scholarly journals Prevalence of Various Sign and Symptoms of Diabetic Peripheral Neuropathy

BioSight ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 24-30
Author(s):  
Kahkshan Asif ◽  
Qurat ul ain
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Large Scale ◽  
Health Management ◽  
Clinical Findings ◽  
Foot Ulcers ◽  
Foot Care ◽  
Relative Deficiency

BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic syndrome marked by hyperglycemia due to absolute or relative deficiency of insulin hormone. Diabetic neuropathy is a complication of both type 1 and type 2 diabetes. Although pain is one of the most dominant symptoms of diabetic neuropathy, its pathophysiological mechanisms yet unknown. Toxic effects of high glucose levels play an important role in the development of this complication. METHODOLOGY: Data was collected through the questionnaire regarding Clinical findings, medical records, weight, age, family history, different habits, and psychogenic behavior. All the patients with the mentioned diseases are included in this study, excluding the mentally ill patients and the pregnant women. RESULT:  The result of the present study showed that diabetic neuropathy is the most common complication of diabetes mellitus. It has been observed that most of the patients due to lack of awareness are suspected to the elevated or extreme blood sugar level which leads to neuropathy. Due to the Diabetic Peripheral Neuropathy (DPN) most of the patients suffering from foot problems, foot ulcers and then amputations. Lack of awareness, lack of health management, obesity, blood pressure changes, less care plays a key role in increasing the chances of diabetic neuropathy. COCLUSION: Diabetic neuropathy had very bad influence on a person’s health and daily activities. The Patient education programs need to emphasize on large scale. The ultimate aim of this study is the foot care education for people with the diabetes and to prevent foot ulcers and amputation.

scholarly journals Effects of sensory stimulation on balance and postural control in diabetic neuropathy: systematic review

2021 ◽  
Vol 9 (7) ◽  
pp. 2090
Author(s):  
Hetal S. Giri ◽  
Pradeep Borkar
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Postural Control ◽  
Diabetic Peripheral Neuropathy ◽  
Sensory Stimulation ◽  
Noncommunicable Disease ◽  
Type I ◽  
Significant Difference

Diabetic peripheral neuropathy is a complication of Diabetes Mellitus and is the most common noncommunicable disease. It involves decreases in the sensations and Lower extremity strength leading to reduce dynamic stability in balance and postural control. The purpose of the study is to review the effects of sensory stimulation interventions on Balance and Postural control in Diabetic peripheral neuropathy. A systematic review was conducted following the centers for Goggle scholar, PUBMED and science direct database using the keywords Sensory Stimulation, Balance, Postural control, Diabetic neuropathy. The time frame of the search was from 2006 to 2021. The review resulted in search of 18 articles with duration from 1 day to 26 weeks with a total population of 1,422 diabetes Mellitus type I and type II patients from the year 2006 to 2021. There were strong evidences of effects of sensory stimulation on postural control and Balance with noticeable difference in DPN. Based on our analysis results, most of the study stated that Vibration, Plantar Massages, Kinesiotaping, Rocker shoe, Vibromedical insole, Conventional exercises with proprioception stimulation, Mechanical noise have shown significant difference on balance and postural control. Whereas, offloading devices did not show any remarkable variance. The currently existing studies require a clear recommendation on whether which intervention is more effective. Thus, longer duration studies are required to improve balance and postural control in Diabetic Neuropathy.

scholarly journals Diagnosis and rational treatment of painful diabetic peripheral neuropathy: an interdisciplinary expert consensus

2019 ◽  
Vol 22 (4) ◽  
pp. 305-327
Author(s):  
Gagik R. Galstyan ◽  
Elena G. Starostina ◽  
Nikolay N. Yakhno ◽  
Irina V. Gurieva ◽  
Maxim V. Churyukanov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Clinical Guidelines ◽  
Diabetic Peripheral Neuropathy ◽  
Large Scale ◽  
Well Being ◽  
Epidemiological Studies ◽  
Painful Diabetic Peripheral Neuropathy ◽  
Chronic Complication ◽  
Rational Therapy

