scholarly journals A case of syphilis with an extremely high RPR titer

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Luqman Dabiri ◽  
Keyword(s):  
Positive Result ◽  
False Positive ◽  
Screening Tests ◽  
False Positive Result ◽  
Rapid Plasma Reagin ◽  
Reverse Sequence ◽  
Traditional Algorithm ◽  
Syphilis Screening

It remains unidentified why this patient has an extremely high Rapid Plasma Reagin Titer (RPR) 1: 2048. A false positive result was ruled out by a Treponemal test. To ensure accuracy, repeat tests were requested for both the Non-Treponemal and Treponemal Tests in the same laboratory, and the results came back the same. In the Traditional Algorithm, Positive Nontreponemal Syphilis screening tests are confirmed by Treponemal tests, although the latter is not quantitative. The lack of full sensitivity in the Traditional Algorithm Testing has led the CDC and some other centers to adopt Reverse Sequence Testing. The resurgence of syphilis after 20 years could lead to mutagenic strain thus making it relevant for a need for heightened awareness.

Clinical characteristics of patients with systemic lupus erythematosus showing a false-positive result of syphilis screening

2019 ◽  
Vol 39 (11) ◽  
pp. 1859-1866 ◽  
Author(s):  
Sung Soo Ahn ◽  
Seung Min Jung ◽  
Juyoung Yoo ◽  
Sang-Won Lee ◽  
Jason Jungsik Song ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Positive Result ◽  
Lupus Erythematosus ◽  
False Positive ◽  
Clinical Characteristics ◽  
False Positive Result ◽  
Systemic Lupus ◽  
Syphilis Screening

scholarly journals Urine opiate screening: false-positive result with levofloxacin

2010 ◽  
Vol 182 (15) ◽  
pp. 1644-1645 ◽  
Author(s):  
Q. Shafiq ◽  
A. Mutgi
Keyword(s):  
Positive Result ◽  
False Positive ◽  
False Positive Result

scholarly journals Subsequent attendance in a breast cancer screening program after a false-positive result in the Local Health Authority of Bologna (Italy)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lorena Squillace ◽  
Lorenzo Pizzi ◽  
Flavia Rallo ◽  
Carmen Bazzani ◽  
Gianni Saguatti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Positive Result ◽  
Breast Cancer Screening ◽  
Health Authority ◽  
False Positive ◽  
Screening Program ◽  
Local Health Authority ◽  
Local Health ◽  
False Positive Result

AbstractWe conducted a cross-sectional study to assess the likelihood of returning for routine breast cancer screening among women who have experienced a false-positive result (FPR) and to describe the possible individual and organizational factors that could influence subsequent attendance to the screening program. Several information were collected on demographic and clinical characteristics data. Electronic data from 2014 to 2016 related to breast screening program of the Local Health Authority (LHA) of Bologna (Italy) of women between 45 and 74 years old were reviewed. A total of 4847 women experienced an FPR during mammographic screening and were recalled to subsequent round; 80.2% adhered to the screening. Mean age was 54.2 ± 8.4 years old. Women resulted to be less likely to adhere to screening if they were not-Italian (p = 0.001), if they lived in the Bologna district (p < 0.001), if they had to wait more than 5 days from II level test to end of diagnostic procedures (p = 0.001), if the diagnostic tests were performed in a hospital with the less volume of activity and higher recall rate (RR) (p < 0.001) and if they had no previous participation to screening tests (p < 0.001). Our results are consistent with previous studies, and encourages the implementation and innovation of the organizational characteristics for breast cancer screening. The success of screening programs requires an efficient indicators monitoring strategy to develop and evaluate continuous improvement processes.

scholarly journals Clinical Performance of the BioPlex 2200 Syphilis Total & RPR Assay at a Tertiary Medical Center with a High Rate of Syphilis

2018 ◽  
Vol 57 (1) ◽  
Author(s):  
Merih T. Tesfazghi ◽  
Neil W. Anderson ◽  
Ann M. Gronowski ◽  
Melanie L. Yarbrough
Keyword(s):  
Clinical Performance ◽  
Medical Center ◽  
High Volume ◽  
High Rate ◽  
Rapid Plasma Reagin ◽  
Antibody Absorption ◽  
Traditional Algorithm ◽  
Syphilis Screening ◽  
Manual Methods ◽  
Positive Population

