The Relationship Between Salivary Dehydroepiandrosterone Sulphate (DHEAS) Levels and Skeletal Maturation Parameters Before and During Pubertal Growth Spurt in Children

2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Tahseen Sultana ◽  
Penmetcha Sarada ◽  
Namineni Srinivas ◽  
C H Sampath Reddy ◽  
S Ojass KUMAR ◽  
...  
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Cervical Vertebra ◽  
Skeletal Maturation ◽  
Growth Spurt ◽  
P Value ◽  
Group I ◽  
Lateral Cephalograms ◽  
Group Ii ◽  
Two Stages

Objectives: This study aimed to assess the skeletal maturation by using salivary DHEAS levels and its correlation with existing skeletal maturity parameters represented by cervical vertebrae and MP3 region radiographs in adolescents in pre-pubertal and pubertal age groups. Methods: In this study, 80 children in the age range of 8 - 14 years were divided into two equal groups based on their chronological age as group I (pre-pubertal group) and group II (pubertal group). Pre-existing lateral cephalograms and medial phalanx of third finger (MP3) radiographs of their left hands were assessed. The levels of the DHEAS of each individual were analysed by ELISA kit. ANOVA with post-hoc Tukey’s test and student t-test were used for statistical analysis. P-value < 0.05 was considered significant. Results: The mean level of DHEAS values shown in the present study was 4.36 +/- 0.32 ng/mL in group I and 5.73+/-0.39 ng/mL in group II. This study showed that in group I, more subjects were in stage 1 of cervical vertebral maturation than stage 2 and there were significant differences between the two stages (P-value = 0.011); also, in group II, more subjects were in stage 3 than 4 and there were significant differences between the two stages (P-value = 0.017). This study revealed the highest salivary DHEAS levels to be in the F stage of pre-pubertal MP3 development in addition to the H stage of MP3 development in pubertal children. This study noted that there were significant differences for salivary DHEAS levels between males and females not only in pre-pubertal (P-value = 0.031), but also in pubertal stages (P-value < 0.001). Conclusions: Salivary DHEAS, like cervical vertebra and MP3 radiographs, can be used for growth assessment in young adolescents.

Assessment of Skeletal Maturation using Mandibular Second Molar Maturation Stages

2014 ◽  
Vol 39 (1) ◽  
pp. 79-84 ◽  
Author(s):  
S Goyal ◽  
S Goyal ◽  
N Gugnani
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Skeletal Maturation ◽  
Growth Spurt ◽  
Pubertal Growth Spurt ◽  
Second Molar ◽  
Pubertal Growth ◽  
Lateral Cephalograms ◽  
Mandibular Second Molar ◽  
Pre Treatment

Objectives: To investigate the relationship between cervical vertebrae maturation and mandibular second molar calcification stages.Study design: The study was designed as a retrospective, descriptive and crosssectional research project. Pre-treatment lateral cephalograms and panoramic radiographs of 99 males and 110 females in the age range of 7 to 18 years 7 months were evaluated with Demirjian Index (DI) and cervical vertebrae maturation indicators (CVMI) of Hassel and Farman. A null hypothesis was proposed that there is no relation between CVMI and DI. Results: A highly significant association (Pearson's contingency coefficient 0.713 for males and 0.863 for females) was found between DI and CVMI. In males, the DI stage E corresponded to stage 2 of CVMI (pre–peak of pubertal growth spurt) and DI stages F and G corresponded to stages 3 and 4 of CVMI (peak of pubertal growth spurt). DI stage H was associated with stages 5 and 6 of CVMI (end of pubertal growth spurt). In females, the DI stages C, D corresponded to CVMI stages 1, 2; DI stages E, F with CVMI stages 3, 4; DI stages G, H with CVMI stages 5, 6. Conclusion: Mandibular second molar calcification stages can be used as indicators for assessment of skeletal maturity.

scholarly journals Objective Evaluation of Cervical Vertebral Bone Age— Its Reliability in Comparison with Hand-Wrist Bone Age: By TW3 Method

2013 ◽  
Vol 14 (5) ◽  
pp. 806-813
Author(s):  
Vamsi Nilay Reddy ◽  
Gojja Sreedevi ◽  
CMS Krishna Prasad ◽  
Swaroopa Rani Ponnada ◽  
K Padma Priya ◽  
...  
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Bone Age ◽  
Objective Evaluation ◽  
Ease Of Use ◽  
Skeletal Maturation ◽  
Potential Growth ◽  
Vertebral Bone ◽  
Therapeutic Decisions ◽  
Lateral Cephalograms

