scholarly journals Henoch-Schoenlein Purpura Following Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Case Report

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Saeed Soleiman-Meigooni ◽  
Ramin Yaghmayee ◽  
Ramin Hamidi-Farahani ◽  
Mousa Ahmadi ◽  
Allahyar Taheri ◽  
...  
Keyword(s):  
Oral Prednisolone ◽  
Small Vessel Vasculitis ◽  
Histopathological Study ◽  
The Novel ◽  
Case Presentation ◽  
Immune Mediated ◽  
Perivascular Inflammation ◽  
Infection Disease ◽  
Maculopapular Rashes ◽  
Novel Coronavirus

Introduction: As the novel coronavirus pandemic continues to affect people worldwide, immune-mediated inflammatory syndromes related to this virus have been reported. SARS Coronavirus-2 infection disease (COVID-19) may accompany various cutaneous symptoms, such as viral exanthems or wheels. These symptoms may occur at the early course of the disease or after that. Cutaneous symptoms of COVID-19 usually have a favorable outcome. Case Presentation: We presented a rare case of inpatient COVID-19 pneumonia, who developed a purpuric rash, abdominal pain, and hematuria. His dermal histopathological study revealed small-vessel vasculitis. We diagnosed Henoch–Schoenlein purpura based on clinical and histopathological findings and treated him with intravenous dexamethasone followed by oral prednisolone. The purpuric rashes disappeared in two weeks. Conclusions: Cutaneous manifestation of COVID-19 is usually diffuse maculopapular rashes. Other presentations include vesicular rashes and acral cyanosis. Dermal histopathological study in most patients with COVID-19 who developed cutaneous symptoms revealed perivascular inflammation and microthrombus in some cases. Thus, COVID-19 should be considered in any patient with a new onset of cutaneous symptoms.

scholarly journals Acute motor-sensory axonal polyneuropathy variant of Guillain–Barre syndrome complicating the recovery phase of coronavirus disease 2019 infection: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ahmed Maseh Haidary ◽  
Sarah Noor ◽  
Esmatullah Hamed ◽  
Tawab Baryali ◽  
Soma Rahmani ◽  
...  
Keyword(s):  
Recovery Phase ◽  
Sudden Onset ◽  
Therapeutic Interventions ◽  
Guillain Barre Syndrome ◽  
The Novel ◽  
Case Presentation ◽  
Progressive Muscle Weakness ◽  
Guillain Barré Syndrome ◽  
Novel Coronavirus ◽  
Guillain Barré

Abstract Introduction The novel coronavirus, since its first identification in China, in December 2019, has shown remarkable heterogeneity in its clinical behavior. It has affected humans on every continent. Clinically, it has affected every organ system. The outcome has also been variable, with most of the older patients showing grave outcomes as compared with the younger individuals. Here we present a rare and severe variant of Guillain–Barre syndrome that complicated the disease in recovery phase. Case presentation A 60-year-old Afghan man, who had been recovering from symptoms related to novel coronavirus associated disease, presented with sudden onset of progressive muscle weakness and oxygen desaturation. Electrophysiological workup confirmed the diagnosis of Guillain–Barre syndrome, and early institution of intravenous immunoglobulin resulted in complete resolution. Conclusion Guillain–Barre syndrome has recently been reported in many patients diagnosed with novel coronavirus associated disease. While clinical suspicion is mandatory to guide towards an effective diagnostic workup, early diagnosis of this complication and timely institution of therapeutic interventions are indispensable and lifesaving.

scholarly journals Nonepileptic Myoclonus in COVID-19: Case Report

2021 ◽  
pp. 194187442110043
Author(s):  
Henly Hewan ◽  
Annie Yang ◽  
Aparna Vaddiparti ◽  
Benison Keung
Keyword(s):  
Case Report ◽  
Critically Ill ◽  
Recovery Phase ◽  
Critically Ill Patient ◽  
High Dose ◽  
The Novel ◽  
Neurological Manifestations ◽  
Immune Mediated ◽  
Novel Coronavirus ◽  
Post Infectious

