scholarly journals Synthesis, Characterization, Fluorescence and Antimicrobial studies of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes derived from Schiff’s base (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide

2021 ◽  
Vol 23 (09) ◽  
pp. 81-111
Author(s):  
Fazlur Rahaman ◽  
◽  
Priti Gupta ◽  
Prabhat Gautam ◽  
Subrata Monadal ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Powder Xrd ◽  
1H And 13C Nmr ◽  
Strong Emission ◽  
Xrd Pattern ◽  
Spectral Techniques ◽  
Fluorescence Studies ◽  
Antimicrobial Studies

A series of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes of (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide (HL) with ONO donor ligand was synthesized. The ligand (HL) was prepared by the condensation of N-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 5-chloro-2-hydroxybenzaldehyde. The HL and its metal complexes have been characterized using elemental analysis and various spectral techniques such as, FTIR, 1H and 13C NMR, Mass, UV–Visible, ESR, thermal analysis (TGA), magnetic moment, conductivity and powder-XRD. The Powder XRD pattern indicates hexagonal or tetragonal system for HL and its metal complexes. The fluorescence studies exhibits strong emission in the range of 400-500 nm for HL. Further in comparison the HL, Zn(II) and Cd(II) complexes showed enhanced emission whereas Cu(II), Co(II) and Ni(II) showed poor emission. The antimicrobial activities of the HL and its metal complexes were studied by minimum inhibitory concentration (MIC) method wherein the metal complexes showed better activity as compare to free ligand.

scholarly journals Synthesis, Spectral Characterization and Antimicrobial Studies of Co(II) Complexes with Tetradentate Schiff bases Derived from Ortho-Phthalaldehyde

2016 ◽  
Vol 9 (1) ◽  
pp. 1873-1882
Author(s):  
V. Sreenivas ◽  
G. Srikanth ◽  
Ch. Vinutha ◽  
M. Shailaja ◽  
P. Muralidhar Reddy ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Thermal Conductance ◽  
Antimicrobial Activities ◽  
Aqueous Methanol ◽  
Schiff Base Ligands ◽  
Potential Donor ◽  
Spectral Techniques ◽  
Antimicrobial Studies

A series of cobalt (II) complexes have been synthesized with Schiff bases derived from ortho-phthalaldehyde and various amines in aqueous methanol solution. The newly synthesized Schiff bases and their Co (II) complexes have been characterized  by elemental analysis, magnetic susceptibility, thermal, conductance measurements, mass, IR, electronic, 1H,13C-NMR spectral techniques. These ligands act as tetradentate species and coordinate to the metal center through the different potential donor atoms such as N, O and S. The probable octahedral structures have been assigned to these complexes. All the synthesized Schiff base ligands and Co(II) metal complexes have also been screened for their antimicrobial activities and metal complexes found to be more active than respective Schiff-base ligands.

scholarly journals Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
K. Savithri ◽  
B. C. Vasantha Kumar ◽  
H. K. Vivek ◽  
H. D. Revanasiddappa
Keyword(s):  
Metal Complexes ◽  
Antimicrobial Activities ◽  
Spectroscopic Studies ◽  
Docking Studies ◽  
Bacterial Strains ◽  
Spectral Techniques ◽  
Light Reduction ◽  
Drug Candidates ◽  
Ft Ir

A bidentate (N- and O-) imine-based ligand (L1) and its metal complexes of types [CuII(L1)2] (C1), [CuII(L1)(Phen)] (C2), [CoIII(L1)2] (C3), and [CoIII(L1)(Phen)] (C4) (L1 = 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-4-chlorophenol and phen = 1,10-phenanthroline) were synthesized as potential chemotherapeutic drug candidates. The prepared complexes were structurally characterized by spectral techniques (NMR, FT-IR, LC-MS, EPR, and electronic absorption), thermogravimetric analysis (TGA/DTA), magnetic moment, and CHNO elemental analysis. Spectroscopic studies suggested the distorted octahedral structure for all complexes. In vitro bioassay studies include binding and nuclease activities of the ligand and its complexes with target calf thymus- (CT-) DNA were carried out by employing UV-Vis, fluorescence spectroscopy, viscosity, and gel electrophoresis techniques. The extent of binding propensity was determined quantitatively by Kb and Ksv values which revealed a higher binding affinity for C2 and C4 as compared to C1 and C3. In addition, the scavenging superoxide anion free radical (O∙-2) activity of metal complexes was determined by nitroblue tetrazolium (NBT) light reduction assay. Molecular docking studies with DNA and SOD enzyme were also carried out on these compounds. The antimicrobial study has shown that all the compounds are potential antibacterial agents against Gram-negative bacterial strains and better antifungal agents with respect to standard drugs used.

scholarly journals Synthesis, Characterization and Biological Evaluation of Fe(III) and Cu(II) Complexes with 2,4-Dinitrophenyl hydrazine and Thiocyanate Ions

2019 ◽  
Vol 31 (4) ◽  
pp. 780-784
Author(s):  
P. Manimaran ◽  
S. Balasubramaniyan
Keyword(s):  
Antioxidant Activity ◽  
Metal Complexes ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Spectral Studies

