scholarly journals Preliminary Study on the Homeostatic Role of Organic Silicon and Trace Elements for Osteoarticular Well-Being

2021 ◽  
Vol 3 (2) ◽  
pp. 1-6
Author(s):  
Bruno Riccardi ◽  
◽  
Sergio Resta ◽  
Rita Storelli ◽  
◽  
...  
Keyword(s):  
Clinical Trials ◽  
Trace Elements ◽  
Well Being ◽  
Organic Silicon ◽  
Prevention And Treatment ◽  
Preliminary Study

Numerous evidence and clinical trials have been published in recent years on the role of silicon for the maintenance of general well-being and of bones in particular. However, no study has so far investigated which fundamental contribution to health could provide silicon when taken with other trace elements in cases, very frequent, of their insufficient contribution. In this work we present a preliminary open-air study on a group of patients, using an original and innovative formulation containing organic SI G5 plus other trace elements, for the prevention and treatment of osteoarticular diseases of various origins.

scholarly journals Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

2021 ◽  
Vol 10 (13) ◽  
pp. 2903
Author(s):  
Jiezhong Chen ◽  
Luis Vitetta
Keyword(s):  
Clinical Trials ◽  
Trace Elements ◽  
Gut Microbiota ◽  
Human Health ◽  
Intestinal Microbiota ◽  
Narrative Review ◽  
Bacterial Metabolites ◽  
Gut Dysbiosis ◽  
Prevention And Treatment

The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms.

scholarly journals Role of Factor Xa Inhibitors in Cancer-Associated Thrombosis: Any New Data?

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Ali Zalpour ◽  
Michael H. Kroll ◽  
Vahid Afshar-Kharghan ◽  
Syed Wamique Yusuf ◽  
Carmen Escalante
Keyword(s):  
Clinical Trials ◽  
Cancer Patients ◽  
Anticoagulation Therapy ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
The Us ◽  
Prevention And Treatment ◽  
Cancer Associated Thrombosis ◽  
Current Guidelines

The association between cancer and venous thromboembolism (VTE) has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative. Typically, the mainstay regimen for VTE prevention and treatment has been anticoagulation therapy, unless contraindicated. This therapy consists of unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), factor Xa inhibitor, or vitamin K antagonist (VKA). Current guidelines recommend LMWH over VKA for the treatment of VTE in cancer patients. Factor-specific anticoagulants have been proven safe and effective, and recently factor Xa inhibitors have emerged as a treatment alternative to heparins and VKA. Currently, three factor Xa inhibitors have been identified: fondaparinux (the only one approved so far by the US Food and Drug Administration), idraparinux (in clinical trials), and idrabiotaparinux (in clinical trials). This paper will examine the role of these agents, focusing on fondaparinux, for the prevention and treatment of VTE in cancer patients.

The role of social desirability in the assessment of mnestic and metacognitive efficiencies in adulthood: a preliminary study

2011 ◽  
Vol 26 (S2) ◽  
pp. 1175-1175 ◽  
Author(s):  
M.C. Fastame ◽  
M.P. Penna ◽  
B. Leone ◽  
C. Puddu
Keyword(s):  
Social Desirability ◽  
Life Quality ◽  
Well Being ◽  
Self Esteem ◽  
Self Report ◽  
Socially Desirable Responding ◽  
Cognitive Failures ◽  
High Prevalence ◽  
Preliminary Study

Ageing is part of a continuum which is characterized by developmental and emotional changes as well as cognitive losses and gains. There is evidence that the perception of life quality in the elders is influenced by the level of efficiency of cognitive functions and personal beliefs on the senescence (e.g., De Beni, 2009). Indeed, when the early cognitive decline is negatively perceived, the late adults tend to show low self-esteem, social retirement, depression, low general life satisfaction. Overall, in geriatric studies scales designed to detect subjective psychological well-being are usually administrated ignoring the disturbing effect of several factors, such as the socially desirable responding, a construct referring to the attitude to project favorable images of themselves on questionnaires or during social interaction (e.g., Knauper et al., 2004). The present study was aimed to investigate whether social desirability is related to several measures of memory and metacognitive efficiencies. Forty-eight young (i.e., 20–30 years old) and old (i.e., 65–74 years aged) participants recruited in Ogliastra (e.g., an area in Sardinia known for the high prevalence of centenarians) were individually administrated a battery of tests including the Italian version of the Crowne-Marlowe Social Desirability Scale (Saggino and Perfetti, 2003) together with a measure of subjective mnestic efficiency for daily life facts (Questionnaire on Cognitive Failures, De Beni et al., 2008) and a self-report memory beliefs questionnaire (Cornoldi and De Beni, 2003). The results show that the measurement of the perceived mnestic and metacognitive efficiencies are susceptible to socially desirable responding.

