scholarly journals Effects of dietary fats with different n-3 polyunsaturated fatty acid and n-6 polyunsaturated fatty acid on lipid metabolism in rats.

1989 ◽  
Vol 47 (3) ◽  
pp. 141-150
Author(s):  
Toshichika Takita ◽  
Kaoru Nakamura ◽  
Takashi Hayakawa ◽  
Asako Fukutomi ◽  
Satoshi Innami
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Polyunsaturated Fatty Acid ◽  
Dietary Fats

Effects of feeding ryegrass of varying maturity on the metabolism and composition of lipids in the rumen of sheep

1986 ◽  
Vol 106 (3) ◽  
pp. 445-448 ◽  
Author(s):  
T. Gerson ◽  
A. John ◽  
A. S. D. King
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Linoleic Acid ◽  
Blood Plasma ◽  
Polyunsaturated Fatty Acid ◽  
Perennial Ryegrass ◽  
Crude Protein ◽  
Linseed Oil ◽  
Triacyl Glycerol

SummaryTwo experiments were carried out to test the effects of ryegrass maturity on rumen lipid metabolism. In the first experiment the effect of stage of maturity of perennial ryegrass on lipid metabolism in the rumen was studied with grazing sheep fitted with rumen cannulae. The pasture was either immature (13·8% crude protein), mature (8·1% crude protein) or senescent (5·5% crude protein).The ratesin vitroof triacyl glycerol lipolysis and linoleic acid (18: 2w6) hydrogenation were found to decrease with increasing age of the ryegrass.In the second experiment the sheep were dosed with emulsified linseed oil (30 g) via rumen cannulae while grazing immature or senescent ryegrass and the rumen digesta and blood plasma sampled at 0, 4 and 8 h after dosing.The proportions of linseed oil retained in the rumen were greater and blood plasma linoleic (18:2w6) and linolenic (18:3w3) acid concentrations higher when senescent ryegrass was fed.It was concluded that the rates of rumen lipolysis and hydrogenation decreased with the age of pasture and that after dosing with linseed oil the polyunsaturated fatty acid concentrations in blood plasma increased.

scholarly journals Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

2020 ◽  
Vol 117 (51) ◽  
pp. 32433-32442
Author(s):  
Ji-Yoon Lee ◽  
Miso Nam ◽  
Hye Young Son ◽  
Kwangbeom Hyun ◽  
Seo Young Jang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Cancer Cells ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
Intestinal Type ◽  
Biosynthesis Pathway ◽  
Gastric Cancer Cells ◽  
Regulated Necrosis

Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer cells survive under metabolic stress conditions by altering lipid metabolism, which may alter their sensitivity to ferroptosis. However, the association between lipid metabolism and ferroptosis is not completely understood. In this study, we found that the expression of elongation of very long-chain fatty acid protein 5 (ELOVL5) and fatty acid desaturase 1 (FADS1) is up-regulated in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization. In contrast, these enzymes are silenced by DNA methylation in intestinal-type GCs, rendering cells resistant to ferroptosis. Lipid profiling and isotope tracing analyses revealed that intestinal-type GCs are unable to generate arachidonic acid (AA) and adrenic acid (AdA) from linoleic acid. AA supplementation of intestinal-type GCs restores their sensitivity to ferroptosis. Based on these data, the polyunsaturated fatty acid (PUFA) biosynthesis pathway plays an essential role in ferroptosis; thus, this pathway potentially represents a marker for predicting the efficacy of ferroptosis-mediated cancer therapy.

Effect of dietary fats containing each fatty acid of the n-3, n-6 and n-9 series on lipid metabolism in hypercholesterolemic rats.

1988 ◽  
Vol 41 (4) ◽  
pp. 279-286
Author(s):  
Seung-Yong CHUNG ◽  
Toshichika TAKITA ◽  
Kaoru NAKAMURA ◽  
Takashi HAYAKAWA ◽  
Asako FUKUTOMI ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Dietary Fats

The changes in growth performance and lipid metabolism of pigs with yellow fat induced by high dietary fish oil

2020 ◽  
Vol 100 (1) ◽  
pp. 154-164
Author(s):  
Qiuping Guo ◽  
Fengna Li ◽  
Chaoyue Wen ◽  
Lingyu Zhang ◽  
Yehui Duan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fish Oil ◽  
Growth Performance ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Synthase ◽  
Basal Diet ◽  
Final Body Weight ◽  
Fresh Fish ◽  
High Fish

The aim of this study was to investigate the alteration in growth performance and lipid metabolism during the development of yellow fat in pigs. A total of 30 pigs (9.23 ± 0.21 kg) were assigned to three treatments: (1) low fish oil (LFO), basal diet + 2% fresh fish oil; (2) high fish oil (HFO), basal diet + 8% fresh fish oil; and (3) oxidized fish oil (OFO), basal diet + 8% OFO (peroxide value = 250 meqO2 kg−1). Pigs fed HFO and OFO diets showed yellow staining of fat and decreased growth performance, including average daily gain, average daily feed intake, and final body weight (P < 0.01). The oxidized lipid markers malondialdehyde, yellowness b* of backfat, perirenal fat, and abdominal fat were markedly increased in the pigs fed with HFO and OFO (P < 0.05). Furthermore, following HFO feeding, pigs showed significant decreases in n-6 polyunsaturated fatty acid, n-6/n-3 polyunsaturated fatty acid ratio and mRNA expression levels of CCAAT-/enhancer-binding protein alpha, fatty acid synthase, lipoprotein lipase, and hormone-sensitive lipase in backfat (P < 0.01). Overall, pigs with yellow-fat trait showed decreased growth performance and altered lipid metabolism by the high fish oil feeding.

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