Diabetic peripheral neuropathy is a common chronic complication of diabetes mellitus, significantly impairing well-being, quality of life and functioning of patients. The prevalence of diabetic peripheral neuropathy in the Russian Federation ranges from 0.1% to 67.2% in type 1 and from 0.1 to 42.4% in type 2 diabetes mellitus. However, based on the large-scale epidemiological studies, the true prevalence of diabetic peripheral neuropathy is much higher (50 to 70%), with its painful variant occurring in 16% to 30% of patients. Despite the fact that diabetic peripheral neuropathy remains the most common chronic complication of diabetes mellitus, its diagnosis and therapy leave much to be desired. To optimize diagnostic and treatment approaches to painful diabetic peripheral neuropathy, a group of experts representing the leading Russian professional medical associations has developed clinical guidelines for the diagnosis and rational therapy of patients with painful diabetic peripheral neuropathy. This document presents practical aspects of the clinical diagnosis of painful diabetic peripheral neuropathy and an algorithm for differential diagnosis of pain in the lower extremities in patients with diabetes mellitus. The use of symptomatic analgesics with central action, such as anticonvulsants, antidepressants and opioids, is based on the main aspects of neuropathic pain pathophysiology. The characteristics of each drug class are given, with consideration of evidence on their efficacy, tolerability, and the possibility of combination therapy. The data on the first, second, and third lines of agents is presented in accordance with several international clinical guidelines. The need for a tailored drug choice, taking into account the evidence-based data on their efficacy and safety, concomitant drug therapy, tolerability, cost and preferences of the patient, age of the patient and concomitant disorders, is emphasized.

scholarly journals Understanding the Signaling Pathways Related to the Mechanism and Treatment of Diabetic Peripheral Neuropathy

Endocrinology ◽  
2019 ◽  
Vol 160 (9) ◽  
pp. 2119-2127 ◽  
Author(s):  
He-yong Tang ◽  
Ai-juan Jiang ◽  
Jun-long Ma ◽  
Fan-jing Wang ◽  
Guo-ming Shen
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Pain Management ◽  
Signaling Pathways ◽  
Diabetic Peripheral Neuropathy ◽  
Metabolic Disorder ◽  
Signaling Cascades ◽  
Foot Ulcers ◽  
Molecular Signaling ◽  
Important Condition

Abstract Worldwide, the most prevalent metabolic disorder is diabetes mellitus (DM), an important condition that has been widely studied. Diabetic peripheral neuropathy (DPN), a complication that can occur with DM, is associated with pain and can result in foot ulcers and even amputation. DPN treatments are limited and mainly focus on pain management. There is a clear need to develop treatments for DPN at all stages. To make this progress, it is necessary to understand the molecular signaling pathways related to DPN. For this review, we aimed to concentrate on the main signaling cascades that contribute to DPN. In addition, we provide information with regard to treatments that are being explored.

scholarly journals Ayurvedic review on diabetic peripheral neuropathy

2021 ◽  
Vol 2 (1) ◽  
pp. 65-69
Author(s):  
Sarita Bajagain ◽  
Shiv Mangal Prasad
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Hospital Stay ◽  
Diabetic Peripheral Neuropathy ◽  
Limb Amputation ◽  
Foot Ulcers ◽  
Effective Management ◽  
Major Health ◽  
Depth Study ◽  
Major Health Issue

Diabetes mellitus is a major health issue in today's world. Main threat is not the disease itself but its complications like nephropathy, retinopathy and neuropathy etc. Diabetic peripheral neuropathy is one of the earliest complications which has the highest prevalence of about 40-50% and is becoming the leading cause of hospital stay among diabetic mallitus and also the leading cause of foot ulcers, their complications like limb amputation and cost associated with it. Madhumeha which has been described as 'Maharogas' i.e. difficult to treat disease has many similarities with Diabetes mellitus can be understood and studied as same disease. Ayurveda has mentioned the causes, pathophysiology and symptoms of DPN as 'karapada daha -suptata' in purvarupa lakshanas and upadrava lakshanas but in  scattered form. Applying the ayurveda principals in diagnosis and management of diabetes mellitus and its complications like DPN can considerably reduce the chance of foot ulcers, and its consequences. But it needs depth study to understand the concept of DPN so as to form an effective management protocal.

