thiophene derivative
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2021 ◽  
pp. 2100058
Author(s):  
Somaya A. Abdel‐Rahman ◽  
Emad I. Wafa ◽  
Kareem Ebeid ◽  
Sean M. Geary ◽  
Youssef W. Naguib ◽  
...  

2021 ◽  
Author(s):  
Kotaro Obayashi ◽  
Taiki Higashino ◽  
Keiichi Imato ◽  
Yousuke Ooyama

We report an efficient synthetic method for 1,1′,3,3′-tetrasubstituted-4,4′-bibenzo[c]thiophene derivative with different substituents on the thiophene rings and its photophysical properties in the solution and the solid state, electrochemical properties and...


RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 9894-9900
Author(s):  
Cătălin C. Anghel ◽  
Ioan Stroia ◽  
Alexandra Pop ◽  
Atilla Bende ◽  
Ion Grosu ◽  
...  

Serendipitous synthesis of a novel naphtho[2,3-b]thiophene derivative. Detailed investigation of the structure and properties as well as a possible mechanism for its formation.


Heliyon ◽  
2020 ◽  
Vol 6 (11) ◽  
pp. e05520
Author(s):  
Ryldene Marques Duarte da Cruz ◽  
Renan Marinho Braga ◽  
Humberto Hugo Nunes de Andrade ◽  
Álefe Brito Monteiro ◽  
Isadora Silva Luna ◽  
...  
Keyword(s):  

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3821
Author(s):  
Jih Ru Hwu ◽  
Avijit Panja ◽  
Srinivasan Jayakumar ◽  
Shwu-Chen Tsay ◽  
Kui-Thong Tan ◽  
...  

The modern world has no available drugs for the treatment of enteroviruses (EV), which affect millions of people worldwide each year. The EV71 is a major causative disease for hand, foot, and mouth disease; sometimes it is associated with severe central nervous system diseases. Treatment for enteroviral infection is mainly supportive; treatment for aseptic meningitis caused by enteroviruses is also generally symptomatic. Upon the urgent request of new anti-enterovirus drugs, a series of hinged aromatic compounds with polynulei were synthesized through two different chemical pathways. Among these morpholine–furan/thiophene/pyrrole–benzene–pyrazole conjugates, three new agents exhibited inhibitory activity with EC50 = 2.29–6.16 μM toward EV71 strain BrCr in RD cells. Their selectivity index values were reached as high as 33.4. Their structure–activity relationship was deduced that a thiophene derivative with morpholine and trifluorobenzene rings showed the greatest antiviral activity, with EC50 = 2.29 μM.


2020 ◽  
Vol 51 (2) ◽  
pp. 647-655
Author(s):  
Wendell Wons Neves ◽  
Rejane Pereira Neves ◽  
Danielle Patrícia Cerqueira Macêdo ◽  
Giovanna Rodrigues de Araújo Eleamen ◽  
Elisângela Afonso de Moura Kretzschmar ◽  
...  

2020 ◽  
Vol 219 ◽  
pp. 116919 ◽  
Author(s):  
Zhixiang Gao ◽  
Fang Zhang ◽  
Long Gao ◽  
Xiangbin Tian ◽  
Wenshan Qu ◽  
...  

2020 ◽  
Vol 330 ◽  
pp. 135186 ◽  
Author(s):  
Lin-Xin Li ◽  
Zhi-Hui Xie ◽  
Carlos Fernandez ◽  
Liang Wu ◽  
Daojian Cheng ◽  
...  

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