scholarly journals Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Kristin J. Flores ◽  
Michael Craig ◽  
Adam Wanekaya ◽  
Lifeng Dong ◽  
Kartik Ghosh ◽  
...  
Keyword(s):  
Clinical Trials ◽  
First Generation ◽  
Dna Vaccines ◽  
Clinical Use ◽  
Important Advance ◽  
Prevention And Treatment

Since the first generation of DNA vaccines was introduced in 1988, remarkable improvements have been made to improve their efficacy and immunogenicity. Although human clinical trials have shown that delivery of DNA vaccines is well tolerated and safe, the potency of these vaccines in humans is somewhat less than optimal. The development of a gene-based vaccine that was effective enough to be approved for clinical use in humans would be one of, if not the most important, advance in vaccines to date. This paper highlights the literature relating to gene-based vaccines, specifically DNA vaccines, and suggests possible approaches to boost their performance. In addition, we explore the idea that combining RNA and nanomaterials may hold the key to successful gene-based vaccines for prevention and treatment of disease.

scholarly journals The modern approaches to prevention and treatment of urine tract infections during pregnancy

2005 ◽  
Vol 54 (4) ◽  
pp. 81-87
Author(s):  
Е. G. Gumenyuk
Keyword(s):  
Antibiotic Resistance ◽  
Literature Review ◽  
Pregnant Women ◽  
Well Being ◽  
Labor And Delivery ◽  
Prevention And Treatment ◽  
Tract Infections

The article presents literature review dedicated by problem of urine tract infections during pregnancy. There were analysed the changes of urine tract organs during pregnancy, problems of antibiotic resistance, the modem approaches to treatment in pregnant women. The peculiarities of pregnancy and labor and delivery in women with urine tract infections, newborns well-being were studied. There were shown the role of Canephrone in urine tract sanation, and its effects on fetus and newborn

scholarly journals Warp Speed for COVID-19 Vaccines: Why are Children Stuck in Neutral?

2020 ◽  
Author(s):  
Evan J Anderson ◽  
James D Campbell ◽  
C Buddy Creech ◽  
Robert Frenck ◽  
Satoshi Kamidani ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Well Being ◽  
Vaccine Safety ◽  
Social Success ◽  
Phase Ii Clinical Trials ◽  
The Us ◽  
Direct And Indirect Benefits ◽  
Pediatric Vaccination

Abstract While adult clinical trials of COVID-19 vaccines have moved quickly into Phase 3 clinical trials, clinical trials have not started in children in the US. The direct COVID-19 impact upon children is greater than that observed for a number of other pathogens for which we now have effective pediatric vaccines. Additionally, the role of children in SARS-CoV-2 transmission has clearly been underappreciated. Carefully conducted Phase II clinical trials can adequately address potential COVID-19 vaccine safety concerns. Delaying Phase II vaccine clinical trials in children will delay our recovery from COVID-19 and unnecessarily prolong its impact upon children’s education, health and emotional well-being, and equitable access to opportunities for development and social success. Given the potential direct and indirect benefits of pediatric vaccination, implementation of Phase II clinical trials for COVID-19 vaccines should begin now.

scholarly journals Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity

1996 ◽  
Vol 10 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Michelle M Pluhator ◽  
Alan Br Thomson ◽  
Richard N Fedorak
Keyword(s):  
Trace Elements ◽  
Gastrointestinal Disease ◽  
Well Being ◽  
Nutrition Therapy ◽  
Human Nutrition ◽  
Acrodermatitis Enteropathica ◽  
Clinical Aspects ◽  
Zinc Toxicity ◽  
Malabsorption Syndromes

Available evidence suggests that trace elements, such as zinc, once thought to have no nutritional relevance, are possibly deficient in large sections of the human population. Conditioned deficiencies have been reported to result from malabsorption syndromes, acrodermatitis enteropathica, alcoholism, gastrointestinal disease, thermal injury, chronic diseases (eg, diabetes, sickle cell anemia), and in total parenteral nutrition therapy. Awareness that patients with these problems are at risk has led health professionals to focus increasingly on the importance of zinc therapy in the prevention and treatment of deficiency. More recently zinc toxicity and its role in human nutrition and well-being have come under investigation. Reports have focused on the role of zinc toxicity in causes of copper deficiency, changes in the immune system and alterations in blood lipids. As the numerous challenges presented by the study of zinc in human nutrition are met, more appropriate recommendations for dietary and therapeutic zinc intake are being made.