ABSTRACT Aim The aim of this study was to establish the validity of a new method for evaluating skeletal maturation by assessing the 3rd and 4th cervical vertebrae seen in the cephalometric radiograph. Materials and methods This study consisted of a sample of 50 patients in the age group of 8 to 14 years of age. Chronologically, they were divided into six groups, based on the age consisting of a minimum of six to a maximum of 10 subjects. All the patients included in the study were females. The selected subjects were clinically examined and then age and date of birth of the patient in years and months was noted. Then lateral cephalograms and hand-wrist radiographs of the patient were taken on the same day with good clarity and contrast. Results The results suggested that cervical vertebral bone age on cephalometric radiographs calculated with this method is as reliable at estimating bone age as is the Tanner-Whitehouse 3 (TW3) method on hand-wrist radiographs. By determining the cervical vertebral bone age, skeletal maturity can be evaluated in a detailed and objective manner with cephalometric radiographs. Conclusion The ability to accurately appraise skeletal maturity from cervical vertebral maturation, without the need for additional radiographs, has the potential to improve orthodontic diagnostic and therapeutic decisions. The technique's simplicity and ease of use should encourage this method as a first level diagnostic tool to assess skeletal maturation. Clinical significance This study revealed that the timing and sequence of ossification of the bones in hand and wrist and cervical vertebrae were able to relate the skeletal development of the various skeletal maturity indicators to a child's development. This method provided a mean with which one can determine the skeletal maturity of a person and thereby determine whether the possibility of potential growth existed. How to cite this article Prasad CMSK, Reddy VN, Sreedevi G, Ponnada SR, Priya KP, Naik BR. Objective Evaluation of Cervical Vertebral Bone Age—Its Reliability in Comparison with Hand-Wrist Bone Age: By TW3 Method. J Contemp Dent Pract 2013;14(5):806-813.

scholarly journals Correlation between Chronological Age, Cervical Vertebral Maturation and Fishman’s Skeletal Maturity Indicators in Central India Population

2019 ◽  
Vol 9 (2) ◽  
pp. 52-56
Author(s):  
Natasha Patil ◽  
Neha Maheshwari ◽  
Rohit Sharma ◽  
Shashank Soni ◽  
Ashish Kushwah
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Rank Correlation ◽  
Cervical Vertebra ◽  
Central India ◽  
Growth Period ◽  
Growth Spurt ◽  
Chronological Age ◽  
Spearman Rank Correlation Analysis ◽  
Cervical Vertebral Maturation

Introduction: Skeletal maturity indicators are very important indicators when diagnosing and panning the treatment in growing population. Cervical Vertebrae Method (CVM) and Fishman’s Skeletal Maturity Indicators are two commonly used methods for the diagnosis and treatment planning. The aim of the study was to investigate the correlation between cervical vertebral maturation (CVM)and Fishman’s hand-wrist skeletal maturity indicator and chronological age by including subjects within the range of circumpubertal growth spurt in Central India. Materials & Method: One Twenty Five contemporary hand-wrist and lateral cephalometric radiographs from population of Central India were randomly selected and analyzed. All subjects were within the circumpubertal period i.e. female subjects were between 10 and 15 years of age, and the male subjects were between 12 and 17 years of age. The hand-wrist bone analysis was evaluated using the method developed by Fishman whereas cervical vertebra bone analysis was evaluated using the method developed by Baccetti and co-workers. These two methods and chronological age were correlated using the Spearman rank correlation analysis. Result: CVM was significantly correlated with hand-wrist maturation (r=0.8868). However low correlation was found between the CVM and chronological age( r =0.7139) and little correlation was found between the HWM and chronological age ( r =0.6892). Conclusion: CVM is a valid indicator of skeletal growth during the circumpubertal growth period and has a high correlation with the HWM for the Central India population. However chronological age is not suitable to measure skeletal maturity as shown by the low correlations found between the chronological age and both CVM and HWM.

scholarly journals Correlation between chronological age and skeletal age using CVMI and modified MP3 methods

2020 ◽  
Vol 16 (12) ◽  
pp. 1045-1050
Author(s):  
Ravindra Kumar Jain ◽  
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Skeletal Age ◽  
Chronological Age ◽  
Accurate Estimation ◽  
P Value ◽  
Positive Correlation ◽  
Lateral Cephalograms ◽  
Rough Approximation ◽  
Method R