The metal complexes of Fe(III) and Cu(II) were prepared by using 2,4-dinitrophenyl hydrazine (DNPH) and thiocyanate (SCN) with stirrer refluxed for about 6 h. The prepared Fe(III) and Cu(II) complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility and electronic spectrum, FT-IR spectral studies. The result suggested the octahedral geometry for Fe(III) and Cu(II) complexes. Powder X-ray diffraction indicate the crystalline nature of the metal complexes. The antimicrobial activities of the Fe(III) and Cu(II) complexes were tested with various micro organisms by disc diffusion method. The antimicrobial results indicate that the metal complexes are highly active with compared to the free ligand. The in vitro antioxidant activity of the free ligand and its metal complexes was assayed by radical scavenging activity (DPPH). The result proposed that Fe (III) and Cu(II) complexes exhibited strong antioxidant activity than that of the ligand.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Sulekh Chandra ◽  
Smriti Raizada ◽  
Monika Tyagi ◽  
Archana Gautam
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Copper Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal Complexes

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Khlood S. Abou Melha ◽  
Gamil A. Al-Hazmi ◽  
Ismail Althagafi ◽  
Arwa Alharbi ◽  
Ali A. Keshk ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Energy Gap ◽  
Free Ligand ◽  
Schiff’S Base ◽  
Strong Activity ◽  
Spectral Techniques ◽  
Dft Modeling ◽  
Base Derivative ◽  
Coordinated Water ◽  
Average Size

The newly synthesized Schiff’s base derivative, N-allyl-2-(2-oxoacenaphthylen-1(2H)-ylidene)hydrazine-1-carbothioamide, has been characterized by different spectral techniques. Its reaction with Co(II), Ni(II), and Zn(II) acetate led to the formation of 1 : 1 (M:L) complexes. The IR and NMR spectral data revealed keto-thione form for the free ligand. On chelation with Co(II) and Ni(II), it behaved as mononegative and neutral tridentate via O, N1, and S donors, respectively, while it showed neutral bidentate mode via O and N1 atoms with Zn(II). The electronic spectra indicated that all the isolated complexes have an octahedral structure. The thermal gravimetric analyses confirmed the suggested formula and the presence of coordinated water molecules. The XRD pattern of the metal complexes showed that both Co(II) and Ni(II) have amorphous nature, while Zn(II) complex has monoclinic crystallinity with an average size of 9.10 nm. DFT modeling of the ligand and complexes supported the proposed structures. The calculated HOMO-LUMO energy gap, ΔEH-L, of the ligand complexes was 1.96–2.49 eV range where HAAT < Zn(II) < Ni(II) < Co(II). The antioxidant activity investigation showed that the ligand and Zn(II) complex have high activity than other complexes, 88.5 and 88.6%, respectively. Accordingly, the antitumor activity of isolated compounds was examined against the hepatocellular carcinoma cell line (HepG2), where both HAAT and Zn(II) complex exhibited very strong activity, IC50 6.45 ± 0.25 and 6.39 ± 0.18 μM, respectively.

GREEN SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF MIXED LIGAND COMPLEXES OF Co (II), Ni (II) and V(III) METALS USING SOME AMINO ACIDS AS LIGANDS

2021 ◽  
Vol 4 (4) ◽  
pp. 191-199
Author(s):  
N. S. Gwaram ◽  
A. Salisu ◽  
Muhammad Manir
Keyword(s):  
Amino Acids ◽  
Metal Complexes ◽  
Conductivity Measurement ◽  
Antimicrobial Activities ◽  
Decomposition Temperature ◽  
Infrared Analysis ◽  
Antimicrobial Studies ◽  
Mixed Ligands ◽  
Method Of Continuous Variation ◽  
Job's Method

Co (II), Ni (II) and V (III) metal complexes were synthesized mechanochemically using L-Leucine, L-Tyrosine and Creatinine as mixed ligands. The metals and the ligands were grounded using an agate mortar with a pestle. The compounds formed were characterized using their melting/decomposition temperature, solubility, magnetic susceptibility, conductivity measurement, Infrared analysis and scanning electron microscope (SEM). The Metal – ligand ratios were investigated via Job’s method of continuous variation. The shifts of bands (for instance 1693-1677 cm-1 to 1674-1607 cm-1) in C=O and the appearance of new bands in the complexes (683-669 and 713-750 cm-1 indicates the complexation. The lower conductivity measurement values (15.00 to 32.40) µS.cm-1 suggested the non-electrolytic nature of the complexes. The magnetic effective value of the metal complexes showed that all the three complexes are paramagnetic and octahedral. It was concluded that the amino acids (ligands) coordinated in a bidentate way through the nitrogen from the amino group and oxygen from carboxylate. The complexes were screened for their antimicrobial activities against two bacterial isolates (Streptococcus pneumoniae and Klebsiella pneumoniae). All the complexes exhibited good activity against the organisms

scholarly journals Synthesis, Characterization and in Vitro Antimicrobial Studies of Ternary Mn(II) Complexes with Isatinphenylhydrazone, Glycine and 8-hydroxyquinoline

