scholarly journals Сhronic kidney disease in children: principles of ambulatory management

Author(s):  
Albina A. Vyalkova ◽  
Svetlana A. Chesnokova ◽  
Oksana O. Ustinova ◽  
Larisa A. Gaikova

Introduction. The term «chronic kidney disease» (CKD) is used to define the outcomes of various forms of chronic progressive kidney disease, characterized by kidney damage, or a decrease in their function for three months or more, regardless of the nosological diagnosis. The aim of the work was to determine the frequency, structure, and clinical and paraclinical features of CKD in children to substantiate the principles of its management in primary health care. Results. In CKD patients, tubulointerstitial renal lesions were established to prevail (80%). Associated with congenital malformations of the urinary system, reflux uropathy, and urolithiasis in 98% of cases tubulointerstitial renal lesions are complicated by renal infection. In 8.9% of children, CKD was formed as an outcome of glomerulopathies; in 6.7% of children - with congenital and hereditary nephropathies; in 4.4% of children an outcome of a hemolytic uremic syndrome. The observed children dominated by I-II (74.3%), less often III and IV (25.7%) stages of CKD. The revealed clinical and paraclinical features of CKD in children are presented. The modern principles of early diagnosis of CKD in children and the identification of risk factors for the progression of nephropathy have been substantiated. For the diagnosis of CKD in childhood there has been created a. n algorithm, including at the outpatient stage. Authors suggested a set of measures for the prevention of nephropathy. Conclusion. For early diagnosis of CKD in childhood there was developed an algorithm based on the analysis of a complex of clinical and paraclinical, structural and functional parameters of the kidneys in combination with the parameters of endothelial function and cytokine status.

Nephrology ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 308-315 ◽  
Author(s):  
Hywel Lloyd ◽  
Grace Li ◽  
Andrew Tomlin ◽  
Murray W Tilyard ◽  
Robert Walker ◽  
...  

2020 ◽  
Author(s):  
Zaher Nazzal ◽  
Zakaria Hamdan ◽  
Donia Masri ◽  
Oday Abu-Kaf ◽  
Mohammad Hamad

Abstract Background Chronic kidney disease (CKD) is a worldwide public health problem and diabetes is one of major risk factor for its development and progression. The aim of this study is to assess the prevalence of chronic kidney disease in a cross-sectional population of patients with type 2 diabetes treated in primary health care centers in North West Bank. Methods Patients’ data including patient characteristics, creatinine level, blood pressure, HbA1c, and hypertension and diabetes duration was collected from primary health care centers. eGFR was calculated using the CKD-EPI equation. CKD was staged according to the Kidney Disease Improving Global Outcomes System (KDIGO) 2012 guidelines. Both univariate and multivariate statistical analysis was conducted using SPSS. Results The prevalence of chronic kidney disease among diabetic adults in North West Bank was found to be 23.6% (95% CI: 19.4%-28.1%) distributed as follows: 19.7% had stage 3 CKD, 2.6% had stage 4 CKD and 1.3% had stage 5 CKD. In multivariate logistic regression, CKD was significantly associated with hypertension [adjusted OR= 4.43, P value=0.005], smoking [adjusted OR= 2.1, P value=0.01], and age [adjusted OR= 1.1, P value <0.001] Conclusions CKD is highly prevalent among Palestinian diabetic adults. Co-morbid hypertension, smoking and older age were found to increase the probability of developing this condition. Intensive screening for diabetic patients to detect CKD at earlier stages and implementation of more aggressive treatment modalities for diabetes as well as other important risk factors, especially hypertension and smoking are recommended.


Author(s):  
G. R. Muratov ◽  
T. F. Kolibaeva ◽  
I. V. Sorokina ◽  
M. S. Myroshnychenko

Urinary system pathology in children now is one of the most important problems of medical science. The aim of this study – to analyze the morbidity and reveal the risk factors for development of urinary system diseases in children of Kharkiv region. Materials and methods. The material of the study was the information (gender, age, weight and body length at birth, gestational age, clinical diagnosis), obtained during hospitalization of 663 patients aged from 3 months to 17 years in the nephrological center of Kharkiv regional children clinical hospital during the period from 2012 to 2013 years. Results. The authors found that in children population of Kharkiv region among all diseases of urinary system a significant number of cases occur in congenital malformations, dismetabolic nephropathy, urolithiasis. Conclusions. Regional risk factors for development of urinary system pathology in children are female and living in the village. Decreased weight and body length at birth are risk factors for development in children urinary system congenital malformations.


1980 ◽  
Vol 61 (6) ◽  
pp. 22-24
Author(s):  
G. P. Petrova ◽  
I. Sh. Trofimova ◽  
M. S. Halitova

The territorial-nesting method examined 3000 children. 84 of them (2.8%) had diseases of the urinary system. Most of the patients are girls (70). Urenal infection prevailed (76 children). In 71 children, kidney damage was detected for the first time during the examination. An unfavorable prenatal period of child development, a hereditary predisposition to kidney disease, hereditary allergic burden, and allergic reactivity in children are the most significant risk factors for urinary system disease in childhood.