Chronological age conveys only a rough approximation of the maturational status of a person whereas skeletal maturity indicators give a more accurate estimation. Therefore, it is of interest to document the correlation between chronological and skeletal age using CVMI and modified MP3 methods. A total of 39 subjects between the age ranges of 9-16 years were selected for this study. Pre-treatment lateral cephalograms and hand-wrist radiographs of the subjects were used. The skeletal age was analyzed by the Cervical Vertebrae Maturity Index (CVMI) and modified MP3 methods. The data was analyzed with SPSS software version 23.00. Kendall’s Tau correlation test was performed to estimate the correlation between chronological age and skeletal age among the subjects and a linear regression test was also performed. Positive correlation was found between chronological age and skeletal age assessed by CVMI method (r= 0.398) and modified MP3 method (r=0.382) with p value <0.003. Thus it can be concluded that there was a positive correlation between chronological age and skeletal age among all the subjects.

scholarly journals Diagnostic assessment of skeletal maturity through dental maturation in Hispanic growing individuals

2017 ◽  
Vol 7 ◽  
pp. 35-40 ◽  
Author(s):  
Alejandra Cisternas ◽  
Rolando Morales ◽  
Valeria Ramirez ◽  
Alberto Del Real ◽  
Rodrigo Oyonarte
Keyword(s):  
Operating Characteristic ◽  
Skeletal Maturity ◽  
Characteristic Curve ◽  
Curve Analysis ◽  
Diagnostic Assessment ◽  
Skeletal Maturation ◽  
Growth Spurt ◽  
Dental Maturation ◽  
Lateral Cephalograms ◽  
Dental Maturity

Background The aim of this study was to explore dental maturation as a diagnostic test for skeletal maturation. Materials and Methods Six hundred and fifty-seven growing individuals were classified according to their cervical vertebral maturity and dental maturity, both determined in lateral cephalograms and panoramic radiographs, respectively. The correlation between cervical and dental stages was established for each gender. A receiver operating characteristic curve analysis was made, and sensitivity and specificity values were established. Results Correlation was found between cervical and dental maturation for females (r = 0.73; P < 0.001) and males (r = 0.60; P < 0.001). Sensitivity for dental Stage F, as an indicator of a postmaturation peak stage, was 87.21% for females and 97.1% for males, whereas specificity for the same stage was 82.92% and 72.3% for females and males, respectively. Conclusions Dental maturation evaluation could contribute determining whether a patient is in a pre- or post-growth spurt stage.

scholarly journals Evaluation of the Skeletal Maturation Using Lower First Premolar Mineralisation

2013 ◽  
Vol 59 (6) ◽  
pp. 289-292 ◽  
Author(s):  
Mártha I. Krisztina ◽  
Ogodescu A ◽  
Gyergyay Réka ◽  
Burján Zsuzsa
Keyword(s):  
Skeletal Maturity ◽  
Cervical Vertebrae ◽  
Skeletal Maturation ◽  
Growth Spurt ◽  
Optimal Time ◽  
Dental Age ◽  
Clinical Value ◽  
Mandibular First Premolar ◽  
Growth Evaluation ◽  
Treatment Procedures

Abstract Background: Dental age assessment is very useful in the pediatric dentist’s and orthodontist’s everyday practice. The eventual lack of correlation between dental age, skeletal maturation and chronological age can influence treatment procedures regarding mostly their application time. The aim of our study was to investigate the relationship between dental age based on the calcification stages of the first lower premolar (PM1i) and skeletal maturity stages using cervical vertebrae (C2, C3, C4) among Romanian individuals and to determine the clinical value of the first premolar as a growth evaluation index. Material and methods: In a sample of 30 patients (13 males, 17 females) ranging in age from 9 to 15 years (mean age 11.2 years) we examined the orthopantomography radiographs (OPT) and lateral cephalometric radiographs of each case. Results: The biological development of girls is about 1.5 years more advanced than in boys. When the Demirjian Index was at stage F, then CVS was at stage 3.4, which means that in developmental stage “F” (according to Demirjian index) premolars are indicators of the optimal time for orthodontic treatment. We found a significant correlation (R = 0.871, p <0.001) between CVM and Demirjian's index. Conclusions: The correlation shown in this study will allow clinicians to use mandibular first premolar as an adjunctive tool to assess adolescent growth spurt, combined with the evaluation of the cervical vertebrae. The results also show the usefulness of the assessment of the development of dental status as a simple diagnostic test to determine the biological age of the population

