scholarly journals MIRACLE AYURVEDIC HERB - ASHWAGANDHA (WITHANIA SOMNIFERA DUNAL)

2021 ◽  
Vol 9 (8) ◽  
pp. 1778-1788
Author(s):  
Bargale Sushant Sukumar
Keyword(s):  
Withania Somnifera ◽  
Chemical Constituents ◽  
Immunomodulatory Activity ◽  
Indian Ginseng ◽  
Aerial Parts ◽  
Wide Range ◽  
The World ◽  
Anti Inflammatory ◽  
Ayurvedic Herb ◽  
Present World

Ayurveda is successfully implemented as a primary healthcare system in India, and it is flourishing in the promotion of health around the world. Ayurveda aims to create a society happily, healthy, and peaceful. In general, the simple regimes mentioned in Ayurveda texts are of immense use faced by the present world today regarding health pro- motion. Ashwagandha (Withania Somnifera) is usually referred to as 'Indian winter cherry' or 'Indian Ginseng'. It is a shrub grown in India and North America whose roots have been used by Ayurvedic practitioners for thousands of years. Ashwagandha is one of Ayurveda's most essential herbs, used as Rasayana for its wide range of health benefits for centuries. Chemicals constitute of Ashwagandha (Withania Somnifera)- The chemistry of Ashwagan- dha (Withania Somnifera) has been widely studied and numerous categories of chemical constituents have been described, extracted, and isolated, such as steroidal lactones, alkaloids, flavonoids, tannin, etc. More than 12 alka- loids, 40 withanolides and several sitoindosides have currently been isolated from the aerial parts, roots, and berries of the Withania species and have been recorded. The principal biochemical element of Ashwagandha (WS) root is withanolides, which are steroidal alkaloids and steroidal lactones. The pharmacological activity of Ashwagan- dha- It has been shown to have pharmacological importance as an Adaptogen, Antibiotic, abortifacient, aphrodisiac, Astringent, Anti-inflammatory, deobstructive, diuretic, narcotic, sedative, and tonic through centuries of Ayurvedic medicinal practice using Ashwagandha (Withania Somnifera). Along with these Ashwagandha acts as Anti-stress,Anticarcinogenic activity, Anti-inflammatory activity, Anti-aging activity, Cardioprotective activity, hypothyroid activity and Immunomodulatory activity. Keywords: Ashwagandha, Withania Somnifera, Alkaloids, Withanoids, sitoindosides

scholarly journals Pharmacological perspectives and phytochemical reservoir of Withania somnifera: A review

2021 ◽  
Vol 1 (1) ◽  
pp. 06-14
Author(s):  
Yashdeep Srivastava ◽  
◽  
Swati Upadhyay ◽  
Pankaj Gupta
Keyword(s):  
Withania Somnifera ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Human Life ◽  
The Body ◽  
Neuroprotective Activity ◽  
Immunomodulatory Activity ◽  
Indian Ginseng ◽  
Anti Cancer ◽  
Mental And Physical Health

Plants have always been an indispensable part of human life since the beginning of human civilisation. Withania somnifera (L.) DUNAL, popularly known as Wintercherry or Indian Ginseng, is widely considered as Ashwagandha. In Ayurveda, it is classified as a Rasayana (rejuvenation) and projected to promote mental and physical health, rejuvenate the body in debilitated conditions and increase longevity. Due to its beneficial chemical constituents, the herb possesses a broad spectrum of biological activities and is used to treat a variety of diseases affecting human health. These include Cardioprotective activity, Anti-cancer activity, Immunomodulatory activity, Neuroprotective activity, Antimicrobial activity, Anti-stress activity,Anti-diabetic activity and Anti-inflammatory activity. The present review discusses the pharmacological importance of Withania somnifera and its important constituents.

scholarly journals Chemical Constituents of the Aerial Parts of Scoparia dulcis and Anti-cancer, Anti-inflammatory Activities

