Ligand- and catalyst-free intramolecular C-S bond formation: direct access to indalothiochromen- 4-ones

2015 ◽  
Vol 21 (3) ◽  
pp. 159-163 ◽  
Author(s):  
T.A. Jenifer Vijay ◽  
Nagarakere C. Sandhya ◽  
C.S. Pavankumar ◽  
Kanchugarakoppal S. Rangappa ◽  
Kempegowda Mantelingu
Keyword(s):  
Functional Group ◽  
Direct Synthesis ◽  
Bond Formation ◽  
Direct Access ◽  
Mild Conditions ◽  
Catalyst Free

AbstractAn efficient ligand- and catalyst-free intramolecular S-arylation leading to the direct synthesis of indalothiochromen-4-ones from simple dithioesters under mild conditions has been developed. This method is particularly noteworthy given its experimental simplicity, high generality, and good functional group toleration.

scholarly journals PIDA-mediated intramolecular oxidative C–N bond formation for the direct synthesis of quinoxalines from enaminones

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 7718-7722 ◽  
Author(s):  
Hong Zhang ◽  
Jinhai Shen ◽  
Zhenhui Yang ◽  
Xiuling Cui
Keyword(s):  
Direct Synthesis ◽  
Bond Formation ◽  
Hypervalent Iodine ◽  
Mild Conditions

An expedient hypervalent iodine(iii)-mediated approach to obtain substituted quinoxalines from readily available enaminones has been developed under mild conditions.

Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon

Synlett ◽  
2019 ◽  
Vol 30 (03) ◽  
pp. 319-324 ◽  
Author(s):  
Zhaozhan Wang ◽  
Tao Song ◽  
Yong Yang
Keyword(s):  
Functional Group ◽  
Direct Synthesis ◽  
Biologically Active ◽  
One Pot ◽  
Mild Conditions ◽  
Wide Range ◽  
High Yields

A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.

scholarly journals FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction

2020 ◽  
Vol 11 (3) ◽  
pp. 206-212
Author(s):  
Thalishetti Krishna ◽  
Eppakayala Laxminarayana ◽  
Dipak Kalita
Keyword(s):  
Thermal Stability ◽  
Functional Group ◽  
Direct Synthesis ◽  
Biginelli Reaction ◽  
Environmentally Benign ◽  
Green Catalyst ◽  
Mild Conditions ◽  
Highly Efficient ◽  
High Acidity ◽  
Water Tolerance

A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction. These reactions proceed at low-catalyst loadings with high functional group tolerance under mild conditions. This method provides efficient reusability of the catalyst and good to excellent yields of the products, making the protocol more attractive, economical, and environmentally benign. FeF3 is an attractive catalyst for the Biginelli reaction because of its high acidity, thermal stability and water tolerance.

Lewis Acid-Mediated Efficient Synthesis of 4H-1,3-benzo-xazines and Their Derivatives 4,5-dihydro-1,3-benzo-xazepines

2020 ◽  
Vol 24 (11) ◽  
pp. 1263-1273
Author(s):  
An Junkai ◽  
Liu Jikun ◽  
Shi Ying ◽  
Zhu Weiwei ◽  
Guo Guoying ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Lewis Acid ◽  
Functional Group ◽  
Materials Science ◽  
Pharmaceutical Research ◽  
Direct Access ◽  
Efficient Synthesis ◽  
Mild Conditions ◽  
Promising Strategy ◽  
Characteristic Features

: Compounds containing 4H-1,3-benzo-xazine core usually possess characteristic features and have been applied in the fields of organic synthesis, pharmaceutical research, materials science and bioscience. Here we reported convenient and direct access to 4H-1,3- benzo-xazines and their derivatives through intramolecular cyclization of olefinic amides or ureas with good to excellent yields in the presence of TMSOTf. The properties (mild conditions, metal or additives-free, wide substrate scope and functional group tolerance) of the process made it a promising strategy to synthesize various benzo-xazines and their derivatives.

Catalyst-free amidation of aldehyde with amine under mild conditions

2015 ◽  
Vol 39 (8) ◽  
pp. 5912-5915 ◽  
Author(s):  
Hongyin Yang ◽  
Wenjian Hu ◽  
Shengjue Deng ◽  
Tiantian Wu ◽  
Haiman Cen ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Highly Efficient

A highly efficient, catalyst-free and one-pot procedure for the direct synthesis of amides from aldehydes and amines under mild conditions has been developed.

