ReNPAD: a brazilian network for researchers in High Dilution

Some pertinent questions in the practice of science is to know what one is researching, with whom and where. These questions are even more crucial for those involved in High Dilution studies, an emergent and multidisciplinary scientific field, where concepts, methods and models are still to be validated. In this research field, such questions can be addressed through networks because communication between peers accelerates the process of conceiving and refining the concepts, methodologies and standards that give consistency to emergent knowledge. A thematic network can be effective in building an identity for the science of HDs and related community. This article introduces the project ReNPAD (National Network of Researchers in High Dilutions), a Brazilian initiative aiming to put together researchers involved in studies in HDs in order to stimulate interaction and give visibility to the theirs efforts.

ReNPAD: a brazilian network for researchers in High Dilution

Some pertinent questions in the practice of science is to know what one is researching, with whom and where. These questions are even more crucial for those involved in High Dilution studies, an emergent and multidisciplinary scientific field, where concepts, methods and models are still to be validated. In this research field, such questions can be addressed through networks because communication between peers accelerates the process of conceiving and refining the concepts, methodologies and standards that give consistency to emergent knowledge. A thematic network can be effective in building an identity for the science of HDs and related community. This article introduces the project ReNPAD (National Network of Researchers in High Dilutions), a Brazilian initiative aiming to put together researchers involved in studies in HDs in order to stimulate interaction and give visibility to the theirs efforts

Remaining Human in COVID-19: Dialogues on Psychogeography

Post-COVID-19 environments have challenged our embodied identities with these challenges coming from a variety of domains, that is, microbiological, semiotic, and digital. We are embedded in a new complex set of relations, with other species, with cultural signs, and with technology and venturing further into an era that pushes back on our anthropocentrism to create a post-human dystopia. This does not imply that we are less human or forfeit ethics in this state of flux, but can lead to considering new ways of being alive and humanists. The aim of this project was to explore walking through our associated psychogeographies as captured in photographs and text from individual walks, as the means by which to characterize responses to the distress of the pandemic and to assess resistance to non-being. The psychogeographies were the starting points for our dialogic enquiry between authors who each represent living theory, representing their own emergent knowledge, inseparable from personal commitments and history. Walking and the associated images and reflections, provided a way to regulate our affect, reconnecting with our bodies, leading to understand and adapt to new meanings of context and ways of coping and healing in this new becoming. The interdisciplinarity of philosophy, social psychology, botany, and clinical psychology is nonetheless rejected in favour of multi-vocality; each author representing their own emergent, living theory, inseparable from personal commitments, and history.

Emergent Knowledge in the Third Space of Art-Science

The locus of encounter between art, science and the public can be conceptualized as third space—a generative site of shared experience. This article reports on a group-based psychosocial method led by imagery and affect—the visual matrix—that enables researchers to capture and characterize knowledge emerging in third space, where disciplinary boundaries are fluid and there is no settled discourse. It presents an account of the visual matrix process in the context of an artscience collaboration on memory and forgetting. The authors show how the method illuminates aesthetic and affective dimensions of participant experience and captures the emerging, empathic and ethical knowing that is characteristic of third space.

The Episteme of Meta-Modernity: Order, Value, and Citizenship in the Space of ‘Digital Finitudes’

Fuelled by the neo-liberal division of labour, complexification acquired a life of its own. This gave a novel dimension to the growing gap between emergent knowledge and human systems, knowing and being, between the human content of work and its outcomes, value and citizenship. It is argued that here is one of the key reasons why most decisions are made in the chaotic space of ephemeral price relations manufactured by the data-rich, runaway ‘surveillance commoditism’. However, advances in quantitative, empirical methodologies also open an action space for a fresh research agenda. It is to recast our past and present into transparent, directional genealogical accounts of order generation and actualisation recording the ascent and limits of development as well as its pathways between the ‘lab & cloister’ and the social systems. It grounds a new, ‘meta-modern’ Foucauldian episteme in which the notion of order freed of power-hungry impositions assumes the role of an onto-epistemic variable and offers a rational base for defeating the prospect of ‘digitally enhanced serfdom’. The necessary condition for this agenda to begin to assert itself is a radical methodological transformation of educational and management programmes aimed at bottom up ownership of, and responsibility for the making, choosing, and symbolising, with a view to restoring value as a measure of actualisation of human independence and ability. Only then can knowledge live up to its foundational mission of liberation by reason.

RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease

One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination has been studied extensively. Here we focus on AID/APOBEC-catalyzed editing, and review the emergent knowledge regarding C-to-U editing consequences in the context of human disease.