Introduction. The use of repellents and insecticides is the most important method of protection against mosquitoes. In the scientific literature, there is practically no information about the risk from mosquito bitesl to human health due to the non-use of these funds. The information on the prevalence, infection of mosquito-carriers of infectious agents was studied; biological risks from non-use of repellents and insecticides. The aim of the study is to develop methodological approaches to assessing the reduction of health risk from mosquito bites due to the use of repellent and insecticidal agents. Materials and methods. The methods of studying relevant scientific literature, analysis of statistical reporting data, the main stages of the methodology for assessing health risks were used. Results. The proposed methodological approaches have been tested in various scenarios for the use of repellents and insecticides in comparison with the averted risks associated with the development of infectious diseases carried by mosquitoes. Conclusion. For the implementation of methodological approaches, scenarios and parameters of the development of the situation with the use of repellents and insecticides or their non-use are proposed. Indicators of individual, population and prevented health risks were calculated, considering the severity of harm to health. The personal health risk of West Nile fever (WNF) and dirofilariasis in non-endemic areas without application repellents and insecticides is assessed as acceptable - 1.2•10-8 and 1.7•10-5, respectively. At the territory with constantly recorded WNV incidence, the application of repellents or insecticides diminished the population risk of contracting fever by ten times. The averted health risk is 0.297 cases per 2.8 million population. When using repellents or insecticides, the population risk of dirofilariasis is significantly reduced. The averted health risk is 8.8 cases per population of 579 103 people.