Sertoli cell tumor of the testis causing intracranial metastasis two years after orchiectomy. Report of a rare case and review of the literature

Sertoli cell tumor of the testis (SCTT) accounts for less than 1% of all testicular tumors with only 10% of cases exhibiting malignant behavior. In the present report, a case of malignant SCTT causing multiple metastases in a 32-year-old man is described. After being diagnosed and treated for bone and lymph nodes metastases, the patient presented with a brief history of worsening headaches and visual impairment. A head MRI demonstrated an extra-axial tumor located in the right fronto-parietal junction exhibiting avid contrast enhancement and leptomeningeal involvement. To the best of the authors’ knowledge, this represents the second case of intracranial metastasis from SCTT described to date.

HISTOPATHOLOGICAL DIAGNOSTICS OF TESTICULAR SERTOLI CELL TUMOR IN INGUINAL CRYPTORCHIDISM

The research was carried out in the Interdepartmental Scientific Veterinary Center of Veterinary Medicine based in the Ulyanovsk State Agricultural University. We studied the testis tumor - sertoli cell tumor, according to histological classification, in a male dog with inguinal cryptorchidism. The research goal was to study possible changes in the differentiation, hormonal and metastatic activity of sertoli cell tumor in case of inguinal cryptorchidism in comparison with this type of tumor in physiologically located testes, described in literature. The clinical examination revealed the presence of left-sided inguinal cryptorchidism as well as signs of hyperestrogenism: hyperpigmentation and non-inflammatory alopecia of scrotum, prepuce, located sym-metrically in the right and left iliac regions of the abdomen. The studied neoplasm showed the presence of a dense capsule, the absence of infiltrative growth and metastases in the regional lymph nodes, distinct secretory activity. Fragments of tumor tissue from the testis, epididymis and spermatic cord were obtained for histological examination by the means of excisional biopsy. As a result, the neo-plasm was found to be a sertoli cell tumor of a high degree of differentiation. The tissues of the epididymis showed a significant thickening of the stroma due to the proliferation of connective tissue - a sign of severe sclerosis. The mi-croslides of the spermatic cord and epididymis did not show any signs of infiltrative growth or metastatic spread of tumor cells which meant that the relative benign quality of sertoli cell tumor was found in this clinical study of inguinal cryptorchidism.