Bremelanotide for Treatment of Female Hypoactive Sexual Desire

Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity, reduced responsiveness to erotic cues, a loss of interest during sexual activity, and avoidance of situations that could lead to sexual activity. The pathophysiology of HSDD is thought to be centered around inhibitory and excitatory hormones, neurotransmitters, and specific brain anatomy. Due to the multifactorial nature of HSDD, treatment can be complex and must attempt to target the biological and psychosocial aspects of the disorder. Bremelanotide is a melanocortin receptor agonist and has been recently approved by the FDA to treat HSDD. Bremelanotide is administered intranasally or as a subcutaneous injection. The recommended dosage of bremelanotide is 1.75 mg injected subcutaneously in the abdomen or thigh at least 45 min before sexual activity. Studies showed improvements in desire, arousal, and orgasm scores when 1.75 mg of bremelanotide was administered before sexual activity compared to a placebo. Bremelanotide is a promising way to treat HSDD.

Visual Histories of Sex

Increased access to visual archives and the proliferation of digitized images related to sexuality have led a growing number of scholars in recent years to place images and visual practices at the center of critical historical inquiries of sexual desire, subjectivity, and embodiment. At the same time, new critical histories of sexual science serve both to expand the temporal and geographical frames for investigating the historical relationships of sex and visual production, and to generate new lines of inquiry and reshape visual studies more broadly. The contributors to this issue invite us to ask: What new questions and challenges for the study of sex and sexual science are posed by critical studies of the visual? How are new visual methodologies that focus on archives changing the contours of historical knowledge about sex and sexuality? What—and where—are new methodologies still needed? “Visual Archives of Sex” aims to illuminate current research that centers visual media in the history of sexuality and that interrogates contemporary historiographies.

The Prevalence of Online Violence Against Female Students at a Private University in Malawi

This chapter presents findings of the study that investigated the prevalence of online violence against female students at the University of Livingstonia in Malawi. The study noted that female students experienced online bullying, online harassment, online defamation, online stalking, sexual exploitation, online hate speech, and revenge pornography. Perpetrators used digital platforms such Facebook, WhatsApp, dating sites, and smartphones to carry out their evil acts. The motivations by perpetrators were driven by revenge, anger, jealousy, and sexual desire, with the intentions to harm the victims socially, psychologically, academically, and physically. The female students confronted and blocked the perpetrator or left the online platform as a coping mechanism. Overall, the study confirmed that the prevalence of online violence against female students is burgeoning in universities in Malawi and urgent strategies are needed to address the vice.

Associations between Fluctuating Shame, Self-Esteem, and Sexual Desire: Comparing Frequent Porn Users and a General Population Sample

In the present study, we explore the proposed cyclic models for problematic hypersexuality (PH) that involve shame, self-esteem, and sexual desire. These cyclic models are characterized by temporal associations but have not been investigated previously with intensive longitudinal designs. In this study, we collected up to 70 measurements per participant within a period of seven consecutive days, which allowed us to investigate associations between fluctuations of shame, self-esteem, and sexual desire. Participants were divided in four subgroups: (1) women (n = 87); (2) men (n = 46) from a general population convenience sample; (3) men watching porn >2 times per week, showing non-problematic hypersexuality (NH; n = 10); and (4) men watching porn >2 times per week, experiencing PH (n = 11). Multilevel analyses, including cross-level interactions, were used to investigate between-group differences in intraindividual processes. Results showed that prior increases in shame forecasted higher current sexual desire for men with PH, but not for the other groups, suggesting that men with PH use sexual desire to downregulate dysphoric feelings of shame. Differences between groups in associations between self-esteem and sexual desire were also found. Based on our results, we propose the Split Pleasure/Shame model, which represents emotion dysregulation in PH, and juxtapose this with the pleasurable experience of sex by non-PH groups. Further intensive longitudinal research is necessary to test this model and, more generally, to investigate the fluctuating nature of sexual desire.