scholarly journals Cushing response

2016 ◽  
Author(s):  
Craig Hacking ◽  
Henry Knipe
Keyword(s):  
Cushing Response

Transcranial Doppler and Cortical Microcirculation at Increased Intracranial Pressure and during the Cushing Response

Neurosurgery ◽  
1995 ◽  
Vol 36 (1) ◽  
pp. 147???157
Author(s):  
Karl Ungersb??ck ◽  
Dirk Tenckhoff ◽  
Axel Heimann ◽  
Wolfgang Wagner ◽  
Oliver S. Kempski
Keyword(s):  
Intracranial Pressure ◽  
Transcranial Doppler ◽  
Increased Intracranial Pressure ◽  
Cushing Response

Spinal vasomotor reflex and Cushing response

1980 ◽  
Vol 52 (1-2) ◽  
pp. 85-97 ◽  
Author(s):  
A. P�sztor ◽  
E. P�sztor
Keyword(s):  
Cushing Response ◽  
Vasomotor Reflex

Cerebral blood flow and evoked potentials during Cushing response in sheep

1989 ◽  
Vol 256 (3) ◽  
pp. H779-H788
Author(s):  
R. C. Koehler ◽  
J. E. Backofen ◽  
R. W. McPherson ◽  
M. D. Jones ◽  
M. C. Rogers ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Cerebral Blood Flow ◽  
Intracranial Pressure ◽  
Arterial Pressure ◽  
Evoked Potentials ◽  
Aortic Pressure ◽  
Base Line ◽  
Auditory Evoked Responses ◽  
Cushing Response

We determined how alterations in systemic hemodynamics, characteristic of the Cushing response, are related to changes in cerebral blood flow (CBF), cerebral metabolic rate of O2 (CMRO2), and brain electrical conductive function, as assessed by somatosensory-evoked potentials (SEP) and brain stem auditory-evoked responses (BAER). In three groups of eight pentobarbital-anesthetized sheep, intracranial pressure was gradually elevated to within 50, 25, or 0 mmHg of base-line mean arterial pressure and then held constant for 40 min by intraventricular infusion of mock cerebrospinal fluid. Microsphere-determined CBF fell when cerebral perfusion pressure was less than 50 mmHg. CMRO2 fell when CBF fell greater than 30-40%. Mean aortic pressure and cardiac output increased when CBF fell greater than 40%, i.e., at approximately the level at which CMRO2 fell. Furthermore, the magnitude of the increase in arterial pressure and cardiac output correlated with the reduction of CMRO2. SEP latency did not increase unless CBF fell greater than 55-65%, corresponding to a 20-30% reduction of CMRO2. Increased latency of BAER wave V was associated with a fall in midbrain blood flow of greater than 65-70%. Thus increase in SEP and BAER latencies required reductions of flow greater than those required to elicit a systemic response. This demonstrates that there is a range of intracranial pressure over which the increase in arterial pressure preserves sufficient CBF to sustain minimal electrical conductive function. The best predictor of the onset and magnitude of the Cushing response in adult sheep is the decrease in CMRO2.

Cerebral blood flow and evoked potentials during cushing response in sheep

1989 ◽  
Vol 4 (3) ◽  
pp. 232 ◽  
Author(s):  
R.C. Koehler ◽  
J.E. Backofen ◽  
R.W. McPherson
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Evoked Potentials ◽  
Cushing Response

THE EFFECT OF BARBITURATE ANESTHESIA ON THE CUSHING RESPONSE IN FETAL SHEEP

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A912
Author(s):  
A P Harris ◽  
R C Koehler ◽  
M D Jones ◽  
R J Traystman
Keyword(s):  
Fetal Sheep ◽  
Cushing Response

Effect on the Cushing response of different rates of expansion of a supratentorial mass

1978 ◽  
Vol 49 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Abdul Hamid Zidan ◽  
John P. Girvin
Keyword(s):  
Heart Rate ◽  
Full Range ◽  
Blood Gases ◽  
Systemic Arterial Pressure ◽  
Critical Volume ◽  
Experimental Conditions ◽  
Content Type ◽  
Cerebral Dysfunction ◽  
Cushing Response ◽  
Supratentorial Mass

✓ The effects on the three components (respiration, blood pressure, and heart rate) of the Cushing response (CR) were studied in cats by the continuous expansion of a supratentorial balloon. The rate of expansion was varied over the range of 0.006 to 0.6 ml/min, during which systemic arterial pressure, heart rate, respiratory rate, and blood gases were monitored. For the different rates the time the CR took to develop, and the balloon volume required for that development were measured. The final volume (“critical volume”) for eliciting the CR was more or less constant over the full range of rates of infusion (balloon expansion), a fact that supports the Monro-Kellie doctrine. This constancy of critical volume (CCV) gives rise to a highly statistically significant relationship between the rate of infusion and the latency to the production of the CR, and it is described by a power curve. Thus the development of cerebral dysfunction under these experimental conditions is independent of the rate of expansion and only dependent upon this critical volume. Exceptions to this concept of a critical volume, at the extreme of rates of expansion of lesions in patients, are predicted.

Intracranial baroreflex yielding an early Cushing response in human

2006 ◽  
pp. 253-256 ◽  
Author(s):  
E. A. Schmidt ◽  
Z. Czosnyka ◽  
S. Momjian ◽  
M. Czosnyka ◽  
R. A. Bech ◽  
...  
Keyword(s):  
Cushing Response

Effect of preexisting brain ischemia on sympathetic nerve response to intracranial hypertension

1991 ◽  
Vol 70 (5) ◽  
pp. 2181-2187 ◽  
Author(s):  
B. Kocsis ◽  
L. Fedina ◽  
E. Pasztor
Keyword(s):  
Intracranial Hypertension ◽  
Sympathetic Nerve ◽  
Actual State ◽  
Phase Reaction ◽  
Two Phase ◽  
Ischemic Brain ◽  
Reperfusion Period ◽  
Control Response ◽  
Cushing Response ◽  
Nerve Discharge

The performance of the sympathetic nervous system during sustained moderate cerebral ischemia (CI) was examined in the present study. For this purpose, a Cushing response was elicited repeatedly during incomplete global CI in anesthetized artificially ventilated cats after vagotomy and baroreceptor denervation. In control animals without CI, sympathetic activity in response to brief elevation of intracranial pressure (ICP) showed a well-repeatable two-phase reaction. During CI there was a progressive deterioration of background sympathetic nerve discharge (SND) over a period of 30 min. SND response to repeated elevation of ICP was initially similar to control response but later with progression of CI was seriously changed. 1) Instead of the usual hyperactivation, sympathetic nerve activity was depressed during intracranial hypertension. 2) The characteristic desynchronized activity either appeared later during the reperfusion period or remained absent. The progressive loss of SND response to raised ICP in developed CI was compared with the changes seen in experiments in which repeated ICP elevations were superimposed on asphyxia. These findings suggest that the sympathetic component of the Cushing reaction strongly depends on the actual state of brain stem autonomic circuits and may be seriously altered in pathological situations involving ischemic brain injury.

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