scholarly journals Morphometric features of blood vessels in adenomas and carcinomas of the parathyroid gland

2021 ◽  
pp. 8-13
Author(s):  
Bogdan Ya. Serbin ◽  
Sergiy G. Gychka ◽  
Sofiia I. Nikolaienko ◽  
Olori Oboghene ◽  
Rachel Adekunle ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Blood Vessels ◽  
Parathyroid Gland ◽  
Parathyroid Cancer ◽  
Tissue Samples ◽  
Vascular Growth ◽  
Neoplastic Processes ◽  
Morphometric Features ◽  
Vascular Factor ◽  
Morphometric Methods

In this article discussed the problem of neoangiogenesis in neoplastic processes of the parathyroid gland. Applying morphometric methods for the assessment of sectional tissue samples of patients with adenoma and carcinoma of the parathyroid gland, we obtained the results of quantitative and qualitative vascular growth during neoangiogenesis. At present, there are not many studies that assess vascular factor in parathyroid cancer. This study may be useful in research cancer treatment, as it highlights the pathological aspects of the formation of new blood vessels, which is similar in all malignant processes.

Abstract 1674: Quantifying tumor-infiltrating leukocytes in hematoxylin stained NSCLC tissue samples using morphometric features

2017 ◽  
Author(s):  
Elliott Ergon ◽  
Allison S. Harney ◽  
Nathan Martin ◽  
Will Paces ◽  
Famke Aeffner ◽  
...  
Keyword(s):  
Nsclc Tissue ◽  
Tissue Samples ◽  
Morphometric Features

Simulating the Effects of Angiogenesis on Tumorigenesis Through Computational Modeling

2009 ◽  
Author(s):  
Michele D. Cooper ◽  
Martin L. Tanaka ◽  
Ishwar K. Puri
Keyword(s):  
Computational Modeling ◽  
Cancer Treatment ◽  
Blood Vessels ◽  
Central Region ◽  
Oxygen Diffusion ◽  
Physiological Process ◽  
Hallmarks Of Cancer ◽  
Sustained Growth ◽  
Nutrient Influx

Angiogenesis is a physiological process in which new blood vessels are formed from pre-existing vessels. It is one of the hallmarks of cancer and contributes greatly to the sustained growth of a tumor. Without the nutrient influx provided by newly formed capillaries, tumors growth is curtailed due to a lack of oxygen diffusion into the central region of the tumor body. Angiogenesis substantially increases the risk of developing cancer and as a result, anti-angiogenic therapies are being developed for cancer treatment.

scholarly journals Effects of Adenosine A2A Receptor Agonist on Histopathology of Some Oral Tissues in Rabbits

2020 ◽  
Vol 11 (4) ◽  
pp. 5173-5178
Author(s):  
Faehaa Azher Al-Mashhadane
Keyword(s):  
Treatment Group ◽  
Salivary Glands ◽  
Blood Vessels ◽  
Rabbit Model ◽  
Inflammatory Cells ◽  
The Body ◽  
Control Group ◽  
Serum Samples ◽  
Tissue Samples ◽  
Group 15

Adenosine is a protective regulator that act endogenously to restore equilibrium of cellular energy in response to tissue trauma. It can perform such function of different systems in the body by activation of adenosine receptors. Study the effects of systemic administration of the adenosine on tongue and salivary glands tissues in the rabbit model. Thirty male rabbits of body weight of 1.5 ± 0.25kg were included in the study. In control group (15 animals), one ml of distilled water was injected intraperitoneally while in treatment group (15 animals) were injected by adenosine intraperitoneally at a dose of one mg/ml, All animals were sacrificed after 30 days. Serum samples were separated and used for analysis of adenosine deaminase (ADA)and glutathione(GSH). Tissue samples sections from tongue and salivary glands were stained with hematoxylin-eosin (H&E) and examined under a light microscope for histological changes by a blinded pathologist. Histological sections in treatment group showed congestion of blood vessels and infiltration of inflammatory cells with mild hemorrhage among acini of salivary glands. Increased level of adenosine in the body microenvironment may affect tongue and salivary glands tissues by modulating some processes including inflammation and blood vessels.