In late 2019, the novel coronavirus, SARS-CoV-2, and the disease it causes, COVID-19, was identified. Since then many different neurological manifestations of COVID-19 have been well reported. Movement abnormalities have been rarely described. We report here a critically ill patient with COVID-19 who developed generalized myoclonus during the recovery phase of the infection. Myoclonus was associated with cyclical fevers and decreased alertness. Movements were refractory to conventional anti-epileptic therapies. There was concern that myoclonus could be part of a post-infectious immune-mediated syndrome. The patient improved fully with a 4-day course of high-dose steroids. Our experience highlights a rare, generalized myoclonus syndrome associated with COVID-19 that may be immune-mediated and is responsive to treatment.

scholarly journals Immunopathogenesis of COVID-19 and early immunomodulators

2020 ◽  
Vol 63 (7) ◽  
pp. 239-250 ◽  
Author(s):  
Kyung-Yil Lee ◽  
Jung-Woo Rhim ◽  
Jin-Han Kang
Keyword(s):  
Lung Injury ◽  
Early Stage ◽  
Severe Pneumonia ◽  
Biochemical Properties ◽  
Etiologic Agent ◽  
Host Immune System ◽  
The Novel ◽  
Immune Mediated ◽  
Novel Coronavirus ◽  
Current Guidelines

The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ cells are unknown. It has been suggested that in viral pneumonia, virus itself is not a direct cause of acute lung injury; rather, aberrant immune reactions of the host to the insults from viral infection are responsible. According to its epidemiological and clinical characteristics, SARS-CoV-2 may be a virus with low virulence in nature that has adapted to the human species. Current immunological concepts have limited ability to explain such unsolved issues, and a presumed immunopathogenesis of COVID-19 is presented under the proteinhomeostasis-system hypothesis. Every disease, including COVID-19, has etiological substances controlled by the host immune system according to size and biochemical properties. Patients with severe pneumonia caused by SARS-CoV-2 show more severe hypercytokinemia with corresponding lymphocytopenia than patients with mild pneumonia; thus, early immunomodulator treatment, including corticosteroids, has been considered. However, current guidelines recommend their use only for patients with advanced pneumonia or acute respiratory distress syndrome. Since the immunopathogenesis of pneumonia may be the same for all patients regardless of age or severity and the critical immune-mediated lung injury may begin in the early stage of the disease, early immunomodulator treatment, including corticosteroids and intravenous immunoglobulin, can help reduce morbidity and possibly mortality rates of older patients with underlying conditions.

scholarly journals The First Case of Reactive Arthritis Associated with SARS-CoV-2-Infection in A 4-Year Old Child

2020 ◽  
Author(s):  
Stephanie Gabriele Werner ◽  
Hans-Eckhard Langer
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Reactive Arthritis ◽  
Virus Disease ◽  
The Novel ◽  
Case Presentation ◽  
Corona Virus ◽  
First Case ◽  
Novel Coronavirus ◽  
The Right

Abstract Background: The novel coronavirus SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2) and its associated disease COVID‐19 (Corona Virus Disease 19) has become a worldwide pandemic since its first cases in December 2019 in Wuhan Province in China. In Germany the pandemic started in February 2020.Case presentation: A 4 year old boy was presented and suffered from pain in the right hip. Arthrosonography demonstrated a significant effusion in the involved joint. The extended history revealed a slight but long lasting cold before. Serological findings were inconspicuous except for positive ELISA (Enzyme-linked Immuno Sorbent Assay) - test for SARS-CoV-2. Conclusion: In conclusion we believe that we can report the first case of reactive arthritis associated with SARS-CoV-2 in children.

scholarly journals Atypical Respiratory Distress Suspect of COVID-19 in Eastern Democratic Republic of the Congo prior to the Pandemic. A Case Report

2020 ◽  
Author(s):  
Guy-Quesney Mateso ◽  
Marius BAGUMA ◽  
Pacifique Mwene-Batu ◽  
Ghislain Maheshe Balemba ◽  
Fabrice Nzabara ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Democratic Republic ◽  
Atypical Pneumonia ◽  
X Rays ◽  
The Novel ◽  
Case Presentation ◽  
Republic Of The Congo ◽  
Novel Coronavirus ◽  
Laboratory Changes ◽  
Official Declaration

