Venous Malformation ◽

Dorsal Column ◽

Venous Hypertension ◽

Neurogenic Claudication ◽

Subtotal Resection ◽

Migraine Headaches ◽

Postoperative Mri ◽

Percutaneous Sclerotherapy ◽

Mri Study ◽

Spinal Epidural

While spinal epidural arteriovenous malformations, fistulas, and shunts are well reported, the presence of a venous malformation in the spinal epidural space is a rare phenomenon. Herein, the authors report the clinical presentation, imaging findings, pathological features, and the outcome of surgical and percutaneous interventional management of a mediastinal and spinal epidural venous malformation in a young woman who presented clinically with neurogenic claudication from presumed venous hypertension precipitating the formation of a syrinx. The patient underwent a C6–T5 osteoplastic laminectomy for decompression of the spinal canal and subtotal resection of the epidural venous malformation, followed by percutaneous sclerotherapy of the mediastinal and residual anterior spinal venous malformation. She developed transient loss of dorsal column sensation, which returned to baseline within 3 weeks of the surgery. A 6-month postoperative MRI study revealed complete resolution of the syrinx and the mediastinal venous malformation. Twelve months after the surgery, the patient has had resolution of all neurological symptoms with the exception of her premorbid migraine headaches. A multidisciplinary approach with partial resection and the use of percutaneous sclerotherapy for the residual malformation can be used to successfully treat a complex venous malformation.

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SCLEROTHERAPY OR SCLERODISTRESS? ARDS CAUSED BY SCLEROSING AGENTS USED FOR ROUTINE ARTERO-VENOUS MALFORMATION (AVM) EMBOLIZATION

CHEST Journal ◽

10.1016/j.chest.2020.08.933 ◽

2020 ◽

Vol 158 (4) ◽

pp. A1003 ◽

Cited By ~ 1

Author(s):

Shireen George ◽

Jojo Alunilkummannil ◽

Tariq Sallam

Keyword(s):

Venous Malformation ◽

Sclerosing Agents

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Treatment outcome of tuberculosis patients at Debretabor General Hospital, Amhara, Northwest Ethiopia

10.21203/rs.2.10748/v1 ◽

2019 ◽

Author(s):

Tesfaye Andualem ◽

Wubet Taklual

Keyword(s):

Treatment Outcome ◽

Pulmonary Tuberculosis ◽

Success Rate ◽

General Hospital ◽

Treatment Success ◽

Control Program ◽

Northwest Ethiopia ◽

Treatment Success Rate ◽

Tuberculosis Patients ◽

Good Treatment Outcome

Abstract Introduction Tuberculosis is still a global health problem. Especially, in developing countries where overcrowded and lack of awareness is existed. According to WHO, to monitor the effectiveness of tuberculosis prevention and control program, assessing tuberculosis outcome is important. The aim of this study was to determine treatment outcome of tuberculosis patients in Debretabor General Hospital, Debretabor, Northwest Ethiopia, 2019. Materials and methods A retrospective study was carried out between December 2016 to December 2018 from TB patients attending the health institutions of Debretabor General Hospital. All tuberculosis cases reported between 2016-2018 were reviewed carefully and analyzed. A total of 455 Tb patients were enrolled in this study and data were coded and entered in to the computer for statistical analysis using SPSS version 20 and Epi-info soft wares. Result and Discussion Within the study period a total of 455 study participants were requireted. Tuberculosis type was categorized as 88(18.0%) were smear positive pulmonary tuberculosis, 192(42.2%) were smear negative pulmonary tuberculosis and 181(39.8%) were extra pulmonary tuberculosis. Among the study subjects 86(18.9%) were HIV seropositive. Of the total study subjects, treatment completed (357)78.5%, cured (57)12.%, death (16)3.5%, treatment failure(4)0.9%, transfer out (21)4.6%. Good proportion of TB treatment success rate was in 15-44 yrs 310/326(95.0%) where as poor treatment success rate was in 0-14 years 26/42 (61.9%). Being an urban also has a high treatment success rate310/325(95.4%). 408(89.7%) were successfully treated. Conclusion The treatment success rate of tuberculosis patients was satisfactory 89.7%. In the study, treatment of HIV-TB co-infection need a better attention for good treatment outcome.

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Predictors of Treatment Outcomes among Pediatric Patients Hospitalized with Pneumonia in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Advances in Pharmacological and Pharmaceutical Sciences ◽

10.1155/2021/6690622 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Hilina Tsegaw ◽

Mohammed Yimam ◽

Dejen Nureye ◽

Workineh Woldeselassie ◽

Solomon Hambisa

Keyword(s):

Treatment Outcome ◽

Sample Size ◽

Treatment Outcomes ◽

Pediatric Patients ◽

Addis Ababa ◽

Good Treatment Outcome ◽

Specialized Hospital ◽

Tikur Anbessa Specialized Hospital ◽

Poor Treatment ◽

Poor Treatment Outcome

Background. Pneumonia remains the leading cause of hospitalization and mortality in young children in low- and middle-income countries. This study is aimed to assess predictors of treatment outcomes among pediatric patients hospitalized with pneumonia in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods. A facility-based retrospective cross-sectional study was conducted among pediatric patients admitted with pneumonia, considering patient medical charts recorded for a 1-year period from February 2017 to February 2018. The sample size was computed based on a single population proportion formula and giving a total sample size of 207. The systematic random sampling method was employed to select patient cards from the sampling frame. The data extraction format was used to extract any relevant information from patient chart. The processed data were analyzed by using Statistical Package for Social Sciences (SPSS, version 21). Descriptive statistics were used to summarize the patients’ baseline characteristics and related information. The logistic regression model was fitted to determine factors associated with treatment outcomes. To identify predictors of poor treatment outcome, the level of significance was set at P < 0.05 . Results. From a total of 207 patient charts reviewed, more than half (55.6%) of the study participants were males. Majority of patients, 130 (62.8%), were in the age range of 1 month–11 months. Furthermore, 191 (92.3%) patients had good treatment outcome. Patients who treated with ceftriaxone + azithromycin were less likely to have poor treatment outcome compared with patients who were placed on crystalline penicillin (AOR = 0.86, 95% CI 0.01–0.83). On the contrary, patients who stayed ≥ 8 days were about 14.3 times more likely to have poor treatment outcome compared with patients who stayed ≤ 3 days (AOR = 14.3, 95% CI 1.35–151.1). Conclusion. Even though the study revealed good treatment outcome among the pediatric patients, particular consideration should be given to children in need of other interventions.

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