scholarly journals Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits

2000 ◽  
Vol 24 (2) ◽  
pp. 121-133
Author(s):  
Mashi S. K. ◽  
Al-Ar'rak J. K.
Keyword(s):  
Parathyroid Gland ◽  
Physiological Saline ◽  
Secretory Activity ◽  
Treated Group ◽  
Control Group ◽  
Tissue Samples ◽  
Functional Changes ◽  
Parathyroid Function ◽  
Physiological Saline Solution ◽  
Therapeutic Doses

This experiment was carried out to determine structural functional changes which could be caused due to uses of dexamethasone at daily therapeutic doses in rabbits for a reasonable period. Ten adult male rabbits were randomly divided into two equal groups control and treatment. Animals of the treatment group were intramuscularly injected with dexamethasone sod. citrate (0.06 mg/100g.B.W.) for 14 days. Animals of control group received the same dose of normal physiological saline solution blood samples were collected every other day until 48 hours after the last injection serum was isolated for measurement of calcium concentrations. At the end of the experiment tissue samples from the parathyroid glands were isolate to prepare histological stained sections . Dexamethasone did not cause significant changes in serum concentration of calcium of treated group compared with its concentrations in control group. Light microscopic examination of hematoxylin eosion stained sections of parathyroid gland showed enlargement and increase in number of light chief cells indicating increased secretory activity due to dexamethasone injection. The increased of parathyroid gland activity explain the maintenance of total calcium level within the normal range in spite of the expected hypocalcemia due to dexamethasone administration. 

scholarly journals Therapeutic vascular growth in the heart

2019 ◽  
Vol 1 (1) ◽  
pp. H9-H15
Author(s):  
Ebba Brakenhielm ◽  
Vincent Richard
Keyword(s):  
Blood Vessels ◽  
Therapeutic Angiogenesis ◽  
Clinical Translation ◽  
Preclinical Research ◽  
Vascular Growth ◽  
Ischemic Diseases

Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging. In this mini review, we briefly present the current main approaches applied to improve pro-angiogenic therapies. Specific examples from research on therapeutic cardiac angiogenesis and arteriogenesis will be discussed, and finally some suggestions for future therapeutic developments will be presented.

scholarly journals Widespread decrease of cerebral vimentin-immunoreactive astrocytes in depressed suicides

2020 ◽  
Author(s):  
Liam Anuj O’Leary ◽  
Claudia Belliveau ◽  
Maria Antonietta Davoli ◽  
Jie Christopher Ma ◽  
Arnaud Tanti ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
White Matter ◽  
Blood Vessels ◽  
Close Association ◽  
Brain Regions ◽  
Quantitative Comparison ◽  
Postmortem Brain ◽  
Dorsomedial Prefrontal Cortex ◽  
Morphometric Features ◽  
Fine Morphology

1AbstractPostmortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However, it remains unclear whether astrocytic subpopulations IR for other astrocytic markers are similarly affected. Astrocytes IR to vimentin (VIM) display different regional densities than GFAP-IR astrocytes in the healthy brain, and so may be differently altered in depression and suicide. To investigate this, we compared the densities of GFAP-IR astrocytes and VIM-IR astrocytes in postmortem brain samples from depressed suicides and matched non-psychiatric controls in three brain regions (dorsomedial prefrontal cortex, dorsal caudate nucleus and mediodorsal thalamus). A quantitative comparison of the fine morphology of VIM-IR astrocytes was also performed in the same regions and subjects. Finally, given the close association between astrocytes and blood vessels, we also assessed densities of CD31-IR blood vessels. Like for GFAP-IR astrocytes, VIM-IR astrocyte densities were found to be globally reduced in depressed suicide relative to controls. By contrast, CD31-IR blood vessel density and VIM-IR astrocyte morphometric features in these regions were similar between groups, except in prefrontal white matter, in which vascularization was increased and astrocytes displayed fewer primary processes. By revealing a widespread reduction of cerebral VIM-IR astrocytes in cases vs. controls, these findings further implicate astrocytic dysfunctions in depression and suicide.