2019 ◽  
Vol 544 ◽  
pp. 012029
Author(s):  
Nguyen Ngoc Thanh Tin ◽  
Nguyen Dang Thanh Truc ◽  
Hoang Thi Thu Hang ◽  
Pham Thi Nhat Trinh ◽  
Tri Duc Lam ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Scoparia Dulcis ◽  
Aerial Parts ◽  
Anti Cancer ◽  
Anti Inflammatory

scholarly journals Chemical Constituents from Farfugium Japonicum Var. formosanum

2012 ◽  
Vol 7 (4) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Sung-Fei Hsieh ◽  
Tain-Jye Hsieh ◽  
Mohamed El-Shazly ◽  
Ying-Chi Du ◽  
Chin-Chung Wu ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Cancer Cell Line ◽  
Inflammatory Activity ◽  
Human Neutrophils ◽  
Spectral Techniques ◽  
Methanolic Extracts ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Farfugium Japonicum ◽  
First Time

Two new eremophilenolides, 6β8β10β-trihydroxyeremophil-7(11)-en-12,8-olide (1) and 3βacetoxy-8α-hydroxy-6β-methoxyeremophila-7(11),9-dien-12,8-olide (2) along with twenty-nine other compounds were obtained from the methanolic extracts of the aerial parts and rhizomes of Farfugium japonicum (L.) Kitam. v ar. formosanum (Hayata) Kitam. (Compositae = Asteraceae). The structures of the isolated compounds were characterized and identified by spectral techniques. Compounds 5, 6, 10, 12-24, 29, and 30, were reported for the first time from this genus. Cytotoxicity and anti-inflammatory activity of the isolated compounds were evaluated. Compounds 3 and 16 possessed moderate cytotoxicity against human breast cancer cell line (MCF 7). Compounds 3, 16, 25 and 26 exhibited moderate cytotoxicity against hepatoma cells (Hep G2 and Hep 3B). With respect to the anti-inflammatory activity, compounds 15 and 16 (each 10 μg/mL) inhibited superoxide anion generation by human neutrophils in response to fMLP/CB by 92.0% and 87.3%, respectively.

scholarly journals Solidago virgaurea L.: A Review of Its Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activities

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1619
Author(s):  
Cornelia Fursenco ◽  
Tatiana Calalb ◽  
Livia Uncu ◽  
Mihaela Dinu ◽  
Robert Ancuceanu
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Inflammatory Agent ◽  
Aerial Parts ◽  
Solidago Virgaurea ◽  
Clinical Models ◽  
Potential Benefits ◽  
Anti Inflammatory ◽  
Ethnomedicinal Uses ◽  
Published Research

Solidago virgaurea L. (European goldenrod, Woundwort), Asteraceae, is a familiar medicinal plant in Europe and other parts of the world, widely used and among the most researched species from its genus. The aerial parts of European goldenrod have long been used for urinary tract conditions and as an anti-inflammatory agent in the traditional medicine of different peoples. Its main chemical constituents are flavonoids (mainly derived from quercetin and kaempferol), C6-C1 and C6-C3 compounds, terpenes (mostly from the essential oil), and a large number of saponin molecules (mainly virgaureasaponins and solidagosaponins). Published research on its potential activities is critically reviewed here: antioxidant, anti-inflammatory, analgesic, spasmolitic, antihypertensive, diuretic, antibacterial, antifungal, antiparasite, cytotoxic and antitumor, antimutagenic, antiadipogenic, antidiabetic, cardioprotective, and antisenescence. The evidence concerning its potential benefits is mainly derived from non-clinical studies, some effects are rather modest, whereas others are more promising, but need more confirmation in both non-clinical models and clinical trials.

Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry

2020 ◽  
Vol 6 (1) ◽  
pp. 13-23
Author(s):  
Reyaz Hassan ◽  
Mubashir Hussain Masoodi
Keyword(s):  
Biological Activity ◽  
Adverse Effects ◽  
Chemical Constituents ◽  
Literature Survey ◽  
Perennial Herb ◽  
Comprehensive Review ◽  
Saussurea Lappa ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Inflammatory

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke which is perennial herb and has been traditionally used as anticancer, anti-inflammatory, antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, anti-inflammatory, anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone, dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical constituents. This review aims to cover published work from public databases (e.g. PubMed, Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina, Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Saussurea lappa.

scholarly journals Zuccagnia punctata: A Review of its Traditional Uses, Phytochemistry, Pharmacology and Toxicology

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
María Inés Isla ◽  
María Alejandra Moreno ◽  
Gabriela Nuño ◽  
Fabiola Rodriguez ◽  
Antonella Carabajal ◽  
...  
Keyword(s):  
Comprehensive Overview ◽  
Herbal Medicinal Products ◽  
Traditional Medicines ◽  
Traditional Uses ◽  
Aerial Parts ◽  
Wide Range ◽  
History Of ◽  
Anti Inflammatory ◽  
History Of Use ◽  
Chemical Groups

Zuccagnia punctata Cav. (Fabaceae, Caesalpiniaceae) is a plant with a long history of use in Argentine traditional medicines; it belongs to a monotypic genus, and is an endemic species of Argentina. This review provides a comprehensive overview of the traditional uses, phytochemistry, pharmacological activity and toxicology of Z. punctata. A wide range of traditional uses are cited in the literature such as antibacterial, antifungal, anti-inflammatory, and antitumor, among others. Pharmacological studies to date have demonstrated significant activities that support the traditional uses of this plant. No human clinical trials had been completed up to the time of this review and no toxic effect had been detected in animals. Compounds from different chemical groups have been isolated such as phenolic compounds and essential oils. Plant extracts and phytochemicals isolated exhibit a broad range of activities, anti-inflammatory, antibacterial, antifungal, antigenotoxic, antioxidant, antiulcer, and nematicidal. The main bioactive phytochemicals in the aerial parts (leaf, stem and flower) were identified as 2′, 4′-dihydroxy-3′-methoxychalcone and 2′, 4′-dihydroxychalcone and were proposed as chemical markers. Consequently, standardized dry extracts of aerial parts of Z. puntacta could be used in herbal medicinal products. Also, they could be included in phytotherapeutic preparations such as capsules, creams, and gels, and for microencapsulation.

Chemical constituents and anti-inflammatory activity of the aerial parts of Curcuma longa

2016 ◽  
Vol 26 ◽  
pp. 485-493 ◽  
Author(s):  
Dae Wook Kim ◽  
Seon Min Lee ◽  
Hyun Sim Woo ◽  
Ji-Young Park ◽  
Byoung Seob Ko ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Curcuma Longa ◽  
Inflammatory Activity ◽  
Aerial Parts ◽  
Anti Inflammatory

scholarly journals Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera)

Plants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 527 ◽  
Author(s):  
Su Cheol Baek ◽  
Seoyoung Lee ◽  
Sil Kim ◽  
Mun Seok Jo ◽  
Jae Sik Yu ◽  
...  
Keyword(s):  
Protein Expression ◽  
Withania Somnifera ◽  
No Production ◽  
Ionization Mass ◽  
Inos Protein ◽  
Bioactive Natural Products ◽  
Indian Ginseng ◽  
Ionization Mass Spectroscopy ◽  
Inos Protein Expression ◽  
Anti Inflammatory

Withania somnifera (L.) Dunal (Solanaceae), known as Indian ginseng or ashwagandha, has been used in Indian Ayurveda for the treatment of a variety of disorders, such as diabetes and reproductive and nervous system disorders. It is particularly used as a general health tonic, analgesic, and sedative. As part of continuing projects to discover unique bioactive natural products from medicinal plants, phytochemical investigation of the roots of W. somnifera combined with a liquid chromatography–mass spectrometry (LC/MS)-based analysis has led to the isolation of two novel phenylpropanoid esters, Withaninsams A (1) and B (2), as an inseparable mixture, along with three known phenolic compounds (3, 4, and 6) and a pyrazole alkaloid (5). The structures of the new compounds were elucidated using a combination of spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HR-ESIMS). Withaninsams A (1) and B (2) are phenylpropanoid esters that contain a side chain, 4-methyl-1,4-pentanediol unit. To the best of our knowledge, the present study is the first to report on phenylpropanoid esters with 4-methyl-1,4-pentanediol unit. The anti-inflammatory activity of the isolated compounds (1–6) was evaluated by determining their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, where compound 3 inhibited LPS-induced NO production (IC50 = 33.3 μM) and TNF-α production, a pro-inflammatory cytokine (IC50 = 40.9 μM). The anti-inflammatory mechanism through the inhibition of transcriptional iNOS protein expression was confirmed by western blotting experiments for the active compound 3, which showed decreased iNOS protein expression.