Role of ranolazine in the prevention and treatment of atrial fibrillation: A meta-analysis of randomized clinical trials

Heart Rhythm ◽  
2017 ◽  
Vol 14 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Mengqi Gong ◽  
Zhiwei Zhang ◽  
Nikolaos Fragakis ◽  
Panagiotis Korantzopoulos ◽  
Konstantinos P. Letsas ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Prevention And Treatment

scholarly journals DEVELOPMENT OF PENITENTIARY HYGIENE AND SANITATION IN RUSSIA (END XVIII-EARLY XX CENTURY)

2019 ◽  
Vol 96 (8) ◽  
pp. 789-792
Author(s):  
R. U. Khabriev ◽  
Boris A. Spasennikov ◽  
L. F. Pertli ◽  
S. A. Kopytkin
Keyword(s):  
Infectious Diseases ◽  
Well Being ◽  
Russian Empire ◽  
The State ◽  
Legal Basis ◽  
Historical Aspect ◽  
Good Level ◽  
Prevention And Treatment ◽  
The Russian Empire

The article considers the historical aspect of sanitary development in the domestic penitentiary system. In 1788, the Regulations on Prisons were adopted, in which the sanitary requirements of the penitentiary systems of European states were used. Since 1819, the Ministry of Internal Affairs of the Russian Empire organized sanitary affair. This provided the conditions for the development of penitentiary sanitation. The legal basis for sanitation for prisoners was established in 1831. In 1850 in prison died 1598 criminals of a 980,000 who were in prison (0.16%). This is evidence of a good level of sanitation in Russia at this time. In 1879, the Chief Prison Directorate of the Russian Empire appointed an inspector for the sanitary unit. He developed sanitary measures and coordinated their implementation. The role of professor A.P. Dobroslavina is shown in the development of penitentiary hygiene and sanitation. The primary link of the domestic penitentiary system was the administration of prisons. According to the law of June 15, 1887, doctors and paramedics were assigned to them. They organized and conducted sanitary measures. Treatment of sick prisoners and sanitation was carried out at the expense of the state. It was revealed that more attention was paid to the prevention and treatment of infectious diseases. Normative sanitary acts in the penitentiary system must have mandatory for the administration of places of detention. For the purposes of sanitary and epidemiological well-being, it is not possible to subordinate medical workers to the prison director. This was provided for by the General Prison Regulations of 1915. But, unfortunately, has not been implemented so far. The authors believe that the time has come to implement this norm in practice.

scholarly journals Cognitive impairment in patients with migraine: causes, principles of effective prevention and treatment

2018 ◽  
Vol 10 (3) ◽  
pp. 141-149
Author(s):  
V. A. Golovacheva ◽  
K. A. Pozhidaev ◽  
A. A. Golovacheva
Keyword(s):  
Clinical Trials ◽  
Cognitive Impairment ◽  
Anxiety Disorder ◽  
White Matter ◽  
Effective Prevention ◽  
Pathogenetic Role ◽  
Brain White Matter ◽  
Prevention And Treatment ◽  
The Brain

Cognitive impairment (CI) is common in patients with migraine; its causes and pathogenesis continue to be discussed. Some authors consider that migraine proper does not lead to decreased cognitive functions, neuroimaging changes in the brain white matter are asymptomatic in migraine; and CI in patients with this condition is caused by comorbidities (depression, anxiety disorder) and/or concurrent cerebrovascular and neurodegenerative diseases. Other authors report the pathogenetic role of migraine in the development of CI and the importance of the frequency of headache attacks and neuroimaging changes in the brain matter in migraine. The paper reviews clinical trials dealing with the prevalence, causes, and pathogenesis of CI in patients with migraine. It sets forth the current principles of prevention and treatment of CI in patients with this condition.

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