ABSTRACT Manual treponemal and nontreponemal serologic testing has historically been used for the diagnosis of syphilis. This approach is simple and reproducible but labor intensive. Recently, the FDA cleared the fully automated BioPlex 2200 Syphilis Total & RPR assay for the detection of treponemal and nontreponemal antibodies. We evaluated the clinical performance of this assay at a tertiary medical center with a high syphilis prevalence. Prospective consecutively collected (n = 400) and known RPR-positive (n = 100) specimens were compared using predicate manual rapid plasma reagin (RPR) and fluorescent treponemal antibody absorption (FTA) methods and the BioPlex 2200 Syphilis Total & RPR assay. Positive and negative percent agreements (PPA and NPA, respectively) between the assays were calculated. The PPA and NPA between the manual and BioPlex 2200 RPR results for the prospective population were 85% (17/20; 95% confidence interval [CI], 69% to 100%) and 98% (373/380; 95% CI, 97% to 99%), respectively. The PPA for the manual RPR-positive population was 88% (88/100; 95% CI, 82% to 94%). Overall, the manual and BioPlex 2200 RPR titers demonstrated 78% (99/127) concordance within ±1 dilution and 94% (120/127) within ±2 dilutions. An interpretation of the syphilis serologic profile using the traditional algorithm showed a concordance of 99.5% in the prospective population and 85% in the manual RPR-positive cohort. The performance of the BioPlex 2200 Syphilis Total & RPR assay is comparable to those of manual methods. The high NPA of this assay combined with the ability to automate a historically labor-intensive assay is an appealing attribute for syphilis screening in a high-volume laboratory.

Positron Emission Tomography: False Positive Result Due to Splenic Uptake in an Extension Study in Bronchial Carcinoma. A Case Report

2007 ◽  
Vol 93 (3) ◽  
pp. 316-318
Author(s):  
David Orts Giménez ◽  
Rosa Jiménez Yáñez ◽  
Gaspar Esquerdo Galiana ◽  
Antonia Galán Dávila ◽  
Eleuterio Llorca Martínez ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Case Report ◽  
Positive Result ◽  
False Positive ◽  
Bronchial Carcinoma ◽  
Emission Tomography ◽  
Extension Study ◽  
False Positive Result ◽  
Positron Emission ◽  
Splenic Uptake

False-positive result with BinaxNOW Legionella Antigen immunochromatographic (ICT) assay: response to Helbig et al. (2001)

2004 ◽  
Vol 53 (2) ◽  
pp. 173-173 ◽  
Author(s):  
E. Bailleul ◽  
K. Magerman ◽  
A. Mewis ◽  
V. Peeters ◽  
J. -L. Rummens ◽  
...  
Keyword(s):  
Positive Result ◽  
False Positive ◽  
False Positive Result

False-positive result when a diphenylcarbazide spot test is used on trivalent chromium-passivated zinc surfaces

2018 ◽  
Vol 78 (5) ◽  
pp. 315-320 ◽  
Author(s):  
Valeriia Reveko ◽  
Felix Lampert ◽  
Rameez U. Din ◽  
Jacob P. Thyssen ◽  
Per Møller
Keyword(s):  
Positive Result ◽  
False Positive ◽  
Trivalent Chromium ◽  
Spot Test ◽  
False Positive Result

scholarly journals False-Positive Result and Reattendance in the Ontario Breast Screening Program

2003 ◽  
Vol 10 (3) ◽  
pp. 129-133 ◽  
Author(s):  
A M Chiarelli ◽  
V Mai ◽  
V Moravan ◽  
E Halapy ◽  
V Majpruz ◽  
...  
Keyword(s):  
Positive Result ◽  
False Positive ◽  
Breast Screening ◽  
Screening Programme ◽  
Screening Program ◽  
False Positive Result ◽  
Positive Screen ◽  
Assessment Programme ◽  
Second Screen ◽  
Screen Result

Objective: To determine the association between initial screen result and returning for a second screen in an organised breast screening programme for women with a biennial screening recommendation. Setting: Women who attended the Ontario Breast Screening Program (OBSP). Methods: A retrospective cohort study was conducted of 140,723 Ontario women aged 50 years ond older who had an initial screen at the OBSP between 1 July 1990 and 31 December 1995 and were followed until 30 June 1998. Rescreening rates at 36 months and risk ratio estimates were calculated using survival methods. Age of women, year of screen, region (within Ontario) and initial screen result were compared. For initial screen results, returning for a second screen was examined by integration of screening centre with an assessment programme and by modality of referral. Results: Women with a false-positive result were less likely to return for a second screen as were women aged 70 and older and those living in regions of Ontario with fewer OBSP screening centres. However, there were minimal differences in reattendance behaviour by initial screen result for women screened at the OBSP centre with an assessment programme. Conclusions: Integration of breast screening and assessment services improved reattendance of women with false-positive screen results within an organised screening programme.

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