scholarly journals RETROSPECTIVE DATA REVIEW TO FIND THE ASSOCIATION OF LUMBOSACRAL TRANSITIONAL VERTEBRA AND DEGENERATIVE DISC DISEASE IN YOUNG PATIENTS

2020 ◽  
Vol 70 (6) ◽  
pp. 1734-39
Author(s):  
Nadia Gul ◽  
Khalid Mehmood ◽  
Muhammad Ikram
Keyword(s):  
Disc Degeneration ◽  
Degenerative Disc Disease ◽  
Lumbar Disc ◽  
Statistical Significance ◽  
Young Patients ◽  
P Value ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Transitional Vertebra ◽  
Lumbosacral Transitional Vertebra

Objective: To find out the frequency of lumbar disc degeneration among the patients having lumbosacraltransitional vertebra between 20-40 years. Study Design: Retrospective cross sectional study. Place and Duration of Study: Radiology department POF Wah Cantt, from Jan 2018 to Dec 2019. Methodology: Six Hundred patients between 20-40 years having lumbosacral transitional vertebra and historyof low back pain >1 year were studied. X ray and MRI lumbar spine of these patients was studied retrospectivelyon PACS. Two hundred patients having history of traumatic or other non-traumatic etiologies, in addition toLumbosacral transitional vertebra were excluded. Four hundred patients with only lumbosacral transitionalvertebra were included. Data analysis was done by SPSS-22. Castellvi types of transitional vertebra was calculated among patients with degenerative lumbar disc. Results: One hundred and four (26.6%) were having degenerative disc disease while 296 (74.4%) patients werenot having degenerative disc disease. Patients having degenerative disc disease were between 24-40 years withthe mean age 29.96 ± 0.417 years. Among the patients having degenerative disc disease were 59 women and45 males but no statistical significance association was found between gender and degenerative disc disease with p-value = 0.55. Castellvi type III had significant association with degenerative disc disease, p-value = 0.006. Conclusion: Age related disc degeneration is commonly seen in middle age people but in younger age group in2nd and 3rd decade it is observed frequently in those patients having lumbosacral transitional vertebra especially in the setting of no other associated traumatic or non-traumatic etiology, which leads to early degenerative disc disease.

scholarly journals Lumbar Degenerative Disc Disease: Current and Future Concepts of Diagnosis and Management

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Fadi Taher ◽  
David Essig ◽  
Darren R. Lebl ◽  
Alexander P. Hughes ◽  
Andrew A. Sama ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
Degenerative Disc Disease ◽  
Lumbar Disc ◽  
Symptomatic Relief ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Lumbar Disc Degeneration ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Novel Treatment

Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine, but novel treatment strategies involving stem cells, growth factors, and gene therapy have the theoretical potential to prevent, slow, or even reverse disc degeneration. Understanding the pathophysiological basis of disc degeneration is essential for the development of treatment strategies that target the underlying mechanisms of disc degeneration rather than the downstream symptom of pain. Such strategies ideally aim to induce disc regeneration or to replace the degenerated disc. However, at present, treatment options for degenerative disc disease remain suboptimal, and development and outcomes of novel treatment options currently have to be considered unpredictable.

Effectiveness of Traction in Young Patients Representing Different Stages of Degenerative Disc Disease

2019 ◽  
Vol 21 (3) ◽  
pp. 187-196 ◽  
Author(s):  
Tomasz Kuligowski ◽  
Agnieszka Dębiec-Bąk ◽  
Anna Skrzek
Keyword(s):  
Young People ◽  
Functional Status ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Degenerative Disc Disease ◽  
Lumbar Disc ◽  
Clinical Status ◽  
Young Patients ◽  
Disc Disease ◽  
Degenerative Disc

Background. Low back pain (LBP) currently ranks among the most frequent musculoskeletal pathologies, and the average age of those affected is constantly decreasing. One of the causes of LBP is lumbar disc herniation (LDH). If untreated, it causes disability and leads to socio-economic problems. Traction techniques are a popular method of treating this condition. The stage of LDH (protrusion, extrusion) in young people appears to determine patients’ clinical status, necessitating diversification of treatment methods with regard to the type of damage. Material and methods. The study enrolled 37 people aged 22-35. The subjects underwent radiological evalu­ation (MRI), which constituted the basis for assigning them to one of two groups: a protrusion group (PRO) or an extrusion group (EXT). During the experiment, the patient was in the supine position while the therapist administered three-dimensional traction using a manual therapy belt. The Oswestry questionnaire, MRC scale, NRS, SLR test, PLE test and measurements of lumbar segment mobility were used for clinical evaluation. Statistica 12.5 was used to perform statistical calculations. Results. An analgesic effect was noted with regard to the following two parameters in both groups: ODI (PRO 28 → 14 and EXT 30 → 28, p <0.01) and NRS (PRO 6 → 2 and EXT 6 → 3, p <0.01). The subjects improved clinically, with regard to PLE (EXT 22% → 0%, p <0.04) and SLR (PRO 100% → 29%, p <0.01, and EXT 100% → 57%, p <0.01). Conclusions. 1. The type of intervertebral disc damage determines the functional status of young people with degenerative disc disease. 2. The study demonstrated and confirmed a positive effect of traction on the functional status of subjects with lumbar disc herniation. 3. Traction techniques are safe and can be successfully used in the treatment of LDH.