Abstract Background: Predictions have been made that Africa would be the most vulnerable continent to the novel Coronavirus disease 2019 (COVID-19). Interestingly, the spread of the disease in Africa seems to have been delayed and initially slower than in many parts of the world. Here we report on two cases which make us suspect that COVID-19 might have been present in our region before the official declaration of the disease in December 2019. Case presentation: These two cases (one 55-year-old man and one 25-year-old woman) of acute respiratory distress secondary to atypical pneumonia were seen in Bukavu, in Eastern Democratic Republic of the Congo (DRC), between September and December 2019. One patient had returned from China and the other had close contacts with travellers from China in the 2 weeks prior to the onset of symptoms. In either case, the aetiology could not be accurately determined. However, the two cases presented a clinical picture (progressive dyspnoea, preceded by dry cough and fever) and laboratory changes (procalcitonin within the normal range, slight inflammation, and lymphopenia) compatible with a viral infection. The chest X-Rays series of the first patient showed lesions (reticulations, ground glass, and nodules ≤ 6 mm) similar to those found in COVID-19. In addition, unlike the 25-year-old female patient who had no comorbidity, the 55-year-old male patient who had hypertension as comorbidity, developed a more severe acute respiratory distress which progressed to death.Conclusion: These cases bring to the attention a number of facts which make us suspect that COVID-19 may have already been present in the region months before the official beginning of the pandemic. This is important, as prior presence of the disease or infections with related virus may account for the delayed and less extensive development of the epidemic in the region.

scholarly journals Henoch–Schoenlein Purpura Following Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Case Report and Short Review of Histopathological Changes in Dermis

2021 ◽  
Author(s):  
Saeed Soleiman-Meigooni ◽  
Ramin Hamidi-Farahani ◽  
Mousa Ahmadi ◽  
Ali Asgari ◽  
Ramin Yaghmaee
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Short Review ◽  
The Novel ◽  
Histopathological Changes ◽  
Immune Mediated ◽  
Novel Coronavirus ◽  
Purpuric Rash

As the novel Coronavirus pandemic continues to affect people worldwide, immune-mediated inflammatory syndromes have been reporting related to this virus. We presented a case of novel Coronavirus pneumonia, who developed a purpuric rash, abdominal pain, and hematuria, diagnosed with Henoch–Schoenlein purpura.

scholarly journals It Takes More than Two to Tango with COVID-19: Analyzing Argentina’s Early Pandemic Response (Jan 2020–April 2020)

2020 ◽  
Vol 18 (1) ◽  
pp. 73
Author(s):  
Analya Romo ◽  
Citlaly Ojeda-Galaviz
Keyword(s):  
Health Systems ◽  
International Travel ◽  
The Novel ◽  
Case Presentation ◽  
Health Authorities ◽  
Control And Prevention ◽  
Rapid Transmission ◽  
Pandemic Response ◽  
Novel Coronavirus

In November 2019, the world was introduced to a new coronavirus that has since ravaged it. Argentina began to see an increase of COVID-19 quickly in the new year and as of April 2020 the country was still being burdened by the transmission of the virus. With the progression of the epidemic turning into a pandemic, health authorities constantly updated health prevention strategies and responses to the novel coronavirus in its first wave. The Center for Disease Control and Prevention (CDC) issued a level three warning for international travel to/from Argentina because of COVID-19′s rapid transmission. With Argentina’s already fragile economy, health systems had to meet the challenge of being able to treat the infected. This case presentation aims to provide an overview of Argentina’s earliest epidemiological situation of the COVID-19 pandemic. The data provided in this study concern Argentina’s COVID-19 situation during the period of January 2020–April 2020. Mathematical modeling was used to forecast COVID-19 transmission after the first wave, specifically focusing on Buenos Aires. The country’s demographics and an impression of its health systems will be analyzed in this case presentation for preparedness. The case study concludes in depicting Argentina’s current and anticipated economic, social, and political disruptions because of the first wave of the pandemic.