scholarly journals Immunohistochemical Expression of the Alpha Nicotinic Acetylcholine Receptor 7 in the Human Normal, Diabetic, and Preeclamptic Placenta and Products of Conception

2020 ◽  
Vol 11 ◽  
Author(s):  
Ahmad Alwazzan ◽  
Riffat Mehboob ◽  
Syed Amir Gilani ◽  
Amber Hassan ◽  
Shahida Perveen ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Acetylcholine Receptor ◽  
First Trimester ◽  
Sudden Infant ◽  
Tissue Samples ◽  
Acetyl Choline ◽  
Α7 Nachr ◽  
Products Of Conception ◽  
Villous Trophoblast ◽  
Two Samples

Preeclampsia (PE) and gestational diabetes (GD) are complications in advanced pregnancy while miscarriage for early pregnancy. However, the etiological factors are not well understood. Smoking has been associated with these complications as well as the sudden intrauterine deaths, sudden infant death, miscarriages, and still births. However, the immunolocalization of alpha 7 nicotine acetylcholine receptor (α7-nAChR) is not studied.Materials and Methods: α7-nAChR subunit expression was evaluated in 10 paraffin-embedded placental tissues after delivery and 10 tissue samples of products of conception during first trimester by immunohistochemistry. Among the placental tissues, two samples were normal placental tissue, four from PE mother, and four from GD mother. The expression of α7-nAChR was compared between the two groups in general and within the subgroups of placenta as well. Protein expression was evaluated using the nuclear labeling index (%) of villi with positive cells stained, positive cells in the decidua, and intensity of staining in the outer villous trophoblast layer.Results: The expression of α7-nAChR protein was high in all the cases of placenta and products of conception (POCs). α7-nAChR expression showed no notable differences among different cases of miscarriages irrespective of the mother’s age and gestational age at which the event occurred. However, there were some changes among the normal, PE, and GD placental groups in the linings of the blood vessels. Changes were restricted to the villi (as opposed to the decidua) lining cells, both cytotrophoblast and syncytiotrophoblast, and were specific to the α7 subunit. PE blood vessel lining was thicker and showed more expression of this receptor in endothelial cells and myofibroblasts in PE and GD groups. In POCs, the strong expression was observed in the decidua myocytes of maternal blood vessels and in syncytiotrophoblast and cytotrophoblast of chronic villi.Conclusion: Nicotine acetyl choline receptors are found to be expressed highly in the placental tissues and in products of conception. They may be associated with the sudden perinatal deaths and miscarriages or complications of pregnancy.

Retinopathy of Prematurity: An Eye Toward Better Outcomes

2009 ◽  
Vol 28 (2) ◽  
pp. 93-101 ◽  
Author(s):  
Charlene Pollan
Keyword(s):  
Risk Factors ◽  
Growth Factors ◽  
Blood Vessels ◽  
Retinopathy Of Prematurity ◽  
Complex Interaction ◽  
Vascular Growth ◽  
Abnormal Growth ◽  
Vascular Bed ◽  
History Of ◽  
The U.S

Retinopathy of prematurity (ROP) results from the abnormal growth of blood vessels in the vascular bed supporting the developing retina. Estimated to cause up to 500 new cases of blindness in the U.S. each year, ROP affects primarily infants born at less than 1,500 g. Although its etiology is not well understood, ROP is thought to occur as a result of a complex interaction between oxygen and vascular growth factors. This article briefly reviews the history of ROP, discusses its pathophysiology, and addresses the risk factors and strategies for prevention.

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