Growth and development in girls with Turner's syndrome during early therapy with low doses of estradiol

1986 ◽  
Vol 113 (4_Suppl) ◽  
pp. S157-S163 ◽  
Author(s):  
K.W. KASTRUP ◽  
_ _
Keyword(s):  
Growth Velocity ◽  
Final Height ◽  
Bone Age ◽  
Growth Spurt ◽  
First Year ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Early Therapy ◽  
Group I ◽  
Group Ii

Abstract Early therapy with a low dose of estrogen (estradiol-17β) was given to 33 girls with Turner's syndrome (T.s.) for a period of 4 years. The dose (0.25-2 mg/day) was adjusted every 3 months to maintain plasma estradiol in the normal concentration range for bone age. Growth velocity was compared with that of untreated girls with T.s. All girls were above age 10 years. Bone age was below 10 years in 11 girls (group I) and above 10 years in 22 girls (group II). Growth velocity in the first year of treatment in group I 7.5 ± 1.3 cm (SD) with mean SD score (SDS) of +4.3 and in group II 4.9 ± 1.3 with mean SDS of +3.5. Growth velocity decreased in the following years to 1.6 ± 1.0 cm, SDS -1.44 in group I and 0.9 ± 0.6cm, SDS -2.34 in group II during the fourth year. Withdrawal bleeding occurred in 16 girls of group II after the mean of 23 (range 15-33) months and in 3 girls of group I after 15 to 51 months of treatment. The treatment did not cause an inappropriate acceleration of pubertal development. Breast development appeared in most girls by 3 months of treatment. Pubic hair appeared by 12 months of treatment in group I; it was present in most girls in group II at start of treatment. Final height is known for 12 girls of group II; it was 144.2 ± 4.5 cm. The final height as predicted at the start of therapy was 142.2 ± 5.3 cm. Bone age advanced in the first year of treatment by 2 years. Early treatment with small doses of estrogens induces a growth spurt and normalizes the events of puberty. This will presumably decrease the psychological risks associated with abnormally delayed development.

Comparison of Outcome of Lateral Pinning Versus Medial and Lateral Cross Pinning in Childhood Supracondylar Fractures of Humerus

2021 ◽  
Vol 15 (9) ◽  
pp. 2873-2875
Author(s):  
Mudassar Nazzar ◽  
Muhammad Adeel-Ur- Rehman ◽  
Rizwan Anwar ◽  
Omer Farooq Tanveer ◽  
Muhammad Abdul Hanan ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Ulnar Nerve ◽  
Functional Outcomes ◽  
P Value ◽  
Supracondylar Fractures ◽  
Group I ◽  
Pin Fixation ◽  
Group Ii ◽  
Carrying Angle ◽  
Ulnar Nerve Injury

Objectives: To compare the complications and outcomes of lateral entry pin fixation with medial and lateral pin fixation for Gartland type III supracondylar fractures of humerus. Methodology: This prospective comparative study involving 190 patients of Gartland type III close supracondylar fractures were included. from March-2019 to Dec-2020. In all patients, initially the elbow was mobilized using the splint placed above the elbow joint at 30 to 45 degrees’ flexion. After closed reduction, lateral pinning was applied in group I and in group II lateral and medial cross pinning was applied using the standard protocol. Patients were followed for iatrogenic ulnar nerve injury, radiologic and function outcomes in-terms of loss of reduction, elbow range of motion, loss in carrying angle and functional outcomes. Results: The two groups were comparable for loss of elbow range of motion, loss of carrying angle and loss of Bauman's angle. On clinical examination, immediate post-operative ulnar nerve injury was diagnosed in 4 (4.2%) cases in group II and in no patient in group I (p-value 0.12). Satisfactory functional outcomes were achieved in 85 (89.5%) patients in group I and in 88 (92.6%) patients in group II (p-value 0.44). Conclusion: Lateral pinning provided stable fixation clinically and radiologically as compared to lateral and medial cross pinning. Keywords: Supracondylar fracture of Humerus, Iatrogenic ulnar nerve injury, Lateral pin entry, lateral and medial cross pin entry.