scholarly journals Sequential use of hemadsorption using Cytosorb® and Biosky® filter- technology in a COVID-19 patient suffering from severe ARDS

2020 ◽  
Author(s):  
Matthias Mezger ◽  
Ingo Eitel ◽  
Stephan Ensminger ◽  
Dirk Pogorzalek ◽  
Zhipan Huang ◽  
...  
Keyword(s):  
Distress Syndrome ◽  
Fluid Management ◽  
Critical Discussion ◽  
World Health ◽  
The Novel ◽  
Case Presentation ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Abstract In March 2020, the World Health Organization (WHO) declared the novel coronavirus disease (COVID- 19) pandemic. Here, we present the case of a patient who was admitted to our hospital with acute respiratory distress syndrome (ARDS) following infection with COVID-19. After initial stabilization through restrictive fluid management, hemadsorption using Cytosorb® was performed and finally temporary extubation of the patient was possible. However, the patient again clinically deteriorated and needed ventilation and finally ECMO-support and high catecholamine application. Whilst being on VV- ECMO, hemadsorption using Biosky® MG 350 filter was performed. In this manuscript, after a brief overview of the role of hemadsorption in ARDS, a detailed case presentation is followed by a critical discussion of the current literature.

scholarly journals First patient management of COVID-19 in Changsha, China: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jian Zhou ◽  
Ziqin Cao ◽  
Wanchun Wang ◽  
Kang Huang ◽  
Fang Zheng ◽  
...  
Keyword(s):  
Low Dose ◽  
Chest Ct ◽  
Interferon Alfa ◽  
The Novel ◽  
Case Presentation ◽  
Negative Results ◽  
Short Period ◽  
Bilateral Lung ◽  
Novel Coronavirus ◽  
Global Health Problem

Abstract Background In December 2019, the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, Hubei Province, China. It rapidly spread and many cases were identified in multiple countries, posing a global health problem. Here, we report the first patient cured of COVID-19 infection in Changsha, China, and the symptoms, diagnosis, treatment, and management of this patient are all described in this report. Case presentation A 57-year-old woman developed cough and fever after returning to Changsha from Wuhan on January 9, 2020. She tested positive for COVID-19 infection, a diagnosis which was supported by chest CT. The patient was treated with lopinavir and ritonavir tablets and interferon alfa-2b injection. A low dose of glucocorticoids was used for a short period to control bilateral lung immune response, and this patient avoided being crushed by cytokine storms that might have occurred. The clinical condition of this patient improved, and a COVID-19 assay conducted on January 25, 2020 generated negative results. This patient recovered and was discharged on January 30, 2020. Conclusions Currently, there are numerous reports on COVID-19 infections focusing on the disease’s epidemiological and clinical characteristics. This case describes the symptoms, diagnosis, treatment, and management of a patient cured of COVID-19 infection, which may serve as reference for future cases, while further studies are needed.

Thoughts of death, depression, and guilt in a healthcare worker who infected her husband with SARS-CoV-2: A case report.

2020 ◽  
Vol 19 ◽  
Author(s):  
Isabella Berardelli ◽  
Antonio Vaia ◽  
Maurizio Pompili
Keyword(s):  
Case Report ◽  
Mental Disorders ◽  
European Country ◽  
Healthcare Worker ◽  
Healthcare Workers ◽  
The Novel ◽  
Psychological Pain ◽  
Case Presentation ◽  
Novel Coronavirus ◽  
Deep Sense

Background: The worldwide spread of the novel coronavirus (SARS-CoV-2) has exposed healthcare workers (HCWs) to physical and mental disorders both directly and indirectly related to the pandemic. Italy was the first European country affected by the SARS-CoV-2 pandemic, and Italian HCWs have presented adverse psychological outcomes related to work and emotional overload and the fears of becoming infected and infecting others, particularly loved ones. Case Presentation: We report the case of a 61-year-old HCW who likely infected her husband with SARS-CoV-2, leading to his death. We assessed the depressive and anxious symptoms that the patient experienced after the death of her husband, which were characterized by a deep sense of guilt, psychological pain, and thoughts of death.

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