Bất thường nhiễm sắc thể và liên quan tới kết quả điều trị sớm lơ xê mi cấp dòng lympho trẻ em tại Viện Huyết học - Truyền máu Trung ương giai đoạn 2016 - 2019

Cytogenetic variables in pediatric acute lymphoblastic leukemia (ALL) plays an important role in prognosis and risk grouping. Evaluation of early result treatment based on cytogenetic mutations provides data for physicians in treatment options for pediatric patients. Objectives: Study on characteristics of chromosomal abnormalities and evaluate the relationship with the early result of treatment according to FRALLE 2000 protocol at the National Institute of Hematology and Blood Transfusion. Subjects and research methods: This was a prospective study conducted on 188 pediatric ALL patients who were treated at the National Institute of Hematology and Blood Transfusion from August 1, 2016 to August 1, 2019. Results: The incidence of chromosomal abnormalities in pediatric ALL patients was 13.8%. Structural abnormalities were more common (57.7% of structural abnormalities alone, 15.4% combined with structural and numberal abnormalities, 26.9% of numberal abnormalities alone). The most common structural abnormality was chromosomal translocations, in which t(9;22) was the most common. Hyperdiploid accounted 90.9% in the abnormal number of chromosomes. The poor prognosis group accounted for a higher proportion in the study. The good prognosis chromosome group had the best treatment results (Overal Survival - OS 12 months reached 100%, Event Free Survival - EFS 12 months reached 80.0 ± 17.9%). The group with the poor prognosis of chromosome: OS 12 was only 66.0 ± 11.3%, EFS 49.4 ± 12.2%. The difference was statistically significant with p <0.01. The normal chromosome group had good OS and EFS for 12 months, 90.4 ± 2.6% and 77.9 ± 3.6%, respectively. Conclusion: The rate of abnormalities chromosome was low. Structural mutations were more common. Hyperdiploid was mainly seen on numberal chromosome abnormalities. This study found the difference in survival time between the groups according to the chromosome prognosis.

PERBAIKAN KINERJA PERUSAHAAN DENGAN METODE KRITERIA PENILAIAN KINERJA UNGGUL (KPKU BUMN)

PT X adalah perusahaan yang bergerak di bidang jasa. Seiring dengan perkembangan bisnis perusahaan dan dinamika bisnis eksternal, perusahaan bermaksud melakukan penilaian kondisi bisnis perusahaan. Kondisi bisnis perusahaan akan menjadi dasar bagi perusahaan untuk melakukan perencanaan bisnis ke depan dan sekaligus mengelola bisnis saat ini. Proses penilaian dilakukan dengan penerapan kriteria penilaian kinerja unggul (KPKU) BUMN. KPKU BUMN sendiri adalah adopsi dan adaptasi kriteria Malcolm Baldrige yang berasal Amerika Serikat. Ouput dari metode KPKU adalah skor dan band skor, yang menggambarkan kinerja perusahaan secara umum. Hasil penerapan KPKU telah menghasilkan perbaikan kinerja dimana pada tahun 2010, skor Perusahaan sebesar 233,1 (early development) dan setelah melakukan perbaikan, skor pada tahun 2013 sebesar 324 (early result), pada tahun 2017 dilakukan assesment dengan skor 441.25(early development). Kata Kunci: early result, early development, malcolm baldrige, kpku