scholarly journals The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine

2017 ◽  
Vol 11 (3) ◽  
pp. 337-347 ◽  
Author(s):  
Ande M. Jakoi ◽  
Gurpal Pannu ◽  
Anthony D'Oro ◽  
Zorica Buser ◽  
Martin H. Pham ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Retrospective Analysis ◽  
Degenerative Disc Disease ◽  
Lumbar Disc ◽  
Degenerative Disease ◽  
Disc Disease ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc ◽  
Number Of Patients ◽  
Insurance Database

<sec><title>Study Design</title><p>Retrospective analysis of a nationwide private insurance database. Chi-square analysis and linear regression models were utilized for outcome measures.</p></sec><sec><title>Purpose</title><p>The purpose of this study was to investigate any relationship between lumbar degenerative disc disease, diabetes, obesity and smoking tobacco.</p></sec><sec><title>Overview of Literature</title><p>Diabetes, obesity, and smoking tobacco are comorbid conditions known to individually have effect on degenerative disc disease. Most studies have only been on a small populous scale. No study has yet to investigate the combination of these conditions within a large patient cohort nor have they reviewed the combination of these conditions on degenerative disc disease.</p></sec><sec><title>Methods</title><p>A retrospective analysis of insurance billing codes within the nationwide Humana insurance database was performed, using PearlDiver software (PearlDiver, Inc., Fort Wayne, IN, USA), to identify trends among patients diagnosed with lumbar disc degenerative disease with and without the associated comorbidities of obesity, diabetes, and/or smoking tobacco. Patients billed for a comorbidity diagnosis on the same patient record as the lumbar disc degenerative disease diagnosis were compared over time to patients billed for lumbar disc degenerative disease without a comorbidity. There were no sources of funding for this manuscript and no conflicts of interest.</p></sec><sec><title>Results</title><p>The total number and prevalence of patients (per 10,000) within the database diagnosed with lumbar disc degenerative disease increased by 241.4% and 130.3%, respectively. The subsets of patients within this population who were concurrently diagnosed with either obesity, diabetes, tobacco use, or a combination thereof, was significantly higher than patients diagnosed with lumbar disc degenerative disease alone (<italic>p</italic> &lt;0.05 for all). The number of patients diagnosed with lumbar disc degenerative disease and smoking rose significantly more than patients diagnosed with lumbar disc degenerative disease and either diabetes or obesity (<italic>p</italic> &lt;0.05). The number of patients diagnosed with lumbar disc degenerative disease, smoking and obesity rose significantly more than the number of patients diagnosed with lumbar disc degenerative disease and any other comorbidity alone or combination of comorbidities (<italic>p</italic> &lt;0.05).</p></sec><sec><title>Conclusions</title><p>Diabetes, obesity and cigarette smoking each are significantly associated with an increased diagnosis of lumbar degenerative disc disease. The combination of smoking and obesity had a synergistic effect on increased rates of lumbar degenerative disc disease. Patient education and preventative care is a vital goal in prevention of degenerative disc disease within the general population.</p></sec>

scholarly journals HISTOLOGICAL MARKERS OF DEGENERATION AND REGENERATION OF THE HUMAN INTERVERTEBRAL DISK

2017 ◽  
Vol 16 (1) ◽  
pp. 42-47
Author(s):  
MANUELA PELETTI-FIGUEIRÓ ◽  
ISRAEL SILVEIRA DE AGUIAR ◽  
SUELEN PAESI ◽  
DENISE CANTARELLI MACHADO ◽  
SERGIO ECHEVERRIGARAY ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Degenerative Disc Disease ◽  
Intervertebral Disc Degeneration ◽  
Disc Disease ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc ◽  
Hematoxylin And Eosin ◽  
Safranin O

ABSTRACT Objective: To define histological scores for intervertebral disc degeneration that would enable the definition of morphological characteristics of disease, besides improving knowledge of the lumbar degenerative disc disease by means of immunohistochemical markers. Methods: Hematoxylin and Eosin, Alcian/PAS, Masson Trichrome and Safranin O/FCF staining was used on the intervertebral disc degeneration sections of patients with lumbar degenerative disc disease. The protein markers defined in immunohistochemistry were cell proliferation (Ki-67) and apoptosis (p53). Results: The study data enabled the determination of Safranin O/FCF stain as the most effective one for evaluating parameters such as area, diameter, and number of chondrocyte clusters. The importance of using stains in association, such as Safranin O/FCF, Masson Trichrome, Alcian/PAS and Hematoxylin and Eosin, was also determined, as they are complementary for the histopathological verification of intervertebral disc degeneration. By expressing proteins using the immunohistochemistry technique, it was possible to consider two stages of disc degeneration: cell proliferation with chondrocyte cluster formation, and induction of apoptosis. Conclusion: This study enabled the histological and immunohistochemical characterization to be determined for lumbar degenerative disc disease, and its degrees of evolution, by determining new disc degeneration scores.

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