Large-Scale DNA Methylation Profiling of Human Diabetic Peripheral Neuropathy in Subjects with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 551-P
Author(s):  
KAI GUO ◽  
SARAH ELZINGA ◽  
STEPHANIE EID ◽  
CLAUDIA FIGUEROA-ROMERO ◽  
BRETT A. MCGREGOR ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Large Scale ◽  
Dna Methylation Profiling ◽  
Methylation Profiling

Vitamin D Status in a Bulgarian Population With Type 2 Diabetes and Diabetic Foot Ulcers

2020 ◽  
pp. 153473462096582
Author(s):  
Ani S. Todorova ◽  
Edward B. Jude ◽  
Rumyana B. Dimova ◽  
Nevena Y. Chakarova ◽  
Mina S. Serdarova ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Diabetic Foot ◽  
Diabetic Peripheral Neuropathy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Vitamin D Status ◽  
Active Infection

The aim of this study was to assess vitamin D status in patients with type 2 diabetes and diabetic foot ulcers (DFU). A total of 242 participants with type 2 diabetes, mean age 59.1 ± 10 years, mean body mass index 31.4 ± 6.3 kg/m2, and estimated glomerular filtration rate ≥45 mL/min/1.73m2, were divided into 2 groups: 73 with DFU (35 with and 38 without active infection) and 169 without DFU (106 with diabetic peripheral neuropathy, 63 without complications). Neuropathy was assessed by 10 g monofilament, Rydel-Seiffer 128 Hz tuning fork, and temperature discrimination. Serum 25(OH)D (25-hydroxy vitamin D) was assessed by ECLIA (electro-chemiluminescence immunoassay) method. Median 25(OH)D level was 12.6 ng/mL (IQR [interquartile range] 9.3-17.6 ng/mL) in the studied cohort. The DFU group presented with lower 25(OH)D level as compared with diabetic patients without foot ulcers (non-DFU group): 11.6 ng/mL (IQR 8.5-15.8 ng/mL) versus 13.5 ng/mL (IQR 9.6-18.6 ng/mL), P = .001; the diabetic peripheral neuropathy subgroup demonstrated lower 25(OH)D level in comparison with participants without complications: 12.5 ng/mL (IQR 9-17.2 ng/mL) versus 15.9 ng/mL (IQR 10.4-20.8 ng/mL), P = .031. This remained significantly different even after correction for age and duration of diabetes. There was no difference in 25(OH)D level between the subgroups according to the presence of active infection. In conclusion, vitamin D deficiency may play a role in the development of diabetes complications.

scholarly journals Diabetic Peripheral Neuropathy and its Association with Diabetes Self-care: A Clinic-based Study in an Urban Health Centre, Kolkata

2021 ◽  
Author(s):  
Mukesh Kumar ◽  
Bobby Paul ◽  
Aparajita Dasgupta ◽  
Lina Bandyopadhyay ◽  
Soumit Roy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Scale Score ◽  
Urban Health ◽  
Diabetic Peripheral Neuropathy ◽  
West Bengal ◽  
Self Care ◽  
Self Management ◽  
Health Clinic ◽  
Training Centre

Introduction: Diabetes mellitus is considered as silent epidemic worldwide including India. Peripheral neuropathy is one of the most common complications of diabetes mellitus. Diabetes Self-Management (DSM) is crucial in mitigating the afflictions of diabetes and it’s after effects. There was dearth of studies in view of Diabetic Peripheral Neuropathy (DPN) and diabetes self-management in Kolkata, West Bengal. Aim: To assess the associations between diabetes self-management and DPN in Type 2 Diabetes Mellitus (T2DM) patients attending an urban health clinic in Kolkata. Materials and Methods: This study was conducted from December 2018 to March 2019 among known case of T2DM patients aged 30 years and above attending the Non-Communicable Disease (NCD) clinic at Chetla, under the purview of field practice areas of Urban Health Unit and Training centre (UHU and TC) of All India Institute of Hygiene and Public Health (AIIH and PH) Kolkata, West Bengal. A pre-designed and pre-tested schedule was used to collect data which were analysed using International Business Machines Statistical Product and Service Solutions (IBM SPSS) version 16.0 and represented using various tables. Results: The mean (SD) age of the participants was 54.89 (8.98) years. About 32.4% of the patients had DPN which was significantly associated with increased duration of T2DM {AOR (95% CI)}={1.52 (1.22-1.91)}, lower glucose management sub-scale score {AOR (95% CI)}={2.84 (1.42-5.67)} and lower healthcare use sub-scale score {AOR (95% CI)}={1.86 (1.05-3.31)}. Conclusion: Early screening and education regarding diabetes self-care would be helpful in glycaemic control and in prevention of DPN.

