AbstractIn building upon the cases presented in Chaps. 10.1007/978-3-030-88455-0_2, 10.1007/978-3-030-88455-0_3, and 10.1007/978-3-030-88455-0_4, we develop a Sociology of Interdisciplinarity that draws our empirical insights together with resources from Science and Technology Studies (STS), in addition to Sociology of Scientific Knowledge, Research Policy, Infrastructure Studies, Anthropology, and Philosophy of Science. The key novelty of this framework is using STS insights to unpick the dynamics and consequences of interdisciplinary science, which distinguishes us from decades of earlier interdisciplinarity studies and gaps in understanding. Moreover, we not only focus on individual scholars and their experiences but pay careful attention to the wider contexts of interdisciplinary research, such as the impacts of funding structures, different access to resources, and power relations. We are careful in our approach so that our units of analyses—which vary from research groups and projects to whole epistemic communities and research policies—are most appropriate for the problem definitions that we put forward. The framework rests on a set of six dimensions, which we discuss in relation to current debates in the literature and our empirical analyses.