2020 ◽  
Author(s):  
Zaher Nazzal ◽  
Zakaria Hamdan ◽  
Donia Masri ◽  
Oday Abu-Kaf ◽  
Mohammad Hamad

Abstract Background: Chronic kidney disease (CKD) is a global public health concern and diabetes is one of the main risk factors for its occurrence and progression. The aim of this research is to determine the prevalence of chronic kidney disease in a cross-sectional population of patients with type 2 diabetes in primary health centers in North West Bank.Methods: Patient data including patient characteristics, creatinine level, blood pressure, HbA1c, and hypertension and period of diabetes were obtained from primary health care centers. The eGFR has been determined using the CKD-EPI equation. CKD was staged according to the 2012 Kidney Disease Improving Global Outcomes Framework (KDIGO) guideline. Both univariable and multivariable statistical analysis was conducted using SPSS. Results: The prevalence of chronic kidney disease among diabetic adults in North West Bank was found to be 23.6% (95% CI: 19.4%-28.1%) divided as follows: 19.7% had stage 3 CKD, 2.6% had stage 4 CKD and 1.3% had stage 5 CKD. In multivariable logistic regression, CKD was significantly associated with Age ≥60 years [adjusted OR: 3.2, 95% CI: 1.8-5.9], hypertension [adjusted OR: 5.7, 95% CI: 2.2-15.2], and smoking [adjusted OR: 2.3, 95% CI: 1.3-4.2].Conclusions: CKD is very prevalent among diabetic adults in Palestine. Co-morbid hypertension, smoking and older age has been shown to increase the risk of developing CKD. Extensive screening for diabetic patients to diagnose CKD at an early stage and to follow more aggressive treatment methods for diabetes as well as other important risk factors, especially hypertension and smoking, is recommended.


2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Zaher Nazzal ◽  
Zakaria Hamdan ◽  
Dunia Masri ◽  
Oday Abu-Kaf ◽  
Mohammad Hamad

Abstract Background Chronic kidney disease (CKD) is a global public health concern and diabetes is one of the main risk factors for its occurrence and progression. The aim of this research is to determine the prevalence of chronic kidney disease in a cross-sectional population of patients with type 2 diabetes in primary health centers in North West Bank. Methods Patient data including patient characteristics, creatinine level, blood pressure, HbA1c, and hypertension and period of diabetes were obtained from primary health care centers. The eGFR has been determined using the CKD-EPI equation. CKD was staged according to the 2012 Kidney Disease Improving Global Outcomes Framework (KDIGO) guideline. Both univariable and multivariable statistical analysis was conducted using SPSS. Results The prevalence of chronic kidney disease among diabetic adults in North West Bank was found to be 23.6% (95% CI: 19.4–28.1%) divided as follows: 19.7% had stage 3 CKD, 2.6% had stage 4 CKD and 1.3% had stage 5 CKD. In multivariable logistic regression, CKD was significantly associated with Age ≥ 60 years [adjusted OR: 3.2, 95% CI: 1.8–5.9], hypertension [adjusted OR: 5.7, 95% CI: 2.2–15.2], and smoking [adjusted OR: 2.3, 95% CI: 1.3–4.2]. Conclusions CKD is very prevalent among diabetic adults in Palestine. Co-morbid hypertension, smoking and older age has been shown to increase the risk of developing CKD. Extensive screening for diabetic patients to diagnose CKD at an early stage and to follow more aggressive treatment methods for diabetes as well as other important risk factors, especially hypertension and smoking, is recommended.


2019 ◽  
Vol 23 (5) ◽  
pp. 29-46
Author(s):  
A. A. Vyalkova ◽  
I. V. Zorin ◽  
S. A. Chesnokova ◽  
S. V. Plotnikova

The goal is to discuss the criteria for the early diagnosis of chronic kidney disease (CKD) in children. The article presents data from modern literature on the epidemiology, classification, and criteria for the diagnosis of CKD, own scientific results on clinical and paraclinical characteristics of CKD and regional characteristics of CKD in children of the Orenburg region. Modern approaches to the early diagnosis of CKD in children, the identification of risk factors for the progression of nephropathy and the algorithm for the diagnosis of CKD in childhood, taking into account unfavorable regional factors, are scientifically substantiated. A set of measures for the prevention of nephropathy and a scheme of follow-up observation of children at high risk has been developed. The ways to improve the children's nephrology service are substantiated. Modern pathogenetic approaches to the diagnosis of CKD in children are presented. An algorithm for diagnosing the initial stages of CKD in children at risk for CKD and children with renal pathology without CKD with a preliminary selection of anamnestic and clinical and paraclinical indicators is proposed.


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