scholarly journals The Changes of Nerve Growth Factor Serum Levels After External Muscle Stimulation and The Correlation with Diabetic Neuropathy Symptom in Diabetic Peripheral Neuropathy

2017 ◽  
Vol 6 (01) ◽  
pp. 7
Author(s):  
Dian Herdiansyah ◽  
Marina Annete Moeliono ◽  
Tertianto Prabowo
Keyword(s):  
Nerve Growth Factor ◽  
Peripheral Neuropathy ◽  
Growth Factor ◽  
Diabetic Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Significant Negative Correlation ◽  
Muscle Stimulation ◽  
Study Objective ◽  
Nerve Growth ◽  
Before And After

Background: Diabetic Peripheral neuropathy (DPN) is a common complication of diabetes mellitus. Recentstudies have demonstrated the involvement of Nerve growth factor (NGF) in the occurrence of DPN. TheDiabetes Mellitus was caused reduced the number and disruption of the function of the NGF. External MuscleStimulation (EMS) might be induced the NGF synthesis. The study objective has to found the effect of EMSon the NGF.Methods: Study design was before and after treatment without control on subjects with DPN. The bloodsample was taken before and after an intervention, as well as the Diabetic Neuropathy symptom (DNSym) andscore (DNSc). The EMS treated all of the participants within three times a week for four weeks.Results: There were 35 subjects were participated. Paired t-test showed a significant increase in NGF serumlevels and decrease both DNSym and DNSc with the difference value 12.64 ± 16.09 (p=0.000), 1.23 ± 0.82(p=0.000), 1.20 ± 0.85 (p=0.000). There was a significant negative correlation between NGF serum level withthe DNS- INA (r= -0.56; p=0.001) and the DNE-INA (r= -0.48; p=0.007).Conclusion: EMS treatment can increase serum NGF level. EMS has a strong correlation with a decrease inthe value of the DNS-INA and DNE-INA.Keywords: Diabetic Peripheral neuropathy, External Muscle Stimulation, Nerve Growth Factor.

scholarly journals PENGARUH AKUPUNKTUR JIN’S 3 NEEDLE TERHADAP PENURUNAN INTENSITAS NYERI DIABETIC NEUROPATHY PERIFER

2020 ◽  
Vol 4 (1) ◽  
pp. 46-51
Author(s):  
Leny Candra Kurniawan ◽  
Ikhwan Abdullah
Keyword(s):  
Peripheral Neuropathy ◽  
Side Effects ◽  
Diabetic Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Fibers ◽  
Significance Level ◽  
Peripheral Diabetic Neuropathy ◽  
Study Population ◽  
Sugar Levels ◽  
Needle Acupuncture

Diabetic Peripheral Neuropathy is a type of nerve damagethat occurs due to diabetes. High blood sugar levels in thelong term can cause damage to nerve fibers throughout thebody, such as legs, feet, blood circulation, heart, digestivesystem, and urinary tract. Diabetic Peripheral Neuropathy isa serious complication of diabetes that often causes pain inthe limbs. Pain management Diabetic Peripheral Neuropathyis usually by administering pain medication for a long periodof time. These medicines will have side effects. The use ofacupuncture as an alternative to help reduce the intensity ofpain in peripheral diabetic neuropathy has proven to beeffective and relatively without side effects. The advantage ofacupuncture therapy is that it has relatively no side effects.The general aim of this study is to reduce the intensity of painin peripheral neuropathy. The research design usesquantitative methods. The study population was all patientswith peripheral neuropathy who visited the Harmoni HealthyClinic in March-May 2019. The sampling method used wasaccidental sampling. The benefits of this study provide analternative for DM sufferers to reduce the intensity ofneuropathic pain naturally with acupuncture without fear.side effects. From the results of this study it is known thatthere is an influence of Jin’s Three Needle acupuncture inreducing the intensity of pain in Peripheral Neuropathy.Calculations using statistical SPSS 21 with paired sample ttest obtained significant results (0.00) from the value of α(0.05), then H1 is accepted. So with a significance level of5%, it can be concluded that Jin's Three Needle acupuncturecan reduce the intensity of pain in diabetic peripheralneuropathy

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