scholarly journals Effects of physical training and potassium supplementation on blood pressure, glucose metabolism and albuminuria of spontaneously hypertensive rats

2014 ◽  
Vol 36 (3) ◽  
Author(s):  
Evelyn Manuella Martins Gomes Jodas ◽  
Aline Francisco Voltera ◽  
Milton Ginoza ◽  
Osvaldo Kohlmann Junior ◽  
Nelson Brancaccio dos Santos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Metabolism ◽  
Physical Training ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Potassium Supplementation

scholarly journals Rice Bran Fractions Improve Blood Pressure, Lipid Profile, and Glucose Metabolism in Stroke-Prone Spontaneously Hypertensive Rats

2006 ◽  
Vol 54 (24) ◽  
pp. 9277-9277
Author(s):  
Ardiansyah ◽  
Hitoshi Shirakawa ◽  
Takuya Koseki ◽  
Kousaku Ohinata ◽  
Katsumi Hashizume ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Rice Bran ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Physical Training as a Blood Pressure Reducer and a Remodeler of Cardiac Fibers in Spontaneously Hypertensive Rats (SHR)

2021 ◽  
pp. 22-30
Author(s):  
Mariana Molinar Mauad Cintra ◽  
Matheus Ribeiro Bizuti ◽  
Octávio Barbosa Neto ◽  
Marlene Antônia dos Reis ◽  
Lenaldo Branco Rocha ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Physical Training ◽  
Spontaneously Hypertensive Rats ◽  
Cardiac Fibrosis ◽  
Left Ventricular ◽  
Type Iii Collagen ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Type Iii

Background: Hypertension is the most prevalent of all cardiovascular diseases, reaching target organs such as the heart. Blood pressure control is critical for preventing organ damage induced by hypertension. Objective: To analyze blood pressure, heart rate, left ventricular thickness, the percentage of cardiac fibrosis and the percentage of type III collagen in Spontaneously Hypertensive Rats (SHR) submitted to swimming physical training. Methods: The experimental groups were composed of male Wistar Kyoto (WKY) rats (309-311g), which were divided into: 1) Normotensive Sedentary group (SN) (n = 6); 2) Trained Normotensive group (TN) (n = 6); 3) Sedentary Hypertensive group (SH) (n = 6); 4) Trained Hypertensive group (TH) (n = 6). After the end of the protocol, the animals were initially anesthetized to measure blood pressure. Results: Physical training was responsible for decreasing blood pressure (F = 16,968; p <0.001) and heart rate (F = 10.710; p = 0.004) in the trained groups (normotensive and hypertensive). Moreover, training was responsible for providing an increase in the thickness of the left ventricle (F = 7,254; p = 0.014) and a reduction in the percentage of cardiac fibrosis (F = 16,081; p <0.001). Furthermore, it was observed that the trained group had lower values of type III collagen (F = 13,166; p = 0.002). Conclusions: Physical swimming training triggered a decrease in blood pressure, heart rate, the percentage of fibrosis and the percentage of type III collagen. In addition, there was also a cardiac remodeling due to the increase in left ventricular hypertrophy.

Rice Bran Fractions Improve Blood Pressure, Lipid Profile, and Glucose Metabolism in Stroke-Prone Spontaneously Hypertensive Rats

2006 ◽  
Vol 54 (5) ◽  
pp. 1914-1920 ◽  
Author(s):  
Ardiansyah ◽  
Hitoshi Shirakawa ◽  
Takuya Koseki ◽  
Kousaku Ohinata ◽  
Katsumi Hashizume ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Rice Bran ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Effect of potassium supplementation on blood pressure and vasodilator mechanisms in spontaneously hypertensive rats

1988 ◽  
Vol 75 (5) ◽  
pp. 527-534 ◽  
Author(s):  
Anne Barden ◽  
Lawrence J. Beilin ◽  
Robert Vandongen
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Hydrolysis Product ◽  
Pressure Rise ◽  
Plasma Renin ◽  
Renin Activity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Potassium Supplementation ◽  
Blood Pressure Rise

1. Supplementation with 1% (w/v) KCl solution significantly attenuated the blood pressure rise with age normally observed in spontaneously hypertensive rats, resulting in a difference in blood pressure of 18 mmHg after 5 weeks. 2. Urinary 6-keto-prostaglandin F1α (the stable hydrolysis product of prostacyclin) and kallikrein excretion were significantly elevated in rats receiving potassium. 3. No difference was observed in sodium excretion during the initial days of potassium supplementation; however, the potassium-supplemented animals excreted relatively more sodium over the 5 week period. 4. Plasma renin activity was significantly reduced in those animals receiving potassium after 5 weeks. 5. It is proposed that a combination of increased systemic and/or renal prostacyclin and kallikrein synthesis may, in combination with reduced renin activity, contribute to the attenuation of blood pressure in potassium-supplemented spontaneously hypertensive rats.

scholarly journals Effects of Chronic Cholinergic Stimulation Associated With Aerobic Physical Training on Cardiac Morphofunctional and Autonomic Parameters in Spontaneously Hypertensive Rats

2021 ◽  
Author(s):  
Camila B. Gardim ◽  
Ana Catarine V. Oliveira ◽  
Bruno Augusto Aguilar ◽  
Stella V. Philbois ◽  
Hugo C. D. Souza
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Physical Training ◽  
Spontaneously Hypertensive Rats ◽  
Low Frequency ◽  
Pyridostigmine Bromide ◽  
Cholinergic Stimulation ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pharmacological Blockade

Abstract We investigated in spontaneously hypertensive rats (SHR) the hemodynamic, cardiac morphofunctional, and cardiovascular autonomic adaptations after a protocol of aerobic physical training associated with chronic cholinergic stimulation. Fifty-four SRH were divided into two groups: trained and untrained. Afterward, each group was subdivided into three smaller groups: vehicle, treated with pyridostigmine bromide at 5mg/kg/day, and at 15mg/kg/day. The following protocols were assessed: echocardiography, autonomic double pharmacological blockade, analysis of heart rate variability (HRV), blood pressure variability (BPV), and baroreflex sensitivity (BRS). Physical training and pyridostigmine bromide reduced blood pressure and heart rate and increased vagal participation in cardiac tonic autonomic balance. Associated the responses were potentialized. Pyridostigmine bromide increased the oscillation of low frequency (LF:0.2-0.75Hz) and high frequency (HF:0.75-3Hz) of HRV. However, the association with physical training attenuated HF oscillations. Pyridostigmine bromide also increased LF oscillations of BPV. Both treatments promoted morphofunctional adaptations and associated increased the ejection volume, ejection fraction, cardiac output, and cardiac index. In conclusion, the association of pyridostigmine bromide and physical training promoted greater benefits in hemodynamic parameters and increase vagal influence on cardiac autonomic tonic balance. Nonetheless, pyridostigmine bromide alone seems to negatively affect BPV, while the association of treatment negatively influences HRV.

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