2021 ◽  
Vol 37 (5) ◽  
pp. 1146-1151
Author(s):  
Suman Kumari ◽  
Shobhana Sharma ◽  
Seema Seema ◽  
Poonam Yadav ◽  
Mamta Ranka
Keyword(s):  
Complex I ◽  
Research Work ◽  
Analytical Techniques ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bacterial Strains ◽  
Spectral Techniques ◽  
Molar Ratios ◽  
Antimicrobial Studies

In our present research work, we have synthesized two ternary metal complexes of Mn(II), complex-I as [Mn(L)(Gly)(Cl)(H2O)] and complex-II as [Mn(L)(Q)(Cl)(H2O)]; where L is Isatinphenylhydrazone (IPH) as primary ligand, whereas glycine (Gly) and 8-hydroxyquinoline (HQ) as secondary ligand in complex-I and II respectively, in 1:1:1 (M : L : Gly or M : L : Q) molar ratios. Above synthesized complexes are employed for characterization using various analytical techniques including elemental analysis, melting point determination, magnetic moment measurements, molar conductance measurements, and spectral techniques (FTIR, UV, 1H NMR) etc. Further, their antimicrobial activities were evaluated against selected bacterial strains i.e., B. subtilis, S. aureus (Gram positive) and P. aeruginosa, E. coli (Gram negative) and fungal strains (T. reesei, A. niger, C. albicans) and found significantly active.

scholarly journals Synthesis, Spectral Characterization, Thermal and In vitro Antimicrobial Studies for Novel Co(II) and Ni(II) Complexes of (N,N'-(1,2-Phenylene)Bis(2-Aminobenzamide)

2019 ◽  
Vol 16 ◽  
pp. 5360-5374 ◽  
Author(s):  
Hanaa A. El-Boraey ◽  
Azza A. Serag El-Din ◽  
Ahmed A. Sakr
Keyword(s):  
Metal Complexes ◽  
Free Ligand ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Antimicrobial Studies ◽  
Positive Strain ◽  
Positive Controls

Novel metal complexes of Co(II) and Ni(II) have been  prepared from reaction of their different salts with previously prepared ligand (L) namely (N,N'-(1,2-phenylene)bis(2-aminobenzamide). Synthesis ligand and its metal (II) complexes (1-5) were reported and characterized with the help of analytical and physiochemical analysis as elemental, IR spectra, thermal (TG/DTG), UV-Vis, magnetic susceptibility and molar conductance in DMF, On the view of the previous data and measurements, the structure and composition species behave as mononuclear and octahedral geometry has been proposed for all the complexes except for complex (1) adopted tetrahedral structure. Furthermore, the in vitro antibacterial Staphylococcus aureus (ATCC 25923) as Gram-positive strain, Escherichia coli (ATCC 25922) as Gram-negative strain and antifungal Candida albicans (ATCC 10231) have been studied for all samples using disc diffusion method against Ampicillin and Fluconazole as positive controls, respectively. The results show that complexation facilitates the activity of most studied metal complexes than the free ligand.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine Thiosemicarbazone

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Sulekh Chandra ◽  
Shikha Parmar ◽  
Yatendra Kumar
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Antimicrobial Studies

A series of metal complexes of Zn(II) and Hg(II) having the general composition [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = , and ] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals A COMPARITIVE VIEW OVER THE SYNTHESIS OF SCHIFF BASE LIGANDS AND METAL COMPLEXES BY CONVENTIONAL AND SOLVENT FREE ROUTES

2020 ◽  
Vol 4 (12) ◽  
pp. 107-117
Author(s):  
Deeksha Sharma ◽  
Prof. Arpan Bhardwaj
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Metal Complexes ◽  
Uv Spectroscopy ◽  
Solvent Free ◽  
Schiff Base Ligands ◽  
Spectral Techniques ◽  
Antimicrobial Studies ◽  
Synthetic Procedure ◽  
Good Agreement

In the present paper, synthesis of Schiff base ligands and the metal complexes are studied and compared by conventional and solvent free route. The synthesis of Schiff base ligands of amino acids (Glycine, Phenylalanine and Tyrosine) with salicylaldehyde and their mixed ligand ternary Cu(II) complexes are discussed. Other ligands are used in co-ordinaion with the schiff base is 1,10- Phenanthroline/thiourea  in equimolar ratio. The environmentally efficient and modern developed method for synthesis is the solid state synthesis of salicylidene amino acids through pestle mortar synthetic procedure. This method is compared with the conventional method that require refluxing the reactant mixture for hours in an organic solvent, here ethanol. The complexes are characterized by spectral techniques IR spectroscopy and UV spectroscopy. The investigations concluded that the pestle mortar assisted method is very rapid , simple and economic for the preparation of  ligands and complexes as well. The Antimicrobial studies were also performed for the complexes. The spectral data for the ligands and complexes obtained from either method, conventional and solventless procedure are in good agreement with one another. The azomethine bonding(-CH=N-) between salicylaldehyde amino acids based Schiff bases is described by the IR spectral peak around 1600 cm-1.                                      

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