The purpose of this study is to identify the factors influencing e-commerce and to evaluate the long and short-term impacts on the development of e-commerce activity. After establishing the hypotheses to verify, we use multiple panel regressions to test the influence of education level, consumer’s residence, consumer’s labour market status, internet banking, mobile and non-mobile users on the development of e-commerce. For this matter, in this paper, by adopting the fully modified ordinary least squares (FMOLS) method and a vector error correction model (VECM), we performed an empirical analysis of the nexus between education level, consumer’s residence, consumer’s labour market status, internet banking and mobile and non-mobile users and e-commerce, based on panel data for EU–27 countries from 2011 to 2020. The results of the study indicate that all the variables involved in the two econometric models and associated with education level, consumer’s residence, labour market status, internet banking, mobile and non-mobile users, all have significant impacts on the development of e-commerce. Most of the variables positively influence the development of e-commerce except for internet purchases by individuals un-employed and for internet purchases by non-mobile users that are negatively correlated with e-commerce activity.