scholarly journals FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction

2020 ◽  
Vol 11 (3) ◽  
pp. 206-212
Author(s):  
Thalishetti Krishna ◽  
Eppakayala Laxminarayana ◽  
Dipak Kalita
Keyword(s):  
Thermal Stability ◽  
Functional Group ◽  
Direct Synthesis ◽  
Biginelli Reaction ◽  
Environmentally Benign ◽  
Green Catalyst ◽  
Mild Conditions ◽  
Highly Efficient ◽  
High Acidity ◽  
Water Tolerance

A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction. These reactions proceed at low-catalyst loadings with high functional group tolerance under mild conditions. This method provides efficient reusability of the catalyst and good to excellent yields of the products, making the protocol more attractive, economical, and environmentally benign. FeF3 is an attractive catalyst for the Biginelli reaction because of its high acidity, thermal stability and water tolerance.

Gold-catalyzed highly efficient benzylation of alcohols with N-Cbz-N-benzyl-propargylamine

2015 ◽  
Vol 2 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Jing-Rui Zhao ◽  
Xiaolong Yuan ◽  
Zhaoyan Wang ◽  
Shiwu Chen ◽  
Zhan-Xin Zhang ◽  
...  
Keyword(s):  
Functional Group ◽  
Mild Conditions ◽  
Highly Efficient

Functional group tolerance under mild conditions eliminates the need for base additives or hygroscopic promoters.

A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms

2020 ◽  
Vol 22 (3) ◽  
pp. 669-672 ◽  
Author(s):  
Shuai Shi ◽  
Ruining Li ◽  
Liangming Rao ◽  
Zhankui Sun
Keyword(s):  
Visible Light ◽  
Functional Group ◽  
Site Specific ◽  
Metal Free ◽  
Mild Conditions ◽  
Highly Efficient ◽  
Radical Approach

Visible light induced desulfurization–deuteration method was developed using D2O as the source of deuterium atoms. This radical approach features mild conditions, broad substrate scope, highly efficient D-incorporation and excellent functional group compatibility.

Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon

Synlett ◽  
2019 ◽  
Vol 30 (03) ◽  
pp. 319-324 ◽  
Author(s):  
Zhaozhan Wang ◽  
Tao Song ◽  
Yong Yang
Keyword(s):  
Functional Group ◽  
Direct Synthesis ◽  
Biologically Active ◽  
One Pot ◽  
Mild Conditions ◽  
Wide Range ◽  
High Yields

A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.

Ligand- and catalyst-free intramolecular C-S bond formation: direct access to indalothiochromen- 4-ones

2015 ◽  
Vol 21 (3) ◽  
pp. 159-163 ◽  
Author(s):  
T.A. Jenifer Vijay ◽  
Nagarakere C. Sandhya ◽  
C.S. Pavankumar ◽  
Kanchugarakoppal S. Rangappa ◽  
Kempegowda Mantelingu
Keyword(s):  
Functional Group ◽  
Direct Synthesis ◽  
Bond Formation ◽  
Direct Access ◽  
Mild Conditions ◽  
Catalyst Free

AbstractAn efficient ligand- and catalyst-free intramolecular S-arylation leading to the direct synthesis of indalothiochromen-4-ones from simple dithioesters under mild conditions has been developed. This method is particularly noteworthy given its experimental simplicity, high generality, and good functional group toleration.

scholarly journals Palladium Catalyzed α,β-Homodiarylation of Vinyl Esters in Aqueous Medium

2021 ◽  
Author(s):  
Ryszard Ostaszewski ◽  
Damian Trzepizur ◽  
Anna Brodzka ◽  
Dominik Koszelewski ◽  
Monika Wilk
Keyword(s):  
Catalytic Activity ◽  
Functional Group ◽  
Reaction Medium ◽  
Environmentally Benign ◽  
Vinyl Esters ◽  
Arylboronic Acid ◽  
Reaction Conditions ◽  
Mild Conditions ◽  
Palladium Catalyzed ◽  
One Step