Synthesis of C3-Cyanomethylated Imidazo[1,2-a]pyridines via Ultrasound-Promoted Three-Component Reaction under Catalyst- and Oxidant-free Conditions

Synlett ◽  
2021 ◽  
Author(s):  
Jie Zhang ◽  
Yufeng Zhang ◽  
Jian Zhang ◽  
Qingguo Wu ◽  
Haifeng Yang
Keyword(s):  
Functional Group ◽  
Efficient Synthesis ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Three Component Reaction

An efficient synthesis of C3-cyanomethylated imidazo[1,2-a]pyridines via ultrasound-promoted three-component reaction under catalyst-free, oxidant-free and mild conditions has been developed. A series of C3-cyanomethylated imidazo[1,2-a]pyridines were rapidly prepared with satisfactory yields and good functional group compatibility. This strategy cloud also be applied to the synthesis of zolpidem and alpidem in short steps.

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

2014 ◽  
Vol 50 (68) ◽  
pp. 9687-9689 ◽  
Author(s):  
Jinmin Miao ◽  
Nigel G. J. Richards ◽  
Haibo Ge
Keyword(s):  
Functional Group ◽  
Direct Synthesis ◽  
Mild Conditions

A novel rhodium–catalyzed imination of sulfoxides using O-(2,4-dinitrophenyl)hydroxylamine is developed under mild conditions with good functional group tolerance.

One-Pot, Catalyst-Free Synthesis of Nitriles from Aldehydes Using Aminating Reagent MsONH3OTf

Synlett ◽  
2021 ◽  
Author(s):  
Tharcisse Gatera ◽  
Daijiao Zhuang ◽  
Rulong Yan
Keyword(s):  
Functional Group ◽  
Triflic Acid ◽  
One Pot ◽  
Aliphatic Aldehydes ◽  
Mild Conditions ◽  
Catalyst Free ◽  
N Source ◽  
Acid Salts

AbstractAn eco-friendly protocol to synthesize nitriles from their corresponding aromatic and aliphatic aldehydes in excellent yields has been developed. This is a catalyst-free protocol which employs an aminating reagent (MsONH3OTf) under mild conditions. The hydroxylamine triflic acid salts (MsONH3OTf) acted as the N source for this protocol. Our protocol proved to be easy to perform and presented good functional group tolerance.

scholarly journals Oxidative Annulation of Diphenylpropanamides via In Situ Hypervalent Iodine-Promoted Intramolecular C–N/C–O Bond Formation

SynOpen ◽  
2021 ◽  
Vol 05 (04) ◽  
pp. 327-334
Author(s):  
Zhi-Peng Liang ◽  
Ying-Xin Yu ◽  
Yang Wang ◽  
Zheng-Guang Wu ◽  
Yuan-Yuan Sun
Keyword(s):  
Functional Group ◽  
Bond Formation ◽  
Single Step ◽  
Hypervalent Iodine ◽  
Target Compound ◽  
Migration Process ◽  
Aryl Iodide ◽  
Mild Conditions ◽  
Straightforward Approach

AbstractAn aryl iodide catalyzed intramolecular oxidative transformation of diphenylpropanamide derivatives is described that can readily afford the C–N/C–O coupling products in a single step. The speed of the 1,3-aryl iodide migration process determines the diversity of target compound generation in this reaction. This straightforward approach can be performed with the use of inexpensive and readily available catalyst, transition-metal-free, mild conditions and good functional group tolerance.

Copper-Catalyzed Intermolecular Thioamination of Maleimides with Thiols and Formamides: A One-Step Construction of 3-Amino-4-thiomaleimides Using Formamides as Nitrogen Sources

Synthesis ◽  
2018 ◽  
Vol 50 (23) ◽  
pp. 4627-4636 ◽  
Author(s):  
Sheng-Yin Zhao ◽  
Zhen-Hua Yang ◽  
Jia-Nan Zhu ◽  
Ze-Hui Jin ◽  
Jian Zheng
Keyword(s):  
Functional Group ◽  
Bond Formation ◽  
Nitrogen Sources ◽  
Diverse Range ◽  
Mild Conditions ◽  
Highly Efficient ◽  
One Step ◽  
Operational Simplicity

A highly efficient copper-catalyzed intermolecular C(sp2)–H thioamination of maleimides with thiols and formamides in the presence of fluoroboric acid is reported using various readily available formamides as nitrogen sources and solvents. A diverse range of 3-amino-4-thiomaleimides is obtained with good yields under mild conditions, involving C–N and C–S bond formation. This methodology enriches current C–N and C–S bond formation chemistry and features operational simplicity and excellent functional-group tolerance.

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