Pharmacological Potential of Natural Herbs against Covid-19: A Review

2021 ◽  
pp. 269-274
Author(s):  
Priyanka K. Shinde ◽  
Dattaprasad N. Vikhe ◽  
Ravindra S. Jadhav ◽  
Ganesh S. Shinde
Keyword(s):  
Withania Somnifera ◽  
Research Unit ◽  
Tinospora Cordifolia ◽  
Immunomodulatory Activity ◽  
Primary Case ◽  
The World ◽  
Prevention And Treatment ◽  
Anti Oxidant ◽  
Pharmacological Potential ◽  
Steroidal Lactone

The unknown coronavirus has been unfold all over within the world. The primary case was declared in Dec 2019, and this coronavirus malady has become a virulent disease. Infection of this virus is directly attacked on the system of the flesh or animals. Nowdays there’s a deficiency of correct management or vaccinum out there to stop this malady that principally attacks the system of body. Hindrance is healthier than cure. This term is extremely renowned to any or all people. Thus currently this time has come back to used for our savings of lives. Ayurveda is the ancient system of drugs which is originated in India. During this covid -19 amount boosting of our system is that the excellent thanks to fight against this corona virus. Many seasoning plants unit accessible in our shut that unit used for immunity boosting throughout Covid 19. Some seasoning plants like Tinospora cordifolia, Withania somnifera, Nyctanthes arbortristis that unit commonly used for immunity boosting. This herb contains compounds like glycosides, steroids, diterpenoid lactones, alkaloids, steroidal lactone,etc. vary of research unit accessible on Tinospora cordifolia, Ashwagandha, and Nyctanthes arbortristis to prove its immunomodulatory activity, anti-oxidant activity, anti- inflammatory activity, anti-pyretic activity. Throughout this general review we’ve a bent to targated on the role, drugs activities of Tinospora cordifolia, Withania somnifera, Nyctanthes arbortristis to prevention and treatment of COVID 19 or CORANA VIRUS infection.

GC-MS Analysis of Antibacterial Phytochemicals from Cassia sophera Linn

2020 ◽  
Vol 13 (5) ◽  
pp. 5131-5137
Author(s):  
Dr. Shyamal K. Jash ◽  
Dilip Gorai ◽  
Lalan Chandra Mandal ◽  
Sekhar Pal
Keyword(s):  
Chemical Constituents ◽  
Research Work ◽  
Enterobacter Aerogenes ◽  
Gas Chromatography Mass Spectrometry ◽  
Gram Negative Bacteria ◽  
Research Groups ◽  
Gram Positive Bacteria ◽  
Aerial Parts ◽  
Ms Analysis ◽  
The World

Cassia sophera Linn (Leguminosae) plants are widely distributed worldwide, and find immense applications in traditional systems of medicine in many countries. The plant has been partly explored by various research groups in the world. In our present study, two oils (OL-1 & OL-2) from aerial parts and roots of Cassia sophera have been evaluated by GC/MS using Perkin-Elmer Gas Chromatography–Mass Spectrometry and comparison of spectral data with the existing in National Institute of Standards and Technology (NIST) library. GC/MS analysis of the two oils revealed the presence of a number of chemical constituents. Again, the isolated oils exhibited considerable antibacterial activity against two Gram positive bacteria viz. Bacillus megaterium & Staphylococcus aureus and two Gram negative bacteria viz. Escherichia coli & Enterobacter aerogenes. Therefore, the present study will definitely inspire the researchers engaged in this direction to undertake further research work on this plant for searching new lead molecules

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