Comparison of Adverse Outcomes in Cirrhotic and Non-Cirrhotic Patients with Covid-19 Disease

2021 ◽  
Vol 15 (7) ◽  
pp. 2289-2291
Author(s):  
Jahangir Anjum ◽  
Talal Safdar ◽  
Muhammad Imran ◽  
Muazzam Fuaad ◽  
Waheed Iqbal ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Teaching Hospital ◽  
Adverse Outcomes ◽  
Chronic Liver ◽  
P Value ◽  
Group I ◽  
Cirrhotic Patients ◽  
Group Ii ◽  
Disease Study

Objective: The aim of this study is to determine the comparison of adverse outcomes in cirrhotic and non-cirrhotic patients presented with coronavirus disease. Study Design: Place and Duration: The department of Medicine of Divisional Headquarters Teaching Hospital Mirpur Azad Kashmir and Mohiuddin Teaching Hospital, Mirpur AJK for six months during the period from October 2020 to March 2021. Methodology: Total 80covid-19 patients of both genders with or without chronic liver disease were enrolled in this study. Patients were aged between 20-55 years. Patients were divided in to two groups. Group I (with cirrhosis 40 patients) and group II (without cirrhosis 40 patients). Outcomes in term of mortality between both groups were examined. All the data was analyzed by SPSS 26.0 version. Results: There were 24 (60%) males and 16 (40%) were females with mean age 44.19±7.65 years in group I while in group II 27 (67.5%) and 13 (32.5%) patients were males and females with mean age 43.62±5.34 years. We found that mortality rate among patients of group I (cirrhotic) had high mortality rate13 (32.5%) as compared to patients without cirrhosis 5 (12.5%) in group II with p-value 0.0003. Conclusion: We concluded in this that frequency of adverse outcomes was significantly high among cirrhotic patients with coronavirus disease as compared to non-cirrhotic patients. Keywords: Corvid-19, Mortality, Chronic Liver Disease

scholarly journals Transport Factors Affecting the Outcome of Referred Neonates Admitted in A Tertiary Care Hospital

2018 ◽  
Vol 41 (3) ◽  
pp. 159-164 ◽  
Author(s):  
Madhabi Baidya ◽  
Mahfuza Shirin ◽  
Liton Chandra Saha
Keyword(s):  
Perinatal Asphyxia ◽  
Care Center ◽  
Tertiary Care ◽  
Preterm Neonates ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Neonatal Transport ◽  
Group I ◽  
Group Ii

Background: Adequate neonatal transport is a key component of care of the sick newborns who require referral to tertiary care center. Poor transportation is one of the iatrogenic factors associated with greater neonatal mortality. Neonatal transport is the greatest challenge faced today in our country. The purpose of this study was to find out characteristics of transport of referred neonates and to idention the factors that contribute to mortality.Methodology: This cross sectional study was conducted in Dhaka Shishu (Children) Hospital from June 2013 to November 2013. Both term and preterm neonates who were referred within first seven days of life were included and those with gross congenital abnormalities and left against medical advice were excluded from the study. After enrollment, data were collected using a structured questionnaire including birth details, interventions before transportation, reasons for referral, and details of transportation. Outcome & duration of hospital stay were also recorded. Neonates who were expired considered as group I and who were survived considered as group II. The study variables were analyzed for their association with immediate outcome by applying chi square test and t test. P value <0.05 was considered significant.Results: This study found that out of 332 neonates 181 were expired with 54.5% mortality rate. One eighty one neonates who were expired, considered as group I and one fifty one neonate were survived, considered as group II. The mortality was significantly high in male neonates [RR 0.80 (0.66-0.97)] and neonates those delivered at home [RR 1.34(1.10-1.64)] (p<0.05). Perinatal asphyxia, pre-term low birth weight, neonatal sepsis were the main causes of referral. It was found that transportation without any referral note [RR 1.40 (1.14- 1.71)], no advice regarding maintenance of airway[RR 1.50(1.17- 1.92)]and keeping warm [RR 1.51(1.17-1.950], resuscitation on admission [RR 1.63(1.23-2.17)] and transportation required > 3hours [RR 1.36(1.09-1.69)] were associated with significantly higher mortality among referred transported neonates(p<0.05).Conclusions: This study found that male neonates, home delivery, transportation without any referral note, no advice regarding maintenance of airway and keeping warm, resuscitation needed on admission and prolonged transportation time were significantly associated with mortality of referred transported neonates.Bangladesh J Child Health 2017; VOL 41 (3) :159-164

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