Masson’s Tumour: A Rare Cause of Cervical Mass

Masson's tumour, also known as intravascular papillary endothelial hyperplasia, is a rare non-neoplastic lesion of vascular origin, caused by an excessive reactive proliferation of endothelial cells in normal blood vessels or vascular malformations. It can affect any part of the body, presenting most frequently in the vessels of the head, neck and upper extremities. The authors describe the case of a 76-year-old female patient presenting an anterior cervical mass, measuring 2×2 cm, which was mobile, tender and slightly painful with no alteration of the overlying skin. Complementary study with ultrasound and computed tomography was inconclusive. Total excision of the lesion was performed with histology compatible with intravascular papillary endothelial hyperplasia.

Masson’s Tumour - Case Report of a Malignant Masquerader with Literature Review

Masson’s tumour, an uncommon, benign vascular disorder was first described by Pierre Masson in 1923 as an intravascular papillary proliferation that emerged from an inflamed hemorrhoidal vein of a 68-year-old man and termed it as “Hemangioendotheliome vegetant intravasculaire”.1 He interpreted the lesion as a form of neoplasm, however, Henschen portrayed it as a reactive phenomenon. The current terminology intravascular papillary endothelial hyperplasia (IPEH) was put forward by Clearkin and Enzinger in 1976 considering it as a reactive change occurring secondary to trauma-related vascular stasis.2 The tumour constitutes 2-4 % of all skin and soft tissue tumours. The common locations are head, neck and extremities.3 Masson’s tumour being a benign entity with an excellent prognosis is essential to differentiate from its closer mimic, angiosarcoma which needs aggressive treatment. This case is put up here because of its rarity and its clinical implications.

Periocular intravascular papillary endothelial hyperplasia: A retrospective study

Introduction: Intravascular papillary endothelial hyperplasia (IPEH) is a rare proliferation of endothelial cells with uncertain etiology related to thrombus formation. Diagnosis is usually confirmed histopathologically. This condition has been previously described in the periocular region but not in the conjunctiva. Methods: It is a retrospective case series in which we evaluated seven patients with histopathologically confirmed IPEH cases. Data regarding the demographics, clinical presentation, radiological description, histopathological features including any IHC staining, suspected underlying vascular etiology, management options, and follow up outcome were collected. Results: A total of seven cases of histologically confirmed IPEH were included. Five out of seven patients were male (71.4%). The age range was between 6 and 69 years with a median age of 36 years. Three cases involved the eyelid (42.8%) and another three were found in the conjunctiva (42.8%). Pre-existing underlying vascular lesions were observed in all patients, five malformations (mostly lymphatic-venous) and two conjunctival hemorrhagic lymphangiectasis. All cases were treated with excisional biopsy with no signs of recurrence within an average of 7 months follow up. Conclusions: Periocular IPEH is a rare tumor that is likely to coexist with underlying vascular lesions and thrombus formation. We are reporting its existence in the conjunctiva for the first time. Therefore, pathologists should be aware of the histopathological spectrum of this lesion.

Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor) of the Submandibular Gland: A Case Report

Intravascular papillary endothelial hyperplasia (IPEH), a rare benign endothelial vascular lesion related to thrombosis, generally develops in fingers, trunk, head, and neck. Nevertheless, it has been rarely reported in the salivary gland. In this article, we report a case of IPEH of the right submandibular gland in a 37-year-old female whose initial impression was sialadenitis secondary to sialolithiasis. To date, our case may be the first well-documented report of IPEH in the submandibular gland. The patient underwent ablation of the submandibular gland, and no evidence of recurrence was found during follow-up.