Abstract A palladium catalyzed 1,2-diarylation of vinyl esters with sustainable arylbornic acids in water has been developed. This newly elaborated protocol features good functional group tolerance and provides a one-step access to 1,2-diaryletahol derivatives under mild reaction conditions. The presented reaction can be carried out in water smoothly without the addition of any ligands at ambient temperature what makes this procedure environmentally benign. The transformation occurs within a single catalytic cycle and is feasible due to the modification of transition metal catalytic activity through the influence of π-acceptor olefin (benzoquinone) as well as the polar protic reaction medium (water in particular). Moreover, the protocol allows to generate entire compounds libraries (highly profitable in medicinal chemistry) and utilizes sustainable arylboronic acid as coupling partners under mild conditions.

Cobalt supported on alumina as green catalyst for Biginelli reaction in mild conditions: effect of catalyst preparation method

2017 ◽  
Vol 6 (6) ◽  
Author(s):  
Chahinaz Khiar ◽  
Mazari Tassadit ◽  
Leila Bennini ◽  
Mourad Halouane ◽  
Manuel Jesús Benito González ◽  
...  
Keyword(s):  
Preparation Method ◽  
Biginelli Reaction ◽  
Catalyst Preparation ◽  
Green Catalyst ◽  
Mild Conditions

AbstractCobalt supported on alumina (10 wt% Co/Al

Catalyst-free amidation of aldehyde with amine under mild conditions

2015 ◽  
Vol 39 (8) ◽  
pp. 5912-5915 ◽  
Author(s):  
Hongyin Yang ◽  
Wenjian Hu ◽  
Shengjue Deng ◽  
Tiantian Wu ◽  
Haiman Cen ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Highly Efficient

A highly efficient, catalyst-free and one-pot procedure for the direct synthesis of amides from aldehydes and amines under mild conditions has been developed.

scholarly journals Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-N,N-disubstituted thioureas as versatile substrate

2019 ◽  
Vol 6 (6) ◽  
pp. 181963 ◽  
Author(s):  
Wael Abdelgayed Ahmed Arafa ◽  
Hamada Mohamed Ibrahim
Keyword(s):  
Functional Group ◽  
The Other ◽  
Environmentally Benign ◽  
Reductive Cyclization ◽  
One Pot ◽  
Mild Conditions ◽  
Ring Nitrogen ◽  
Scalable Synthesis ◽  
Operational Simplicity

An expedient and tandem regioselective one-pot protocol for the sono-synthesis of bis-[1,2,4]-triazol-3-yl amines and bis-2-iminothiazolines from corresponding bis-1,3-disubstituted thioureas has been developed. The products' regioselectivity correlate well with the pKas of the parent amines, in which the amine possessing higher pKagoes to the ring nitrogen, whereas the other nitrogen remains flanked as an exocyclic nitrogen of the bis-triazole or bis-thiazole moieties. Further, the sonochemical preparation of both bis-5-(2-nitrobenzylidene) thiobarbiturates and bis-2-thioxoimidazolidine-4,5-diones from bis-1,3-disubstituted thioureas has also been achieved. The obtained bis-5-(2-nitrobenzylidene)thiobarbiturates easily underwent reductive cyclization to afford the corresponding bis-5-benzo[c]isoxazol-3-ylidenethiobarbiturates. The scope and limitations of these strategies have been studied. Moreover, the suggested methodologies have advantages such as broad functional group tolerance, mild conditions, operational simplicity and applicability on a gram scale. Furthermore, the protocols scored well in a number of green metrics, subsequently showing these approaches to be environmentally benign and sustainable processes.

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

2014 ◽  
Vol 50 (68) ◽  
pp. 9687-9689 ◽  
Author(s):  
Jinmin Miao ◽  
Nigel G. J. Richards ◽  
Haibo Ge
Keyword(s):  
Functional Group ◽  
Direct Synthesis ◽  
Mild Conditions

A novel rhodium–catalyzed imination of sulfoxides using O-(2,4-dinitrophenyl)hydroxylamine is developed under mild conditions with good functional group tolerance.

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